The lncRNA Gm8097 is associated with hypospermatogenesis DOI Open Access
Bin Lei,

L Ye,

Zhuolin Qiu

et al.

Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine, Journal Year: 2024, Volume and Issue: 51(4), P. 314 - 323

Published: June 10, 2024

Objective: To investigate whether long non-coding RNA (lncRNA) Gm8097 (LncGm8097) is associated with male infertility.Methods: The expression and bilogical role of LncGm8097 were investigated.Results: was down-regulated in the testis tissues moderate severe hypospermatogenesis compared those normal spermatogenesis mild (<i>p</i><0.05). down-regulation significantly promoted apoptosis inhibited proliferation GC1 GC2 cells. In addition, mouse model correlated cell proliferation. located immediately upstream PRPS2, Bcl-2/P53/caspase 6/caspase 9 signal pathway.Conclusion: correlates hypospermatogenesis, which may offer new insights into pathogenesis infertility.

Language: Английский

Exosomes: A potential tool for immunotherapy of ovarian cancer DOI Creative Commons

Xiangjin Gong,

Hao Chi,

Dorothee Franziska Strohmer

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 18, 2023

Ovarian cancer is a malignant tumor of the female reproductive system, with very poor prognosis and high mortality rates. Chemotherapy radiotherapy are most common treatments for ovarian cancer, unsatisfactory results. Exosomes subpopulation extracellular vesicles, which have diameter approximately 30–100 nm secreted by many different types cells in various body fluids. highly stable effective carriers immunotherapeutic drugs. Recent studies shown that exosomes involved cellular responses microenvironment, influencing development therapeutic efficacy exhibiting dual roles inhibiting promoting development. also contain variety genes related to immunotherapy could be potential biomarkers diagnosis prognosis. Undoubtedly, great field immunotherapy. However, translation this idea clinic has not occurred. Therefore, it important understand how used regulate progression. In review, we summarize fluids mechanisms influence response. We discuss prospects clinical application exosome-based cancer.

Language: Английский

Citations

55
Transcriptional landscape of long non-coding RNAs (lncRNAs) and its implication in viral diseases DOI
Ankita Rai, Tannu Bhagchandani, Ravi Tandon

et al.

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Journal Year: 2024, Volume and Issue: 1867(2), P. 195023 - 195023

Published: March 19, 2024

Language: Английский

Citations

4
The role and function of autophagy through signaling and pathogenetic pathways and lncRNAs in ovarian cancer DOI Open Access
Seyedsaber Mirabdali, Kimia Ghafouri,

Yalda Farahmand

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154899 - 154899

Published: Oct. 20, 2023

Language: Английский

Citations

10
lncRNA DARS-AS1 Modulates TSPAN1-Mediated ITGA2 Hypomethylation by Interaction with miR-194-5p Thus Promoting Ovarian Cancer Progression DOI Creative Commons
Li Jun, Haoyu Gao, Beibei Chen

et al.

Stem Cells International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 14

Published: Sept. 22, 2022

Ovarian cancer (OC) is usually called the "silent killer" due to its asymptomatic characteristics until advanced stages, thus being a significant threat female health worldwide. In this work, we characterized an oncogenic DARS-AS1 role in OC.

Language: Английский

Citations

3
Recombinant human IL-17D promotes the progression of human ovarian cancer SKOV3 cells and the expression of PD-L by activating the NF-κB pathway DOI Open Access

Yuanchun Fan,

Lei Feng, Yueping Liu

et al.

European Journal of Gynaecological Oncology, Journal Year: 2024, Volume and Issue: 45(1), P. 17 - 17

Published: Jan. 1, 2024

Ovarian cancer (OC) is often diagnosed in its advanced stages with many patients suffering from recurrence.Relapse frequent after standard treatment leading to platinum resistance and poor prognosis patients.Several studies have reported that immune status inflammatory factors, such as Interleukin-17D (IL-17D), are major players the of malignant tumors.IL-17 family an important pro-inflammatory cytokine family, which mediates immunosuppression promotes tumor progression.Our previous exploration revealed promoting role IL-17D expression occurrence development ovarian carcinoma, but specific mechanism remains unclear.In this study, we investigated effects rhIL-17D on proliferation, migration invasion human carcinoma cell SKOV3 vitro.In addition, also detected effect programmed death ligand-1 (PD-L1) cells possible mechanism.We found accelerated proliferation rate, enhanced penetration ability, promoted PD-L1.After knockdown P65 expression,the activated form NF-κB, cells, activity, migration, were significantly reduced.And PD-L1 decreased.In summary, believe can accelerate enhance abilities induce by regulating activation NF-κB pathway.Down-regulation microenvironment may be a new approach inhibit cancer.

Language: Английский

Citations

0
The lncRNA Gm8097 is associated with hypospermatogenesis DOI Open Access
Bin Lei,

L Ye,

Zhuolin Qiu

et al.

Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine, Journal Year: 2024, Volume and Issue: 51(4), P. 314 - 323

Published: June 10, 2024

Objective: To investigate whether long non-coding RNA (lncRNA) Gm8097 (LncGm8097) is associated with male infertility.Methods: The expression and bilogical role of LncGm8097 were investigated.Results: was down-regulated in the testis tissues moderate severe hypospermatogenesis compared those normal spermatogenesis mild (<i>p</i><0.05). down-regulation significantly promoted apoptosis inhibited proliferation GC1 GC2 cells. In addition, mouse model correlated cell proliferation. located immediately upstream PRPS2, Bcl-2/P53/caspase 6/caspase 9 signal pathway.Conclusion: correlates hypospermatogenesis, which may offer new insights into pathogenesis infertility.

Language: Английский

Citations

0