Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(5)
Опубликована: Май 13, 2024
This
review
article
explores
the
intricate
correlation
between
growth
factors
and
bone
metastases,
which
play
a
crucial
role
in
development
of
several
types
malignancies,
namely
breast,
prostate,
lung,
renal
cancers.
The
focal
point
our
discussion
is
on
receptors
for
factors,
including
Epidermal
Growth
Factor
Receptor
(EGFR),
Transforming
Factor-β
(TGFβ),
Vascular
Endothelial
(VEGFR),
Fibroblast
(FGFR).
These
receptors,
are
essential
cellular
activities
growth,
differentiation,
survival,
have
important
involvement
spread
cancer
interactions
tumors
environment.
We
discuss
underlying
mechanisms
with
specific
emphasis
interaction
factor
microenvironment.
EGFR
signaling
specifically
enhances
process
osteoclast
formation
osteolytic
lesions,
especially
breast
lung
malignancies.
TGFβ
both
osteoblastic
metastases
by
releasing
TGFβ,
attracts
cells
promotes
remodeling.
element
prostate
to
bones.
functions
FGFR
VEGFR
processes
tumor
angiogenesis,
respectively,
highlight
complex
diverse
nature
these
interactions.
emphasizes
possibility
targeted
therapeutics
targeting
interrupt
cycle
degradation.
Therapeutic
approaches
include
focusing
VEGF/VEGFR,
EGF/EGFR,
FGF/FGFR,
TGFβ/TGFβR
pathways.
variety
compounds,
such
as
small
molecule
inhibitors
monoclonal
antibodies,
shown
potential
interfere
tumor-induced
alterations
bone.
text
discusses
clinical
trials
preclinical
models,
offering
insights
into
effectiveness
constraints
various
treatments.
Ultimately,
this
study
provides
succinct
but
thorough
summary
present
knowledge
treatment
strategies
focused
metastases.
highlights
significance
comprehending
microenvironment
where
bones,
well
using
therapies
enhance
results
patients
advancement
treating
hinges
treatments
that
target
relationships
malignancies
Cancers,
Год журнала:
2022,
Номер
14(9), С. 2267 - 2267
Опубликована: Май 1, 2022
The
tumor
microenvironment
of
ovarian
cancer
is
the
peritoneal
cavity
wherein
adipose
tissue
a
major
component.
role
in
support
progression
has
been
elucidated
several
studies
from
past
decades.
adipocytes,
particular,
are
source
factors,
which
regulate
all
facets
such
as
acquisition
chemoresistance,
enhanced
metastatic
potential,
and
metabolic
reprogramming.
In
this
review,
we
summarize
relevant
studies,
highlight
adipocytes
offer
insights
into
unanswered
questions
possible
future
directions
research.
Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 601 - 601
Опубликована: Фев. 17, 2023
The
use
of
cold
atmospheric
plasma
(CAP)
in
oncology
has
been
intensively
investigated
over
the
past
15
years
as
it
inhibits
growth
many
tumor
cells.
It
is
known
that
reactive
oxidative
species
(ROS)
produced
CAP
are
responsible
for
this
effect.
However,
to
translate
into
medical
practice,
essential
know
how
treatment
affects
non-malignant
Thus,
current
vitro
study
deals
with
effect
on
human
bone
cancer
cells
and
osteoblasts.
Here,
identical
regimens
were
applied
malignant
their
impact
was
compared.Two
different
cell
types,
U2-OS
(osteosarcoma)
A673
(Ewing's
sarcoma),
primary
osteoblasts
(HOB)
used.
performed
clinically
approved
kINPen
MED.
After
treatment,
kinetics
a
viability
assay
performed.
For
detecting
apoptosis,
caspase-3/7
TUNEL
Accumulated
ROS
measured
culture
medium
intracellular.
To
investigate
influence
motility,
scratch
carried
out.The
showed
strong
inhibition
Apoptotic
processes
enhanced
Osteoblasts
higher
potential
resistance
comparison
There
no
difference
motility
between
benign
following
treatment.Osteoblasts
show
better
tolerance
indicated
by
less
affected
compared
CAP-treated
This
points
toward
selective
sarcoma
represents
further
step
clinical
application
CAP.
Annals of Translational Medicine,
Год журнала:
2022,
Номер
10(6), С. 281 - 281
Опубликована: Март 1, 2022
Background:
Non-small
cell
lung
cancer
(NSCLC)
frequently
metastasizes
to
bone,
leading
poor
prognosis.
Siglec15
has
been
identified
as
a
newly
discovered
immune
checkpoint
and
exists
in
variety
of
tumors.
However,
the
expression
function
NSCLC
bone
metastasis
remains
largely
unclear.
Methods:
correlation
between
clinicopathological
factors
patients
with
were
analyzed
using
The
Cancer
Genome
Atlas
(TCGA)
dataset.
Correlation
analysis
metastasis-related
genes
was
based
on
Molecular
Signatures
Database
(MSigDB).
Western
blotting
immunohistochemistry
applied
detect
spinal
metastasis.
Human
A549
mouse
CMT167
cells
transfected
siRNA
investigate
its
biological
functions
proliferation,
migration,
invasion.
immune-related
signaling
pathways
correlations
tumor-infiltrating
different
checkpoints
tumor
microenvironment
(TME)
Estimating
Relative
Subsets
RNA
Transcripts
(CIBERSORT)
gene
set
enrichment
(GSEA).
To
demonstrate
cell-mediated
T
suppression
potential
mechanism
silencing
antitumor
immunity,
we
used
killing
assay
vitro
high‑throughput
sequencing
approach.
Results:
positively
associated
stage
lymph
node
metastasis,
markedly
up-regulated
Functionally,
knockdown
inhibited
invasion
(A549
lines).
A
total
eight
kinds
found
have
strong
association
cases.
previously
higher
high
group.
Furthermore,
an
showed
that
down-regulation
could
enhance
responses
CD8+
cells.
High‑throughput
revealed
molecular
mechanisms
underlying
Siglec15-mediated
immunosuppression
effect
Conclusions:
may
be
involved
pathogenesis
provide
new
therapeutic
target
for
treatment
Cells,
Год журнала:
2022,
Номер
11(23), С. 3934 - 3934
Опубликована: Дек. 5, 2022
Wnt
signaling
occurs
through
evolutionarily
conserved
pathways
that
affect
cellular
proliferation
and
fate
decisions
during
development
tissue
maintenance.
Alterations
in
these
highly
regulated
pathways,
however,
play
pivotal
roles
various
malignancies,
promoting
cancer
initiation,
growth
metastasis
the
of
drug
resistance.
The
ability
cells
to
metastasize
is
primary
cause
mortality.
Bone
one
most
frequent
sites
metastases
generally
arise
from
breast,
prostate,
lung,
melanoma
or
kidney
cancer.
Upon
their
arrival
bone,
can
enter
a
long-term
dormancy
period,
which
they
be
reactivated,
but
rarely
cured.
activation
bone
process
was
found
enhance
proliferation,
induce
epithelial-to-mesenchymal
transition,
promote
modulation
extracellular
matrix,
angiogenesis
immune
tolerance
thrive
bone.
Due
complexity
landscape
this
mineralized
tissue,
function
metastatic
progression
within
not
yet
fully
understood.
Therefore,
we
believe
better
understanding
could
improve
our
disease
may
constitute
fertile
ground
for
potential
therapeutics.
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(5)
Опубликована: Май 13, 2024
This
review
article
explores
the
intricate
correlation
between
growth
factors
and
bone
metastases,
which
play
a
crucial
role
in
development
of
several
types
malignancies,
namely
breast,
prostate,
lung,
renal
cancers.
The
focal
point
our
discussion
is
on
receptors
for
factors,
including
Epidermal
Growth
Factor
Receptor
(EGFR),
Transforming
Factor-β
(TGFβ),
Vascular
Endothelial
(VEGFR),
Fibroblast
(FGFR).
These
receptors,
are
essential
cellular
activities
growth,
differentiation,
survival,
have
important
involvement
spread
cancer
interactions
tumors
environment.
We
discuss
underlying
mechanisms
with
specific
emphasis
interaction
factor
microenvironment.
EGFR
signaling
specifically
enhances
process
osteoclast
formation
osteolytic
lesions,
especially
breast
lung
malignancies.
TGFβ
both
osteoblastic
metastases
by
releasing
TGFβ,
attracts
cells
promotes
remodeling.
element
prostate
to
bones.
functions
FGFR
VEGFR
processes
tumor
angiogenesis,
respectively,
highlight
complex
diverse
nature
these
interactions.
emphasizes
possibility
targeted
therapeutics
targeting
interrupt
cycle
degradation.
Therapeutic
approaches
include
focusing
VEGF/VEGFR,
EGF/EGFR,
FGF/FGFR,
TGFβ/TGFβR
pathways.
variety
compounds,
such
as
small
molecule
inhibitors
monoclonal
antibodies,
shown
potential
interfere
tumor-induced
alterations
bone.
text
discusses
clinical
trials
preclinical
models,
offering
insights
into
effectiveness
constraints
various
treatments.
Ultimately,
this
study
provides
succinct
but
thorough
summary
present
knowledge
treatment
strategies
focused
metastases.
highlights
significance
comprehending
microenvironment
where
bones,
well
using
therapies
enhance
results
patients
advancement
treating
hinges
treatments
that
target
relationships
malignancies
