The Interplay between Asthma, Obesity, and Obstructive Sleep Apnea DOI
L. Raposo Rodríguez, Sunita Sharma

Seminars in Respiratory and Critical Care Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Abstract The interrelationship between asthma, obesity, and obstructive sleep apnea (OSA) presents a critical area of investigation within medicine, given the rising prevalence these conditions globally. This article explores multifactorial interactions among three disorders that contribute to significant morbidity. Asthma, chronic inflammatory condition airways, is one most common respiratory Asthma in people with obesity associated poor asthma control, increased severity, an frequency exacerbations. Obesity, characterized by excessive fat accumulation, well-established risk factor for development OSA. sleep-related breathing disorder disrupts airflow during due pharyngeal collapse. Conversely, OSA may worsen symptoms through intermittent hypoxia fragmentation, further complicating management. review analyzes existing literature illustrate bidirectional relationships conditions. It discusses role systemic inflammation, hormone dysregulation, lifestyle factors, such as diet physical inactivity, persistence obese patients. Furthermore, it highlights importance comprehensive management strategies address overlapping disorders. Clinical implications are examined, consideration potential targeted therapies interventions could mitigate improve quality life affected individuals. Understanding complex essential healthcare practitioners optimizing patients By recognizing interconnectedness conditions, clinicians can adopt more holistic approach treatment, leading improved outcomes better understanding patient's overall health trajectory. Future research directions suggested investigate therapeutic influence socioeconomic factors on

Язык: Английский

Association between obstructive sleep apnea and visceral adiposity index and lipid accumulation product: NHANES 2015–2018 DOI Creative Commons

Tingfeng Zhou,

Shihao Chen,

Jiesheng Mao

и другие.

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Апрель 10, 2024

Obesity refers to a significant contributor the development of obstructive sleep apnea (OSA). Early prediction OSA usually leads better treatment outcomes, and this study aims employ novel metabolic markers, visceral adiposity index (VAI), lipid accumulation product (LAP) evaluate relationship OSA.

Язык: Английский

Процитировано

22
Association between triglyceride glucose-body mass index and obstructive sleep apnea: a study from NHANES 2015–2018 DOI Creative Commons

Xingru Meng,

Haihua Wen,

Leshen Lian

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Авг. 16, 2024

Background The association between TyG-BMI index and the risk of obstructive sleep apnea (OSA), a recently identified biomarker indicating insulin resistance, has yet to be elucidated. Therefore, this study aimed investigate OSA using NHANES database. Methods Analyses were performed on data conducted 2015 2018. Logistic regression, stratified analyses, curve-fitting threshold effects analyses utilized assess OSA. Results included 4,588 participants. Multifactorial logistic regression found significant increased [OR: 1.54 (CI:1.39–1.70)]. In age interacted with association, being associated only in subgroup subjects younger than 60 years [1.31 (1.14–1.50)], but gender, smoking status, alcohol use, did not influence association. presence diabetes, hypertension, cardiovascular diseases also modified number such conditions was significantly lower, therefore significance associations observed those subgroups. Additionally, non-linearly associated, inflection point at 12.09, after which lower slope observed. Conclusion This demonstrates that elevated levels are correlated for OSA, underscoring these findings facilitating early prevention or timely intervention

Язык: Английский

Процитировано

8
Approach to Endocrine Hypertension: A Case-Based Discussion DOI Creative Commons

Sanja Borozan,

A B Kamrul-Hasan, Sahana Shetty

и другие.

Current Hypertension Reports, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 16, 2025

Hypertension remains a major chronic disease morbidity across the world, even in twenty-first century, affecting ≈40% of global population, adversely impacting healthcare budgets managing high incidence cardiovascular (CVD) complications and mortality because elevated blood pressure (BP). However, evaluation management endocrine hypertension are not optimal clinical practice. With three unique case scenarios, we update evidence base for diagnostic this review to inform appropriate day-to-day practice decisions. Although most individuals with BP suffer from essential (≈85%), some patients may have clear underlying etiology (termed secondary hypertension), significant proportion these (≈10%) consequent hormone excess dysfunction one or more glands. Even if relatively common general correct diagnosis treatment is often delayed poor awareness among clinicians, including primary care providers physicians settings. An accurate timely crucial potentially cure at least properly manage consequences delays can be catastrophic, markedly higher end-organ such as CVD, kidney disease, premature sufferers.

Язык: Английский

Процитировано

1
Assessment of obstructive sleep apnea rate and associated factors among Lebanese adults: a cross-sectional study DOI Creative Commons

Tala Kaddoura,

Mohamad Hodroj,

Bilal Chmeis

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Фев. 13, 2025

Objectives To estimate the rate of obstructive sleep apnea (OSA) and associated factors among Lebanese adults. Methods A cross-sectional study was conducted in February–April 2022; 1,202 adults were enrolled. The sample collected several governorates through an anonymous online self-reported questionnaire. STOP-BANG questionnaire used as a screening tool to OSA risk. “Low risk” is established with 0–2 positive answers, “Intermediate by 3–4 answers while “High 5–8 answers. Results This showed that 743 (62.4%) had low risk for OSA, 357 (30.0%) moderate, 90 (7.6%) high OSA. Older age (aOR = 1.05) having hypertension 7.80) higher odds moderate Female sex 0.04) significantly lower compared males. (OR 1.17), BMI 1.14), 18.55), severe COVID-19 infection mild 4.30) whereas female 0.002) being married single 0.23) Conclusion most have It also confirmed sex, age, obesity, hypertension, These call future research exploring causes including potential effect social, economic, political instability, local customs, environmental factors. Moreover, health campaigns should be assigned increase awareness population regarding prevention lifestyle modifications.

Язык: Английский

Процитировано

1
ANMCO (Italian Association of Hospital Cardiologists) scientific statement: obesity in adults—an approach for cardiologists DOI Creative Commons
Stefania Angela Di Fusco, Edoardo Mocini, Michele Massimo Gulizia

и другие.

Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity, Год журнала: 2024, Номер 29(1)

Опубликована: Янв. 2, 2024

Abstract Obesity is a complex, chronic disease requiring multidisciplinary approach to its management. In clinical practice, body mass index and waist-related measurements can be used for obesity screening. The estimated prevalence of among adults worldwide 12%. With the expected further increase in overall prevalence, clinicians will increasingly managing patients with obesity. Energy balance regulated by complex neurohumoral system that involves central nervous circulating mediators, which leptin most studied. functioning these systems influenced both genetic environmental factors. generally occurs when genetically predisposed individual lives an obesogenic environment long period. Cardiologists are deeply involved evaluating Cardiovascular risk profile one important items quantified understand health due benefit single patient obtain weight loss. At level, appropriate involvement, detection potential causes, tools improve outcomes. near future, we probably have new pharmacological at our disposal facilitate achieving maintaining However, treatment alone cannot cure such disease. aim this paper summarize some key points field, as definition measurement tools, epidemiology, main mechanisms underlying energy homeostasis, consequences focus on cardiovascular diseases paradox. Level evidence V: report expert committees.

Язык: Английский

Процитировано

6
A Narrative Review of Self-Reported Scales to Evaluate Depression and Anxiety Symptoms in Adult Obstructive Sleep Apnea Patients DOI Creative Commons
Diana Raluca Velescu, Monica Marc, Daniel Trăilă

и другие.

Medicina, Год журнала: 2024, Номер 60(2), С. 261 - 261

Опубликована: Фев. 2, 2024

Background and Objectives: Obstructive sleep apnea (OSA) is a prevalent chronic condition that has been associated with mental disorders like depression anxiety. This study intends to provide practical overview of the most relevant self-reported self-rating scales assess anxiety in OSA patients. Materials Methods: A search for articles was performed using PubMed, Google Scholar, Semantic Scholar combination words obstructive apnea, depression, anxiety, scales. The tools were ordered by type (screening rating) arranged chronologically according year publication. Results: Three identified assessing which Center Epidemiologic Studies Depression Scale (CES-D), Hospital Anxiety (HADS-D), Patient Health Questionnaire-9 (PHQ-9). For rating two discussed: Zung Self-Rating (SDS) Beck Inventory (BDI), three versions (the BDI, BDI-II, Fast Screen (BDI-FS)). Generalized Disorder-7 (GAD-7) scale identified. Two reviewed anxiety: State-Trait (STAI) (BAI). Each accompanied brief description its practicality psychometric qualities an analysis strengths limitations. Conclusions: findings this review will contribute understanding importance health comorbidities context OSA, ultimately guiding clinical practice future research area.

Язык: Английский

Процитировано

6
Association between obstructive sleep apnea severity and depression risk: a systematic review and dose-response meta-analysis DOI

Dongfang Zhao,

Yizhu Zhang,

Xue Sun

и другие.

Sleep And Breathing, Год журнала: 2024, Номер 28(5), С. 2175 - 2185

Опубликована: Июнь 18, 2024

Язык: Английский

Процитировано

6
Obesity, Bariatric Surgery and Obstructive Sleep Apnea—A Narrative Literature Review DOI Creative Commons
Krzysztof Wyszomirski, Maciej Wałędziak, Anna Różańska-Walędziak

и другие.

Medicina, Год журнала: 2023, Номер 59(7), С. 1266 - 1266

Опубликована: Июль 7, 2023

The purpose of this review was to analyze the available literature on subject obesity and obstructive sleep apnea. We searched for articles time period from 2013 2023. Obesity is listed as one most important health issues. Complications obesity, with apnea (OSA) among them, are common problems in clinical practice. a well-recognized risk factor OSA, but OSA itself may contribute worsening obesity. Bariatric surgery treatment choice severely obese patients, especially present complications, remains only causative patients OSA. Though improvement control after bariatric well-established knowledge, complete resolution achieved less than half them. determination subpopulations whom would be advantageous an issue management. Increasing potential non-invasive strategies requires studies that assess efficacy safety combined methods.

Язык: Английский

Процитировано

15
Association of modifiable risk factors with obstructive sleep apnea: a Mendelian randomization study DOI Creative Commons
Ye Li, Yuyang Miao, Jin Tan

и другие.

Aging, Год журнала: 2023, Номер 15(23), С. 14039 - 14065

Опубликована: Дек. 11, 2023

Background: The risk factors involved in obstructive sleep apnea (OSA) have not been clearly identified yet. We attempted to systematically investigate genetically predicted modifiable and lifestyle behaviors associated with OSA. Methods: association between 34 OSA was evaluated using the two-sample Mendelian randomization (MR). Genetic variants for were acquired from European-descent genome-wide studies. Data sources extracted FinnGen study 16,761 cases 201,194 controls. primary analysis chosen inverse-variance weighted method. Results: MR analyses provide evidence of poor overall health rating (odds ratio (OR), 2.82; 95% confidence interval (CI), 1.95–4.08), nap during day (OR, 2.01; CI, 1.37–2.93), high body mass index (BMI) 1.14; 1.09–1.19), increased fat 1.83; 1.83–2.05), elevated water 1.50; 1.31–1.70) hypertension 1.81; 1.34–2.45) higher risk, while education level 0.55; 0.40–0.75) correlated reduced risk. Suggestive obtained smoking waist-to-hip (WHR) odds, vigorous physical activity, HDL cholesterol lower odds. After adjusting BMI multivariable analysis, effects smoking, WHR, HDL-cholesterol fully attenuated. Conclusions: This indicates that rating, day, BMI, mass, hypertension, are causally OSA, which means these key targets prevention.

Язык: Английский

Процитировано

13
Genetic Analysis of Obstructive Sleep Apnea and Its Relationship with Severe COVID-19 DOI
Satu Strausz,

Е.А. Агафонова,

Varvara Tiullinen

и другие.

Annals of the American Thoracic Society, Год журнала: 2024, Номер 21(6), С. 961 - 970

Опубликована: Фев. 8, 2024

Rationale: While patients with obstructive sleep apnea (OSA) have a higher risk for COVID-19 hospitalization, the causal relationship has remained unexplored. Objectives: To understand between OSA and leveraging data from vaccination electronic health records, genetic factors genome-wide association studies (GWAS) Mendelian randomization. Methods: We elucidated using FinnGen (N total = 377,277 individuals) performing association. used associated variants as instruments univariate multivariate randomization (MR) analyses computed absolute reduction (ARR) against hospitalization or without vaccination. Measurements Main Results: identified 9 novel loci replicated our findings in Million Veterans Program. Furthermore, MR analysis showed that was factor severe (P=9.41x10-4). Probabilistic modelling strongest at FTO locus reflected signal of BMI, whereas BMI independent seen earlier reported SLC9A4 MECOM which is transcriptional regulator 210-fold enrichment Finnish population. Similarly, Multivariate (MVMR) causality driven by body mass index (BMI), (P MVMR 5.97x10-6, beta=0.47). Finally, reduced more than non-OSA controls: ARR 13.3% vs. 6.3% Conclusions: Our COVID-19. The effect predominantly explained suggests BMI-dependent effects level individual comorbid causality.

Язык: Английский

Процитировано

5