Molecular Mechanisms and Clinical Application of Multipotent Stem Cells for Spinal Cord Injury

Cells, Год журнала: 2022, Номер 12(1), С. 120 - 120

Опубликована: Дек. 28, 2022

Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and psychosocial sequelae. The majority of patients after SCI suffer from permanent disability caused by motor dysfunction, impaired sensation, neuropathic pain, spasticity as well urinary complications, small number experience complete recovery. Current standard treatment modalities the aim to prevent secondary injury provide limited recovery lost functions. Stem Cell Therapy (SCT) represents an emerging approach using differentiation, paracrine, self-renewal capabilities stem cells regenerate injured spinal cord. To date, multipotent including mesenchymal (MSCs), neural (NSCs), hematopoietic (HSCs) represent most investigated types for in preclinical clinical studies. microenvironment has significant impact on survival, proliferation, differentiation transplanted cells. Therefore, deep understanding pathophysiology molecular mechanisms through which act may help improve efficacy SCT find new therapeutic approaches such stem-cell-derived exosomes, gene-modified cells, scaffolds, nanomaterials. In this literature review, pathogenesis action MSCs, NSCs, HSCs are comprehensively described. Moreover, treatment, optimal protocol cell administration, recent based or combined also discussed.

Язык: Английский

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Brain stimulation for chronic pain management: a narrative review of analgesic mechanisms and clinical evidence

Neurosurgical Review, Год журнала: 2023, Номер 46(1)

Опубликована: Май 29, 2023

Abstract Chronic pain constitutes one of the most common chronic complaints that people experience. According to International Association for Study Pain, is defined as persists or recurs longer than 3 months. has a significant impact on individuals’ well-being and psychosocial health economy healthcare systems well. Despite availability numerous therapeutic modalities, treatment can be challenging. Only about 30% individuals with non-cancer achieve improvement from standard pharmacological treatment. Therefore, approaches were proposed potential including non-opioid agents, nerve blocks, acupuncture, cannabidiol, stem cells, exosomes, neurostimulation techniques. Although some methods such spinal cord stimulation successfully introduced into clinical practice therapy pain, current evidence brain efficacy in remains unclear. Hence, this narrative literature review aimed give an up-to-date overview methods, deep stimulation, motor cortex transcranial direct repetitive magnetic cranial electrotherapy reduced impedance non-invasive cortical electrostimulation pain.

Язык: Английский

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Diagnosis and Management of Neuropathic Pain in Spine Diseases

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(4), С. 1380 - 1380

Опубликована: Фев. 9, 2023

Neuropathic pain is generally defined as a non-physiological experience caused by damage to the nervous system. It can occur spontaneously, reaction given stimulus, or independently of its action, leading unusual sensations usually referred firing, burning throbbing. In course spine disorders, symptoms commonly occur. According available epidemiological studies, neuropathic component often present in patients with spinal diseases, frequency ranging from 36% 55% patients. Distinguishing between chronic nociceptive and very remains challenge. Consequently, underdiagnosed diseases. reference current guidelines for treatment pain, gabapentin, serotonin norepinephrine reuptake inhibitors tricyclic antidepressants constitute first-line therapeutic agents. However, long-term pharmacologic leads developing tolerance resistance used medications. Therefore, recent years, plethora methods have been developed investigated improve clinical outcomes. this review, we briefly summarized knowledge about pathophysiology diagnosis pain. Moreover, described most effective approaches discussed their relevance

Язык: Английский

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Impact of Fixation Length for Single-Level Spinal Metastasis Surgery in the Elderly: A Multicenter Study

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Язык: Английский

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Breast cancer: Current status of preclinical research

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 177 - 204

Опубликована: Янв. 1, 2025

Язык: Английский

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Understanding the initiation, delivery and processing of bone cancer pain from the peripheral to the central nervous system

Neuropharmacology, Год журнала: 2023, Номер 237, С. 109641 - 109641

Опубликована: Июнь 30, 2023

Язык: Английский

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Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Май 9, 2024

Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, chronic. In each period there are different alterations in the cells, inflammatory factors, signaling spinal cord. Many biomaterials have been investigated of SCI, including hydrogels fiber scaffolds, some progress has made using multiple materials. However, limitations when individual treatment, these can be significantly improved by combining treatments with stem cells. order to better understand investigate new strategies its several combination therapies that include materials combined drugs, cytokines, etc. summarized current review.

Язык: Английский

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The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3785 - 3785

Опубликована: Фев. 14, 2023

Although many studies have investigated the role of cytokines in bone metastases, our knowledge their function spine metastasis is limited. Therefore, we performed a systematic review to map available evidence on involvement solid tumors. A PubMed search identified 211 articles demonstrating functional link between cytokines/cytokine receptors and including six confirming metastases. total 68 were mediate metastases; 9 (mostly chemokines) played metastases: CXC motif chemokine ligand (CXCL) 5, CXCL12, receptor (CXCR) 4, CXCR6, interleukin (IL) 10 prostate cancer, CX3C (CX3CL) 1 (CX3CR) liver CC (CCL) 2 breast transforming growth factor (TGF) β skin cancer. Except for all shown operate spine, with CX3CL1, CX3CR1, IL10, CCL2, CXCR4 mediating marrow colonization, CXCL5 TGFβ promoting tumor cell proliferation, additionally driving remodeling. The number confirmed spinal low compared vast spectrum participating other parts skeleton. further research needed, validation metastases bones, precisely address unmet clinical need associated

Язык: Английский

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The importance of planning CT-based imaging features for machine learning-based prediction of pain response

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Окт. 13, 2023

Patients suffering from painful spinal bone metastases (PSBMs) often undergo palliative radiation therapy (RT), with an efficacy of approximately two thirds patients. In this exploratory investigation, we assessed the effectiveness machine learning (ML) models trained on radiomics, semantic and clinical features to estimate complete pain response. Gross tumour volumes (GTV) target (CTV) 261 PSBMs were segmented planning computed tomography (CT) scans. Radiomics, collected for all Random forest (RFC) support vector (SVM) classifiers compared using repeated nested cross-validation. The best radiomics classifier was CTV area under receiver-operator curve (AUROC) 0.62 ± 0.01 (RFC; 95% confidence interval). model achieved a comparable AUROC 0.63 (RFC), significantly below (SVM, AUROC: 0.80 0.01); slightly lower than instability neoplastic score (SINS; LR, 0.65 0.01). A combined did not improve performance (AUROC: 0,74 0,01). We could demonstrate that analyses CTs allowed limited prediction response RT. ML predictions based established parameters results.

Язык: Английский

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Pathology of Spinal Tumours

Deleted Journal, Год журнала: 2024, Номер 32(1), С. 13 - 19

Опубликована: Янв. 1, 2024

Abstract Spinal tumours are uncommon lesions, but they may cause significant morbidity and mortality. Majority of the spinal metastatic, that is, spread from in other organs, which mostly seen older patients. Primary sarcomas involving column rare. Benign tumour-like lesions musculoskeletal system young can be subdivided into primary tumours, rare, secondary or metastases, much common. vertebral benign malignant. Common include osteoid osteoma, osteoblastoma, osteochondroma, aneurysmal bone cyst giant cell tumour. There many malignant such as- osteosarcoma, chondrosarcoma, chordoma, Ewing’s sarcoma, plasmacytoma multiple myeloma. However, all them, except myeloma, Intraspinal extradural intradural. intradural extramedullary meningioma, schwannoma neurofibroma, whereas astrocytoma, ependymoma haemangioblastoma a few examples intramedullary tumours.

Язык: Английский

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