Impact of Metabolites from Foodborne Pathogens on Cancer
Foods,
Год журнала:
2024,
Номер
13(23), С. 3886 - 3886
Опубликована: Дек. 1, 2024
Foodborne
pathogens
are
microorganisms
that
cause
illness
through
contamination,
presenting
significant
risks
to
public
health
and
food
safety.
This
review
explores
the
metabolites
produced
by
these
pathogens,
including
toxins
secondary
metabolites,
their
implications
for
human
health,
particularly
concerning
cancer
risk.
We
examine
various
such
as
Salmonella
sp.,
Campylobacter
Escherichia
coli,
Listeria
monocytogenes,
detailing
specific
of
concern
carcinogenic
mechanisms.
study
discusses
analytical
techniques
detecting
chromatography,
spectrometry,
immunoassays,
along
with
challenges
associated
detection.
covers
effective
control
strategies,
processing
techniques,
sanitation
practices,
regulatory
measures,
emerging
technologies
in
pathogen
control.
manuscript
considers
broader
highlighting
importance
robust
policies,
awareness,
education.
identifies
research
gaps
innovative
approaches,
recommending
advancements
detection
methods,
preventive
policy
improvements
better
manage
foodborne
metabolites.
Язык: Английский
Gut microbiota in health and disease: advances and future prospects
MedComm,
Год журнала:
2024,
Номер
5(12)
Опубликована: Ноя. 20, 2024
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Язык: Английский
The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms
Farah Karam,
Yara El Deghel,
Rabah Iratni
и другие.
Cell Biochemistry and Biophysics,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Язык: Английский
Microbiota and Radiotherapy: Unlocking the Potential for Improved Gastrointestinal Cancer Treatment
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 526 - 526
Опубликована: Фев. 19, 2025
Radiotherapy
(RT)
is
one
of
the
major
cornerstones
in
managing
gastrointestinal
(GI)
cancers.
However,
several
side
effects,
such
as
intestinal
inflammation,
mucosal
injury,
and
dysbiosis,
often
compromise
this.
The
gut
microbiota
increasingly
attracts
much
interest
an
essential
modulator
RT
effects
influencing
immune
responses
tissue
repair.
Through
short-chain
fatty
acids
butyrate,
representatives
certain
bacterial
species
play
a
crucial
role
under
normal
conditions,
keeping
integrity
intact
reducing
oxidative
stress-mediated
damage.
Dysbiosis,
state
where
diminished
microbial
diversity
increased
pathogenic
are
seen,
amplifies
RT-induced
toxicity
patients.
Clinical
investigations
highlight
that
microbiota-targeted
interventions,
including
probiotics,
prebiotics,
fecal
transplantation,
hold
means
to
augment
efficacy
lessen
toxicity.
Increased
microflora
specific
profiles
have
yielded
serious
patient
improvements.
Advanced
methods
use
stereotactic
body
radiotherapy
combined
with
modulation
promising
technique
shield
healthy
maximize
immune-mediated
antitumor
effects.
Additionally,
there
implication
tumor
behavior
regulated
by
intratumoral
regarding
response
radiotherapy.
Notably,
provides
avenue
optimize
benefits
GI
cancers,
underscoring
importance
personalized
therapy.
Язык: Английский
The Gut Microbiota and Colorectal Cancer: Understanding the Link and Exploring Therapeutic Interventions
Biology,
Год журнала:
2025,
Номер
14(3), С. 251 - 251
Опубликована: Фев. 28, 2025
CRC
remains
a
significant
public
health
challenge
due
to
its
high
prevalence
and
mortality
rates.
Emerging
evidence
highlights
the
critical
role
of
gut
microbiota
in
both
pathogenesis
efficacy
treatment
strategies,
including
chemotherapy
immunotherapy.
Dysbiosis,
characterized
by
imbalances
microbial
communities,
has
been
implicated
progression
therapeutic
outcomes.
This
review
examines
intricate
relationship
between
composition
CRC,
emphasizing
potential
for
profiles
serve
as
biomarkers
early
detection
prognosis.
Various
interventions,
such
prebiotics,
probiotics,
postbiotics,
fecal
transplantation,
dietary
modifications,
aim
restore
balance
shift
dysbiosis
toward
eubiosis,
thereby
improving
Additionally,
integration
profiling
into
clinical
practice
could
enhance
diagnostic
capabilities
personalize
advancing
field
oncology.
The
study
intratumoral
offers
new
prognostic
tools
that,
combined
with
artificial
intelligence
algorithms,
predict
responses
assess
risk
adverse
effects.
Given
growing
understanding
microbiome–cancer
axis,
developing
microbiota-oriented
strategies
prevention
holds
promise
patient
care
Язык: Английский
Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Март 5, 2025
Colorectal
cancer
(CRC)
poses
a
significant
global
health
burden,
with
gut
microbiota
emerging
as
crucial
modulator
of
CRC
pathogenesis
and
therapeutic
outcomes.
This
review
synthesizes
current
evidence
on
the
influence
tumor
immune
surveillance
responses
to
immunotherapies
chemotherapy
in
CRC.
We
highlight
role
specific
microbial
taxa
promoting
or
inhibiting
growth
potential
microbiota-based
biomarkers
for
predicting
treatment
efficacy.
The
also
discusses
implications
modulation
strategies,
including
diet,
probiotics,
fecal
transplantation,
personalized
management.
By
critically
evaluating
literature,
we
aim
provide
comprehensive
understanding
microbiota’s
dual
inform
future
research
directions
this
field.
Язык: Английский
Therapeutic potential of fecal microbiota transplantation in colorectal cancer based on gut microbiota regulation: from pathogenesis to efficacy
Therapeutic Advances in Gastroenterology,
Год журнала:
2025,
Номер
18
Опубликована: Янв. 1, 2025
Colorectal
cancer
(CRC)
remains
a
leading
cause
of
cancer-related
deaths
worldwide,
with
its
progression
intricately
linked
to
gut
microbiota
dysbiosis.
Disruptions
in
microbial
homeostasis
contribute
tumor
initiation,
immune
suppression,
and
inflammation,
establishing
the
as
key
therapeutic
target.
Fecal
transplantation
(FMT)
has
emerged
transformative
approach
restore
balance,
enhance
responses,
reshape
microenvironment.
This
review
explores
mechanisms
underlying
FMT’s
potential,
evaluates
advantages
over
other
microbiota-based
interventions,
addresses
challenges
such
donor
selection,
safety
concerns,
treatment
standardization.
Looking
forward,
integration
FMT
into
personalized
CRC
therapies
requires
robust
clinical
trials
identification
predictive
biomarkers
optimize
efficacy
safety.
Язык: Английский
Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3733 - 3733
Опубликована: Апрель 15, 2025
The
gut
microbiome,
a
complex
community
of
microorganisms
residing
in
the
intestinal
tract,
plays
dual
role
colorectal
cancer
(CRC)
development,
acting
both
as
contributing
risk
factor
and
protective
element.
This
review
explores
mechanisms
by
which
microbiota
contribute
to
CRC,
emphasizing
inflammation,
oxidative
stress,
immune
evasion,
production
genotoxins
microbial
metabolites.
Fusobacterium
nucleatum,
Escherichia
coli
(pks+),
Bacteroides
fragilis
promote
tumorigenesis
inducing
chronic
generating
reactive
oxygen
species,
producing
virulence
factors
that
damage
host
DNA.
These
can
also
evade
antitumor
response
suppressing
cytotoxic
T
cell
activity
increasing
regulatory
populations.
Additionally,
microbial-derived
metabolites
such
secondary
bile
acids
trimethylamine-N-oxide
(TMAO)
have
been
linked
carcinogenic
processes.
Conversely,
microbiota,
including
Lactobacillus,
Bifidobacterium,
Faecalibacterium
prausnitzii,
homeostasis
short-chain
fatty
(SCFAs)
like
butyrate,
exhibit
anti-inflammatory
anti-carcinogenic
properties.
beneficial
microbes
enhance
barrier
integrity,
modulate
responses,
inhibit
tumor
proliferation.
Understanding
dynamic
interplay
between
pathogenic
is
essential
for
developing
microbiome-based
interventions,
probiotics,
prebiotics,
fecal
transplantation,
prevent
or
treat
CRC.
Future
research
should
focus
on
identifying
biomarkers
early
CRC
detection
exploring
personalized
microbiome-targeted
therapies.
A
deeper
understanding
host–microbiota
interactions
may
lead
innovative
strategies
management
improved
patient
outcomes.
Язык: Английский
Study on the Influence of Intestinal Flora on the Pathogenesis and Treatment Strategy of Related Complications of Liver Cirrhosis
Advances in Clinical Medicine,
Год журнала:
2025,
Номер
15(04), С. 2009 - 2015
Опубликована: Янв. 1, 2025
Язык: Английский
Characteristics of gut microbiota dysbiosis in patients with colorectal polyps
World Journal of Gastrointestinal Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Дек. 11, 2024
This
editorial,
inspired
by
a
recent
study
published
in
the
World
Journal
of
Gastrointestinal
Oncology
,
covers
research
findings
on
microbiota
changes
various
diseases.
In
recurrent
colorectal
polyps,
abundances
Klebsiella
Parvimonas
and
Clostridium
increase,
while
those
Bifidobacterium
Lactobacillus
decrease.
dysbiosis
may
promote
formation
recurrence
polyps.
Similar
microbial
have
also
been
observed
cancer,
inflammatory
bowel
disease,
autism
spectrum
disorder,
metabolic
syndrome,
indicating
role
increased
pathogens
decreased
probiotics
these
conditions.
Regulating
gut
microbiota,
particularly
increasing
probiotic
levels,
help
prevent
polyp
health.
intervention
strategy
holds
promise
as
an
adjunctive
treatment
for
patients
with
Язык: Английский