Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Окт. 4, 2023
The
microbiota
gut
brain
(MGB)
axis
has
been
shown
to
play
a
significant
role
in
the
regulation
of
inflammatory
and
infective
diseases.
Exploring
structure
communication
mode
MGB
is
crucial
for
understanding
its
diseases,
studying
signaling
pathways
regulatory
methods
diseases
also
profound
significance
future
clinical
research.
This
article
reviews
composition,
mechanism
including
Parkinson’s
disease
(PD),
Alzheimer’s
(AD),
multiple
sclerosis
(MS),
autism
spectrum
disorder
(ASD),
depression,
psoriasis,
irritable
bowel
syndrome
(IBS),
(IBD).
In
addition,
our
investigation
delved
into
functions
inflammasome,
IFN-I,
NF-κB,
PARK7/DJ-1
innate
immune
pathway
context
Ultimately,
we
discussed
efficacy
various
interventions,
fecal
transplantation
(FMT),
antibiotics,
probiotics,
prebiotics,
synbiotics,
postbiotics,
management
Understanding
might
make
positive
effects
treatment
Clinical Microbiology Reviews,
Год журнала:
2022,
Номер
35(1)
Опубликована: Янв. 5, 2022
The
human
body
is
full
of
an
extensive
number
commensal
microbes,
consisting
bacteria,
viruses,
and
fungi,
collectively
termed
the
microbiome.
initial
acquisition
microbiota
occurs
from
both
external
maternal
environments,
vast
majority
them
colonize
gastrointestinal
tract
(GIT).
These
microbial
communities
play
a
central
role
in
maturation
development
immune
system,
nervous
GIT
system
are
also
responsible
for
essential
metabolic
pathways.
Various
factors,
including
host
genetic
predisposition,
environmental
lifestyle,
diet,
antibiotic
or
nonantibiotic
drug
use,
etc.,
affect
composition
gut
microbiota.
Recent
publications
have
highlighted
that
imbalance
microflora,
known
as
dysbiosis,
associated
with
onset
progression
neurological
disorders.
Moreover,
characterization
microbiome-host
cross
talk
pathways
provides
insight
into
novel
therapeutic
strategies.
Novel
preclinical
clinical
research
on
interventions
related
to
microbiome
treating
conditions,
autism
spectrum
disorders,
Parkinson's
disease,
schizophrenia,
multiple
sclerosis,
Alzheimer's
epilepsy,
stroke,
hold
significant
promise.
This
review
aims
present
comprehensive
overview
potential
involvement
pathogenesis
particular
emphasis
microbe-based
therapies
and/or
diagnostic
biomarkers.
discusses
health
benefits
administration
probiotics,
prebiotics,
postbiotics,
synbiotics
fecal
transplantation
EBioMedicine,
Год журнала:
2022,
Номер
77, С. 103908 - 103908
Опубликована: Март 1, 2022
The
recent
revelation
that
the
gut
microbiome,
home
to
approximately
100
trillion
microorganisms,
is
implicated
in
development
of
both
health
and
disease
has
spurred
an
exponential
increase
interdisciplinary
research
involving
microbiology.
In
all
this
hype,
there
a
need
better
understand
contextualize
emerging
evidence
for
role
microbiota
neurodegenerative
neurodevelopmental
diseases,
including
central
nervous
system
(CNS)
malignancies.
review,
we
aim
unravel
complex
interactions
microbiota-gut-brain-axis
pave
understanding
microbiota-mediated
pathogenesis,
avenues
noninvasive
prognosis,
therapeutic
possibilities
leveraging
modulations.
We
further
provide
insights
ongoing
transition
from
bench
bedside
discuss
limitations
current
approaches.
Ultimately,
urge
continued
synergistic
models
with
considerable
consideration
many
gut-resident
bacteria
will
enable
significant
progress
treatment
neurological
diseases.
Molecular Neurodegeneration,
Год журнала:
2022,
Номер
17(1)
Опубликована: Март 5, 2022
The
implication
of
gut
microbiota
in
the
control
brain
functions
health
and
disease
is
a
novel,
currently
emerging
concept.
Accumulating
data
suggest
that
exert
its
action
at
least
part
by
modulating
neuroinflammation.
Given
link
between
neuroinflammatory
changes
neuronal
activity,
it
plausible
may
affect
indirectly
impacting
microglia,
key
player
Indeed,
increasing
evidence
suggests
interplay
microglia
synaptic
dysfunction
involve
microbiota,
among
other
factors.
In
addition
to
these
indirect
microglia-dependent
actions
on
has
been
recently
recognized
could
also
activity
directly
stimulation
vagus
nerve.
Brain Behavior and Immunity,
Год журнала:
2022,
Номер
106, С. 76 - 88
Опубликована: Авг. 10, 2022
Gut
microbiota
alterations
might
affect
the
development
of
Alzheimer's
disease
(AD)
through
microbiota-derived
metabolites.
For
example,
Indoles
via
tryptophan
metabolism
prevented
Aβ
accumulation
and
Tau
hyperphosphorylation,
restored
synaptic
plasticity,
then
promoted
cognitive
behavioral
ability
APP/PS1
mice.
The
imbalanced
compositions
Indoles-producing
bacteria
with
deficiency
were
found
in
male
mice,
but
molecular
mechanisms
remained
unclear.
Our
current
study
revealed
that
(including
indole,
indole-3-acetic
acid
indole-3-propionic
acid)
upregulated
production
aryl
hydrocarbon
receptor
(AhR),
inhibited
activation
NF-κB
signal
pathway
as
well
formation
NLRP3
inflammasome,
reduced
release
inflammatory
cytokines,
including
TNF-α,
IL-6,
IL-1β
IL-18,
alleviating
response
These
findings
demonstrated
roles
activating
AhR
to
regulate
neuroinflammation
AD
gut
Indoles,
which
implied
a
novel
way
for
treatment.
The
gut
microbiota
(GM)
and
its
metabolites
affect
the
host
nervous
system
are
involved
in
pathogeneses
of
various
neurological
diseases.
However,
specific
GM
alterations
under
pathogenetic
pressure
their
contributions
to
"microbiota
–
metabolite
brain
axis"
Alzheimer's
disease
(AD)
remain
unclear.
Here,
we
investigated
fecal,
serum,
cortical
metabolomes
APP/PS1
wild-type
(WT)
mice,
revealing
distinct
hub
bacteria
AD
mice
within
scale-free
networks
shared
by
both
groups.
Moreover,
identified
diverse
peripheral
central
metabolic
landscapes
between
WT
that
featured
bile
acids
(e.g.
deoxycholic
isodeoxycholic
acid)
unsaturated
fatty
11Z-eicosenoic
palmitoleic
acid).
Machine-learning
models
revealed
relationships
differential/hub
these
signatures
from
periphery
brain.
Notably,
AD-enriched
Dubosiella
affected
occurrence
via
acid
vice
versa.
Considering
transgenic
background
propose
enrichment
impedes
progression
synthesis
acid,
which
has
protective
properties
against
inflammation
disorders.
We
another
association
involving
fecal
acid-mediated
interactions
Erysipelatoclostridium
occurrence,
was
corroborated
correlation
deoxycholate
levels
cognitive
scores
humans.
Overall,
this
study
elucidated
network
alterations,
landscapes,
mediatory
roles
thus
critical
pathogenesis
communications
pressure.
The
gut
microbial
ecosystem
communicates
bidirectionally
with
the
brain
in
what
is
known
as
gut-microbiome-brain
axis.
Bidirectional
signaling
occurs
through
several
pathways
including
via
vagus
nerve,
circulation
of
metabolites,
and
immune
activation.
Alterations
microbiota
are
implicated
Alzheimer's
disease
(AD),
a
progressive
neurodegenerative
disease.
Perturbations
communities
may
affect
within
axis
altered
production
metabolites
ɣ-aminobutyric
acid
(GABA),
primary
inhibitory
mammalian
neurotransmitter.
GABA
has
been
shown
to
act
on
integrity
modulation
mucins
tight
junction
proteins
be
involved
nerve
signal
inhibition.
GABAergic
pathway
dysregulated
AD,
responsive
interventions.
Gut
recent
interest
neurological
disorders,
AD.
Bacteroides
Lactic
Acid
Bacteria
(LAB),
Lactobacillus,
predominant
producers
GABA.
This
review
highlights
how
temporal
alterations
associated
AD
pathway,
intestinal
barrier
integrity,
AD-associated
inflammation.
Nutrients,
Год журнала:
2022,
Номер
14(10), С. 2161 - 2161
Опубликована: Май 23, 2022
Anthocyanins
are
mainly
purple-coloured
phenolic
compounds
of
plant
origin
that
as
secondary
metabolites
important
in
survival.
Understanding
their
health
benefits
humans
requires
sourcing
these
unstable
sufficient
quantities
at
a
reasonable
cost,
which
has
led
to
improved
methods
extraction.
Dark-coloured
fruits,
cereals
and
vegetables
current
sources
compounds.
The
range
potential
sustainable
is
much
larger
includes
non-commercialised
native
plants
from
around
the
world
agri-waste
containing
anthocyanins.
In
last
5
years,
there
have
been
significant
advances
developing
therapeutic
anthocyanins
chronic
human
diseases.
exert
beneficial
effects
through
improvements
gut
microbiota,
oxidative
stress
inflammation,
modulation
neuropeptides
such
insulin-like
growth
factor-1.
Their
include
reduced
cognitive
decline;
protection
organs
liver,
well
cardiovascular
system,
gastrointestinal
tract
kidneys;
bone
obesity;
regulation
glucose
lipid
metabolism.
This
review
summarises
some
mechanisms
treatment
