Chinese Chemical Letters, Год журнала: 2023, Номер 34(9), С. 108197 - 108197
Опубликована: Фев. 10, 2023
Язык: Английский
ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.
Язык: Английский
Процитировано
189
Chemical Society Reviews, Год журнала: 2022, Номер 51(4), С. 1277 - 1335
Опубликована: Янв. 1, 2022
The review summarizes the exploitations of corrole derivatives in many different fields, where peculiar properties these contracted macrocycles lead to development promising applications.
Язык: Английский
Процитировано
107
ACS Nano, Год журнала: 2022, Номер 16(12), С. 19691 - 19721
Опубликована: Ноя. 15, 2022
The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires innovative solutions for its congenitally deficient shadow penetration the visible-light excitation. X-ray-induced (X-PDT) has been proven to be a successful technique reforming conventional PDT deep-seated tumors by creatively utilizing penetrating X-rays as external excitation sources and witnessed rapid developments over past several years. Beyond proof-of-concept demonstration, recent advances X-PDT have exhibited trend minimizing X-ray radiation doses quite low values. As such, scintillating materials used bridge photosensitizers play significant role, do diverse well-designed irradiation modes smart strategies improving tumor microenvironment. Here this review, we provide comprehensive summary achievements highlight trending efforts using radiation. We first describe concept relationships with radiodynamic radiotherapy then dissect mechanism absorption conversion materials, reactive oxygen species evaluation X-PDT, side effects clinical concerns on Finally, discuss detailed overview progress regarding low-dose present perspectives possible translation. It is expected that pursuit will facilitate breakthroughs, both fundamentally clinically, effective treatment near future.
Язык: Английский
Процитировано
75
Frontiers in Microbiology, Год журнала: 2023, Номер 13
Опубликована: Янв. 5, 2023
Given the emergence of resistant bacterial strains and novel microorganisms that globally threaten human life, moving toward new treatment modalities for microbial infections has become a priority more than ever. Antimicrobial photodynamic therapy (aPDT) been introduced as promising non-invasive local adjuvant in several oral infectious diseases. Its efficacy elimination bacterial, fungal, viral key pathogens such Streptococcus mutans, Porphyromonas gingivalis, Candida albicans, Enterococcus faecalis have investigated by many invitro clinical studies. Researchers also methods increasing amazing developments production natural, nano based, targeted photosensitizers. As studies an important role paving way towards evidence-based applications infection this method, current review aimed to provide overall view potential field summarize data available randomized controlled conducted on aPDT dentistry investigate its future horizons dental practice. Four databases including PubMed (Medline), Web Science, Scopus Embase were searched up September 2022 retrieve related There are reporting effective adjunctive modality capable reducing pathogenic loads periodontal peri-implant, persistent endodontic infections. Clinical evidence reveals therapeutic prevention reduction cariogenic organisms with fungal or origins, however, number these groups much less. Altogether, various photosensitizers used it is still not possible recommend specific irradiation parameters due heterogenicity among Reaching protocols difficult requires further high quality trials focusing PS shown able reduce sufficient follow-up periods.
Язык: Английский
Процитировано
67
Coordination Chemistry Reviews, Год журнала: 2023, Номер 495, С. 215350 - 215350
Опубликована: Авг. 19, 2023
Innovative anticancer therapies based on the activation of immune system offer promise in battle against cancers resistant to traditional treatments. Examples such therapeutic approaches include, along with various types immunotherapies, photodynamic therapy (PDT). PDT is a photochemistry-based strategy that results not only from its direct effects cancer cells but also disruption tumor vasculature and host system. However, achieve success manifested eradication primary distant metastases, it necessary design suitable photosensitizers (PSs) desired optical photophysical properties enable efficient generation ROS under microenvironmental (TME) conditions, especially hypoxia. Thus, this review particular attention paid photochemical PSs, notably sufficiently long-lived triplet states mechanisms energy/electron transfer reactions. Photogenerated initiate inflammatory reaction, expression heat-shock proteins, infiltration long-term memory. These unique features give new possibilities combine agents stimulating response as well immunotherapy, PD-1/PD-L1 blockade. Most systems explored aspect so far are either derivatives naturally occurring metal complexes (Heme, Chlorophyll a, Bacteiochorophyll - inspired PSs), synthetic (metallo)porphyrins, (metallo)phthalocyanines or hybrid materials containing nanoparticles. This work summarizes recent reports synthesis antibody-PS conjugates spectroscopic enhanced selectivity biological activity. Finally, most notable drawbacks presented, scenario outlined for development alone, combined immunotherapy overcome these challenges future.
Язык: Английский
Процитировано
59
Small Methods, Год журнала: 2023, Номер 7(5)
Опубликована: Янв. 27, 2023
Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.
Язык: Английский
Процитировано
48
Frontiers in Chemical Engineering, Год журнала: 2024, Номер 6
Опубликована: Фев. 2, 2024
The emerging field of using titanium dioxide (TiO 2 )-based photosensitizers for enhancing photocatalytic removal thiazine dyes such as methylene blue (MB) from water has long been recognized its exceptional properties, making it an attractive material environmental remediation and energy conversion. However, wide bandgap limits responsiveness to visible light. As such, the utilization TiO -based dyes, presents a promising avenue diverse applications. In addressing dual challenges pollution harnessing sustainable sources, this review focuses on their subsequent application materials. Thiazine ubiquitous in industrial effluents, pose concerns due persistence potential toxicity. Conversely, innovative approach involves employing materials photocatalysts, utilizing unique properties enhance light absorption. Studies have shown that beyond conventional role colorants, they can serve effective when coupled with . This tandem not only facilitates elimination MB, but also augments improvement performance synergy between dye sensitizers enhances overall efficiency processes like degradation splitting. Dye sensitizers, acting absorbers, efficiently transfer , thereby promoting electron generating reactive oxygen species (ROS). These ROS, turn, initiate chemical reactions, rendering valuable applications wastewater treatment, solar conversion, remediation. is crucial acknowledge drawbacks associated including toxicity non-biodegradability. Consequently, careful consideration must be given disposal. Therefore, manuscript delves into comprehensive exploration photosensitizers, shedding efficacy various removal.
Язык: Английский
Процитировано
24
International Journal of Pharmaceutics, Год журнала: 2024, Номер 655, С. 124057 - 124057
Опубликована: Март 27, 2024
Язык: Английский
Процитировано
24
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 26, 2024
Carbon dots (CDs) are novel carbon-based nanomaterials that have been used as photosensitizer-mediated photodynamic therapy (PDT) in recent years due to their good photosensitizing activity. Photosensitizers (PSs) main components of PDT can produce large amounts reactive oxygen species (ROS) when stimulated by light source, which the advantages low drug resistance and high therapeutic efficiency. CDs generate ROS efficiently under irradiation therefore extensively studied disease local phototherapy. In tumor therapy, be PSs or PS carriers participate play an extremely important role. bacterial infectious diseases, exhibit bactericidal activity effective disrupting cell membranes leading death upon photoactivation. We focus on advances cancer bacteria with CDs, also briefly summarize mechanisms requirements for cancer, other diseases. discuss role combination potential future applications against pathogens.
Язык: Английский
Процитировано
20
Biomedicines, Год журнала: 2024, Номер 12(1), С. 187 - 187
Опубликована: Янв. 15, 2024
In recent years, the field of drug delivery has witnessed remarkable progress, driven by quest for more effective and precise therapeutic interventions. Among myriad strategies employed, integration aptamers as targeting moieties stimuli-responsive systems emerged a promising avenue, particularly in context anticancer therapy. This review explores cutting-edge advancements targeted drug-delivery systems, focusing on platforms enhanced spatial aptamer-based we delve into versatile applications aptamers, examining their conjugation with gold, silica, carbon materials. The synergistic interplay between these materials is discussed, emphasizing potential achieving delivery. Additionally, explore an emphasis Tumor microenvironment-responsive nanoparticles are elucidated, capacity to exploit dynamic conditions within cancerous tissues controlled release detailed. External strategies, including ultrasound-mediated, photo-responsive, magnetic-guided examined role effects. integrates diverse approaches precision medicine, showcasing revolutionize
Язык: Английский
Процитировано
18