Stimuli-responsive hydrogel based on natural polymers for breast cancer
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Янв. 18, 2024
Aims:
Breast
cancer
is
the
most
common
malignancy
among
women
in
both
high-
and
low-resource
settings.
Conventional
breast
therapies
were
inefficient
had
low
patient
compliance.
Stimuli-responsive
hydrogels
possessing
similar
physicochemical
features
as
soft
tissue
facilitate
diagnostic
therapeutic
approaches
for
subtypes.
Scope:
Polysaccharides
polypeptides
are
major
natural
polymers
with
unique
biocompatibility,
biodegradability,
feasible
modification
utilized
frequently
hydrogel
fabrication.
Alternating
polymer-based
properties
response
to
external
stimuli
such
pH,
temperature,
light,
ultrasonic,
enzyme,
glucose,
magnetic,
redox,
electric
have
provided
great
potential
evolution
of
novel
drug
delivery
systems
(DDSs)
various
advanced
technologies
medical
applications.
triggered
by
specific
features,
promote
target
techniques,
modify
release
agents
at
localized
sites.
This
narrative
review
presented
innovation
preparing
characterizing
stimuli-responsive
applications
area.
Conclusion:
display
bioinspiration
products
DDSs
subtypes,
protect
shape
tissue,
provide
modified
release,
enhance
efficacy,
minimize
chemotherapy
agents’
side
effects.
The
benefits
smart
make
them
an
exciting
area
practice
diagnosis
treatment.
Язык: Английский
Development and Characterization of Biocompatible Chitosan-Aloe Vera Films Functionalized with Gluconolactone and Sorbitol for Advanced Wound Healing Applications
Beata Kaczmarek,
Patrycja Glajc,
Dorota Chmielniak
и другие.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Chitosan
(CTS)
has
emerged
as
a
promising
biopolymer
for
wound
healing
due
to
its
biocompatibility,
biodegradability,
and
intrinsic
bioactive
properties.
This
study
explores
the
development
characterization
of
CTS-based
films
enhanced
with
natural
agents,
aloe
vera
(A),
gluconolactone
(GL),
sorbitol
(S),
improve
their
mechanical,
antimicrobial,
regenerative
performance
potential
use
in
advanced
care.
A
series
were
fabricated
varying
concentrations
A,
GL,
S,
physicochemical,
biological
properties
comprehensively
evaluated.
Fourier
transform
infrared
(FTIR)
spectroscopy
atomic
force
microscopy
(AFM)
analysis
revealed
modifications
film
structure
attributable
these
additives,
influencing
surface
roughness,
hydrophilicity,
thermal
stability.
Biocidal
assays
confirmed
antimicrobial
activity,
particularly
containing
GL
A.
Biodegradation
studies
demonstrated
significant
enhancement
microbial
decomposition
films,
while
cytocompatibility
tests
minimal
cytotoxic
effects
improved
cellular
response.
research
underscores
combining
CS
S
engineer
multifunctional
biomaterials
tailored
effectively
tackling
different
phases
process,
offering
sustainable
biocompatible
alternative
clinical
applications.
Язык: Английский
Combination of chitin, lignin, and plant oil for high-performance sustainable elastomers with UV-shielding and photothermal properties
Chongxiao Ge,
Rui Hu,
Jing-Yan Zhu
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
306, С. 141553 - 141553
Опубликована: Март 1, 2025
Язык: Английский
Roles of Polymer Concentration and Ionic Strength in the Deposition of Chitosan of Fungal Origin onto Negatively Charged Surfaces
Biomimetics,
Год журнала:
2024,
Номер
9(9), С. 534 - 534
Опубликована: Сен. 4, 2024
This
study
examines
the
potential
of
fungal
chitosan
derived
from
Aspergillus
niger
as
a
sustainable
alternative
to
traditional
petrochemical-based
ingredients
in
cosmetic
products.
Specifically,
research
solubility
aqueous
solutions
varying
ionic
strength
and
its
adsorption
onto
negatively
charged
surfaces
that
mimic
human
hair
keratin.
The
behavior,
water
content,
frictional
properties
films
were
evaluated
using
quartz
crystal
microbalance
with
dissipation
monitoring
surface
force
apparatus
(SFA).
findings
indicated
exhibits
good
at
pH
4.5.
Conversely,
is
subject
influence
both
polymer
concentration
strength.
At
lowest
strengths,
screening-enhanced
process
occurs
consequence
reduction
presence
salt.
results
depletion
chains
solution
their
subsequent
deposition.
An
increase
above
15–20
mM
worsening
chitosan–surface
interaction,
due
simultaneous
screening
charges.
hindrance
process.
deposited
are
highly
hydrated,
this
hydration
increases
Furthermore,
exhibit
predominantly
elastic
response
under
shear
deformations
shows
strong
dependence
on
concentration.
These
contribute
development
environmentally
friendly
formulations
meet
consumer
demands
for
sustainability.
Язык: Английский
Fungal Innovation: Harnessing Mushrooms for Production of Sustainable Functional Materials
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 27, 2024
Abstract
Underutilized
co‐
and
by‐products
are
upgraded
into
materials
with
functional
properties.
The
utilization
of
mushroom
farming
residues
is
investigated,
specifically
spent
substrate
–
whose
chemical
composition
determined
to
produce
cosmetic
face
masks,
packaging
films,
oil
sorbents.
Flexible
sheets
exhibit
conformability
antioxidant
activity
between
82
94%,
better
tensile
strength
in
comparison
commercial
making
them
suitable
for
such
applications.
Plasticization
glycerol
increases
the
flexibility
strain
from
≈1
45%
moisture
sorption
32
100
wt.%.
Spent
pulp
yields
stiff
strong
rigid
Young's
moduli
5
GPa
strengths
42
MPa.
These
show
100%
activity,
having
hydrophobic
behavior
oxygen
barrier
properties
dry
conditions,
thus
promising
bioactive
Foamed
sorbents
demonstrate
high
affinity
both
water,
a
water
uptake
21
28
times
their
weight,
respectively,
while
maintaining
structural
integrity.
make
foams
viable
as
bio‐based
sorbents,
highlighting
potential
advanced
materials.
Язык: Английский
The Formulation of Dermato-Cosmetic Products Using Sanguisorba minor Scop. Extract with Powerful Antioxidant Capacities
Cosmetics,
Год журнала:
2024,
Номер
11(1), С. 8 - 8
Опубликована: Янв. 11, 2024
There
has
been
a
significant
increase
in
the
use
of
botanical
resources
for
formulation
topical
products
designed
medicinal
and
cosmetic
applications.
Sanguisorba
minor
Scop.,
species,
exhibits
variety
properties
potential
applications
field
cosmetics.
The
aim
this
study
was
to
formulate
preparations,
incorporating
an
extract
derived
from
plant
S.
Scop.
comprising
combination
roots,
leaves,
flowers.
In
initial
phase,
total
seven
combinations
were
prepared
using
extracts
flowers
(v/v/v).
These
subsequently
subjected
evaluation
their
antioxidant
capacity
four
distinct
methods:
2,2-diphenyl-1-picrylhydrazyl
(DPPH),
ferric
reducing
power
(FRAP),
cupric
(CUPRAC),
Trolox
equivalent
(TEAC).
An
organs
ratio
1:2:1
(v/v/v),
which
had
strong
demonstrated
synergistic
effects
according
DPPH,
TEAC,
CUPRAC
assays
(with
values
1.58
±
0.1,
1.18
0.09,
1.07
0.07,
respectively),
selected
inclusion
three
dermato-cosmetic
(hydrogel,
emulgel,
cream).
All
preparations
evaluated
terms
attributes
organoleptic
characteristics.
testing
included
assessments
hydrogel,
cream
exhibited
varying
degrees
stretchability.
addition,
carried
out
assess
vitro
release
polyphenols
formulations
Franz
diffusion
cell
system.
results
showed
that
emulgel
containing
highest
most
polyphenols,
with
rate
84.39
1.01%.
This
followed
by
hydrogel
cream,
percentages
80.52
0.89
75.88
0.88,
respectively,
over
8
h
period.
Thus,
first
time
literature,
product
high
developed
optimized.
Язык: Английский