Poultry Science,
Год журнала:
2024,
Номер
103(12), С. 104280 - 104280
Опубликована: Сен. 1, 2024
Lactobacillus
plantarum
(L.
plantarum)
has
been
globally
regarded
as
antibiotic
alternative
in
animal
farming
the
past
few
years.
However,
potential
function
of
L.
broilers
not
systemically
explored.
In
this
study,
a
total
560
one-day-old
yellow-feathered
were
randomly
divided
into
3
groups,
fed
with
basal
diet
and
drank
HJZW08
(LP)
at
concentration
0
(CON),
1000
×
10^5
(LP1000),
2000
CFU/L
(LP2000)
for
70
d.
Results
showed
that
body
weight
(BW),
average
daily
gain
(ADG),
feed
intake
(ADFI),
immunoglobulin
A
(IgA),
IgY,
anti-inflammatory
interleukin
10
(IL-10)
markedly
improved
(P
<
0.05),
while
levels
pro-inflammatory
IL-2,
IL-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α)
serum
decreased
0.05)
LP2000
group
comparing
CON
group.
Besides,
LP
treatment
groups
prominently
increased
activities
antioxidant
enzymes
content
malondialdehyde
(MDA).
Additionally,
isobutyric
acid
LP1000
isovaleric
significantly
improved.
More
importantly,
α-diversity
microbial
structure
intestinal
microbiota
pronounced
altered
by
supplementation.
The
results
only
relative
abundance
Actinobacteriota
was
group,
6
kinds
bacteria
on
genus
level
changed.
For
further
validation,
linear
discriminant
analysis
effect
size
(LEfSe)
plots
revealed
8
amplicon
sequence
variants
(ASVs)
predominant
Bacteroides
other
beneficial
species
such
Lactimicrobium
massiliense
(ASV4
ASV36),
Intestinimonas
butyriciproducens
(ASV71),
Barnesiella
viscericola
(ASV152
ASV571)
enriched
groups.
Taken
together,
dietary
supplementation
obviously
enhanced
immune
status,
capacity,
stabilized
cecal
SCFAs,
contributing
to
improvement
growth
performance
broilers.
Our
study
laid
good
foundation
application
probiotic
industry
future.
Trends in Food Science & Technology,
Год журнала:
2023,
Номер
138, С. 178 - 198
Опубликована: Июнь 11, 2023
The
human
gut
hosts
complex
microbial
communities,
which
are
linked
to
health
and
disease.
microbiota
is
continuously
reshaped
by
multiple
environmental
factors,
especially
diet.
Gut
dysbiosis
may
promote
various
metabolic,
neurological,
intestinal,
cardiovascular
diseases,
even
tumor
development.
Probiotics
have
shown
promising
prophylactic,
mitigating,
or
curative
effects
when
use
as
nutrient
supplements
adjunctive
therapy.
These
beneficial
and/or
symptom
alleviation
often
accompanied
microbiome
metabolome
changes.
Differing
from
other
published
review
articles,
here
we
summarized
the
latest
knowledge
of
evidence-based
health-promoting
probiotics
scouring
literature
recent
animal
probiotic
intervention
studies.
To
elucidate
mechanisms
in
enhancing
intestinal
homeostasis,
barrier
function,
host
immunity,
through
modulating
its
metabolites.
Meanwhile,
also
discussed
challenges
data
analysis
clinical
research
comparison
between
laboratories,
provides
an
outlook
for
future
perspectives
applications
probiotics.
achieved
modulation.
Current
discussed.
Finally,
provided.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Май 5, 2023
A
growing
body
of
research
suggests
that
short-chain
fatty
acids
(SCFAs),
metabolites
produced
by
intestinal
symbiotic
bacteria
ferment
dietary
fibers
(DFs),
play
a
crucial
role
in
the
health
status
symbiotes.
SCFAs
act
on
variety
cell
types
to
regulate
important
biological
processes,
including
host
metabolism,
function,
and
immune
function.
also
affect
function
fate
cells.
This
finding
provides
new
concept
metabolism
better
understanding
regulatory
system,
which
impacts
prevention
treatment
disease.
The
mechanism
induce
or
response
is
becoming
increasingly
clear.
review
summarizes
different
mechanisms
through
According
latest
research,
innate
NLRP3
inflammasomes,
receptors
TLR
family
members,
neutrophils,
macrophages,
natural
killer
cells,
eosinophils,
basophils
lymphocyte
subsets,
emphasized.
adaptive
T-cell
B
plasma
highlighted.
In
addition,
we
discuss
regulating
allergic
airway
inflammation,
colitis,
osteoporosis
influencing
system.
These
findings
provide
evidence
for
determining
options
based
metabolic
regulation.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Май 14, 2024
The
gut
microbiota
plays
a
critical
role
in
the
progression
of
human
diseases,
especially
cancer.
In
recent
decades,
there
has
been
accumulating
evidence
connections
between
and
cancer
immunotherapy.
Therefore,
understanding
functional
regulating
immune
responses
to
immunotherapy
is
crucial
for
developing
precision
medicine.
this
review,
we
extract
insights
from
state-of-the-art
research
decipher
complicated
crosstalk
among
microbiota,
systemic
system,
context
Additionally,
as
can
account
immune-related
adverse
events,
discuss
potential
interventions
minimize
these
effects
clinical
application
five
microbiota-targeted
strategies
that
precisely
increase
efficacy
Finally,
holds
promising
target
immunotherapeutics,
summarize
current
challenges
provide
general
outlook
on
future
directions
field.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1228 - 1228
Опубликована: Янв. 19, 2024
The
intestinal
microbiota
is
a
community
of
microorganisms
inhabiting
the
human
intestines,
potentially
influencing
both
physiological
and
pathophysiological
processes
in
body.
Existing
evidence
suggests
that
nutrients
can
influence
modulation
gut
microbiota.
However,
there
still
limited
regarding
effects
vitamin
mineral
supplementation
on
through
epigenetic
modification.
It
plausible
maintaining
an
adequate
dietary
intake
D,
iron,
fibre,
zinc
magnesium
may
have
beneficial
effect
alleviating
inflammation
body,
reducing
oxidative
stress,
improving
condition
various
mechanisms.
Moreover,
epigenetics
involves
alterations
phenotype
cell
without
changing
its
fundamental
DNA
sequence.
appears
by
lead
to
regulation.
correlations
between
are
interdependent.
Therefore,
primary
objective
this
review
identify
complex
relationships
diet,
microbiota,
These
interactions
could
play
crucial
role
systemic
health.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9366 - 9366
Опубликована: Авг. 29, 2024
The
human
gastrointestinal
tract
hosts
a
complex
and
dynamic
community
of
microorganisms
known
as
the
gut
microbiota,
which
play
pivotal
role
in
numerous
physiological
processes,
including
digestion,
metabolism,
immune
function.
Recent
research
has
highlighted
significant
impact
diet
on
microbiota
composition
functionality,
consequential
effects
host
health.
Concurrently,
there
is
growing
evidence
linking
to
inflammation,
key
factor
many
chronic
diseases
such
inflammatory
bowel
disease
(IBD),
obesity,
diabetes,
cardiovascular
(CVDs).
This
review
explores
how
dietary
components
influence
composition,
these
microbial
changes
affect
pathways,
therapeutic
implications
modulating
this
axis
for
prevention
management.
Beneficial
patterns,
Mediterranean
(MD)
plant-based
diets,
promote
diverse
balanced
supporting
anti-inflammatory
pathways.
Conversely,
Western
(WD),
high
saturated
fats
refined
sugars,
associated
with
dysbiosis
increased
inflammation.
With
all
links
between
three
variables
considered,
attempts
offer
thorough
examination
triangle
formed
by
food.
Microorganisms,
Год журнала:
2025,
Номер
13(1), С. 70 - 70
Опубликована: Янв. 2, 2025
The
mammalian
gastrointestinal
tract
is
a
stage
for
dynamic
inter-kingdom
interactions
among
bacteria,
fungi,
viruses,
and
protozoa,
which
collectively
shape
the
gut
micro-ecology
influence
host
physiology.
Despite
being
modest
fraction,
fungal
community,
also
referred
to
as
mycobiota,
represents
critical
component
of
microbiota.
Emerging
evidence
suggests
that
fungi
act
early
colonizers
intestine,
exerting
lasting
on
development.
Meanwhile,
composition
mycobiota
influenced
by
multiple
factors,
with
diet,
nutrition,
drug
use
(e.g.,
antimicrobials),
physical
condition
standing
primary
drivers.
During
its
establishment,
forms
both
antagonistic
synergistic
relationships
bacterial
communities
within
host.
For
instance,
intestinal
can
inhibit
colonization
producing
alcohol,
while
certain
pathogens
exploit
iron
carriers
enhance
their
growth.
However,
regulatory
mechanisms
governing
these
complex
remain
poorly
understood.
In
this
review,
we
first
introduce
methodologies
studying
microbiota,
then
address
significance
in
especially
during
weaning
when
all
‘primary
drivers’
change,
and,
finally,
discuss
between
bacteria
under
various
influencing
factors.
Our
review
aims
shed
light
dynamics
homeostasis
provide
insights
into
how
they
be
better
understood
managed
improve
health
disease
outcomes.
Heliyon,
Год журнала:
2024,
Номер
10(5), С. e26991 - e26991
Опубликована: Фев. 27, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
stress-induced
injury
related
to
heredity,
environmental
exposure
and
the
gut
microbiome
metabolism.
Short-chain
acids
(SCFAs),
metabolites
of
microbiota
(GM),
participate
in
regulation
hepatic
steatosis
inflammation
through
gut-liver
axis,
which
play
an
important
role
alleviation
NAFLD.
However,
little
progress
has
been
made
systematically
elucidating
mechanism
how
SCFAs
improve
NAFLD,
especially
epigenetic
mechanisms
potential
therapeutic
application
as
clinical
treatment
for
Herein,
we
adopted
PubMed
Medline
search
relevant
keywords
such
'SCFAs',
'NAFLD',
'gut
microbiota',
'Epigenetic',
'diet',
'prebiotic
effect'
review
latest
research
on
NAFLD
up
November
2023.
In
this
review,
firstly,
specifically
discussed
production
function
SCFAs,
well
their
crosstalk
coordination
axis.
Secondly,
provided
updated
summary
intensive
discussion
affect
alleviate
from
perspective
genetic
epigenetic.
Thirdly,
paid
attention
pharmacological
physiological
characteristics
proposed
promising
future
direction
adopt
alone
or
combination
with
prebiotics
drugs
prevent
treat
Together,
aimed
elucidate
provide
new
insights
prospects
target
