The Bio‐Hermes Study: Biomarker database developed to investigate blood‐based and digital biomarkers in community‐based, diverse populations clinically screened for Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(4), P. 2752 - 2765

Published: Feb. 28, 2024

Abstract INTRODUCTION Alzheimer's disease (AD) trial participants are often screened for eligibility by brain amyloid positron emission tomography/cerebrospinal fluid (PET/CSF), which is inefficient as many not positive. Use of blood‐based biomarkers may reduce screen failures. METHODS We recruited 755 non‐Hispanic White, 115 Hispanic, 112 Black, and 19 other minority across groups cognitively normal ( n = 417), mild cognitive impairment 312), or AD 272) participants. Plasma beta (Aβ)40, Aβ42, Aβ42/Aβ40, total tau, phosphorylated tau (p‐tau)181, p‐tau217 were measured; PET/CSF 956) determined positivity. Clinical, blood biomarker, ethnicity/race differences associated with status evaluated. RESULTS Greater impairment, older age, carrying an apolipoprotein E (apoE) ε4 allele greater burden. Areas under the receiver operating characteristic curve plasma p‐tau181, positivity ≥ 0.7117 all ethnoracial (p‐tau217, ≥0.8128). Age apoE adjustments imputation biomarker values outside limit quantitation provided small improvement in predictive power. DISCUSSION Blood‐based highly results diverse populations enrolled at clinical sites. Highlights Amyloid (Aβ)42/Aβ40, p‐tau 217 predicted P‐tau was strongest predictor Biomarkers from ethnic, racial, cohorts Community‐based have similar levels populations. A prescreen process assays number

Language: Английский

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Pathogenesis, Diagnostics, and Therapeutics for Alzheimer's Disease: Breaking the Memory Barrier

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102481 - 102481

Published: Sept. 3, 2024

Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60-70 % all cases. It affects millions people worldwide. AD poses a substantial economic burden on societies healthcare systems. progressive neurodegenerative disorder characterized by cognitive decline, memory loss, impaired daily functioning. As prevalence continues to increase, understanding its pathogenesis, improving diagnostic methods, developing effective therapeutics have become paramount. This comprehensive review delves into intricate mechanisms underlying AD, explores current state techniques, examines emerging therapeutic strategies. By revealing complexities this aims contribute growing body knowledge surrounding devastating disease.

Language: Английский

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Mechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease

Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 235 - 248

Published: Jan. 5, 2025

Language: Английский

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Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations

Mechanisms of Ageing and Development, Journal Year: 2023, Volume and Issue: 211, P. 111787 - 111787

Published: Feb. 1, 2023

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Growing evidence suggests the gut microbiome (GM) plays pivotal role in pathogenesis AD through microbiota-gut-brain axis (MGB). Alterations GM composition and diversity have been observed both animal models human patients with AD. dysbiosis has implicated increased intestinal permeability, blood-brain barrier (BBB) impairment, neuroinflammation development hallmarks Further elucidation could pave way for holistic predictive methods determining risk progression disease. Furthermore, accumulating modulation alleviate adverse symptoms or serve as preventive measure. In addition, increasing shows Type 2 Diabetes Mellitus (T2DM) often comorbid AD, common alterations inflammatory response, which chart GM-related treatment interventions diseases. We conclude by exploring therapeutic potential alleviating reducing risk. we also propose future directions research, namely fecal microbiota transplantation (FMT) precision medicine.

Language: Английский

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Sensitive label-free detection of the biomarker phosphorylated tau−217 protein in Alzheimer's disease using a graphene-based solution-gated field effect transistor

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 228, P. 115174 - 115174

Published: March 12, 2023

Language: Английский

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Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Alzheimer's disease (AD) is a age-related neurodegenerative and major public health concern both in Texas, US Worldwide. This mainly characterized by amyloid-beta (Aβ) phosphorylated Tau (p-Tau) accumulation the brains of patients with AD increasing evidence suggests that these are key biomarkers AD. Both Aβ p-tau can be detected through various imaging techniques (such as positron emission tomography, PET) cerebrospinal fluid (CSF) analysis. The presence individuals, who asymptomatic or have mild cognitive impairment indicate an increased risk developing future. Furthermore, combination often used for more accurate diagnosis prediction progression. Along being disease, it associated other chronic conditions such cardiovascular obesity, depression, diabetes because studies shown comorbid make people vulnerable to In first part this review, we discuss biofluid-based Aβ, p-Tau & plasma could alternative sensitive technique diagnose second part, underlying molecular mechanisms linked how they affect clinical care.

Language: Английский

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A Multi-Label Deep Learning Model for Detailed Classification of Alzheimer's Disease

Actas Españolas de Psiquiatría, Journal Year: 2025, Volume and Issue: 53(1), P. 89 - 99

Published: Jan. 5, 2025

Background: Accurate diagnosis and classification of Alzheimer's disease (AD) are crucial for effective treatment management. Traditional diagnostic models, largely based on binary systems, fail to adequately capture the complexities variations across different stages subtypes AD, limiting their clinical utility. Methods: We developed a deep learning model integrating dot-product attention mechanism an innovative labeling system enhance AD severity levels. This processed various demographic data, emphasizing most relevant features diagnosis. The approach emphasized precision in identifying predicting through advanced computational techniques that mimic expert decision-making. Results: Comparative tests against baseline fully connected neural network demonstrated our proposed significantly improved accuracy. Our achieved accuracy 83.1% subtypes, compared 72.9% by baseline. In prediction, reached 83.3%, outperforming (73.5%). Conclusions: incorporation tailored enhances diagnosing classifying AD. improvement highlights potential support personalized strategies advance medicine neurodegenerative diseases.

Language: Английский

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Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides

Cells, Journal Year: 2023, Volume and Issue: 12(13), P. 1700 - 1700

Published: June 23, 2023

Every cell biological textbook teaches us that the main role of plasma membrane is to separate cells from their neighborhood allow for a controlled composition intracellular space. The mostly hydrophobic nature presents an impenetrable barrier most hydrophilic molecules larger than 1 kDa. On other hand, cell-penetrating peptides (CPPs) are capable traversing this without compromising integrity, and they can do so on own or coupled cargos. Coupling biologically medically relevant cargos CPPs holds great promise delivering membrane-impermeable drugs into cells. If cargo able interact with certain types, uptake CPP–drug complex be tailored cell-type-specific. Besides outlining major penetration pathways CPPs, review aimed at deciphering how properties influence mechanisms CPPs. By summarizing extensive body experimental evidence, we argue more ordered, less flexible structure, often present in very diseases planned treated decreases cellular uptake. These correlations not only understanding biology but also rationally improving value translational clinical applications.

Language: Английский

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Aerobic exercise suppresses cognitive injury in patients with Alzheimer’s disease by regulating long non-coding RNA TUG1

Neuroscience Letters, Journal Year: 2024, Volume and Issue: 826, P. 137732 - 137732

Published: March 1, 2024

Language: Английский

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Epigenetic Peripheral Biomarkers for Early Diagnosis of Alzheimer’s Disease

Genes, Journal Year: 2022, Volume and Issue: 13(8), P. 1308 - 1308

Published: July 22, 2022

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and represents the leading cause of cognitive impairment dementia in older individuals throughout world. The main hallmarks AD include brain atrophy, extracellular deposition insoluble amyloid-β (Aβ) plaques, intracellular aggregation protein tau neurofibrillary tangles. These pathological modifications start many years prior to clinical manifestations

Language: Английский

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