Extending the “One Strain Many Compounds” (OSMAC) Principle to Marine Microorganisms

Marine Drugs, Год журнала: 2018, Номер 16(7), С. 244 - 244

Опубликована: Июль 23, 2018

Genomic data often highlights an inconsistency between the number of gene clusters identified using bioinformatic approaches as potentially producing secondary metabolites and actual chemically characterized produced by any given microorganism. Such are generally considered "silent", meaning that they not expressed under laboratory conditions. Triggering expression these "silent" could result in unlocking chemical diversity control, allowing discovery novel molecules both medical biotechnological interest. Therefore, genetic cultivation-based techniques have been developed aimed at stimulating genes. The principles behind cultivation based conceptualized "one strain many compounds" (OSMAC) framework, which underlines how a single can produce different when grown environmental Parameters such as, nutrient content, temperature, rate aeration be easily changed, altering global physiology microbial turn significantly affecting its metabolism. As direct extension approaches, co-cultivation strategies addition elicitors also used cues to activate clusters. In this review, we aim provide focused comprehensive overview pertain marine microbes. Moreover, underline changes some parameters provided important results terrestrial microbes, but rarely microorganisms, may represent additional awaken Unfortunately, empirical nature OSMAC approach forces scientists perform extensive experiments. Nevertheless, believe computation experimental other disciplines, discuss; effectively employed help streamline approaches. We natural products microorganisms would greatly aided through integration basic microbiological computational methods, technological innovations, thereby helping unearth much yet untapped potential microorganisms.

Язык: Английский

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Marine Actinomycetes, New Sources of Biotechnological Products

Marine Drugs, Год журнала: 2021, Номер 19(7), С. 365 - 365

Опубликована: Июнь 25, 2021

The Actinomycetales order is one of great genetic and functional diversity, including diversity in the production secondary metabolites which have uses medical, environmental rehabilitation, industrial applications. Secondary produced by actinomycete species are an abundant source antibiotics, antitumor agents, anthelmintics, antifungals. These actinomycete-derived medicines circulation as current treatments, but actinomycetes also being explored potential sources new compounds to combat multidrug resistance pathogenic bacteria. Actinomycetes a solve concerns another area recent investigation, particularly their utility bioremediation pesticides, toxic metals, radioactive wastes, biofouling. Other applications include biofuels, detergents, food preservatives/additives. Exploring other unique properties will allow for deeper understanding this interesting taxonomic group. Combined with engineering, microbial experimental evolution, enhancement techniques, it reasonable assume that use marine continue increase. Novel products begin be developed diverse applied research purposes, zymology enology. This paper outlines knowledge usage research, focusing on isolates providing direction future research.

Язык: Английский

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Cophylogeny and convergence shape holobiont evolution in sponge–microbe symbioses

Nature Ecology & Evolution, Год журнала: 2022, Номер 6(6), С. 750 - 762

Опубликована: Апрель 7, 2022

Язык: Английский

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Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects

Antibiotics, Год журнала: 2020, Номер 9(8), С. 441 - 441

Опубликована: Июль 24, 2020

In the actual post-antibiotic era, novel ways of rethinking antimicrobial research approaches are more urgent than ever. Natural compounds with activity such as fatty acids and monoacylglycerols have been investigated for decades. Additionally, interest in other lipid classes agents is rising. This review provides an overview on about plant marine lipids potential activity, methods obtaining analyzing these compounds, emphasis lipidomics, future perspectives bioprospection applications lipids. Lipid extracts or isolated from higher plants, algae invertebrates promising molecules to inactivate a wide spectrum microorganisms. These include variety chemical structures. Present challenges natural origin related investment optimization analytical workflow based lipidomics tools, complementary bioassay-guided fractionation, identify active compound(s). Also, further work needed regarding study their mechanism action, structure-activity relationship, synergistic effect conventional antibiotics, eventual development resistance lipids, which, far known, unlikely.

Язык: Английский

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Antimicrobial activity of bacteria from marine sponge Suberea mollis and bioactive metabolites of Vibrio sp. EA348

Saudi Journal of Biological Sciences, Год журнала: 2020, Номер 27(4), С. 1139 - 1147

Опубликована: Фев. 11, 2020

Discovery of potential bioactive metabolites from sponge-associated bacteria have gained attraction in recent years. The current study explores the sponge (Suberea mollis) associated against bacterial and fungal pathogens. Sponge samples were collected Red sea Obhur region, Jeddah, Saudi Arabia. Of 29 isolated belong to four different classes i.e. Firmicutes (62%), γ-Proteobacteria (21%), α-Proteobacteria (10%) Actinobacteria (7%). Among them nineteen (65%) strains showed antagonistic activity oomycetes only 3 active human pathogenic tested. Most genera include Bacillus (55%), Pseudovibrio (13%) Ruegeria (10%). Enzyme production (protease, lipase, amylase, cellualse) was identified 12 (41%) where belonging groups. Production antimicrobial hydrolysates these suggest their role Further selected strain Vibrio sp. EA348 using LC-MS GC-MS analyses. We many including antibiotics such as Amifloxacin fosfomycin. Plant growth hormones Indoleacetic acid Gibberellin A3 volatile organic compound methyl jasmonate also detected this strain. Our results highlighted importance marine inhabiting sponges source compounds plant pharmaceutical agricultural significance.

Язык: Английский

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Crude oil pollution and biodegradation at the Persian Gulf: A comprehensive and review study

Journal of Environmental Health Science and Engineering, Год журнала: 2020, Номер 18(2), С. 1415 - 1435

Опубликована: Окт. 9, 2020

Язык: Английский

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Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

Diversity, Год журнала: 2017, Номер 9(4), С. 49 - 49

Опубликована: Окт. 28, 2017

Invertebrates account for more than 89% of all extant organisms in the marine environment, represented by over 174,600 species (recorded to date). Such diversity is mirrored (or likely increased by) microbial symbionts associated with this group and natural products MNPs) that they produce. Since early 1950s 20,000 MNPs have been discovered, including compounds produced symbiotic bacteria, chemical from sources has led them being referred as "blue gold" search new drugs. For example, 80% novel antibiotics stemming environment come Actinomycetes, many which can be found sponges, anti-tumorigenic anti-diabetic potential also isolated symbionts. In fact, it estimated formed basis 50% FDA-approved drugs between 1981 2002. review, we explore examining their use producers pharmaceutical actives, together a discussion opportunities constraints offered “blue gold” drug discovery.

Язык: Английский

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Jellyfish-Associated Microbiome in the Marine Environment: Exploring Its Biotechnological Potential

Marine Drugs, Год журнала: 2019, Номер 17(2), С. 94 - 94

Опубликована: Фев. 1, 2019

Despite accumulating evidence of the importance jellyfish-associated microbiome to jellyfish, its potential relevance blue biotechnology has only recently been recognized. In this review, we emphasize biotechnological host–microorganism systems and focus on gelatinous zooplankton as a host for with potential. The basic characteristics microbial communities, mechanisms underlying jellyfish-microbe relationship, role/function are reviewed. It appears that is discrete from community in ambient seawater, exhibiting certain degree specialization some preferences specific jellyfish taxa populations, life stages, body parts. addition, different sampling approaches methodologies study phylogenetic diversity described discussed. Finally, general conclusions drawn existing literature future research directions highlighted microbiome.

Язык: Английский

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Recent Advances of Marine Sponge-Associated Microorganisms as a Source of Commercially Viable Natural Products

Marine Biotechnology, Год журнала: 2022, Номер 24(3), С. 492 - 512

Опубликована: Май 14, 2022

Язык: Английский

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Marine sponge aquaculture towards drug development: An ongoing history of technical, ecological, chemical considerations and challenges

Aquaculture Reports, Год журнала: 2021, Номер 21, С. 100813 - 100813

Опубликована: Авг. 4, 2021

Marine sponges have a long history of farming, starting with bath over 5000 years ago in the Mediterranean. Many species since been found appropriate for distinct types commercial assessment. Drug development relies on isolation sponge-derived secondary metabolites as natural compounds having wide range ecological functions, from deterring predation to preventing microbial infection/proliferation sponge body. For human society, they feature broad array pharmacological properties some applications still being discovered. Their limited supply has however faced major obstacle conduct clinical trials. aquaculture prove more integrated and sustainable remain an interesting way ensure sufficient amounts biological substances early processing production drugs. This review presents farming methods that were tested, undergoing challenges interest raised environmental metabolic factors explain contrasting spatiotemporal performances. Through global experiments, sometimes involving other marine organisms, technicity evolving efficient cost-effective strategies. Further ways make attractive diversify its are investigated, such recent studies collagen or chitin bone tissue engineering bioremediation alternative existing wastewater management. Overall, exhibit astonishing intra interspecific variation, which is why should be considered respect purpose their economic valuation, context all symbiotic interactions rely on.

Язык: Английский

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