Progress on the HIF-1α/VEGF/VEGFR2 signal pathway in hepatic alveolar echinococcosis DOI Creative Commons
Ming Xu, Ke Fei,

Jinping Chai

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 8, 2025

Alveolar echinococcosis (AE), a lethal parasitic zoonosis mimicking malignant tumors, progresses via hepatic infiltration and metastatic spread, causing multiorgan failure. Despite its clinical resemblance to cancer, molecular drivers of aggressiveness remain poorly defined. Recent studies highlight perilesional angiogenesis as pivotal for lesion invasiveness, mediated by VEGF-driven pathological vascularization. VEGF not only fuels proliferation creating nutrient-rich microenvironments but also engages crosstalk with host-parasite interactions, including immune evasion Echinococcus multilocularis, germinal layer hyperplasia, periparasitic inflammation.Targeting the HIF-1α/VEGF/VEGFR2 axis emerges promising therapeutic strategy. Mechanistically, VEGF/VEGFR2 blockade may simultaneously disrupt angiogenesis-dependent expansion survival pathways. Preclinical evidence shows that inhibiting HIF-1α (VEGF's upstream regulator) suppresses metacestode tissue invasion starving lesions vascular support while modulating immune-inflammatory responses. This dual action addresses both resource acquisition host defence subversion.This review synthesizes insights into HIF-1α/VEGF-mediated pathogenesis observations, proposing anti-angiogenic therapy rational adjunct current treatments. By delineating VEGF's role in sustaining metabolic demands regulation, we underscore translational potential pathway-specific inhibitors. Such approaches could mitigate limitations conventional therapies (e.g., benzimidazoles), particularly advanced-stage AE microvascular proliferation. Systematic analysis signalling networks advances our understanding AE's "parasitic cancer" paradigm guiding development targeted interventions improve patient outcomes.

Язык: Английский

The Role of NQO1 in Ovarian Cancer DOI Open Access
Giovanni Tossetta, Sonia Fantone, Gaia Goteri

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7839 - 7839

Опубликована: Апрель 25, 2023

Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high fatality rate because late diagnosis and relapse occurrence due to chemoresistance onset. Several researchers reported that oxidative stress plays key role in ovarian occurrence, growth development. The NAD(P)H:quinone oxidoreductase 1 (NQO1) an antioxidant enzyme that, using NADH or NADPH as substrates reduce quinones hydroquinones, avoids formation highly reactive semiquinones, then protecting cells against stress. In this review, we report evidence from literature describing effect NQO1 on onset progression.

Язык: Английский

Процитировано

60
Metal–Organic Framework Nanocomposites in Conquering Hypoxia for Tumor Therapy DOI

Shizhao Zhou,

Jia Fan, Yingying Wei

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(17)

Опубликована: Янв. 3, 2024

Abstract Hypoxia, as a distinctive feature of tumors, is closely related to tumor recurrence, metastasis, and treatment resistance. Metal–organic framework (MOF) exhibits an increasing number advantages in cancer therapy owing its porous structure, large specific surface area, tunable function. The MOF nanocomposites constructed by adjusting components can effectively overcome hypoxia significantly enhance the anti‐tumor effect. In this review, hypoxic characteristics tumors current strategies for constructing that are summarized, including delivering O 2 or endogenously generating elevate intra‐tumor content; inhibiting HIF‐1 induced products alleviate hypoxia; reducing cellular aerobic respiration decrease consumption, exacerbating improve efficacy hypoxia‐activated pre‐drugs. At same time, applications applied different therapeutic methods at present stage described, finally, challenges opportunities further development discussed.

Язык: Английский

Процитировано

13
3D-Printed Magnesium Peroxide-Incorporated Scaffolds with Sustained Oxygen Release and Enhanced Photothermal Performance for Osteosarcoma Multimodal Treatments DOI

Xu Haixia,

Ziyue Peng,

Lin Jiezhao

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(8), С. 9626 - 9639

Опубликована: Фев. 19, 2024

The hypoxic microenvironment in osteosarcoma inevitably compromises the antitumor effect and local bone defect repair, suggesting an urgent need for sustained oxygenation tumor. currently reported oxygen-releasing materials have short cycles, harmful products, limited effects simply by improving hypoxia. Therefore, PCL/nHA/MgO2/PDA-integrated scaffold with a good photothermal therapy was innovatively constructed this work to achieve tumor cell killing regeneration functions simultaneously. material distributes MgO2 powder evenly on through 3D printing technology achieves of continuous oxygen release (more than 3 weeks) its slow reaction water. vitro vivo results also indicate that has biocompatibility sustained-release properties, which can effectively induce proliferation osteogenic differentiation mesenchymal stem cells, achieving excellent repair. At same time, experiments subcutaneous tumorigenesis confirmed supply promote apoptosis, inhibit proliferation, reduce expression heat shock protein 60, thereby enhancing polydopamine efficiently eliminating osteosarcoma. Taken together, integrated functional provides unique efficient approach tumor-based repair treatment.

Язык: Английский

Процитировано

8
Effects of hypoxia on the heart of the juvenile four-finger threadfin (Eleutheronema tetradactylum) based on physiological indicators and transcriptome analysis DOI Creative Commons
Yi Lu, Eric Amenyogbe, Ye Yang

и другие.

Frontiers in Marine Science, Год журнала: 2025, Номер 12

Опубликована: Фев. 5, 2025

This study evaluated the effects of hypoxia on heart juvenile four-finger threadfin ( Eleutheronema tetradactylum ) through physiological and transcriptome analysis. Juveniles with an average weight 122.82 g length 24.60 cm were used. Hypoxia significantly increased serum myocardial enzyme activities, including creatine kinase (CK), kinase-MB isoenzyme, lactate dehydrogenase (LDH), α-hydroxybutyrate (HDBH). These indicators initially rose then declined, reflecting cardiac stress suggesting their potential as early biomarkers for real-time aquaculture monitoring. Histological analysis revealed structural damage in fibers under hypoxia, increasing severity over time. underscores need to minimize oxygen fluctuations prevent tissue degeneration. Transcriptome identified upregulated genes involved cell communication, immune responses, intracellular signaling, offering targets breeding hypoxia-tolerant species. Kyoto Encyclopedia Genes Genomes pathway enrichment highlighted key pathways such mitogen-activated protein (MAPK), hypoxia-inducible factor-1 (HIF-1), endocytosis, phagosome formation. The MAPK plays a critical role cellular survival, proliferation, apoptosis. Hypoxia-induced activation MAPKs like ERK, JNK, p38 regulates stress-responsive genes. HIF-1 signaling homeostasis, HIF-1α stabilizing hypoxia-responsive VEGFA, which promotes vascular remodeling enhances delivery. findings collectively offer practical applications enhancing management, monitoring biochemical markers, adopting breeding, adjusting environmental conditions mitigate stress, ensuring better productivity sustainability. research provides foundation further studies molecular mechanisms

Язык: Английский

Процитировано

1
Roles of HIF-1α signaling in Mycobacterium tuberculosis infection: New targets for anti-TB therapeutics? DOI
Chaowei Li, Jiajun Wang, Jun‐Fa Xu

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 711, С. 149920 - 149920

Опубликована: Апрель 9, 2024

Язык: Английский

Процитировано

7
A Review of the Efficacy of Nanomaterial-Based Natural Photosensitizers to Overcome Multidrug Resistance in Cancer DOI Creative Commons
Jagadeesh Rajaram,

Lokesh Kumar Mende,

Yaswanth Kuthati

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1120 - 1120

Опубликована: Авг. 24, 2024

Natural photosensitizers (PS) are compounds derived from nature, with photodynamic properties. PSs have a similar action to that of commercial PSs, where cancer cell death occurs by necrosis, apoptosis, and autophagy through ROS generation. garnered great interest over the last few decades because their high biocompatibility good photoactivity. Specific wavelengths could cause phytochemicals produce harmful for therapy (PDT). However, natural some shortcomings, such as reduced solubility lower uptake, making them less appropriate PDT. Nanotechnology offers an opportunity develop suitable carriers various PDT applications. Various nanoparticles been developed improve outcome enhanced solubility, optical adsorption, tumor targeting. Multidrug resistance (MDR) is phenomenon in which cells wide range structurally functionally unrelated drugs. Over decade, several researchers extensively studied effect PS-based treatment (PDT) on MDR cells. Though outcomes clinical trials were inconclusive, significant advancement still required before can be used agent treating tumors. This review addresses increasing literature progression efficacy PDT, emphasizing importance developing new nano-based fight against features photosensitizing regimen.

Язык: Английский

Процитировано

7
Hypoxia and its effect on the cellular system DOI

Dipali Rahane,

Tannu Dhingra,

Guruswami Chalavady

и другие.

Cell Biochemistry and Function, Год журнала: 2024, Номер 42(2)

Опубликована: Янв. 27, 2024

Abstract Eukaryotic cells utilize oxygen for different functions of cell organelles owing to cellular survival. A balanced homeostasis is an essential requirement maintain the regulation normal systems. Any changes in level are stressful and can alter expression regulatory genes proteins. Lack or hypoxia results oxidative stress formation inducible factors (HIF) reactive species (ROS). Substantial damages due have been reported play a major role various pathological conditions. There studies which demonstrated that system disrupted by hypoxia. Currently, study on effects following important field research as it not only helps decipher signaling pathway modulation, but also explore novel therapeutic strategies. On basis beneficial effect preconditioning organelles, many investigations ongoing promising disease management strategy near future. Hence, present review discusses about mechanisms their involvement progression diseases.

Язык: Английский

Процитировано

6
Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders DOI
Sumel Ashique, Neeraj Mishra, Shubhrajit Mantry

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Язык: Английский

Процитировано

6
Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140–3p/HIF-1α/VEGF signaling axis DOI Creative Commons

Nafiseh Payervand,

Katayoon Pakravan,

Ehsan Razmara

и другие.

Heliyon, Год журнала: 2024, Номер 10(11), С. e31584 - e31584

Опубликована: Май 20, 2024

Highlights•This study introduces a signature of six serum-derived circRNAs that can distinguish between CRC and healthy individuals.•Transfer CAF-derived circ_0084043 triggers endothelial cell angiogenesis through the miR-140–3p/HIF-1α/VEGF signaling axis.•Th candidate serve as dual biomarkers therapeutic targets, advancing understanding pathogenesis.AbstractBackgroundCircular RNAs (circRNAs) hold potential diagnostic markers for colorectal cancer (CRC); however, their functional mechanisms remain incompletely elucidated. This work investigates clinical implications unique set comprising derived from serum in CRC. Furthermore, we delve into role exosomal circ_0084043, originating cancer-associated fibroblasts (CAFs), with specific focus on its contribution to angiogenesis.MethodsThe analyzed circRNA levels samples obtained both control groups using qRT-PCR. Additionally, exosomes CAFs normal (NFs) were purified confirmed by electron microscopy Western blotting techniques. The proangiogenic effects assessed cells proliferation, migration, vitro capillary tube formation assays. Gain- loss-of-function experiments employed clarify circ_0084043/miR-140–3p/HIF-1α axis angiogenesis, utilizing luciferase reporter assay, blotting, ELISA mechanism elucidation.ResultsThe (circ_0060745, circ_001569, circ_007142, Circ_BANP, CiRS-7) exhibited notably elevated expression patient sera compared observed individuals. Except CiRS-7, all showed patients positive lymph node metastasis advanced tumor stages. Exosomes released augmented upregulating VEGF secretion. Circ_0084043 was highly detected treated exosomes. Silencing reduced VEGFA diminished CAF exosome-induced processes, indicating pivotal angiogenesis. sponges miR-140–3p, regulating HIF-1α, reverse relationship also identified miR-140–3p cells. Inhibiting mitigated knockdown exosome-treated Co-transfection si-circ_0084043 inhibitor reversed inhibited migration caused rescued due exposed exosomes, modulation circ_0084043/miR-140–3p/VEGF angiogenesis.ConclusionsThis unveiled distinctive circular RNAs, promising Importantly, playing crucial exerting influence axis.

Язык: Английский

Процитировано

5
Hypoxia-Inducible Factor 1-Alpha (HIF-1α): An Essential Regulator in Cellular Metabolic Control DOI Open Access
Mohd Basheeruddin,

Sana Qausain

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Июль 4, 2024

The element that causes hypoxia when the von Hippel-Lindau (VHL) protein is not functioning hypoxia-inducible factor 1-alpha (HIF-1α), which essential linked to cell control under hypoxia. Consequently, in situations where cells are oxygen-deficient, HIF-1α carries out a variety of functions. Citations relevant literature support notion regulates mitochondrial and glycolytic pathways, as well transition from former latter. Cells with limited oxygen supply benefit this change, especially beneficial for inhibition electron transport chain enhanced uptake glucose lactate. During hypoxic stress, also controls proline transporters such lactate dehydrogenase A (LDHA) transporter 1 (GLUT1). These mechanisms help return homeostasis. Therefore, through metabolic change promoting adenosine triphosphate (ATP) synthesis reducing reactive species (ROS) creation, may have role oxidative stress cells. This evidence, describes function many molecular further supports it prognostic contributes adaption. Understanding more about disorders, including inflammation, cancer, ischemia, possible because HIF-1α's effect on changes. Gaining knowledge battle between metabolism, directed by HIF-1α, would advance research pathophysiological involving dysregulated metabolism.

Язык: Английский

Процитировано

5