Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 1, 2024

Abstract Backgrounds Insulin resistance (IR) plays a vital role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, it remains unclear whether triglyceride–glucose (TyG) related parameters, which serve as useful biomarkers to assess IR, have prognostic effects on mortality outcomes MASLD. Methods Participants National Health and Nutrition Examination Survey (NHANES) database from 1999 2018 years were included. TyG its parameters [TyG-waist circumference (TyG-WC) TyG-waist height ratio (TyG-WHtR)] calculated. Kaplan–Meier curves, Cox regression analysis, restricted cubic splines (RCS) conducted evaluate association between TyG-related indices with all-cause cardiovascular adults The concordance index (C-index) was used prediction accuracy indices. Results A total 8208 (4209 men 3999 women, median age 49.00 years) MASLD included this study. Multivariate-adjusted analysis revealed that high quartile levels significantly associated participants [ adjusted hazard (aHR) = 1.25, 95% confidence interval (CI) 1.05–1.50, P 0.014; TyG-WC aHR for 1.28, CI 1.07–1.52, 0.006; TyG-WHtR 1.50, 1.25–1.80, < 0.001; 1.81, 1.28–2.55, 2.22, 1.55–3.17, 0.001]. C-index predicting 0.563 index, 0.579 0.585 respectively. Regarding mortality, 0.561 0.607 0.615 Nonlinear trends observed ( 0.001 0.012, respectively). non-linear relationship 0.025). Subgroup suggested aged 65 old those without comorbidities more sensitive Conclusion Findings study highlight predictive value indices, especially would be surrogate clinical management

Language: Английский

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Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

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Normal triglyceride concentration and the risk of diabetes mellitus type 2 in the general population of China

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 8, 2024

Introduction Hypertriglyceridemia and its derivatives are independent predictors of diabetes mellitus type 2 (T2DM). However, the relationship between triglyceride concentrations within normal range incidence T2DM remains to be clarified. This study investigated potential variations in plasma levels onset using data from a longitudinal health retirement China. Methods Between, 2010 and, 2016, we conducted retrospective cohort involving 36,441 individuals with levels. Using Cox proportional hazards regression model, examined connection incidence. We employed this method smooth curve fitting investigate nonlinear associations. Subgroup analyses were performed based on age, sex, body mass index, smoking drinking status, hypertension, family history diabetes. Results A significant linear was observed T2DM. The hazard ratio for triglycerides 1.81 (95% confidence interval: 1.39, 2.36); P&lt;0.001). Kaplan–Meier analysis further demonstrated prospective association higher tertiles development (P&lt;0.001). revealed stronger positive correlation females risk Discussion An increase is related continuous general population. These findings show that almost everyone can benefit reducing levels, emphasizing importance lifestyle changes

Language: Английский

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

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Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 6, 2025

Lifestyle and dietary intake play a pivotal role in development of metabolic dysfunction-associated fatty liver disease(MAFLD). We performed this cross-sectional study to evaluate the association between lifestyle insulinemic potential odds MAFLD overweight obese children adolescents. The diet was assessed by computing scores empirical index for hyperinsulinemia(EDIH), hyperinsulinemia(ELIH), insulin resistance(EDIR), resistance(ELIR). diagnosed according consensus definitions. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated logistic regression. A total 334 (49.1% boys) with mean ± SD age BMI-for-age-Z-score 9.3 1.8 2.55 0.69, respectively, enrolled. After adjusting all confounders, participants highest quartile ELIH score had greater developing (OR:3.50;95%CI:1.49–8.22) compared those lowest quartile. This remained significant among boys pubertal ones. However, no EDIH, EDIR, or ELIR found. Our suggests that collective intake, BMI, physical activity is associated increased MAFLD.

Language: Английский

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Evaluation of circulating glypican 4 as a novel biomarker in disease – A comprehensive review

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

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Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

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Editorial for Special Issue: “Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment”

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 160 - 160

Published: Feb. 27, 2025

Metabolic-dysfunction-associated fatty liver disease (MAFLD) and alcohol-associated (ALD) represent two of the most prevalent chronic diseases globally, collectively affecting hundreds millions individuals [...]

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837

Published: March 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Language: Английский

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Arecoline Alleviates T2DM via Gut Microbiota Modulation and Liver Gene Regulation in Mice

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT Scope Arecoline, the main alkaloid in areca nut, has shown potential modulating metabolism and gut microbiota. This study aimed to evaluate its therapeutic effects on glucose lipid metabolism, inflammation, liver function, mechanisms a Type 2 diabetes mellitus (T2DM) mouse model. Methods results T2DM was established mice with high‐fat, high‐sugar diet, streptozotocin injections. Arecoline significantly reduced fasting blood glucose, enhanced tolerance, increased insulin sensitivity. Serum profiles showed marked decreases total cholesterol, triglycerides, LDL‐C levels. Systemic as measured by serum levels of IL‐1β, IL‐6, MCP‐1, decreased significantly. Improvements function were observed, indicated reductions ALT AST Liver transcriptomic analysis revealed modulation pathways related glutathione MAPK signaling, cAMP which involved signaling oxidative stress response. Additionally, arecoline mitigated dysbiosis restoring microbial diversity, altering microbiota composition, regulating key NAD biosynthesis fatty acid β‐oxidation, critical for maintaining energy homeostasis. Conclusion improves profiles, while metabolic pathways, showing agent T2DM.

Language: Английский

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