Current Topics in Medicinal Chemistry,
Год журнала:
2023,
Номер
24(9), С. 797 - 809
Опубликована: Дек. 23, 2023
Abstract:
Sesamol,
one
of
the
key
bioactive
ingredients
sesame
seeds
(Sesamum
indicum
L.),
is
responsible
for
many
its
possible
nutritional
benefits.
Both
Chinese
and
Indian
medical
systems
have
recognized
therapeutic
potential
seeds.
It
has
been
shown
to
significant
against
oxidative
stress,
inflammatory
diseases,
metabolic
syndrome,
neurodegeneration,
mental
disorders.
Sesamol
a
benign
molecule
that
inhibits
expression
indicators
like
numerous
enzymes
inducing
inflammation,
protein
kinases,
cytokines,
redox
status.
This
review
summarises
beneficial
effects
sesamol
neurological
diseases
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
Huntington’s
(HD).
Recently,
reduce
amyloid
peptide
accumulation
attenuate
cognitive
deficits
in
AD
models.
also
demonstrated
severity
PD
HD
animal
models
by
decreasing
stress
pathways.
The
mechanism
sesamol's
pharmacological
activities
neurodegenerative
will
be
discussed
this
review.
Medicina,
Год журнала:
2024,
Номер
60(1), С. 115 - 115
Опубликована: Янв. 7, 2024
Neuropsychiatric
symptoms
(NPS),
including
depression,
anxiety,
apathy,
visual
hallucinations,
and
impulse
control
disorders,
are
very
common
during
the
course
of
Parkinson’s
disease
(PD),
occurring
even
at
prodromal
premotor
stages.
Mild
behavioral
impairment
(MBI)
represents
a
recently
described
neurobehavioral
syndrome,
characterized
by
emergence
persistent
impactful
NPS
in
later
life,
reflecting
arisk
dementia.
Accumulating
evidence
suggests
that
MBI
is
highly
prevalent
non-demented
patients
with
PD,
also
being
associated
an
advanced
stage,
more
severe
motor
deficits,
as
well
global
multiple-domain
cognitive
impairment.
Neuroimaging
studies
have
revealed
PD
may
be
related
todistinct
patterns
brain
atrophy,
altered
neuronal
connectivity,
distribution
dopamine
transporter
(DAT)
depletion,
shedding
light
on
its
pathophysiological
background.
Genetic
shown
specific
single-nucleotide
polymorphisms
(SNPs)
MBI,
paving
way
for
future
research
this
field.
In
review,
we
summarize
critically
discuss
emerging
frequency,
clinical
genetic
factors,
neuroanatomical
neurophysiological
correlates
aiming
to
elucidate
underlying
pathophysiology
potential
role
early
“marker”
decline,
particularly
population.
addition,
aim
identify
gaps,
propose
novel
relative
areas
interest
could
aid
our
better
understanding
relationship
newly
defined
diagnostic
entity
PD.
NeuroImage Clinical,
Год журнала:
2025,
Номер
46, С. 103767 - 103767
Опубликована: Янв. 1, 2025
Functional
neurological
disorder
(FND)
in
children
and
adolescents
is
a
biopsychosocially
complex
condition
characterized
by
wide
range
of
symptoms.
Using
magnetic
resonance
spectroscopy
to
study
neurometabolites
has
become
an
important
approach
studying
the
mechanisms
FND.
Unlike
previous
studies
focusing
on
concentration-level
analysis,
this
examines
conditional
dependencies
between
six
neurometabolites:
N-acetyl
aspartate,
creatine,
glutathione,
choline,
myo-inositol,
glutamate.
Conditional
dependence
implies
that
two
have
joint
variability
not
mediated
other
neurometabolites.
A
Bayesian
graphical
lasso
was
used
estimate
neurometabolites'
three
regions
interest:
anterior
default
mode
network
(aDMN),
supplementary
motor
area
(SMA),
posterior
(pDMN).
We
introduce
term
neurometabolic
(NMetNet)
describe
these
dependencies.
Children
with
FND
(vs.
healthy
controls)
showed
loss
related
creatine
glutathione
aDMN
SMA/pDMN.
Glutathione
primary
antioxidant
brain.
Creatine
plays
key
role
maintaining
bioenergetics
also
acts
as
antioxidant.
These
findings
suggest
dysregulated
increased
vulnerability
oxidative
stress.
Understanding
NMetNet
offers
novel
insights
into
disorder's
neurobiology,
implications
for
therapeutic
interventions
restore
energy
homeostasis
balance.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 9, 2025
Over
the
years,
global
disease
burden
of
neurological
disorders
(NDs)
and
mental
(MDs)
has
significantly
increased,
making
them
one
most
critical
concerns
challenges
to
human
health.
In
pursuit
novel
therapies
against
MD
ND,
there
been
a
growing
focus
on
nutrition
Dietary
sulfur,
primarily
derived
from
various
natural
sources,
plays
crucial
role
in
numerous
physiological
processes,
including
brain
function.
This
review
offers
an
overview
chemical
composition
several
sources
sulfur-rich
substances
such
as
isothiocyanates,
sulforaphane,
glutathione,
taurine,
sulfated
polysaccharides,
allyl
sulfides,
sulfur-containing
amino
acids,
all
which
have
neuroprotective
properties.
A
multitude
studies
documented
that
consuming
foods
are
high
sulfur
enhances
function
by
improving
cognitive
parameters
reduces
severity
neuropathology
exhibiting
antioxidant
anti-inflammatory
properties
at
molecular
level.
addition,
compounds
repairing
endothelial
dysfunction,
compromising
blood-brain
barrier
cerebral
blood
flow,
here.
Furthermore,
this
covers
encouraging
results
supplementing
diets
many
animal
models
clinical
investigations,
along
with
their
targets
MD,
schizophrenia,
depression,
anxiety,
bipolar
disorder,
autism
spectrum
Alzheimer's
(AD),
Parkinson's
(PD),
Amyotrophic
Lateral
Sclerosis
(ALS),
Multiple
(MS).
The
prospects
show
great
promise
they
potential
applications
nutraceuticals,
medicines,
functional
enhance
prevent
diseases.
However,
additional
research
is
required
clarify
mechanisms
it
works,
its
bioavailability,
evaluate
long-term
safety
for
broad
use.
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 982 - 982
Опубликована: Апрель 17, 2025
Background/Objectives:
Prenatal
hypoxia
(PH)
is
a
leading
cause
of
nervous
system
disorders
in
early
childhood
and
subsequently
leads
to
decline
the
cognitive
mnemonic
functions
central
(such
as
memory
impairment,
reduced
learning
ability,
information
processing).
It
also
increases
anxiety
risk
brain
adulthood.
Compensatory–adaptive
mechanisms
mother–placenta–fetus
system,
which
enhance
fetus’s
CNS
resilience,
are
known,
including
activation
endogenous
neuroprotection
response
hypoxic
injury
through
pharmacological
modulation
HSP70.
Methods:
To
evaluate
effect
HSP70
modulators—Cerebrocurin,
Angiolin,
Tamoxifen,
Glutaredoxin,
Thiotriazoline,
HSF-1
(heat
shock
factor
1
protein),
well
Mildronate
Mexidol—on
motor
skills,
exploratory
behaviors,
psycho-emotional
activities,
learning,
memories
offspring
after
PH.
Experimental
PH
was
induced
by
daily
intraperitoneal
injections
sodium
nitrite
solution
into
pregnant
female
rats
from
16th
21st
day
pregnancy
at
dose
50
mg/kg.
The
newborns
received
Angiolin
(50
mg/kg),
Thiotriazoline
Mexidol
(100
Cerebrocurin
(150
µL/kg),
L-arginine
(200
Glutaredoxin
µg/kg),
or
mg/kg)
for
30
days.
At
month,
were
tested
open
field
test,
2
months,
they
trained
working
spatial
radial
maze.
Results:
Modeling
led
persistent
impairments
activity,
behavior,
decrease
cognitive–mnestic
CNS.
found
that
had
most
pronounced
effects
on
indicators
activity
status
1-month-old
animals
They
exhibited
significant
cognitive-enhancing
memory-supporting
during
training
evaluation
skill
retention
maze
2-month-old
Conclusions:
first
time,
we
obtained
experimental
data
modulators
following
intrauterine
hypoxia.
Based
results
this
study,
identified
agents
promising
neuroprotective
perinatal
Oxygen,
Год журнала:
2024,
Номер
4(3), С. 325 - 337
Опубликована: Авг. 19, 2024
Oxidative
stress,
characterized
by
an
imbalance
between
the
production
of
reactive
oxygen
species
and
body’s
antioxidant
defenses,
plays
important
role
in
pathogenesis
various
health
conditions,
including
cancer
neurological
disorders.
For
example,
excessive
ROS
can
lead
to
mutations,
genomic
instability,
uncontrolled
cell
proliferation
cancer.
In
disorders,
oxidative
stress
contributes
neuronal
damage,
inflammation,
progression
diseases
such
as
Alzheimer’s
Parkinson’s
diseases.
Adenosine,
a
nucleoside
involved
energy
transfer
signal
transduction,
is
crucial
maintaining
cellular
homeostasis.
Its
extends
modulating
stress.
Adenosine
receptors
are
implicated
physiological
processes
pathophysiology
The
interplay
adenosine
signaling
complex
critical.
modulate
responses,
providing
therapeutic
potential
for
conditions
where
key
player.
Understanding
this
connection
opens
up
avenues
novel
strategies
targeting
mitigate
damage.
Regenerative medicine reports .,
Год журнала:
2024,
Номер
1(2), С. 222 - 231
Опубликована: Дек. 1, 2024
Nicotine
withdrawal
precipitates
anxiety-
and
depression-like
behaviors
associated
with
disruptions
in
neurotransmitter
systems,
alterations
glial
neurotrophic
factors,
heightened
oxidative
stress.
This
study
aimed
to
investigate
the
potential
therapeutic
effects
of
magnesium
sulfate
(MgSO₄)
on
nicotine
withdrawal-induced
anxiety
depression
rats
as
well
its
implications
for
regenerative
psychiatry.
These
findings
indicated
that
MgSO₄
administration
effectively
attenuated
induced
by
rat
model.
The
beneficial
were
accompanied
modulation
cortical
serotonin
metabolism,
a
reduction
monoamine
oxidase
A
activity,
upregulation
brain-derived
factor,
downregulation
fibrillary
acidic
protein,
amelioration
stress
behaviors.
Therefore,
can
ameliorate
detrimental
at
cellular
behavioral
levels
has
certain
psychiatry,
paving
way
application
substance
abuse-related
diseases.
