Pharmaceuticals,
Год журнала:
2025,
Номер
18(4), С. 580 - 580
Опубликована: Апрель 16, 2025
The
World
Health
Organization
has
recently
underlined
the
increasing
global
burden
of
cancer,
with
a
particularly
alarming
impact
on
underserved
populations.
In
recent
years,
1,3,4-thiadiazole
emerged
as
versatile
pharmacophore
to
obtain
bioactive
compounds.
pharmacological
properties
this
ring
are
primarily
attributed
its
role
bioisostere
pyrimidine,
core
structure
three
nucleic
bases.
This
structural
feature
endows
derivatives
ability
interfere
DNA
replication
processes.
Additionally,
mesoionic
behavior
heterocycle
gives
it
important
properties,
such
cross
biological
membranes
and
interact
target
proteins.
Noteworthy,
in
analogy
other
sulfur
heterocycles,
presence
C-S
σ*
orbitals,
conferring
small
regions
low
electron
density
atom,
makes
interaction
easier.
review
focuses
most
promising
anticancer
agents
reported
past
five
providing
information
that
may
be
useful
medicinal
chemists
who
intend
develop
new
derivatives.
Cancer Drug Resistance,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 8, 2025
Metabolic
reprogramming
within
the
tumor
microenvironment
(TME)
plays
a
critical
role
in
driving
drug
resistance
gastrointestinal
cancers
(GI),
particularly
through
pathways
of
fatty
acid
oxidation
and
glycolysis.
Cancer
cells
often
rewire
their
metabolism
to
sustain
growth
reshape
TME,
creating
conditions
such
as
nutrient
depletion,
hypoxia,
acidity
that
impair
antitumor
immune
responses.
Immune
TME
also
undergo
metabolic
alterations,
frequently
adopting
immunosuppressive
phenotypes
promote
progression
reduce
efficacy
therapies.
The
competition
for
essential
nutrients,
glucose,
between
cancer
compromises
functions
effector
cells,
T
cells.
Additionally,
by-products
like
lactate
kynurenine
further
suppress
activity
populations,
including
regulatory
M2
macrophages.
Targeting
glycolysis
presents
new
opportunities
overcome
improve
therapeutic
outcomes
GI
cancers.
Modulating
these
key
has
potential
reinvigorate
exhausted
shift
toward
phenotypes,
enhance
effectiveness
immunotherapies
other
treatments.
Future
strategies
will
require
continued
research
into
metabolism,
development
novel
inhibitors,
clinical
trials
evaluating
combination
Identifying
validating
biomarkers
be
crucial
patient
stratification
treatment
monitoring.
Insights
may
have
broader
implications
across
multiple
types,
offering
avenues
improving
treatment.
Advanced Materials,
Год журнала:
2023,
Номер
35(46)
Опубликована: Авг. 17, 2023
Pancreatic
ductal
adenocarcinoma
(PDAC)
has
a
devastating
prognosis
without
effective
treatment
options.
Thus,
there
is
an
urgent
need
for
more
and
safe
therapies.
Here,
inorganic-organic
hybrid
nanoparticles
(GMP-IOH-NPs)
are
presented
as
novel
drug-delivery
system
the
selective
delivery
of
extraordinarily
high
concentrations
gemcitabine
monophosphate
(GMP),
not
only
to
primary
tumor
but
also
metastatic
sites.
GMP-IOH-NPs
have
composition
[ZrO]2+
[GMP]2-
with
GMP
drug
anion
(76%
total
IOH-NP
mass).
Multiscale
fluorescence
imaging
confirms
efficient
uptake
in
cells,
independent
activity
human-equilibrative-nucleoside
transporter
(hENT1),
being
responsible
(GEM)
transport
into
cells
key
factor
GEM
resistance.
Delivering
already
phosphorylated
via
allows
cellular
resistance
induced
by
downregulation
deoxycytidine
kinase
be
overcome.
show
accumulation
lesions
minor
liver
trapping
when
given
intraperitoneally.
result
higher
antitumor
efficacy
compared
free
GEM,
which
further
enhanced
applying
cetuximab-functionalized
GMP-CTX-IOH-NPs.
By
maximizing
therapeutic
benefits
load,
tumor-specific
delivery,
minimizing
undesired
side
effects,
overcoming
mechanisms
chemoresistance,
preventing
systemic
inactivation,
anticipated
chance
significantly
improve
current
PDAC-patient
outcome.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Июль 17, 2024
Pancreatic
adenocarcinoma,
a
clinically
challenging
malignancy
constitutes
significant
contributor
to
cancer-related
mortality,
characterized
by
an
inherently
poor
prognosis.
This
review
aims
provide
comprehensive
understanding
of
pancreatic
adenocarcinoma
examining
its
multifaceted
etiologies,
including
genetic
mutations
and
environmental
factors.
The
explains
the
complex
molecular
mechanisms
underlying
pathogenesis
summarizes
current
therapeutic
strategies,
surgery,
chemotherapy,
emerging
modalities
such
as
immunotherapy.
Critical
pathways
driving
cancer
development,
KRAS,
Notch,
Hedgehog,
are
discussed.
Current
radiation,
discussed,
with
emphasis
on
their
limitations,
particularly
in
terms
postoperative
relapse.
Promising
research
areas,
liquid
biopsies,
personalized
medicine,
gene
editing,
explored,
demonstrating
potential
for
enhancing
diagnosis
treatment.
While
immunotherapy
presents
promising
prospects,
it
faces
challenges
related
immune
evasion
mechanisms.
Emerging
directions,
encompassing
CRISPR/Cas9
genome
computational
intelligence
applications,
hold
promise
refining
diagnostic
approaches
interventions.
By
integrating
insights
from
genetic,
molecular,
clinical
research,
innovative
strategies
that
improve
patient
outcomes
can
be
developed.
Ongoing
these
fields
holds
advancing
treatment
this
formidable
malignancy.
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1801 - 1801
Опубликована: Авг. 8, 2024
Resistance
to
cancer
drugs
is
a
complex
phenomenon
that
poses
significant
challenge
in
the
treatment
of
various
malignancies.
This
review
comprehensively
explores
resistance
mechanisms
and
discusses
emerging
strategies
modalities
overcome
this
obstacle.
Many
factors
contribute
resistance,
including
genetic
mutations,
activation
alternative
signaling
pathways,
alterations
tumor
microenvironment.
Innovative
approaches,
such
as
targeted
protein
degradation,
immunotherapy
combinations,
precision
medicine,
novel
drug
delivery
systems,
hold
promise
for
improving
outcomes.
Understanding
intricacies
leveraging
innovative
are
essential
advancing
therapy.
Biomolecules,
Год журнала:
2022,
Номер
12(10), С. 1450 - 1450
Опубликована: Окт. 9, 2022
The
signal
transducer
and
activator
of
transcription
(STAT)
is
a
family
intracellular
cytoplasmic
factors
involved
in
many
biological
functions
mammalian
transduction.
Among
them,
STAT3
cell
proliferation,
differentiation,
apoptosis,
inflammatory
responses.
Despite
the
advances
treatment
pancreatic
cancer
past
decade,
prognosis
for
patients
with
remains
poor.
has
been
shown
to
play
pro-cancer
role
variety
cancers,
inhibitors
are
used
pre-clinical
clinical
studies.
We
reviewed
relationship
between
latest
results
on
use
cancer,
aim
providing
insights
ideas
around
new
generation
chemotherapeutic
modalities
cancer.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(39), С. 14727 - 14735
Опубликована: Сен. 19, 2023
In
this
work,
we
demonstrate
the
development
and
first
application
of
nanocapillary
sampling
followed
by
analytical
flow
liquid
chromatography-mass
spectrometry
for
single-cell
lipidomics.
Around
260
lipids
were
tentatively
identified
in
a
single
cell,
demonstrating
remarkable
sensitivity.
Human
pancreatic
ductal
adenocarcinoma
cells
(PANC-1)
treated
with
chemotherapeutic
drug
gemcitabine
can
be
distinguished
from
controls
solely
on
basis
their
lipid
profiles.
Notably,
relative
abundance
LPC(0:0/16:0)
was
significantly
affected
gemcitabine-treated
cells,
agreement
previous
work
bulk.
This
serves
as
proof
concept
that
live
sampled
selectively
then
characterized
using
automated
widely
available
workflows,
providing
biologically
relevant
outputs.
