Ferroptosis in the neurovascular unit after spinal cord injury

Experimental Neurology, Год журнала: 2024, Номер 381, С. 114943 - 114943

Опубликована: Сен. 4, 2024

Язык: Английский

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DEAD-Box Helicase 17 circRNA (circDDX17) Reduces Sorafenib Resistance and Tumorigenesis in Hepatocellular Carcinoma

Digestive Diseases and Sciences, Год журнала: 2024, Номер 69(6), С. 2096 - 2108

Опубликована: Апрель 23, 2024

Язык: Английский

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The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 8, 2024

Stroke ranks as the second most significant contributor to mortality worldwide and is a major factor in disability. Ischemic strokes account for 71% of all stroke incidences globally. The foremost approach treating ischemic prioritizes quick reperfusion, involving methods such intravenous thrombolysis endovascular thrombectomy. These techniques can reduce disability but necessitate immediate intervention. After cerebral ischemia, inflammation rapidly arises vascular system, producing pro-inflammatory signals that activate immune cells, which turn worsen neuronal injury. Following an overload intracellular iron triggers Fenton reaction, resulting excess free radicals cause lipid peroxidation damage cellular membranes, ultimately leading ferroptosis. relationship between ferroptosis increasingly recognized vital process ischemia-reperfusion (I/R). Inflammatory processes disturb balance encourage (LPO) through neuroglial while also reducing activity antioxidant systems, contributing Furthermore, products generated during ferroptosis, along with damage-associated molecular patterns (DAMPs) released from ruptured cell incite inflammation. Given complex inflammation, investigating their interaction brain I/R crucial understanding disease development creating innovative therapeutic options. Consequently, this article will provide comprehensive introduction mechanisms linking neuroinflammation, well evaluate potential treatment modalities, goal presenting various insights alleviating injury exploring new avenues.

Язык: Английский

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M1 Microglia-Derived Exosomes Promote A1 Astrocyte Activation and Aggravate Ischemic Injury via circSTRN3/miR-331-5p/MAVS/NF-κB Pathway

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 9285 - 9305

Опубликована: Ноя. 1, 2024

After ischemic stroke (IS), microglia and astrocytes undergo polarization, transforming into a pro-inflammatory phenotype (M1 or A1). According to previous studies, exosomes might play an important role in the interplay between M1 A1 after IS.

Язык: Английский

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Research Progress of Neurogenic Exosomes in the Treatment of Alzheimer’s Disease

Advances in Clinical Medicine, Год журнала: 2024, Номер 14(09), С. 1034 - 1041

Опубликована: Янв. 1, 2024

Язык: Английский

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Targeting ferroptosis in the neurovascular unit: A promising approach for treating diabetic cognitive impairment

International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113146 - 113146

Опубликована: Сен. 19, 2024

Язык: Английский

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Regulation of nerve cells and therapeutic potential in central nervous system injury using microglia-derived exosomes

Neuroscience, Год журнала: 2024, Номер 563, С. 84 - 92

Опубликована: Ноя. 8, 2024

Язык: Английский

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