Arhiv za farmaciju,
Год журнала:
2024,
Номер
74(3), С. 375 - 390
Опубликована: Янв. 1, 2024
Obesity
represents
a
serious
medical
condition
and
has
nowadays
reached
pandemic
proportions.
Comorbidities
associated
with
obesity
are
severe,
affect
almost
all
organ
systems.
Adipose
tissue
several
important
functions:
to
provide
energy
storage,
maintain
body
temperature
through
the
process
of
thermogenesis,
balance
in
variety
metabolic
patterns.
is
an
endocrine
numerous
biochemical
roles,
obese
individuals
adipose
becomes
either
hypertrophic
or
hyperplastic,
impaired
function.
The
immune
system
activity
regulation
extremely
related
processes.
A
loss
on
this
axis
causes
disorders
obesity,
basis
these
insulin
resistance,
which
hallmark
obesity.
Hormones
that
exclusively
produced
adipocytes
studied
various
biochemistry
processes
leptin,
adiponectin
resistin.
Successful
treatment
involves
lifestyle
diet
modification,
pharmacotherapy,
mainly
glucagon-like
peptide-1
agonists,
bariatric
surgery,
remains
most
effective
method
for
selected
population
severely
individuals.
Positive
effects
surgery
reflected
not
only
restriction
food
intake,
but
hormonal
changes,
especially
those
gut
hormones
responsible
hunger
metabolism.
The
prevalence
and
incidence
of
obesity
the
comorbidities
linked
to
it
are
increasing
in
world
population.
Current
therapies
for
associated
pathologies
have
proven
cause
a
broad
number
adverse
effects
often,
they
overpriced
or
not
affordable
all
patients.
Among
alternatives
currently
available,
natural
bioactive
compounds
stand
out.
These
frequently
contained
pharmaceutical
presentations,
nutraceutical
products,
supplements,
functional
foods.
clinical
evidence
these
molecules
is
increasingly
solid,
among
which
epigallocatechin-3-gallate,
ellagic
acid,
resveratrol,
berberine,
anthocyanins,
probiotics,
carotenoids,
curcumin,
silymarin,
hydroxy
citric
α-lipoic
acid
molecular
mechanisms
signaling
pathways
been
shown
interact
with
endocrine,
nervous,
gastroenteric
systems,
as
well
regulate
expression
multiple
genes
and,
therefore,
proteins
involved
starvation-satiety
processes,
activation
brown
adipose
tissue,
increased
lipolysis,
decreased
lipogenesis,
inflammation,
beneficial
changes
metabolism
improved
insulin
sensitivity.
This
review
provides
comprehensive
view
nature-based
therapeutic
options
address
obesity.
It
offers
valuable
perspective
future
research
subsequent
practice,
addressing
everything
from
molecular,
genetic,
physiological
bases
study
compound.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2671 - 2671
Опубликована: Фев. 25, 2024
The
prevalence
and
incidence
of
obesity
the
comorbidities
linked
to
it
are
increasing
worldwide.
Current
therapies
for
associated
pathologies
have
proven
cause
a
broad
number
adverse
effects,
often,
they
overpriced
or
not
affordable
all
patients.
Among
alternatives
currently
available,
natural
bioactive
compounds
stand
out.
These
frequently
contained
in
pharmaceutical
presentations,
nutraceutical
products,
supplements,
functional
foods.
clinical
evidence
these
molecules
is
increasingly
solid,
among
which
epigallocatechin-3-gallate,
ellagic
acid,
resveratrol,
berberine,
anthocyanins,
probiotics,
carotenoids,
curcumin,
silymarin,
hydroxy
citric
α-lipoic
acid
molecular
mechanisms
signaling
pathways
been
shown
interact
with
endocrine,
nervous,
gastroenteric
systems.
They
can
regulate
expression
multiple
genes
proteins
involved
starvation–satiety
processes,
activate
brown
adipose
tissue,
decrease
lipogenesis
inflammation,
increase
lipolysis,
improve
insulin
sensitivity.
This
review
provides
comprehensive
view
nature-based
therapeutic
options
address
obesity.
It
offers
valuable
perspective
future
research
subsequent
practice,
addressing
everything
from
molecular,
genetic,
physiological
bases
study
compounds.
AJP Cell Physiology,
Год журнала:
2024,
Номер
327(3), С. C684 - C697
Опубликована: Июль 16, 2024
We
sought
to
advance
our
understanding
of
skeletal
muscle
lipid
metabolism
and
dynamics
in
cancer
cachexia.
Cachexia
increased
the
number
size
intramyocellular
droplets
(LDs).
Furthermore,
decreases
LD-mitochondrial
touch,
contact
length,
relative
along
with
LD
shape
complexity
circularity
roundness.
Dysregulation
LD-associated
proteins
was
also
documented.
Collectively,
we
show
that
myosteatosis,
altered
morphology,
decreased
interactions
occur
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 557 - 557
Опубликована: Янв. 10, 2025
Lipid
droplets
(LDs),
highly
dynamic
cellular
organelles
specialized
in
lipid
storage
and
maintenance
of
homeostasis,
contain
several
proteins
on
their
surface,
among
which
the
perilipin
(Plin)
family
stands
out
as
most
abundant
group
LD-binding
proteins.
They
play
a
pivotal
role
influencing
behavior
functionality
LDs,
regulating
lipase
activity,
preserving
balance
between
synthesis
degradation,
is
crucial
development
obesity
abnormal
accumulation
fat
non-adipose
tissues,
causing
negative
adverse
biological
effects,
such
insulin
resistance,
mitochondrial
dysfunction,
inflammation.
The
expression
levels
Plins
are
often
associated
with
various
diseases,
hepatic
steatosis
atherosclerotic
plaque
formation.
Thus,
it
becomes
interest
to
investigate
Plin
roles
by
using
appropriate
"omics"
approaches
that
may
provide
additional
insight
into
mechanisms
through
these
contribute
tissue
homeostasis.
This
review
intended
give
an
overview
significant
omics
studies
focused
characterization
identification
potential
targets
involved
progression
cardiovascular
cardiometabolic
complications,
well
interactors
could
be
useful
for
more
efficient
therapeutic
preventive
patients.
Cell Death and Disease,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 27, 2025
Abstract
Glioma
is
a
common
and
destructive
brain
tumor,
which
highly
heterogeneous
with
poor
prognosis.
Developing
diagnostic
prognostic
markers
to
identify
treat
glioma
early
would
significantly
improve
the
therapeutic
outcomes.
Here,
we
conducted
RNA
next-generation
sequencing
33
samples
15
normal
samples.
We
found
Perilipin
1
(PLIN1)
downregulated
in
correlated
poorer
outcome.
Subsequent
experiments
revealed
that
up
regulation
of
PLIN1
led
repressed
cell
growth
invasion
glioma.
Moreover,
overexpression
increased
lipid
accumulation
cells,
increasing
expression
biosynthesis
related
genes
decreasing
lipolysis
genes.
Mechanically,
PI3K/AKT
axis
could
regulate
levels
glioma,
inhibition
activity
increase
In
conclusion,
dysregulation
downregulation
following
tumor
proliferation,
metabolism
reprogramming
Frontiers in Genetics,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 18, 2025
Cancer-associated
fibroblasts
are
an
essential
part
of
the
tumor
immunoenvironment,
playing
key
roles
in
malignancy
progression
and
treatment
response.
This
study
was
to
characterize
cancer-associated
fibroblasts-related
genes
(CAFs)
colorectal
cancer
(CRC)
establish
signature
associated
with
CAF
for
prognosis
prediction.
We
downloaded
single-cell
RNA
sequencing
(scRNA-seq)
data
from
GEO
database
bulk
RNA-seq
TCGA
identify
differentially
expressed
related
fibroblasts.
In
set,
DEGs
were
identified
samples,
WGCNA
method
utilized
module
genes.
By
comparing
fibroblast-related
DEGs,
we
took
overlapped
cohorts
as
crucial
CAFs.
Moreover,
prognostic
CAFs
using
univariate
analysis.
A
risk
model
established
LASSO
algorithm
then
validated
external
datasets.
Ultimately,
expression
CRC
confirmed
qRT-PCR.
large
cohort
CAFs,
eight
demonstrating
significance.
These
primarily
seven
pathways,
including
peroxisome
function,
B
cell
receptor
signal,
adhesion
molecule.
The
exhibited
high
accuracy
predicting
prognosis,
through
validation
independent
cohorts.
Additionally,
showed
significant
correlations
immune-related
scores,
purity,
estimate,
stromal
scores.
qRT-PCR
that
level
RAB36
significantly
downregulated
HCT116
HT29
lines
compared
NCM460
cells.
Conversely,
CD177,
PBX4
CCDC78
upregulated
lines,
ACSL6
KCNJ14
only
cells
(P
<
0.05).
trends
CD177
consistent
our
predicted
results.
accurately
immune
infiltration,
estimates.
(CD177
CCDC78)
may
be
potential
therapeutic
targets
CRC.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Май 16, 2024
Over
the
past
10
years,
biological
role
of
lipid
droplets
(LDs)
has
gained
significant
attention
in
context
both
physiological
and
pathological
conditions.
Considerable
progress
been
made
elucidating
key
aspects
these
organelles,
yet
much
remains
to
be
accomplished
fully
comprehend
myriad
functions
they
serve
progression
hepatic
tumors.
Our
current
perception
is
that
LDs
are
complex
active
structures
managed
by
a
distinct
set
cellular
processes.
This
understanding
represents
paradigm
shift
from
earlier
perspectives.
In
this
review,
we
aim
recapitulate
function
within
liver,
highlighting
their
pivotal
pathogenesis
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
(Hsu
Loomba,
2024)
contribution
towards
more
advanced
stages
up
hepatocellular
carcinoma
(HC)
(Farese
Walther,
2009).
We
aware
molecular
complexity
changes
occurring
neoplastic
evolution
liver.
attempt,
however,
summarize
most
important
recent
roles
across
healthy
all
states,
hepatocarcinoma.
For
detailed
insights,
direct
readers
some
many
excellent
reviews
already
available
literature
(Gluchowski
et
al.,
2017;
Hu
2020;
Seebacher
Paul
2022).
