Unveiling the Chemical Composition and Biofunctionality of Hericium spp. Fungi: A Comprehensive Overview

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5949 - 5949

Опубликована: Май 29, 2024

In recent years, research on mushrooms belonging to the Hericium genus has attracted considerable attention due their unique appearance and well-known medicinal properties. These are abundant in bioactive chemicals like polysaccharides, hericenones, erinacines, hericerins, resorcinols, steroids, mono- diterpenes, corallocins, alongside essential nutrients. compounds demonstrate beneficial bioactivities which related various physiological systems of body, including digestive, immune, nervous systems. Extensive been conducted isolation identification numerous chemicals, both vitro vivo studies have confirmed antimicrobial, antioxidant, immunomodulatory, antidiabetic, anticholesterolemic, anticancer, neuroprotective Therefore, this review aims provide a comprehensive summary latest scientific literature chemical composition secondary metabolites profile spp. through an introduction characteristics, speculated biosynthesis pathways for key families, potential toxicological aspects, detailed description updates regarding bioactivity these metabolites.

Язык: Английский

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Antimicrobial, Probiotic, and Immunomodulatory Potential of Cannabis sativa Extract and Delivery Systems

Antibiotics, Год журнала: 2024, Номер 13(4), С. 369 - 369

Опубликована: Апрель 17, 2024

The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary metabolites, mainly cannabinoids, terpenes, and flavonoids, synergy their aim this study was assess activity Henola Cannabis sativae extract its combinations with selected carriers (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer, magnesium aluminometasilicate, hydroxypropyl-β-cyclodextrin) terms antimicrobial, probiotic, immunobiological effects. As a result conducted research, antimicrobial confirmed relation following microorganisms: Clostridium difficile, Listeria monocytogenes, Enterococcus faecalis, Staphylococcus aureus, pyrogenes, Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, Pseudomonas aereuginosa, Candida albicans (microorganism count reduced from ~102 CFU mL−1 <10 most cases). Additionally, for system hydroxypropyl-β-cyclodextrin, significant probiotic potential against bacterial strains established Lactobacillus acidophilus, casei, plantarum, brevis, rhamnosus, reuteri, Pediococcus pentosaceus, Lactococcus lactis, fermentum, Streptococcus thermophilus increased 104–107). In immunomodulatory properties, it determined that tested systems caused changes IL-6, IL-8, TNF-α levels.

Язык: Английский

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Bitter Perception and Effects of Foods Rich in Bitter Compounds on Human Health: A Comprehensive Review

Foods, Год журнала: 2024, Номер 13(23), С. 3747 - 3747

Опубликована: Ноя. 22, 2024

Bitter food, because of its unique taste, is not popular with the public, and even considered to be difficult swallow. By binding specific sites bitter receptors (26 hTAS2Rs), compounds activate downstream signaling pathways mediated by G protein, which convert chemical signals into electrical that are ultimately transmitted brain produce perception. The intensity bitterness mainly determined hydrophobic recognition region receptors. in foods include alkaloids, polyphenols, terpenoids, amino acids, etc. Foods rich taste mostly natural such as beans, nuts, coffee, Studies have proven biological activities preventing hyperlipidemia, hypertension, hyperglycemia, anti-inflammatory, antitumor, antibacterial, antioxidant, exhibit neuroprotective effects other activities. purpose this review explore perception activity compounds, clarify mechanism their action on human health, provide theoretical guidance for development application functional foods.

Язык: Английский

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Comprehensive metabolic profiling of three plants of Ardisia based on UPLC-QTOF-MS coupled with bioactivity assays

Journal of Ethnopharmacology, Год журнала: 2025, Номер 342, С. 119327 - 119327

Опубликована: Янв. 5, 2025

Язык: Английский

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The key role of cytochrome P450s in the biosynthesis of plant derived natural products

Plant Physiology and Biochemistry, Год журнала: 2025, Номер 222, С. 109695 - 109695

Опубликована: Фев. 25, 2025

Язык: Английский

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Brazilian Organic Honeydew Reduces In Vitro and In Vivo Periodontal Disease-Related Subgingival Biofilm

Foods, Год журнала: 2025, Номер 14(6), С. 997 - 997

Опубликована: Март 14, 2025

We investigated the antimicrobial properties and effects on bone resorption of Brazilian organic honeydew (OHD) from Bracatinga tree (Mimosa scabrella Benth.), a rare honey certified with Denomination Origin, using periodontal disease model. Antibiofilm activity was assessed subgingival biofilm adhered to Calgary device. Biofilms were treated OHD, chlorhexidine (0.12%), or vehicle twice daily for 1 min starting day 3, at concentrations 2× 10× minimum inhibitory concentration (MIC). employed ligature-induced chronic model challenged it Porphyromonas gingivalis in C57BL/6 mice. The chemical profile OHD analyzed LC-ESI-IT-MS/MS. Results evaluated by measuring loss microbial composition ligature through DNA-DNA hybridization. demonstrated significant against P. (MIC 4%, MBC 6%) reduced viability 80% vitro. In vivo, decreased populations associated disease. Chemical analysis identified seven compounds including five flavonoids two lignans. This Atlantic Forest exhibits strong potential as functional food oral health, offering promising alternative control prevention

Язык: Английский

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Potential Benefits of In Silico Methods: A Promising Alternative in Natural Compound’s Drug Discovery and Repurposing for HBV Therapy

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 419 - 419

Опубликована: Март 16, 2025

Hepatitis B virus (HBV) is an important global public health issue. The World Health Organization (WHO) 2024 Global Report estimated that the prevalence of people living with HBV infection 254 million, incidence 1.2 million new infections yearly. Previous studies have shown natural compounds antiviral inhibition potentials. In silico methods such as molecular docking, virtual screening, pharmacophore modeling, quantitative structure–activity relationship (QSAR), and dynamic simulations been successfully applied in identifying bioactive strong binding energies treatment targets. COVID-19 pandemic necessitated importance repurposing already approved drugs using methods. This study aimed at unveiling benefits techniques a potential alternative compounds’ drug discovery for therapy. Relevant articles from PubMed, Google Scholar, Web Science were retrieved analyzed. Furthermore, this comprehensively reviewed literature containing identified essential proteins. Notably, hesperidin, quercetin, kaempferol, myricetin, flavonoids hepatitis surface antigen (HBsAg). investigation reveals offer understanding mechanisms action, reveal previously overlooked viral targets (including PreS1 Domain HBsAg cccDNA (Covalently Closed Circular DNA) regulators, facilitate creation specific inhibitors. integration silico, vitro, vivo insights further highlight Moreover, combination compounds, approach, improves chances personalized precision medicine treatment. Therefore, we recommend strategies combine vivo, approaches to effective drugs.

Язык: Английский

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In vitro study of anti-coccidial activity of Ocimum gratissimum and Vernonia amygdalina leaves extracts against Eimeria magna and Eimeria media

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Background Ocimum gratissimum and Vernonia amygdalina are used in traditional medicine for their various biological properties, but few studies have assessed antioxidant anticoccidial capacities toxicity. The aim of this study was to evaluate the capacity, activity (against Eimeria magna media), phytochemical content toxicity leaves extracts from two plants. Methodology: Aqueous acetonic both plants were prepared analysed polyphenol, flavonoid tannin contents. Antioxidant measured via DPPH method. effects increasing concentrations tested on Eimeria oocysts sporozoites. Toxicity by mortality tests Artemia salina larvae clinical rats. Result results show that V. greater than those O. gratissimum. acetone presented lower EC₅₀ values (2.4025 ± 0.0385) 3.541 0.112 amygdalina) did aqueous extracts. With respect anti-ocyst activity, inhibited sporulation E. up 91% at 40 mg/mL (p˂0.05). revealed not toxic salina. No major histological changes observed. significant properties nontoxic applications. Conclusion This shows possess with superior efficacy amygdalina. These potential as natural alternatives management coccidiosis farm animals, helping reduce use synthetic antiparasitics promote sustainable agricultural practices. Further long-term application livestock farming required.

Язык: Английский

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Determination of the Phytochemical Profile and Antioxidant Activity of Some Alcoholic Extracts of Levisticum officinale with Pharmaceutical and Cosmetic Applications

Separations, Год журнала: 2025, Номер 12(4), С. 79 - 79

Опубликована: Март 28, 2025

Levisticum officinale (lovage) is an aromatic and medicinal plant traditionally used for its antioxidant, anti-inflammatory antimicrobial properties. The aim of this study was to evaluate the phytochemical composition antioxidant activity hydroalcoholic extracts obtained from leaves, roots whole plant, as well develop hydrogels with pharmaceutical potential. (70% ethanol) were characterized by spectrophotometric HPLC-DAD methods determine total content phenolic compounds, acids, flavonoids condensed tannins. evaluated DPPH ABTS methods. included in 2% carbopol-based tested stability efficacy. extract leaves showed highest compounds (20.84 ± 2.18 mg GAE/g), flavones (11.39 2.48 QE/g) tannins (1.98 1.55 CE/g), also richest quercetin (3.32 1.25 mg/g), kaempferol (1.84 1.63 luteolin (2.12 1.19 rutin (4.38 1.84 mg/g) apigenin (1.91 1.44 mg/g). root had including ferulic acid (3.86 1.37 vanillic (2.53 1.76 caffeic (3.28 1.28 extract, values 276.2 3.4 µmol TE/g (ABTS) 246.4 3.6 (DPPH). whole-plant intermediate values, offering a balance between acids. Hydrogels formulated 5% demonstrated sustained over time. Leaf extracts, due their high flavonoid content, are recommended formulations photoprotective effects, while suitable applications. based on carbopol represent promising delivery system dermato-cosmetic applications because they exhibited significant action.

Язык: Английский

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Deciphering drought adaptation in Eucommia ulmoides: From the rhizosphere microbiota to root metabolites

Applied Soil Ecology, Год журнала: 2025, Номер 210, С. 106064 - 106064

Опубликована: Март 31, 2025

Язык: Английский

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