Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 397(5), С. 2793 - 2833
Опубликована: Ноя. 22, 2023
Язык: Английский
Journal of Controlled Release, Год журнала: 2021, Номер 332, С. 312 - 336
Опубликована: Фев. 27, 2021
Polymeric micelles, i.e. aggregation colloids formed in solution by self-assembling of amphiphilic polymers, represent an innovative tool to overcome several issues related drug administration, from the low water-solubility poor permeability across biological barriers. With respect other nanocarriers, polymeric micelles generally display smaller size, easier preparation and sterilization processes, good solubilization properties, unfortunately associated with a lower stability fluids more complicated characterization. Particularly challenging is study their interaction environment, essential predict real vivo behavior after administration. In this review, general presentation on features different characterization techniques are discussed, ones used for determination basic characteristics (critical micellar concentration, surface charge, morphology) complex approaches figure out kinetic stability, release presence substrates (fluids, cells tissues). The presented (such as dynamic light scattering, AFM, cryo-TEM, X-ray FRET, symmetrical flow field-flow fractionation (AF4) density ultracentrifugation), each one own advantages limitations, can be combined achieve deeper comprehension behavior. set-up validation adequate methods description starting point development clinical success.
Язык: Английский
Процитировано
728
Polymers, Год журнала: 2022, Номер 14(12), С. 2510 - 2510
Опубликована: Июнь 20, 2022
Self-assembly of amphiphilic polymers with hydrophilic and hydrophobic units results in micelles (polymeric nanoparticles), where polymer concentrations are above critical micelle (CMCs). Recently, metal nanoparticles (MNPs) have been utilized many bio-applications because their excellent biocompatibility, pharmacokinetics, adhesion to biosurfaces, targetability, longevity. The size the is range 10 100 nm, different shapes developed for applications. Micelles focused recently on unique properties, size, shape, which enhance drug loading target release a controlled manner. This review how CMC has calculated using various techniques. Further, importance explained briefly, types discussed, further extensions application addressed. In summary outlook, points that need focus future research discussed. will help researchers development
Язык: Английский
Процитировано
209
Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 176, С. 113891 - 113891
Опубликована: Июль 26, 2021
CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9) is a potent technology for gene-editing. Owing to its high specificity and efficiency, extensity used human diseases treatment, especially cancer, which involves multiple genetic alterations. Different concepts of cancer treatment by are established. However, significant challenges remain clinical applications. The greatest challenge therapy how safely efficiently deliver it target sites in vivo. Nanotechnology has greatly contributed drug delivery. Here, we present the action mechanisms CRISPR/Cas9, application focus on nanotechnology-based delivery gene editing immunotherapy pave way translation. We detail difficult barriers CRISIR/Cas9 vivo discuss relative solutions encapsulation, delivery, controlled release, cellular internalization, endosomal escape.
Язык: Английский
Процитировано
181
Frontiers in Bioengineering and Biotechnology, Год журнала: 2019, Номер 7
Опубликована: Ноя. 22, 2019
While ultrasound is most widely known for its use in diagnostic imaging, the energy carried by waves can be utilized to influence cell function and drug delivery. Consequently, our ability at a given intensity unlocks opportunity therapeutic applications. Indeed, last decade ultrasound-based therapies have emerged with promising treatment modalities several medical conditions. More recently, combination nanomedicines, i.e. nanoparticles, has been shown substantial potential enhance efficacy of many treatments including cancer, Alzheimer disease or osteoarthritis. The concept combined delivery still infancy more research needed unfold mechanisms interactions different nanoparticles types various types. Here we present state-of-art ultrasound-assisted particular focus on cancer treatments. Notably, this review discusses application high non-invasive tumour ablation immunomodulatory effects ultrasound, as well nanoparticle-enhanced Furthermore, presents safety considerations related technology gives recommendations context system design operation.
Язык: Английский
Процитировано
176
Materials Chemistry Frontiers, Год журнала: 2021, Номер 5(10), С. 3788 - 3812
Опубликована: Янв. 1, 2021
Photodynamic therapy (PDT) uses photosensitizers (PSs) to treat some skin and eye diseases, certain types of cancer. In this review, we summarise the strategies design PSs how they can be incorporated into different nanostructures.
Язык: Английский
Процитировано
155
Acta Pharmaceutica Sinica B, Год журнала: 2021, Номер 11(4), С. 903 - 924
Опубликована: Фев. 27, 2021
The beneficial or deleterious effects of nanomedicines emerge from their complex interactions with intracellular pathways and subcellular fate. Moreover, the dynamic nature plasma membrane accounts for movement these nanocarriers within cell towards different organelles thereby not only influencing pharmacokinetic pharmacodynamic properties but also bioavailability, therapeutic efficacy toxicity. Therefore, an in-depth understanding underlying parameters controlling nanocarrier endocytosis fate is essential. In order to direct nanoparticles specific sub-cellular physicochemical attributes can be manipulated. These include particle size, shape surface charge/chemistry. Restricting size below 200 nm contributes internalization via clathrin caveolae mediated pathways. Similarly, a moderate negative potential confers endolysosomal escape targeting mitochondria, endoplasmic reticulum (ER) Golgi. This review aims provide insight into fabricated using amphiphilic graft copolymers affecting cellular internalization. Fundamental principles understood experimental studies have been extrapolated draw general conclusion designing optimized nanoparticulate drug delivery systems enhanced uptake endocytic pathway.
Язык: Английский
Процитировано
154
Cancers, Год журнала: 2022, Номер 14(3), С. 622 - 622
Опубликована: Янв. 26, 2022
Several drug-delivery systems have been reported on and often successfully applied in cancer therapy. Cell-targeted delivery can reduce the overall toxicity of cytotoxic drugs increase their effectiveness selectivity. Besides traditional liposomal micellar formulations, various nanocarrier recently become focus developmental interest. This review discusses preparation targeting techniques as well properties several liposome-, micelle-, solid-lipid nanoparticle-, dendrimer-, gold-, magnetic-nanoparticle-based systems. Approaches for targeted drug release under a range stimuli are also discussed.
Язык: Английский
Процитировано
91
Journal of Controlled Release, Год журнала: 2023, Номер 355, С. 552 - 578
Опубликована: Фев. 15, 2023
Язык: Английский
Процитировано
89
Frontiers in Oncology, Год журнала: 2022, Номер 12
Опубликована: Март 29, 2022
Cancer is a prominent cause of mortality globally, and it becomes fatal incurable if delayed in diagnosis. Chemotherapy type treatment that used to eliminate, diminish, or restrict tumor progression. Chemotherapeutic medicines are available various formulations. Some tumors require just one chemotherapy medication, while others may combination surgery and/or radiotherapy. Treatments might last from few minutes many hours several days. Each medication has potential adverse effects associated with it. Researchers have recently become interested the use natural bioactive compounds anticancer therapy. phytochemicals on cellular processes signaling pathways antitumor properties. Beneficial were observed both vivo vitro investigations. Encapsulating different drug delivery methods improve their efficacy. Greater stability bioavailability, as well reduction undesirable an enhancement target-specific activity, will increase effectiveness compounds. This review work focuses novel system entraps substances. It also provides idea bioavailability phytochemicals, challenges limitations standard cancer encompasses recent patents nanoparticle formulations containing anti-cancer molecule.
Язык: Английский
Процитировано
86
Life, Год журнала: 2023, Номер 13(5), С. 1099 - 1099
Опубликована: Апрель 27, 2023
A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it currently major hurdle bringing new drug molecules market. According some estimates, up 40% of commercialized products 70–90% candidates development stage are poorly soluble, which results low bioavailability, diminished therapeutic effects, dosage escalation. Because this, must be taken into consideration when developing fabricating pharmaceutical products. To date, number approaches have been investigated address problem poor solubility. This review article attempts summarize several conventional methods utilized increase soluble drugs. These include principles physical chemical such particle size reduction, solid dispersion, supercritical fluid technology, cryogenic inclusion complex formation techniques, floating granules. It includes structural modification (i.e., prodrug, salt formation, co-crystallization, use co-solvents, hydrotrophy, polymorphs, amorphous dispersions, pH variation). Various nanotechnological liposomes, nanoparticles, dendrimers, micelles, metal organic frameworks, nanogels, nanoemulsions, nanosuspension, carbon nanotubes, so forth also widely for enhancement. All these brought forward enhancement bioavailability orally administered drugs by improving water-soluble However, issues not completely resolved, owing challenges associated with current approaches, reproducibility large scale production. Considering that there no universal approach solving issues, more research needed simplify existing technologies, could commercially available employing techniques.
Язык: Английский
Процитировано
82