International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5949 - 5949
Published: May 29, 2024
In
recent
years,
research
on
mushrooms
belonging
to
the
Hericium
genus
has
attracted
considerable
attention
due
their
unique
appearance
and
well-known
medicinal
properties.
These
are
abundant
in
bioactive
chemicals
like
polysaccharides,
hericenones,
erinacines,
hericerins,
resorcinols,
steroids,
mono-
diterpenes,
corallocins,
alongside
essential
nutrients.
compounds
demonstrate
beneficial
bioactivities
which
related
various
physiological
systems
of
body,
including
digestive,
immune,
nervous
systems.
Extensive
been
conducted
isolation
identification
numerous
chemicals,
both
vitro
vivo
studies
have
confirmed
antimicrobial,
antioxidant,
immunomodulatory,
antidiabetic,
anticholesterolemic,
anticancer,
neuroprotective
Therefore,
this
review
aims
provide
a
comprehensive
summary
latest
scientific
literature
chemical
composition
secondary
metabolites
profile
spp.
through
an
introduction
characteristics,
speculated
biosynthesis
pathways
for
key
families,
potential
toxicological
aspects,
detailed
description
updates
regarding
bioactivity
these
metabolites.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(4), P. 369 - 369
Published: April 17, 2024
The
compounds
present
in
hemp
show
multidirectional
biological
activity.
It
is
related
to
the
presence
of
secondary
metabolites,
mainly
cannabinoids,
terpenes,
and
flavonoids,
synergy
their
aim
this
study
was
assess
activity
Henola
Cannabis
sativae
extract
its
combinations
with
selected
carriers
(polyvinyl
caprolactam–polyvinyl
acetate–polyethylene
glycol
graft
copolymer,
magnesium
aluminometasilicate,
hydroxypropyl-β-cyclodextrin)
terms
antimicrobial,
probiotic,
immunobiological
effects.
As
a
result
conducted
research,
antimicrobial
confirmed
relation
following
microorganisms:
Clostridium
difficile,
Listeria
monocytogenes,
Enterococcus
faecalis,
Staphylococcus
aureus,
pyrogenes,
Escherichia
coli,
Klebsiella
pneumoniae,
Salmonella
typhimurium,
Pseudomonas
aereuginosa,
Candida
albicans
(microorganism
count
reduced
from
~102
CFU
mL−1
<10
most
cases).
Additionally,
for
system
hydroxypropyl-β-cyclodextrin,
significant
probiotic
potential
against
bacterial
strains
established
Lactobacillus
acidophilus,
casei,
plantarum,
brevis,
rhamnosus,
reuteri,
Pediococcus
pentosaceus,
Lactococcus
lactis,
fermentum,
Streptococcus
thermophilus
increased
104–107).
In
immunomodulatory
properties,
it
determined
that
tested
systems
caused
changes
IL-6,
IL-8,
TNF-α
levels.
Foods,
Journal Year:
2024,
Volume and Issue:
13(23), P. 3747 - 3747
Published: Nov. 22, 2024
Bitter
food,
because
of
its
unique
taste,
is
not
popular
with
the
public,
and
even
considered
to
be
difficult
swallow.
By
binding
specific
sites
bitter
receptors
(26
hTAS2Rs),
compounds
activate
downstream
signaling
pathways
mediated
by
G
protein,
which
convert
chemical
signals
into
electrical
that
are
ultimately
transmitted
brain
produce
perception.
The
intensity
bitterness
mainly
determined
hydrophobic
recognition
region
receptors.
in
foods
include
alkaloids,
polyphenols,
terpenoids,
amino
acids,
etc.
Foods
rich
taste
mostly
natural
such
as
beans,
nuts,
coffee,
Studies
have
proven
biological
activities
preventing
hyperlipidemia,
hypertension,
hyperglycemia,
anti-inflammatory,
antitumor,
antibacterial,
antioxidant,
exhibit
neuroprotective
effects
other
activities.
purpose
this
review
explore
perception
activity
compounds,
clarify
mechanism
their
action
on
human
health,
provide
theoretical
guidance
for
development
application
functional
foods.
Foods,
Journal Year:
2025,
Volume and Issue:
14(6), P. 997 - 997
Published: March 14, 2025
We
investigated
the
antimicrobial
properties
and
effects
on
bone
resorption
of
Brazilian
organic
honeydew
(OHD)
from
Bracatinga
tree
(Mimosa
scabrella
Benth.),
a
rare
honey
certified
with
Denomination
Origin,
using
periodontal
disease
model.
Antibiofilm
activity
was
assessed
subgingival
biofilm
adhered
to
Calgary
device.
Biofilms
were
treated
OHD,
chlorhexidine
(0.12%),
or
vehicle
twice
daily
for
1
min
starting
day
3,
at
concentrations
2×
10×
minimum
inhibitory
concentration
(MIC).
employed
ligature-induced
chronic
model
challenged
it
Porphyromonas
gingivalis
in
C57BL/6
mice.
The
chemical
profile
OHD
analyzed
LC-ESI-IT-MS/MS.
Results
evaluated
by
measuring
loss
microbial
composition
ligature
through
DNA-DNA
hybridization.
demonstrated
significant
against
P.
(MIC
4%,
MBC
6%)
reduced
viability
80%
vitro.
In
vivo,
decreased
populations
associated
disease.
Chemical
analysis
identified
seven
compounds
including
five
flavonoids
two
lignans.
This
Atlantic
Forest
exhibits
strong
potential
as
functional
food
oral
health,
offering
promising
alternative
control
prevention
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 419 - 419
Published: March 16, 2025
Hepatitis
B
virus
(HBV)
is
an
important
global
public
health
issue.
The
World
Health
Organization
(WHO)
2024
Global
Report
estimated
that
the
prevalence
of
people
living
with
HBV
infection
254
million,
incidence
1.2
million
new
infections
yearly.
Previous
studies
have
shown
natural
compounds
antiviral
inhibition
potentials.
In
silico
methods
such
as
molecular
docking,
virtual
screening,
pharmacophore
modeling,
quantitative
structure–activity
relationship
(QSAR),
and
dynamic
simulations
been
successfully
applied
in
identifying
bioactive
strong
binding
energies
treatment
targets.
COVID-19
pandemic
necessitated
importance
repurposing
already
approved
drugs
using
methods.
This
study
aimed
at
unveiling
benefits
techniques
a
potential
alternative
compounds’
drug
discovery
for
therapy.
Relevant
articles
from
PubMed,
Google
Scholar,
Web
Science
were
retrieved
analyzed.
Furthermore,
this
comprehensively
reviewed
literature
containing
identified
essential
proteins.
Notably,
hesperidin,
quercetin,
kaempferol,
myricetin,
flavonoids
hepatitis
surface
antigen
(HBsAg).
investigation
reveals
offer
understanding
mechanisms
action,
reveal
previously
overlooked
viral
targets
(including
PreS1
Domain
HBsAg
cccDNA
(Covalently
Closed
Circular
DNA)
regulators,
facilitate
creation
specific
inhibitors.
integration
silico,
vitro,
vivo
insights
further
highlight
Moreover,
combination
compounds,
approach,
improves
chances
personalized
precision
medicine
treatment.
Therefore,
we
recommend
strategies
combine
vivo,
approaches
to
effective
drugs.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Abstract
Background
Ocimum
gratissimum
and
Vernonia
amygdalina
are
used
in
traditional
medicine
for
their
various
biological
properties,
but
few
studies
have
assessed
antioxidant
anticoccidial
capacities
toxicity.
The
aim
of
this
study
was
to
evaluate
the
capacity,
activity
(against
Eimeria
magna
media),
phytochemical
content
toxicity
leaves
extracts
from
two
plants.
Methodology:
Aqueous
acetonic
both
plants
were
prepared
analysed
polyphenol,
flavonoid
tannin
contents.
Antioxidant
measured
via
DPPH
method.
effects
increasing
concentrations
tested
on
Eimeria
oocysts
sporozoites.
Toxicity
by
mortality
tests
Artemia
salina
larvae
clinical
rats.
Result
results
show
that
V.
greater
than
those
O.
gratissimum.
acetone
presented
lower
EC50
values
(2.4025
±
0.0385)
3.541
0.112
amygdalina)
did
aqueous
extracts.
With
respect
anti-ocyst
activity,
inhibited
sporulation
E.
up
91%
at
40
mg/mL
(p˂0.05).
revealed
not
toxic
salina.
No
major
histological
changes
observed.
significant
properties
nontoxic
applications.
Conclusion
This
shows
possess
with
superior
efficacy
amygdalina.
These
potential
as
natural
alternatives
management
coccidiosis
farm
animals,
helping
reduce
use
synthetic
antiparasitics
promote
sustainable
agricultural
practices.
Further
long-term
application
livestock
farming
required.
Separations,
Journal Year:
2025,
Volume and Issue:
12(4), P. 79 - 79
Published: March 28, 2025
Levisticum
officinale
(lovage)
is
an
aromatic
and
medicinal
plant
traditionally
used
for
its
antioxidant,
anti-inflammatory
antimicrobial
properties.
The
aim
of
this
study
was
to
evaluate
the
phytochemical
composition
antioxidant
activity
hydroalcoholic
extracts
obtained
from
leaves,
roots
whole
plant,
as
well
develop
hydrogels
with
pharmaceutical
potential.
(70%
ethanol)
were
characterized
by
spectrophotometric
HPLC-DAD
methods
determine
total
content
phenolic
compounds,
acids,
flavonoids
condensed
tannins.
evaluated
DPPH
ABTS
methods.
included
in
2%
carbopol-based
tested
stability
efficacy.
extract
leaves
showed
highest
compounds
(20.84
±
2.18
mg
GAE/g),
flavones
(11.39
2.48
QE/g)
tannins
(1.98
1.55
CE/g),
also
richest
quercetin
(3.32
1.25
mg/g),
kaempferol
(1.84
1.63
luteolin
(2.12
1.19
rutin
(4.38
1.84
mg/g)
apigenin
(1.91
1.44
mg/g).
root
had
including
ferulic
acid
(3.86
1.37
vanillic
(2.53
1.76
caffeic
(3.28
1.28
extract,
values
276.2
3.4
µmol
TE/g
(ABTS)
246.4
3.6
(DPPH).
whole-plant
intermediate
values,
offering
a
balance
between
acids.
Hydrogels
formulated
5%
demonstrated
sustained
over
time.
Leaf
extracts,
due
their
high
flavonoid
content,
are
recommended
formulations
photoprotective
effects,
while
suitable
applications.
based
on
carbopol
represent
promising
delivery
system
dermato-cosmetic
applications
because
they
exhibited
significant
action.
