Cited by Regulation of nerve cells and therapeutic potential in central nervous system injury using microglia-derived exosomes

Ferroptosis in the neurovascular unit after spinal cord injury DOI

Yushan Huang,

Jinzhu Bai

Experimental Neurology, Journal Year: 2024, Volume and Issue: 381, P. 114943 - 114943

Published: Sept. 4, 2024

Language: Английский

Citations

DEAD-Box Helicase 17 circRNA (circDDX17) Reduces Sorafenib Resistance and Tumorigenesis in Hepatocellular Carcinoma DOI

Xiaochuan Zhang, Wenyu Wang, Shanshan Mo

et al.

Digestive Diseases and Sciences, Journal Year: 2024, Volume and Issue: 69(6), P. 2096 - 2108

Published: April 23, 2024

Language: Английский

Citations

The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion DOI

Yuxuan He, Jingyi Wang,

Chun-Miao Ying

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Stroke ranks as the second most significant contributor to mortality worldwide and is a major factor in disability. Ischemic strokes account for 71% of all stroke incidences globally. The foremost approach treating ischemic prioritizes quick reperfusion, involving methods such intravenous thrombolysis endovascular thrombectomy. These techniques can reduce disability but necessitate immediate intervention. After cerebral ischemia, inflammation rapidly arises vascular system, producing pro-inflammatory signals that activate immune cells, which turn worsen neuronal injury. Following an overload intracellular iron triggers Fenton reaction, resulting excess free radicals cause lipid peroxidation damage cellular membranes, ultimately leading ferroptosis. relationship between ferroptosis increasingly recognized vital process ischemia-reperfusion (I/R). Inflammatory processes disturb balance encourage (LPO) through neuroglial while also reducing activity antioxidant systems, contributing Furthermore, products generated during ferroptosis, along with damage-associated molecular patterns (DAMPs) released from ruptured cell incite inflammation. Given complex inflammation, investigating their interaction brain I/R crucial understanding disease development creating innovative therapeutic options. Consequently, this article will provide comprehensive introduction mechanisms linking neuroinflammation, well evaluate potential treatment modalities, goal presenting various insights alleviating injury exploring new avenues.

Language: Английский

Citations

M1 Microglia-Derived Exosomes Promote A1 Astrocyte Activation and Aggravate Ischemic Injury via circSTRN3/miR-331-5p/MAVS/NF-κB Pathway DOI

Zhongyuan Li, Pengfei Xu, Yang Deng

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9285 - 9305

Published: Nov. 1, 2024

After ischemic stroke (IS), microglia and astrocytes undergo polarization, transforming into a pro-inflammatory phenotype (M1 or A1). According to previous studies, exosomes might play an important role in the interplay between M1 A1 after IS.

Language: Английский

Citations

Research Progress of Neurogenic Exosomes in the Treatment of Alzheimer’s Disease DOI

思柔黄

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(09), P. 1034 - 1041

Published: Jan. 1, 2024

Language: Английский

Citations

Targeting ferroptosis in the neurovascular unit: A promising approach for treating diabetic cognitive impairment DOI

Wenlan Zhang,

Yijing Yan,

Chunmei Yi

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113146 - 113146

Published: Sept. 19, 2024

Language: Английский

Citations

Regulation of nerve cells and therapeutic potential in central nervous system injury using microglia-derived exosomes DOI

Dongxiao Lu,

Haohan Sun,

Hao Fan

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 563, P. 84 - 92

Published: Nov. 8, 2024

Language: Английский

Citations