Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases DOI
Hayate Javed, Mohamed Fizur Nagoor Meeran, Niraj Kumar Jha

et al.

Current Topics in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 24(9), P. 797 - 809

Published: Dec. 23, 2023

Abstract: Sesamol, one of the key bioactive ingredients sesame seeds (Sesamum indicum L.), is responsible for many its possible nutritional benefits. Both Chinese and Indian medical systems have recognized therapeutic potential seeds. It has been shown to significant against oxidative stress, inflammatory diseases, metabolic syndrome, neurodegeneration, mental disorders. Sesamol a benign molecule that inhibits expression indicators like numerous enzymes inducing inflammation, protein kinases, cytokines, redox status. This review summarises beneficial effects sesamol neurological diseases including Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD). Recently, reduce amyloid peptide accumulation attenuate cognitive deficits in AD models. also demonstrated severity PD HD animal models by decreasing stress pathways. The mechanism sesamol's pharmacological activities neurodegenerative will be discussed this review.

Language: Английский

Transdermal delivery of resveratrol loaded solid lipid nanoparticle as a microneedle patch: a novel approach for the treatment of Parkinson’s disease DOI

Akshay Bandiwadekar,

Jobin Jose, Gopika Gopan

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 29, 2024

Language: Английский

Citations

10
Mild Behavioral Impairment in Parkinson’s Disease: An Updated Review on the Clinical, Genetic, Neuroanatomical, and Pathophysiological Aspects DOI Creative Commons
Efthalia Angelopoulou, Anastasia Bougea, Alexandros Hatzimanolis

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(1), P. 115 - 115

Published: Jan. 7, 2024

Neuropsychiatric symptoms (NPS), including depression, anxiety, apathy, visual hallucinations, and impulse control disorders, are very common during the course of Parkinson’s disease (PD), occurring even at prodromal premotor stages. Mild behavioral impairment (MBI) represents a recently described neurobehavioral syndrome, characterized by emergence persistent impactful NPS in later life, reflecting arisk dementia. Accumulating evidence suggests that MBI is highly prevalent non-demented patients with PD, also being associated an advanced stage, more severe motor deficits, as well global multiple-domain cognitive impairment. Neuroimaging studies have revealed PD may be related todistinct patterns brain atrophy, altered neuronal connectivity, distribution dopamine transporter (DAT) depletion, shedding light on its pathophysiological background. Genetic shown specific single-nucleotide polymorphisms (SNPs) MBI, paving way for future research this field. In review, we summarize critically discuss emerging frequency, clinical genetic factors, neuroanatomical neurophysiological correlates aiming to elucidate underlying pathophysiology potential role early “marker” decline, particularly population. addition, aim identify gaps, propose novel relative areas interest could aid our better understanding relationship newly defined diagnostic entity PD.

Language: Английский

Citations

7
N-acetyl cysteine through modulation of HDAC2 and GCN5 in the hippocampus mitigates behavioral disorders in the first and second generations of socially isolated mice DOI Creative Commons
Najmeh Asgharzadeh,

Ali Noori Diziche,

Hossein Amini‐Khoei

et al.

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Neurometabolic network (NMetNet) for functional neurological disorder in children and adolescents DOI Creative Commons
Zhou Lan, Sheryl Foster, Molly Charney

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: 46, P. 103767 - 103767

Published: Jan. 1, 2025

Functional neurological disorder (FND) in children and adolescents is a biopsychosocially complex condition characterized by wide range of symptoms. Using magnetic resonance spectroscopy to study neurometabolites has become an important approach studying the mechanisms FND. Unlike previous studies focusing on concentration-level analysis, this examines conditional dependencies between six neurometabolites: N-acetyl aspartate, creatine, glutathione, choline, myo-inositol, glutamate. Conditional dependence implies that two have joint variability not mediated other neurometabolites. A Bayesian graphical lasso was used estimate neurometabolites' three regions interest: anterior default mode network (aDMN), supplementary motor area (SMA), posterior (pDMN). We introduce term neurometabolic (NMetNet) describe these dependencies. Children with FND (vs. healthy controls) showed loss related creatine glutathione aDMN SMA/pDMN. Glutathione primary antioxidant brain. Creatine plays key role maintaining bioenergetics also acts as antioxidant. These findings suggest dysregulated increased vulnerability oxidative stress. Understanding NMetNet offers novel insights into disorder's neurobiology, implications for therapeutic interventions restore energy homeostasis balance.

Language: Английский

Citations

0
Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies DOI Creative Commons

Apeksha Rana,

Ashutosh Katiyar,

Alok Arun

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Over the years, global disease burden of neurological disorders (NDs) and mental (MDs) has significantly increased, making them one most critical concerns challenges to human health. In pursuit novel therapies against MD ND, there been a growing focus on nutrition Dietary sulfur, primarily derived from various natural sources, plays crucial role in numerous physiological processes, including brain function. This review offers an overview chemical composition several sources sulfur-rich substances such as isothiocyanates, sulforaphane, glutathione, taurine, sulfated polysaccharides, allyl sulfides, sulfur-containing amino acids, all which have neuroprotective properties. A multitude studies documented that consuming foods are high sulfur enhances function by improving cognitive parameters reduces severity neuropathology exhibiting antioxidant anti-inflammatory properties at molecular level. addition, compounds repairing endothelial dysfunction, compromising blood-brain barrier cerebral blood flow, here. Furthermore, this covers encouraging results supplementing diets many animal models clinical investigations, along with their targets MD, schizophrenia, depression, anxiety, bipolar disorder, autism spectrum Alzheimer's (AD), Parkinson's (PD), Amyotrophic Lateral Sclerosis (ALS), Multiple (MS). The prospects show great promise they potential applications nutraceuticals, medicines, functional enhance prevent diseases. However, additional research is required clarify mechanisms it works, its bioavailability, evaluate long-term safety for broad use.

Language: Английский

Citations

0
HSP70 Modulators for the Correction of Cognitive, Mnemonic, and Behavioral Disorders After Prenatal Hypoxia DOI Creative Commons
E. Aliyeva, И. Ф. Беленичев, Іван Михайлович Білай

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 982 - 982

Published: April 17, 2025

Background/Objectives: Prenatal hypoxia (PH) is a leading cause of nervous system disorders in early childhood and subsequently leads to decline the cognitive mnemonic functions central (such as memory impairment, reduced learning ability, information processing). It also increases anxiety risk brain adulthood. Compensatory–adaptive mechanisms mother–placenta–fetus system, which enhance fetus’s CNS resilience, are known, including activation endogenous neuroprotection response hypoxic injury through pharmacological modulation HSP70. Methods: To evaluate effect HSP70 modulators—Cerebrocurin, Angiolin, Tamoxifen, Glutaredoxin, Thiotriazoline, HSF-1 (heat shock factor 1 protein), well Mildronate Mexidol—on motor skills, exploratory behaviors, psycho-emotional activities, learning, memories offspring after PH. Experimental PH was induced by daily intraperitoneal injections sodium nitrite solution into pregnant female rats from 16th 21st day pregnancy at dose 50 mg/kg. The newborns received Angiolin (50 mg/kg), Thiotriazoline Mexidol (100 Cerebrocurin (150 µL/kg), L-arginine (200 Glutaredoxin µg/kg), or mg/kg) for 30 days. At month, were tested open field test, 2 months, they trained working spatial radial maze. Results: Modeling led persistent impairments activity, behavior, decrease cognitive–mnestic CNS. found that had most pronounced effects on indicators activity status 1-month-old animals They exhibited significant cognitive-enhancing memory-supporting during training evaluation skill retention maze 2-month-old Conclusions: first time, we obtained experimental data modulators following intrauterine hypoxia. Based results this study, identified agents promising neuroprotective perinatal

Language: Английский

Citations

0
Investigation of the Protective Effects of Aripiprazole on Methylphenidate-induced Neurotoxicity in Rats DOI

Afrooz Mohammadgholi-Beiki,

Helia Aghamiri,

Rojin Rashidian

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

Citations

0
Exploring Oxidative Stress in Disease and Its Connection with Adenosine DOI Creative Commons
Ana Salomé Correia, Nuno Vale

Oxygen, Journal Year: 2024, Volume and Issue: 4(3), P. 325 - 337

Published: Aug. 19, 2024

Oxidative stress, characterized by an imbalance between the production of reactive oxygen species and body’s antioxidant defenses, plays important role in pathogenesis various health conditions, including cancer neurological disorders. For example, excessive ROS can lead to mutations, genomic instability, uncontrolled cell proliferation cancer. In disorders, oxidative stress contributes neuronal damage, inflammation, progression diseases such as Alzheimer’s Parkinson’s diseases. Adenosine, a nucleoside involved energy transfer signal transduction, is crucial maintaining cellular homeostasis. Its extends modulating stress. Adenosine receptors are implicated physiological processes pathophysiology The interplay adenosine signaling complex critical. modulate responses, providing therapeutic potential for conditions where key player. Understanding this connection opens up avenues novel strategies targeting mitigate damage.

Language: Английский

Citations

2
Epigallocatechin-3-gallate-synthesized gold nanoparticles modulate reactive oxygen species and antioxidant parameters in brain and heart tissues using a chicken embryo model DOI
Allisson Benatti Justino,

María Sol Peña Carrillo,

Vinícius Prado Bittar

et al.

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 322, P. 129557 - 129557

Published: June 3, 2024

Language: Английский

Citations

1
Magnesium sulfate ameliorates nicotine withdrawal–induced anxiety and depression: implications for regenerative psychiatry DOI
Murtaza Haidary, Maryam Nazari,

Sayed Mohammad Jawad Wasiq

et al.

Regenerative medicine reports ., Journal Year: 2024, Volume and Issue: 1(2), P. 222 - 231

Published: Dec. 1, 2024

Nicotine withdrawal precipitates anxiety- and depression-like behaviors associated with disruptions in neurotransmitter systems, alterations glial neurotrophic factors, heightened oxidative stress. This study aimed to investigate the potential therapeutic effects of magnesium sulfate (MgSO₄) on nicotine withdrawal-induced anxiety depression rats as well its implications for regenerative psychiatry. These findings indicated that MgSO₄ administration effectively attenuated induced by rat model. The beneficial were accompanied modulation cortical serotonin metabolism, a reduction monoamine oxidase A activity, upregulation brain-derived factor, downregulation fibrillary acidic protein, amelioration stress behaviors. Therefore, can ameliorate detrimental at cellular behavioral levels has certain psychiatry, paving way application substance abuse-related diseases.

Language: Английский

Citations

1