Biomedical rare-earth magnesium alloy: Current status and future prospects

Journal of Magnesium and Alloys, Год журнала: 2024, Номер 12(4), С. 1260 - 1282

Опубликована: Апрель 1, 2024

Biomedical magnesium (Mg) alloys have garnered significant attention because of their unique biodegradability, favorable biocompatibility, and suitable mechanical properties. The incorporation rare earth (RE) elements, with distinct physical chemical properties, has greatly contributed to enhancing the performance, degradation behavior, biological performance biomedical Mg alloys. Currently, a series RE-Mg are being designed investigated for orthopedic implants cardiovascular stents, achieving substantial encouraging research progress. In this work, comprehensive summary state-of-the-art in is provided. physiological effects design standards RE elements discussed. Particularly, behavior including underlying action studied in-depth. Furthermore, preparation techniques current application status reviewed. Finally, we address ongoing challenges propose future prospects guide development high-performance Mg-RE

Язык: Английский

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Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends

Bioactive Materials, Год журнала: 2024, Номер 35, С. 306 - 329

Опубликована: Фев. 10, 2024

To examine the 16-year developmental history, research hotspots, and emerging trends of zinc-based biodegradable metallic materials from perspective structural temporal dynamics. The literature on in WoSCC was searched. Historical characteristics, evolution active topics development field were analyzed using bibliometric tools CiteSpace HistCite. Over past 16 years, metal has remained a hotspot stage, with extensive scientific collaboration. In addition, there are 45 subject categories 51 keywords different periods, 80 papers experience citation bursts. Keyword clustering anchored 3 subfields, namely, #1 plastic deformation #4 additive manufacturing #5 surface modification. keyword alluvial map shows that longest-lasting concepts mechanical property, microstructure, corrosion behavior, etc., manufacturing, modification, dynamic recrystallization, etc. most recent reference six subfields. Namely, #0 #2 sem, #3 laser powder bed fusion, implant, #7 Zn–1Mg. results study provide current status materials, which can help researchers identify hot spots explore new directions field.

Язык: Английский

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A Comprehensive Review of the Current Research Status of Biodegradable Zinc Alloys and Composites for Biomedical Applications

Materials, Год журнала: 2023, Номер 16(13), С. 4797 - 4797

Опубликована: Июль 3, 2023

Zinc (Zn)-based biodegradable materials show moderate degradation rates in comparison with other (Fe and Mg). Biocompatibility non-toxicity also make them a viable option for implant applications. Furthermore, Pure Zn has poor mechanical behavior, tensile strength of around 100–150 MPa an elongation 0.3–2%, which is far from reaching the required as orthopedic material (tensile more than 300 MPa, 15%). Alloy composite fabrication have proven to be excellent ways improve performance Zn. Therefore, their alloys composites emerged innovative category materials. This paper summarizes most important recent research results on biological characteristics Zn-based implants applications commonly added components composites.

Язык: Английский

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Recent advances in 3D printing of biodegradable metals for orthopaedic applications

Journal of Biological Engineering, Год журнала: 2023, Номер 17(1)

Опубликована: Авг. 29, 2023

Abstract The use of biodegradable polymers for treating bone-related diseases has become a focal point in the field biomedicine. Recent advancements material technology have expanded range materials suitable orthopaedic implants. Three-dimensional (3D) printing prevalent healthcare, and while organ is still its early stages faces ethical technical hurdles, 3D capable creating structures that are supportive controllable. technique shown promise fields such as tissue engineering regenerative medicine, new innovations cell bio-printing possibilities. In clinical settings, metals mainly used orthopedics stomatology. 3D-printed patient-specific osteotomy instruments, orthopedic implants, dental implants been approved by US FDA use. Metals often to provide support hard prevent complications. Currently, 70–80% clinically made from niobium, tantalum, nitinol, titanium alloys, cobalt-chromium stainless steels. However, there increasing interest magnesium, calcium, zinc, iron, with numerous recent findings. advantages printing, low manufacturing costs, complex geometry capabilities, short fabrication periods, led widespread adoption academia industry. controllable represents cutting-edge developing metallic biomedical applications. This review explores existing biomaterials printing-based well their applications medical devices. challenges future directions this also discussed.

Язык: Английский

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The Effectiveness Mechanisms of Carbon Nanotubes (CNTs) as Reinforcements for Magnesium-Based Composites for Biomedical Applications: A Review

Nanomaterials, Год журнала: 2024, Номер 14(9), С. 756 - 756

Опубликована: Апрель 25, 2024

As a smart implant, magnesium (Mg) is highly biocompatible and non-toxic. In addition, the elastic modulus of Mg relative to other biodegradable metals (iron zinc) close natural bone, making an attractive alternative hard tissues. However, high corrosion rates low strength under load bone are some challenges for widespread use in orthopedics. Composite fabrication has proven be excellent way improve mechanical performance control Mg. result, their composites emerge as innovative material. Carbon nanotubes (CNTs) have superb properties like density, tensile strength, strength-to-volume ratio, thermal conductivity, relatively good antibacterial properties. Therefore, using CNTs reinforcements matrix been proposed essential option. lack understanding mechanisms effectiveness mechanical, corrosion, antibacterial, cellular fields through presence challenge application. This review focuses on recent findings Mg/CNT fabricated biological applications. The literature mentions effective antimicrobial, domains with Mg-based nanobiocomposites.

Язык: Английский

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Microstructural and Electrochemical Influence of Zn in MgCaZn Biodegradable Alloys

Materials, Год журнала: 2023, Номер 16(6), С. 2487 - 2487

Опубликована: Март 21, 2023

In recent years, biodegradable materials have included magnesium alloys with homogenous disintegration and a controllable degradation rate. Utilized in medical applications, based on been widely explored throughout the years. It is well-known that alloying Mg biocompatible non-toxic elements increases biodegradability of surgical alloys. The purpose this study was to examine microstructure electrochemical response (corrosion resistance) new experimental Mg-based alloy-Mg-0.5%Ca additions Zn as follows: 0.5, 1.5, 3.0 wt.% order control corrosion Immersion tests were performed for different periods simulated body fluid electrolyte solution at 37 °C, mass loss appreciated calculate rate (CR). investigation led discovery dendritic solid solution, lamellar Mg2Ca compound, MgZn2 intermetallic phase. Scanning electron microscopy, optical energy dispersive spectroscopy used surface analysis after immersion electro-corrosion resistance tests. metallic ceramic compounds detached themselves from sample passed into evaluated using SEM-EDS system. All samples presented generalized anodic cathodic reactions similar intensity. regardless percentage zinc, smaller value higher than 3 more protective zinc oxide appeared surface.

Язык: Английский

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Attaining High Functional Performance in Biodegradable Mg-Alloys: An Overview of Challenges and Prospects for the Mg-Zn-Ca System

Materials, Год журнала: 2023, Номер 16(3), С. 1324 - 1324

Опубликована: Фев. 3, 2023

This article presents a concise overview of modern achievements and existing knowledge gaps in the area biodegradable magnesium alloys. Hundreds Mg-based alloys have been proposed as candidates for temporary implants, this number tends to increase day by day. Therefore, while reviewing common aspects research field, we confine ourselves primarily popular Mg-Zn-Ca system, taken representative example. Over last decades, activities grown enormously produced many exciting results. Aiming at highlighting areas where efforts are still scarce, review state-of-the-art processing techniques summarize functional properties attained via wide variety routes devised towards achieving desired profile, including mechanical response terms strength, ductility, fatigue resistance paired with biocompatibility bio-corrosion or controlled degradability. We pay keen attention summary corrosion mechano-chemical interactions between an aggressive environment loaded structures, resulting stress cracking premature failures. The polemic issues challenges practitioners face their laboratory identified discussed.

Язык: Английский

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A Critical Review on Improving the Fatigue Life and Corrosion Properties of Magnesium Alloys via the Technique of Adding Different Elements

Journal of Marine Science and Engineering, Год журнала: 2023, Номер 11(3), С. 527 - 527

Опубликована: Фев. 28, 2023

Magnesium is the eighth-most abundant element in world and its alloys have a widespread application various industries such as electronic transport (i.e., air, land, sea) engineering, due to their significant mechanical properties, excellent machinability, high strength weight ratios, low cost. Although monolithic Mg metal known lightest industrial (magnesium density 30% less than of aluminum, this unique property increases attractiveness usage transportation industry), one limitations magnesium, which affects on applications industries, very reactivity with an electronegativity 31.1 can give electrons almost all metals corrodes quickly). To overcome problem, scholars are trying produce magnesium (Mg) that more resistant variety loads environmental conditions. In regard, include well-known materials aluminum (Al), Zinc (Zn), Manganese (Mn), Silicon (Si), Copper (Cu), etc., amount directly properties final products. present review paper, authors attempted latest achievements, methods, influential factors (finish-rolling, pore defects, pH value, microstructure, manufacturing processes, etc.) fatigue life corrosion resistance most alloys, including AM50, AM60, AZ31, AZ61, AZ80, AZ91, ZK60, WE43, under The summarized results practical hints presented paper be useful enhance reliability quality Mg-made structures.

Язык: Английский

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An Overview of Scaffolds and Biomaterials for Skin Expansion and Soft Tissue Regeneration: Insights on Zinc and Magnesium as New Potential Key Elements

Polymers, Год журнала: 2023, Номер 15(19), С. 3854 - 3854

Опубликована: Сен. 22, 2023

The utilization of materials in medical implants, serving as substitutes for non-functional biological structures, supporting damaged tissues, or reinforcing active organs, holds significant importance modern healthcare, positively impacting the quality life millions individuals worldwide. However, certain implants may only be required temporarily to aid healing process diseased injured tissues and tissue expansion. Biodegradable metals, including zinc (Zn), magnesium (Mg), iron, others, present a new paradigm realm implant materials. Ongoing research focuses on developing optimized that meet standards, encompassing controllable corrosion rates, sustained mechanical stability, favorable biocompatibility. Achieving these objectives involves refining alloy compositions tailoring processing techniques carefully control microstructures properties. Among under investigation, Mg- Zn-based biodegradable their alloys demonstrate ability provide necessary support during regeneration while gradually degrading over time. Furthermore, essential elements human body, Mg Zn offer additional benefits, promoting wound healing, facilitating cell growth, participating gene generation interacting with various vital functions. This review provides an overview physiological function significance health usage using scaffolds. scaffold qualities, such biodegradation, characteristics, biocompatibility, are also discussed.

Язык: Английский

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Recent Advances in Processing of Titanium and Titanium Alloys through Metal Injection Molding for Biomedical Applications: 2013–2022

Materials, Год журнала: 2023, Номер 16(11), С. 3991 - 3991

Опубликована: Май 26, 2023

Metal injection molding (MIM) is one of the most widely used manufacturing processes worldwide as it a cost-effective way producing variety dental and orthopedic implants, surgical instruments, other important biomedical products. Titanium (Ti) Ti alloys are popular modern metallic materials that have revamped sector they superior biocompatibility, excellent corrosion resistance, high static fatigue strength. This paper systematically reviews MIM process parameters extant studies to produce alloy components between 2013 2022 for medical industry. Moreover, effect sintering temperature on mechanical properties MIM-processed sintered has been reviewed discussed. It concluded by appropriately selecting implementing processing at different stages process, defect-free alloy-based can be produced. Therefore, this present study could greatly benefit future examine using develop products applications.

Язык: Английский

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