Exosomes: A potential tool for immunotherapy of ovarian cancer
Xiangjin Gong,
Hao Chi,
Dorothee Franziska Strohmer
и другие.
Frontiers in Immunology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 18, 2023
Ovarian
cancer
is
a
malignant
tumor
of
the
female
reproductive
system,
with
very
poor
prognosis
and
high
mortality
rates.
Chemotherapy
radiotherapy
are
most
common
treatments
for
ovarian
cancer,
unsatisfactory
results.
Exosomes
subpopulation
extracellular
vesicles,
which
have
diameter
approximately
30–100
nm
secreted
by
many
different
types
cells
in
various
body
fluids.
highly
stable
effective
carriers
immunotherapeutic
drugs.
Recent
studies
shown
that
exosomes
involved
cellular
responses
microenvironment,
influencing
development
therapeutic
efficacy
exhibiting
dual
roles
inhibiting
promoting
development.
also
contain
variety
genes
related
to
immunotherapy
could
be
potential
biomarkers
diagnosis
prognosis.
Undoubtedly,
great
field
immunotherapy.
However,
translation
this
idea
clinic
has
not
occurred.
Therefore,
it
important
understand
how
used
regulate
progression.
In
review,
we
summarize
fluids
mechanisms
influence
response.
We
discuss
prospects
clinical
application
exosome-based
cancer.
Язык: Английский
Transcriptional landscape of long non-coding RNAs (lncRNAs) and its implication in viral diseases
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms,
Год журнала:
2024,
Номер
1867(2), С. 195023 - 195023
Опубликована: Март 19, 2024
Язык: Английский
The role and function of autophagy through signaling and pathogenetic pathways and lncRNAs in ovarian cancer
Pathology - Research and Practice,
Год журнала:
2023,
Номер
253, С. 154899 - 154899
Опубликована: Окт. 20, 2023
Язык: Английский
lncRNA DARS-AS1 Modulates TSPAN1-Mediated ITGA2 Hypomethylation by Interaction with miR-194-5p Thus Promoting Ovarian Cancer Progression
Stem Cells International,
Год журнала:
2022,
Номер
2022, С. 1 - 14
Опубликована: Сен. 22, 2022
Ovarian
cancer
(OC)
is
usually
called
the
"silent
killer"
due
to
its
asymptomatic
characteristics
until
advanced
stages,
thus
being
a
significant
threat
female
health
worldwide.
In
this
work,
we
characterized
an
oncogenic
DARS-AS1
role
in
OC.
Язык: Английский
Recombinant human IL-17D promotes the progression of human ovarian cancer SKOV3 cells and the expression of PD-L by activating the NF-κB pathway
European Journal of Gynaecological Oncology,
Год журнала:
2024,
Номер
45(1), С. 17 - 17
Опубликована: Янв. 1, 2024
Ovarian
cancer
(OC)
is
often
diagnosed
in
its
advanced
stages
with
many
patients
suffering
from
recurrence.Relapse
frequent
after
standard
treatment
leading
to
platinum
resistance
and
poor
prognosis
patients.Several
studies
have
reported
that
immune
status
inflammatory
factors,
such
as
Interleukin-17D
(IL-17D),
are
major
players
the
of
malignant
tumors.IL-17
family
an
important
pro-inflammatory
cytokine
family,
which
mediates
immunosuppression
promotes
tumor
progression.Our
previous
exploration
revealed
promoting
role
IL-17D
expression
occurrence
development
ovarian
carcinoma,
but
specific
mechanism
remains
unclear.In
this
study,
we
investigated
effects
rhIL-17D
on
proliferation,
migration
invasion
human
carcinoma
cell
SKOV3
vitro.In
addition,
also
detected
effect
programmed
death
ligand-1
(PD-L1)
cells
possible
mechanism.We
found
accelerated
proliferation
rate,
enhanced
penetration
ability,
promoted
PD-L1.After
knockdown
P65
expression,the
activated
form
NF-κB,
cells,
activity,
migration,
were
significantly
reduced.And
PD-L1
decreased.In
summary,
believe
can
accelerate
enhance
abilities
induce
by
regulating
activation
NF-κB
pathway.Down-regulation
microenvironment
may
be
a
new
approach
inhibit
cancer.
Язык: Английский
The lncRNA Gm8097 is associated with hypospermatogenesis
Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine,
Год журнала:
2024,
Номер
51(4), С. 314 - 323
Опубликована: Июнь 10, 2024
Objective:
To
investigate
whether
long
non-coding
RNA
(lncRNA)
Gm8097
(LncGm8097)
is
associated
with
male
infertility.Methods:
The
expression
and
bilogical
role
of
LncGm8097
were
investigated.Results:
was
down-regulated
in
the
testis
tissues
moderate
severe
hypospermatogenesis
compared
those
normal
spermatogenesis
mild
(<i>p</i><0.05).
down-regulation
significantly
promoted
apoptosis
inhibited
proliferation
GC1
GC2
cells.
In
addition,
mouse
model
correlated
cell
proliferation.
located
immediately
upstream
PRPS2,
Bcl-2/P53/caspase
6/caspase
9
signal
pathway.Conclusion:
correlates
hypospermatogenesis,
which
may
offer
new
insights
into
pathogenesis
infertility.
Язык: Английский