Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июнь 1, 2024

Abstract Backgrounds Insulin resistance (IR) plays a vital role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, it remains unclear whether triglyceride–glucose (TyG) related parameters, which serve as useful biomarkers to assess IR, have prognostic effects on mortality outcomes MASLD. Methods Participants National Health and Nutrition Examination Survey (NHANES) database from 1999 2018 years were included. TyG its parameters [TyG-waist circumference (TyG-WC) TyG-waist height ratio (TyG-WHtR)] calculated. Kaplan–Meier curves, Cox regression analysis, restricted cubic splines (RCS) conducted evaluate association between TyG-related indices with all-cause cardiovascular adults The concordance index (C-index) was used prediction accuracy indices. Results A total 8208 (4209 men 3999 women, median age 49.00 years) MASLD included this study. Multivariate-adjusted analysis revealed that high quartile levels significantly associated participants [ adjusted hazard (aHR) = 1.25, 95% confidence interval (CI) 1.05–1.50, P 0.014; TyG-WC aHR for 1.28, CI 1.07–1.52, 0.006; TyG-WHtR 1.50, 1.25–1.80, < 0.001; 1.81, 1.28–2.55, 2.22, 1.55–3.17, 0.001]. C-index predicting 0.563 index, 0.579 0.585 respectively. Regarding mortality, 0.561 0.607 0.615 Nonlinear trends observed ( 0.001 0.012, respectively). non-linear relationship 0.025). Subgroup suggested aged 65 old those without comorbidities more sensitive Conclusion Findings study highlight predictive value indices, especially would be surrogate clinical management

Язык: Английский

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Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3694 - 3694

Опубликована: Март 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Язык: Английский

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354

Опубликована: Окт. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Язык: Английский

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Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 6, 2025

Lifestyle and dietary intake play a pivotal role in development of metabolic dysfunction-associated fatty liver disease(MAFLD). We performed this cross-sectional study to evaluate the association between lifestyle insulinemic potential odds MAFLD overweight obese children adolescents. The diet was assessed by computing scores empirical index for hyperinsulinemia(EDIH), hyperinsulinemia(ELIH), insulin resistance(EDIR), resistance(ELIR). diagnosed according consensus definitions. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated logistic regression. A total 334 (49.1% boys) with mean ± SD age BMI-for-age-Z-score 9.3 1.8 2.55 0.69, respectively, enrolled. After adjusting all confounders, participants highest quartile ELIH score had greater developing (OR:3.50;95%CI:1.49–8.22) compared those lowest quartile. This remained significant among boys pubertal ones. However, no EDIH, EDIR, or ELIR found. Our suggests that collective intake, BMI, physical activity is associated increased MAFLD.

Язык: Английский

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Editorial for Special Issue: “Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment”

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 160 - 160

Опубликована: Фев. 27, 2025

Metabolic-dysfunction-associated fatty liver disease (MAFLD) and alcohol-associated (ALD) represent two of the most prevalent chronic diseases globally, collectively affecting hundreds millions individuals [...]

Язык: Английский

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Normal triglyceride concentration and the risk of diabetes mellitus type 2 in the general population of China

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Фев. 8, 2024

Introduction Hypertriglyceridemia and its derivatives are independent predictors of diabetes mellitus type 2 (T2DM). However, the relationship between triglyceride concentrations within normal range incidence T2DM remains to be clarified. This study investigated potential variations in plasma levels onset using data from a longitudinal health retirement China. Methods Between, 2010 and, 2016, we conducted retrospective cohort involving 36,441 individuals with levels. Using Cox proportional hazards regression model, examined connection incidence. We employed this method smooth curve fitting investigate nonlinear associations. Subgroup analyses were performed based on age, sex, body mass index, smoking drinking status, hypertension, family history diabetes. Results A significant linear was observed T2DM. The hazard ratio for triglycerides 1.81 (95% confidence interval: 1.39, 2.36); P&lt;0.001). Kaplan–Meier analysis further demonstrated prospective association higher tertiles development (P&lt;0.001). revealed stronger positive correlation females risk Discussion An increase is related continuous general population. These findings show that almost everyone can benefit reducing levels, emphasizing importance lifestyle changes

Язык: Английский

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Association Between Ultraprocessed Food Consumption and Metabolic Disorders in Children and Adolescents with Obesity

Nutrients, Год журнала: 2024, Номер 16(20), С. 3524 - 3524

Опубликована: Окт. 17, 2024

Background/Objectives: We investigated the effects of ultraprocessed food (UPF) consumption on metabolic disorders (e.g., adiposity, associated steatotic liver disease [MASLD], and insulin resistance) in children adolescents with obesity to improve dietary guidelines public health strategies. Methods: The intake 149 participants (aged 8–17 years) was assessed diaries. NOVA classification system used classify according degree processing. Metabolic outcomes, including fat mass index (FMI), hepatic percentage, resistance, were measured via dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging proton density fraction (MRI-PDFF), biochemical analysis, respectively. Results: Greater UPF from baseline 6-month follow-up significantly increased decreased total cholesterol LDL-cholesterol. positively prevalence MASLD (liver MRI-PDFF ≥ 5%; odds ratio T3 vs. T1 = 1.75; 95% confidence interval [CI] 1.03, 3.00), moderate-to-severe 10%; OR 4.19; CI 1.72, 10.22), resistance (OR 2.44; 1.33, 4.48), after adjusting for covariates. A linear dose-response relationship observed between resistance. Conclusions: strongly obesity, underscoring importance reducing through interventions mitigate risk obesity-related conditions young populations.

Язык: Английский

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Associations of Insulin Resistance and High-Sensitivity C-Reactive Protein with Metabolic Abnormalities in Korean Patients with Type 2 Diabetes Mellitus: A Preliminary Study

Metabolites, Год журнала: 2024, Номер 14(7), С. 371 - 371

Опубликована: Июнь 30, 2024

We conducted this single-center, retrospective, cohort study to examine whether insulin resistance (IR) and high-sensitivity C-reactive protein (hsCRP) have a relationship with metabolic abnormalities in patients type 2 diabetes mellitus (T2DM). In total of 3758 (

Язык: Английский

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Exploring Fibrosis Pathophysiology in Lean and Obese Metabolic-Associated Fatty Liver Disease: An In-Depth Comparison

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7405 - 7405

Опубликована: Июль 5, 2024

While obesity-related nonalcoholic fatty liver disease (NAFLD) is linked with metabolic dysfunctions such as insulin resistance and adipose tissue inflammation, lean NAFLD more often progresses to fibrosis even in the absence of syndrome. This review aims summarize current knowledge regarding mechanisms NAFLD. The most commonly used models include a methionine/choline-deficient (MCD) diet, high-fat diet carbon tetrachloride (CCl4), high-fructose high-cholesterol diet. major pro-fibrogenic increased activation extracellular signal-regulated kinase (ERK) pathway, elevated expression α-smooth muscle actin (α-SMA), collagen type I, TGF-β, modulation fibrogenic markers tenascin-X metalloproteinase inhibitors. Additionally, macrophage signaling pathways promoting hepatic stellate cell (HSC) further contributes development. Animal cannot cover all clinical features that are evident patients or obese NAFLD, implicating need for novel models, well deeper comparisons experimental studies. Having mind prevalence patients, by addressing specific pathways, studies can reveal new targeted therapies along biomarkers early detection enhancement management patients.

Язык: Английский

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Pathophysiological Relationship between Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Therapeutic Approaches

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8731 - 8731

Опубликована: Авг. 10, 2024

Type 2 diabetes mellitus (T2DM), often featuring hyperglycemia or insulin resistance, is a global health concern that increasing in prevalence the United States and worldwide. A common complication metabolic dysfunction-associated steatotic liver disease (MASLD), hepatic manifestation of syndrome also rapidly prevalence. The majority patients with T2DM will experience MASLD, likewise, individuals MASLD are at an increased risk for developing T2DM. These two disorders may act synergistically, part due to lipotoxicity inflammation within liver, among other causes. However, pathophysiological mechanisms by which this occurs unclear, as how improvement one disorder can ameliorate other. This review aims discuss pathogenic interactions between T2D highlight novel therapeutic targets ongoing clinical trials treatment these diseases.

Язык: Английский

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