Hydrogel systems for targeted cancer therapy

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Фев. 16, 2023

When hydrogel materials with excellent biocompatibility and biodegradability are used as new drug carriers in the treatment of cancer, they confer following three advantages. First, can be a precise controlled release systems, which continuously sequentially chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents other substances widely cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy photothermal therapy. Second, have multiple sizes delivery routes, targeted to different locations types cancer. This greatly improves targeting thereby reducing dose drugs improving effectiveness. Finally, intelligently respond environmental changes according internal external stimuli so that anti-cancer active remotely released on demand. Combining abovementioned advantages, transformed into hit field treatment, bringing hope further increase survival rate quality life patients

Язык: Английский

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Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 6, 2023

Sonodynamic therapy (SDT) has emerged as a highly effective modality for the treatment of malignant tumors owing to its powerful penetration ability, noninvasiveness, site-confined irradiation, and excellent therapeutic efficacy. However, traditional SDT, which relies on oxygen availability, often fails generate satisfactory level reactive species because widespread issue hypoxia in tumor microenvironment solid tumors. To address this challenge, various approaches are developed alleviate improve efficiency SDT. These strategies aim either increase supply or prevent exacerbation, thereby enhancing effectiveness In view this, current review provides an overview these their underlying principles, focusing circulation from consumption external supply. The detailed research examples conducted using combination with SDT also discussed. Additionally, highlights future prospects challenges hypoxia-alleviated along key considerations clinical applications. include development efficient delivery systems, accurate methods detection, exploration therapies optimize outcomes.

Язык: Английский

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From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy

Cancers, Год журнала: 2023, Номер 15(5), С. 1394 - 1394

Опубликована: Фев. 22, 2023

(1) Background: Mild hyperthermia (mHT, 39-42 °C) is a potent cancer treatment modality when delivered in conjunction with radiotherapy. mHT triggers series of therapeutically relevant biological mechanisms, e.g., it can act as radiosensitizer by improving tumor oxygenation, the latter generally believed to be commensurate result increased blood flow, and positively modulate protective anticancer immune responses. However, extent kinetics flow (TBF) changes oxygenation are variable during after application mHT. The interpretation these spatiotemporal heterogeneities currently not yet fully clarified. (2) Aim methods: We have undertaken systematic literature review herein provide comprehensive insight into potential impact on clinical benefits therapeutic modalities such radio- immuno-therapy. (3) Results: mHT-induced increases TBF multifactorial differ both spatially time. In

Язык: Английский

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Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity

Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2406 - 2406

Опубликована: Сен. 30, 2023

The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads an increase in potency radiation therapy and allows for decreasing dose concomitant side effects. Radiosensitization by metal oxide nanoparticles widely discussed, but range mechanisms studied not sufficiently codified often does reflect ability nanocarriers have a specific impact on cells. This review focused magnetic iron while they occupied special niche among prospective radiosensitizers due unique physicochemical characteristics reactivity. We collected data about possible molecular underlying radiosensitizing effects (IONPs) approaches their therapeutic efficacy variable modifications.

Язык: Английский

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Hyperthermia in Combination with Emerging Targeted and Immunotherapies as a New Approach in Cancer Treatment

Cancers, Год журнала: 2024, Номер 16(3), С. 505 - 505

Опубликована: Янв. 24, 2024

Despite significant advancements in the development of novel therapies, cancer continues to stand as a prominent global cause death. In many cases, cornerstone standard-of-care therapy consists chemotherapy (CT), radiotherapy (RT), or combination both. Notably, hyperthermia (HT), which has been clinical use last four decades, proven enhance effectiveness CT and RT, owing its recognized potency sensitizer. Furthermore, HT exerts effects on all steps cancer–immunity cycle impact key oncogenic pathways. Most recently, there noticeable expansion research related treatment options involving immunotherapy (IT) targeted (TT), trend also visible pipelines pharmaceutical companies. However, potential results arising from these innovative therapeutic approaches with remain largely unexplored. Therefore, this review aims explore oncology major companies, primary objective identifying principal targets forthcoming therapies that have be advantageous for patients by specifically targeting molecular pathways involved HT. The ultimate goal is pave way future initiatives trials harness synergy between emerging IT TT medications when used conjunction

Язык: Английский

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Augmentation of the EPR effect by mild hyperthermia to improve nanoparticle delivery to the tumor

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(4), С. 189109 - 189109

Опубликована: Май 14, 2024

The clinical translation of the nanoparticle (NP)-based anticancer therapies is still unsatisfactory due to heterogeneity enhanced permeability and retention (EPR) effect. Despite promising preclinical outcome pharmacological EPR enhancers, their systemic toxicity can limit application. Hyperthermia (HT) presents an efficient tool augment by improving tumor blood flow (TBF) vascular permeability, lowering interstitial fluid pressure (IFP), disrupting structure extracellular matrix (ECM). Furthermore, HT-triggered intravascular release approach overcome In contrast approaches, HT safe be focused cancer tissues. Moreover, conveys direct anti-cancer effects, which improve efficacy agents encapsulated in NPs. However, application challenging heterogeneous distribution temperature within tumor, length treatment complexity monitoring.

Язык: Английский

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Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications

Progress in Materials Science, Год журнала: 2025, Номер 151, С. 101428 - 101428

Опубликована: Янв. 9, 2025

Язык: Английский

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Exploring the molecular mechanism of cancer radiosensitization: the impact of physical stimulation therapy

Strahlentherapie und Onkologie, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

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A translational review of hyperthermia biology

International Journal of Hyperthermia, Год журнала: 2025, Номер 42(1)

Опубликована: Янв. 12, 2025

This review was written to be included in the Special Collection 'Therapy Ultrasound: Medicine's Swiss Army Knife?' The purpose of this is provide basic presentation and interpretation fundamentals hyperthermia biology, as it pertains uses therapeutic ultrasound. are presented but setting a translational view toward future. Subjects that require future research development highlighted. effects time temperature dependent. Because intra-tumoral temperatures non-uniform tumors, one has account for differential biologic different parts tumor occur simultaneously during after hyperthermia.

Язык: Английский

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In Vitro Measurement and Mathematical Modeling of Thermally-Induced Injury in Pancreatic Cancer Cells

Cancers, Год журнала: 2023, Номер 15(3), С. 655 - 655

Опубликована: Янв. 21, 2023

Thermal therapies are under investigation as part of multi-modality strategies for the treatment pancreatic cancer. In present study, we determined kinetics thermal injury to cancer cells in vitro and evaluated predictive models injury. Cell viability was measured two murine cell lines (KPC, Pan02) a normal fibroblast (STO) line following heating range 42.5-50 °C 3-60 min. Based on data, kinetic parameters were used predict extent heat-induced damage. Of three considered this Arrhenius model with time delay provided most accurate prediction (root mean square error = 8.48%) all lines. Pan02 STO resistant susceptible hyperthermia treatments, respectively. The presented data may contribute studies investigating use inform design planning strategies.

Язык: Английский

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