International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(22), С. 16469 - 16469
Опубликована: Ноя. 17, 2023
Polyamines
(Pas)
are
short
molecules
that
exhibit
two
or
three
amine
groups
positively
charged
at
a
physiological
pH.
These
small
present
in
high
concentrations
wide
variety
of
organisms
and
tissues,
suggesting
they
play
an
important
role
cellular
physiology.
include
spermine,
spermidine,
putrescine,
which
roles
age-related
diseases
have
not
been
completely
elucidated.
Aging
is
natural
process,
defined
as
the
time-related
deterioration
functions;
it
considered
risk
factor
for
degenerative
such
cardiovascular,
neurodegenerative,
musculoskeletal
diseases;
arthritis;
even
cancer.
In
this
review,
we
provide
new
perspective
on
participation
Pas
molecular
processes
related
to
diseases,
focusing
our
attention
Alzheimerߣs
disease,
Parkinsonߣs
osteoarthritis,
sarcopenia,
osteoporosis.
This
leads
us
propose
function
novel
biomarkers
with
main
purpose
achieving
alternatives
healthier
aging.
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2023,
Номер
Volume 16, С. 1541 - 1554
Опубликована: Май 1, 2023
Abstract:
Diabetes
and
sarcopenia
are
emerging
as
serious
public
health
issues.
Sarcopenia,
an
age-related
disorder
characterized
by
loss
of
skeletal
muscle
mass
function,
is
recognized
a
new
complication
in
elderly
patients
with
type
2
diabetes
mellitus
(T2DM).
Type
insulin
resistance,
chronic
inflammation,
accumulation
advanced
glycation
products
increased
oxidative
stress,
which
can
negatively
affect
mass,
strength
function
leading
to
sarcopenia.
There
mutual
interrelationship
between
T2DM
light
pathophysiology
mechanism
long-term
outcome.
will
accelerate
the
decline
turn
lead
glucose
metabolism
disorders,
reduced
physical
activity
risk
diabetes.
However,
specific
involved
has
not
been
thoroughly
studied.
Therefore,
this
review
aims
explore
therapeutic
strategy
related
provide
insight
for
future
investigations,
great
significance
improving
quality
life
concurrently
reducing
incidence
complications.
Keywords:
mellitus,
sarcopenia,
gut
microbiota,
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2415 - 2415
Опубликована: Янв. 26, 2023
The
progressive
loss
of
skeletal
muscle
mass
and
concomitant
reduction
in
contractile
strength
plays
a
central
role
frailty
syndrome.
Age-related
neuronal
impairments
are
closely
associated
with
sarcopenia
the
elderly,
which
is
characterized
by
severe
muscular
atrophy
that
can
considerably
lessen
overall
quality
life
at
old
age.
Mass-spectrometry-based
proteomic
surveys
senescent
human
muscles,
as
well
animal
models
sarcopenia,
have
decisively
improved
our
understanding
molecular
cellular
consequences
fiber-type
shifting
during
aging.
This
review
outlines
spectrometric
identification
proteome-wide
changes
atrophying
focus
on
proteins
potential
markers
distribution
patterns.
observed
trend
fast-to-slow
transitions
individual
muscles
aging
process
most
likely
linked
to
preferential
susceptibility
fast-twitching
fibers
atrophy.
Studies
models,
including
mostly
aged
rodent
confirmed
shifting.
analysis
fast
versus
slow
isoforms
key
proteins,
such
myosin
heavy
chains,
light
actins,
troponins
tropomyosins,
suggests
them
suitable
bioanalytical
tools
The journal of nutrition health & aging,
Год журнала:
2024,
Номер
28(4), С. 100184 - 100184
Опубликована: Фев. 12, 2024
The
aim
of
the
study
was
to
comprehensively
analyze
effects
whey
protein
(WP)-enriched
supplement
intake
with
or
without
resistance
training
(RT)
in
older
patients,
either
from
community
hospital,
who
were
diagnosed
sarcopenia
according
EWGSOP
AWGS
criteria.
Chronic
inflammatory
responses
have
been
reported
to
be
associated
with
low
muscle
mass
and
systemic
immune-inflammation
index(SII)
is
a
novel
indicator
of
inflammation.
The
purpose
our
study
was
clarify
the
relationship
between
SII
mass.This
cross-sectional
based
on
National
Health
Nutrition
Examination
Survey
(2011-2018).
calculated
as
platelet
count
×
neutrophil
count/lymphocyte
count.
Appendicular
skeletal
index
used
define
mass.
individuals
were
divided
into
four
groups
by
quartile
(Q1-Q4).
Multivariate
weighted
logistic
regression
analysis,
smooth
curve
fitting
subgroup
analysis
investigate
sarcopenia.
Subgroup
demographic
clinical
variables.There
10,367
enrolled
in
final
analysis.
overall
mean
age
39.39
years
49.17%
males.
prevalence
population
8.77%.
indicated
near-linear
In
multivariate
odds
ratio
(OR)
Q4
1.28
(95%
CI,
1.16-1.40)
for
when
compared
lowest
SII.
still
increased
risk
independently.The
levels
an
large
population.
Our
understanding
inflammation
Anti-inflammation
therapy
may
important
Abstract
Background
It
has
been
proposed
that
inflammation
plays
a
role
in
the
development
of
sarcopenia.
This
study
aimed
to
investigate
links
complete
blood
cell
count
(CBC)
parameters
and
CBC-derived
inflammatory
indicators
with
sarcopenia
mortality.
Methods
Data
pertaining
were
extracted
from
1999–2006
National
Health
Nutrition
Examination
Survey
(NHANES),
mortality
events
ascertained
through
Death
Index
up
December
31,
2019.
The
assessed
this
included
neutrophil-to-lymphocyte
ratio
(NLR),
derived
(dNLR),
monocyte-to-lymphocyte
(MLR),
neutrophil-monocyte
lymphocyte
(NMLR),
systemic
response
index
(SIRI),
immune-inflammation
(SII).
prognostic
significance
these
was
evaluated
using
random
survival
forests
(RSF)
analysis.
Results
encompassed
cohort
12,689
individuals,
among
whom
1,725
diagnosed
Among
individuals
sarcopenia,
782
experienced
all-cause
mortality,
195
succumbed
cardiovascular
causes.
Following
adjustment
for
confounding
variables,
it
observed
elevated
levels
NLR,
dNLR,
NMLR,
SIRI,
SII
associated
an
increased
prevalence
participants
those
highest
quartile
NLR
(HR
=
1.336
[1.095–1.631]),
dNLR
1.274
[1.046–1.550]),
MLR
1.619
[1.290–2.032]),
NMLR
1.390
[1.132–1.707]),
SIRI
1.501
[1.210–1.862])
exhibited
risk
compared
lowest
inflammation-derived
indicators.
These
associations
similarly
1.874
[1.169–3.003]
MLR,
HR
1.838
[1.175–2.878]
SIRI).
RSF
analysis
indicated
predictive
power
both
Conclusions
Our
findings
underscore
association
between
adults
Of
note,
emerged
as
most
robust
predictor
population.
Journal of Orthopaedic Surgery and Research,
Год журнала:
2024,
Номер
19(1)
Опубликована: Май 28, 2024
Sarcopenia
is
associated
with
increased
morbidity
and
mortality.
The
systemic
immune-inflammation
index
(SII)
has
been
correlated
to
a
variety
of
disorders.
present
study
conducted
systematic
review
meta-analysis
investigate
the
relationship
between
SII
sarcopenia.
World Journal of Surgical Oncology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 24, 2024
Abstract
Background
In
recent
years,
the
research
on
relationship
between
sarcopenia
before
and
after
treatment
of
esophageal
cancer,
as
well
its
impact
prognosis
has
increased
rapidly,
which
aroused
people’s
attention
to
disease
patients
with
cancer
complicated
sarcopenia.
This
review
examines
prevalence
in
(before
surgery
or
chemotherapy)
cancer.
Moreover,
we
summarized
potential
pathogenesis
pharmacologic
non-pharmacologic
therapies.
Methods
A
narrative
was
performed
PubMed
Web
Science
using
keywords
(“esophageal
cancer”
“esophageal
neoplasm”
“neoplasm,
esophageal”
“esophagus
neoplasms”
esophagus”
“neoplasms,
“cancer
“cancer,
“cancers,
cancers”
cancers”)
(“sarcopenia”
“muscular
atrophy”
“aging”
“senescence”
“biological
aging”
“aging,
biological”
“atrophies,
muscular”
“atrophy,
atrophies”
muscle”
“muscle
atrophies”).
Studies
reporting
were
analyzed.
Results
The
results
suggest
that
average
46.3%
±
19.6%
ranging
from
14.4
81%
can
be
an
important
predictor
poor
Patients
suffer
due
their
nutritional
deficiencies,
reduced
physical
activity,
chemotherapy,
effects
certain
inflammatory
factors
pathways.
When
classic
diagnostic
values
for
such
skeletal
muscle
index
(SMI)
are
not
available
clinically,
it
is
also
feasible
predict
simpler
metrics,
calf
circumference
(CC),
five-count
sit-up
test
(5-CST),
six-minute
walk
distance
(6MWD).
Conclusions
Identifying
mechanism
implementing
appropriate
interventions
may
hold
key
improving
these
patients.
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 404 - 404
Опубликована: Янв. 23, 2025
Sarcopenia
is
a
condition
characterized
by
the
loss
of
muscle
mass
and
function.
It
risk
factor
for
adverse
clinical
outcomes,
including
falls,
disability,
mortality
in
patients
with
chronic
kidney
disease
(CKD).
The
progression
CKD
leads
to
metabolic
disturbances
pathophysiological
changes.
These
alterations,
such
as
acidosis,
dysregulated
proteostasis,
excessive
inflammation,
contribute
accelerated
wasting,
resulting
sarcopenia.
Proper
nutritional
interventions
are
essential
management
sarcopenia
CKD.
Appropriate
dietary
intake
protein
specific
micronutrients,
carefully
considering
needs
restrictions
CKD,
may
help
maintain
Specific
patterns,
an
anti-inflammatory
diet,
Dietary
Approaches
Stop
Hypertension
plant-based
be
beneficial
attenuating
wasting
patients.
underlying
mechanisms
how
these
patterns
affect
multifaceted,
oxidative
stress,
defects
homeostasis.
This
review
summarizes
current
evidence
on
relationship
between
sarcopenia,
well
modulate
