Innovative landscapes in intraperitoneal therapy of ovarian cancer
K. Kumar,
M. S. Madhusoodanan,
Meghna Pangath
и другие.
Drug Delivery and Translational Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Язык: Английский
The latest applications of exosome-mediated drug delivery in anticancer therapies
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
249, С. 114500 - 114500
Опубликована: Янв. 6, 2025
Язык: Английский
The Role of Non-coding RNAs in Diabetic Retinopathy: Mechanistic Insights and Therapeutic Potential
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Harnessing Extracellular Vesicles for Targeted Drug Delivery in Ovarian Cancer
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 528 - 528
Опубликована: Апрель 17, 2025
Ovarian
cancer
remains
one
of
the
most
lethal
gynecologic
malignancies,
primarily
due
to
late-stage
diagnosis,
high
recurrence
rates,
and
development
chemoresistance.
Although
targeted
therapies
have
improved
patient
outcomes,
their
efficacy
is
often
limited
by
off-target
toxicity
acquired
drug
resistance.
Extracellular
vesicles
(EVs),
nanoscale
naturally
released
cells,
emerged
as
promising
carriers
for
precision
delivery.
This
review
provides
a
comprehensive
overview
recent
advances
in
EV-based
therapeutic
strategies
ovarian
cancer,
including
delivery
chemotherapeutic
agents,
nucleic
acid
therapeutics,
immunomodulatory
molecules.
We
further
explore
innovative
engineering
approaches
enhance
targeting
specificity,
such
surface
modification,
cell
source
selection,
biomaterial
integration,
magnetic
nanoparticle-assisted
Key
translational
challenges
bringing
clinical
application
are
also
addressed.
Collectively,
these
insights
underscore
transformative
potential
platforms
advancing
personalized
treatment
cancer.
Язык: Английский
Exosomes: Key Factors in Ovarian Cancer Peritoneal Metastasis and Drug Resistance
Biomolecules,
Год журнала:
2024,
Номер
14(9), С. 1099 - 1099
Опубликована: Сен. 2, 2024
Ovarian
cancer
remains
a
leading
cause
of
death
among
gynecological
cancers,
largely
due
to
its
propensity
for
peritoneal
metastasis
and
the
development
drug
resistance.
This
review
concentrates
on
molecular
underpinnings
these
two
critical
challenges.
We
delve
into
role
exosomes,
nano-sized
vesicles
integral
cellular
communication,
in
orchestrating
complex
interactions
within
tumor
microenvironment
that
facilitate
metastatic
spread
thwart
therapeutic
efforts.
Specifically,
we
explore
how
exosomes
drive
by
promoting
epithelial–mesenchymal
transition
mesothelial
cells,
altering
extracellular
matrix,
supporting
angiogenesis,
which
collectively
enable
dissemination
cells
across
cavity.
Furthermore,
dissect
mechanisms
contribute
emergence
resistance,
including
sequestration
expulsion
chemotherapeutic
agents,
horizontal
transfer
resistance
genes,
modulation
DNA
repair
apoptotic
pathways.
By
shedding
light
exosome-mediated
processes,
underscore
potential
exosomal
pathways
as
novel
targets,
offering
hope
more
effective
interventions
against
ovarian
cancer’s
relentless
progression.
Язык: Английский
Cancer-associated Fibroblasts-derived Exosomes with HOXD11 Overexpression Promote Ovarian Cancer Cell Angiogenesis Via FN1
Reproductive Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 11, 2024
Язык: Английский
Emerging strategies to overcome ovarian cancer: advances in immunotherapy
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 5, 2024
Ovarian
cancer
is
the
second
most
common
malignant
neoplasm
of
gynecological
origin
and
leading
cause
death
from
in
female
reproductive
system
worldwide.
This
scenario
largely
due
to
late
diagnoses,
often
advanced
stages,
development
chemoresistance
by
cells.
These
challenges
highlight
need
for
alternative
treatments,
with
immunotherapy
being
a
promising
option.
Cancer
involves
triggering
an
anti-tumor
immune
response
developing
immunological
memory
eliminate
cells,
prevent
recurrence,
inhibit
metastasis.
Some
ongoing
research
investigate
potentially
advancements
field
vaccines,
checkpoint
blockade,
CAR-T
cell,
other
strategies.
Язык: Английский
Exosomes as promising frontier approaches in future cancer therapy
World Journal of Gastrointestinal Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Дек. 11, 2024
In
this
editorial,
we
will
discuss
the
article
by
Tang
et
al
published
in
recent
issue
of
World
Journal
Gastrointestinal
Oncology
.
They
explored
an
innovative
approach
to
enhancing
gemcitabine
(GEM)
delivery
and
efficacy
using
human
bone
marrow
mesenchymal
stem
cells
(HU-BMSCs)-derived
exosomes.
The
manufacture
GEM-loaded
HU-BMSCs-derived
exosomes
(Exo-GEM)
has
been
optimized.
’s
study
demonstrated
that
Exo-GEM
exhibits
enhanced
cytotoxicity
apoptosis-inducing
effects
compared
free
GEM,
highlighting
potential
exosome-based
drug
systems
as
a
more
effective
targeted
chemotherapy
pancreatic
cancer.
Additional
vivo
studies
are
required
confirm
safety
effectiveness
before
it
can
be
considered
for
clinical
use.
Язык: Английский