Oxidative Stress, Endothelial Dysfunction, and N-Acetylcysteine in Type 2 Diabetes Mellitus

Antioxidants and Redox Signaling, Год журнала: 2024, Номер 40(16-18), С. 968 - 989

Опубликована: Март 18, 2024

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally. Endothelial dysfunction is closely associated with development progression CVDs. Patients diabetes mellitus (DM) especially type 2 DM (T2DM) exhibit a significant endothelial cell (EC) substantially increased risk for

Язык: Английский

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Endothelial Reprogramming in Atherosclerosis

Bioengineering, Год журнала: 2024, Номер 11(4), С. 325 - 325

Опубликована: Март 27, 2024

Atherosclerosis (AS) is a severe vascular disease that results in millions of cases mortality each year. The development atherosclerosis associated with structural lesions, characterized by the accumulation immune cells, mesenchymal lipids, and an extracellular matrix at intimal resulting formation atheromatous plaque. AS involves complex interactions among various cell types, including macrophages, endothelial cells (ECs), smooth muscle (SMCs). Endothelial dysfunction plays essential role initiation progression AS. can encompass constellation non-adaptive dynamic alterations biology function, termed “endothelial reprogramming”. This phenomenon transitioning from quiescent, anti-inflammatory state to pro-inflammatory proatherogenic identity, such as transition (EndMT) endothelial-to-immune cell-like (EndIT). Targeting these processes restore balance prevent identity shifts, alongside modulating epigenetic factors, attenuate progression. In present review, we discuss summarize studies reprogramming pathogenesis

Язык: Английский

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Prognostic significance of triglyceride-glucose index in acute coronary syndrome patients without standard modifiable cardiovascular risk factors

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 23, 2024

Abstract Background A significant percentage of patients with acute coronary syndrome (ACS) without standard modifiable cardiovascular risk factors (SMuRFs) are being identified. Nonetheless, the prognostic influence TyG index on adverse events in this type patient remains unexplored. The aim study was to assess value among ACS SMuRFs for predicting outcomes. Methods This involved 1140 consecutive who were diagnosed at Beijing Anzhen Hospital between May 2018 and December 2020 underwent angiography. Each followed up a period 35 66 months after discharge. objective examine major cardiac cerebrovascular (MACCE), which included all-cause mortality, non-fatal myocardial infarction, ischemic stroke, as well ischemia-driven revascularization. Results During median follow-up 48.3 months, 220 (19.3%) MACCE occurred. average age participants 59.55 ± 10.98 years, 8.67 0.53. In fully adjusted model, when considering either continuous/categorical variable, associations outcomes observed. Specifically, each 1 deviation increase within highest group, there hazard ratio (HR) 1.245 (95% confidence interval CI 1.030, 1.504) 1.303 1.026, 1.653) revascularization (both P < 0.05), analyzed continuous variable. Similarly, examined categorical HR CI) group 1.693 1.051, 2.727) (P 0.05) while 1.855 0.998, 3.449) = 0.051). Additionally, found be associated poor prognosis subgroup. Conclusion is correlated SMuRFs, suggesting that it may an independent predictive factor these individuals.

Язык: Английский

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The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases

Molecules, Год журнала: 2024, Номер 29(4), С. 758 - 758

Опубликована: Фев. 6, 2024

Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, hypertension, which increase the risk of CVDs’ initiation development. Although there many availabile drugs for treating CVDs, some side effects also occur. Considering low-level effects, natural products have been tried treat CVDs. A five-cyclic triterpenoid product, oleanolic acid (OA), has reported pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, liver protection. OA specific advantages in treatment achieves therapeutic through variety pathways, attracting great interest playing vital role Consequently, this article, we aim review pharmacological potential mechanisms

Язык: Английский

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Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2-ⅡA signaling in macrophages in mice

Journal of Ethnopharmacology, Год журнала: 2024, Номер 327, С. 118006 - 118006

Опубликована: Март 3, 2024

Язык: Английский

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