UPLC-MS/MS Analysis of Naturally Derived Apis mellifera Products and Their Promising Effects against Cadmium-Induced Adverse Effects in Female Rats DOI Open Access

Alaa Amr,

Aida A. Abd El‐Wahed, Hesham R. El‐Seedi

и другие.

Nutrients, Год журнала: 2022, Номер 15(1), С. 119 - 119

Опубликована: Дек. 27, 2022

Honeybee products arouse interest in society due to their natural origin and range of important biological properties. Propolis (P) royal jelly (RJ) attract scientists' attention because they exhibit antioxidant, anti-inflammatory, anti-bacterial, anti-tumor, immunomodulatory abilities. In this study, we tested whether P RJ could mitigate the adverse effects cadmium (Cd) exposure, with particular emphasis on reproductive function female rats. line, one week pretreatment was established. Six experimental groups were created, including (i) control group (without any supplementation), (ii) Cd (receiving CdCl2 a dose 4.5 mg/kg/day), (iii) (50 mg P/kg/day), (iv) (200 RJ/kg/day), (v) + (rats pretreated then treated simultaneously), (vi) (animals before receiving simultaneously RJ). treatment rats adversely affected number measured parameters, body weight, ovarian structure ultrastructure, oxidative stress increased content prolonged estrous cycle. Pretreatment cotreatment or alleviated Cd, transferring clusters PCA analysis chart toward group. However, for cotreated still distinctly separated from P, alone groups. Most likely, investigated honeybee can alter absorption gut and/or increase its excretion through kidneys by various components. Undoubtedly, effectively prepare organism overcome harmful insults. Although chemical composition is relatively well known, focusing proportion, duration, scheme treatment, as components, may provide interesting data future. era returning products, both seem valuable materials further consideration anti-infertility agents.

Язык: Английский

Propolis: An update on its chemistry and pharmacological applications DOI Creative Commons
Rajib Hossain, Cristina Quispe, Rasel Ahmed Khan

и другие.

Chinese Medicine, Год журнала: 2022, Номер 17(1)

Опубликована: Авг. 26, 2022

Propolis, a resinous substance produced by honeybees from various plant sources, has been used for thousands of years in traditional medicine several purposes all over the world. The precise composition propolis varies according to source, seasons harvesting, geography, type bee flora, climate changes, and honeybee species at site collection. This apiary product broad clinical applications such as antioxidant, anti-inflammatory, antimicrobial, anticancer, analgesic, antidepressant, anxiolytic well asimmunomodulatory effects. It is also known uses treating purulent disorders, improving wound healing, alleviating many related discomforts. Even if its use was already widespread since ancient times, after First Second World War, it grown even more studies identify chemical pharmacological features, allowing discriminate qualities terms profile relative biological activity based on geographic place origin. Recently, vitro vivo have carried out new insights into pharmaceutical prospects this management different highlighted. Specifically, available literature confirms efficacy bioactive compounds reduction cancer progression, inhibition bacterial viral infections mitigation parasitic-related symptoms, paving way an alternative approach improve human health. However, conscious standardized extracts are needed substantiate these health claims.

Язык: Английский

Процитировано

96
Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties DOI Creative Commons
Hesham R. El‐Seedi,

Nehal Eid,

Aida A. Abd El‐Wahed

и другие.

Frontiers in Nutrition, Год журнала: 2022, Номер 8

Опубликована: Янв. 3, 2022

Graphical Abstract The anti-inflammatory and immunomodulatory possible mechanisms of action bee products suggested by preclinical clinical studies.

Язык: Английский

Процитировано

90
Methodology-Centered Review of Molecular Modeling, Simulation, and Prediction of SARS-CoV-2 DOI Creative Commons
Kaifu Gao, Rui Wang, Jiahui Chen

и другие.

Chemical Reviews, Год журнала: 2022, Номер 122(13), С. 11287 - 11368

Опубликована: Май 20, 2022

Despite tremendous efforts in the past two years, our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus-host interactions, immune response, virulence, transmission, and evolution is still very limited. This limitation calls for further in-depth investigation. Computational studies have become an indispensable component combating disease 2019 (COVID-19) due to their low cost, efficiency, fact that they are free from safety ethical constraints. Additionally, mechanism governs global transmission SARS-CoV-2 cannot be revealed individual experiments was discovered by integrating genotyping massive viral sequences, biophysical modeling protein-protein deep mutational data, learning, advanced mathematics. There exists a tsunami literature on molecular modeling, simulations, predictions related developments drugs, vaccines, antibodies, diagnostics. To provide readers with quick update about this literature, we present comprehensive systematic methodology-centered review. Aspects such as biophysics, bioinformatics, cheminformatics, machine mathematics discussed. review will beneficial researchers who looking ways contribute those interested status field.

Язык: Английский

Процитировано

58
Bee Pollen: Clinical Trials and Patent Applications DOI Open Access
Jari S. Algethami, Aida A. Abd El‐Wahed, Mohamed H. Elashal

и другие.

Nutrients, Год журнала: 2022, Номер 14(14), С. 2858 - 2858

Опубликована: Июль 12, 2022

Bee pollen is a natural cocktail of floral nectar, flower pollen, enzymes, and salivary secretions produced by honeybees. one the bee products most enriched in proteins, polysaccharides, polyphenols, lipids, minerals, vitamins. It has significant health medicinal impact provides protection against many diseases, including diabetes, cancer, infectious, cardiovascular. commonly promoted as cost-effective functional food. In particular, been applied clinical trials for allergies prostate illnesses, with few investigations on cancer skin problems. However, it involved several patents recipes to combat chronic This review aimed highlight involving different cases present role supplementary food potential product cosmetic applications.

Язык: Английский

Процитировано

48
Potential Inhibitors Targeting Papain-Like Protease of SARS-CoV-2: Two Birds With One Stone DOI Creative Commons

Haihai Jiang,

Peiyao Yang,

Jin Zhang

и другие.

Frontiers in Chemistry, Год журнала: 2022, Номер 10

Опубликована: Фев. 23, 2022

Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of Coronavirus disease-19 (COVID-19), is still devastating world causing significant chaos to international community and posing a threat global health. Since first outbreak in late 2019, several lines intervention have been developed prevent spread this virus. Nowadays, some vaccines approved extensively administered. However, fact that SARS-CoV-2 rapidly mutates makes efficacy safety approach constantly under debate. Therefore, antivirals are needed combat infection SARS-CoV-2. Papain-like protease (PLpro) supports viral reproduction suppresses innate immune response host, which PLpro an attractive pharmaceutical target. Inhibition could not only replication but also restore antiviral immunity resulting speedy recovery patient. In review, we describe structural functional features on latest development searching for inhibitors. Currently available inhibitors targeting as well their basis summarized.

Язык: Английский

Процитировано

43
Propolis: Encapsulation and application in the food and pharmaceutical industries DOI
Loleny Tavares, Slim Smaoui, Paulo S. Lima

и другие.

Trends in Food Science & Technology, Год журнала: 2022, Номер 127, С. 169 - 180

Опубликована: Июнь 7, 2022

Язык: Английский

Процитировано

38
Propolis and Their Active Constituents for Chronic Diseases DOI Creative Commons
Vivek P. Chavda, Amit Z. Chaudhari, Divya Teli

и другие.

Biomedicines, Год журнала: 2023, Номер 11(2), С. 259 - 259

Опубликована: Янв. 18, 2023

Propolis is a mass of chemically diverse phytoconstituents with gummy textures that are naturally produced by honeybees upon collection plant resins for utilization in various life processes beehives. Since ancient times, propolis has been unique traditional remedy globally utilized several purposes, and it secured value pharmaceutical nutraceutical areas recent years. The chemical composition comprises constituents deviations the precise honeybee species, source used production bees, climate conditions harvesting season. Over 300 molecular structures have discovered from propolis, important classes include phenolic acids, flavonoids, terpenoids, benzofurans, benzopyrene chalcones. also reported to pharmacological activities, such as antidiabetic, anti-inflammatory, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral, antifungal, anticaries. As chronic diseases risen global health threat, abundant research conducted track its alternative therapies diseases. Several clinical trials revealed potency preventing curing some This review explores beneficial effect active credible mechanisms computational studies on

Язык: Английский

Процитировано

29
The Effects of Propolis on Viral Respiratory Diseases DOI Creative Commons
Marcin Ożarowski, Tomasz M. Karpiński

Molecules, Год журнала: 2023, Номер 28(1), С. 359 - 359

Опубликована: Янв. 1, 2023

Propolis remains an interesting source of natural chemical compounds that show, among others, antibacterial, antifungal, antiviral, antioxidative and anti-inflammatory activities. Due to the growing incidence respiratory tract infections caused by various pathogenic viruses, complementary methods prevention therapy supporting pharmacotherapy are constantly being sought out. The properties propolis may be important in treatment diseases viruses such as severe acute syndrome coronavirus 2, influenza parainfluenza virus rhinoviruses. One main challenges recent years has been 2 (SARS-CoV-2), causing COVID-19. Recently, increasing number studies focusing on activity preparations against SARS-CoV-2 adjuvant for this infection. shown a few key mechanisms anti-SARS-CoV-2 action as: inhibition interaction S1 spike protein ACE-2 protein; decreasing replication diminishing synthesis RNA transcripts cells; particles coronaviruses. anti-viral effect is observed not only with extracts but also single biologically active found (e.g., apigenin, caffeic acid, chrysin, kaempferol, quercetin). Moreover, effective hyperglycemia, which increases risk infections. aim literature review was summarize from PubMed database evaluating antiviral terms (in vitro, vivo, clinical trials). Based upon review, it have focused mainly assessment effectiveness its components exerts wide-spectrum antimicrobial activities; thus, can option co-infections associated tract.

Язык: Английский

Процитировано

25
Chemical Profiling and Nutritional Evaluation of Bee Pollen, Bee Bread, and Royal Jelly and Their Role in Functional Fermented Dairy Products DOI Creative Commons
Amira M.G. Darwish, Aida A. Abd El‐Wahed, Mohamed G. Shehata

и другие.

Molecules, Год журнала: 2022, Номер 28(1), С. 227 - 227

Опубликована: Дек. 27, 2022

Honeybee products, as multicomponent substances, have been a focus of great interest. The present work aimed to perform the nutritional and chemical profiling biochemical characterization bee pollen (BP), bread (BB), royal jelly (RJ) study their applications in fortification functional fermented dairy products. Their effects on starter cultures physicochemical sensorial quality products were monitored. A molecular networking analysis identified total 46 compounds three that could be potential medicines, including flavonoids, fatty acids, peptides. BB showed highest protein sugar contents (22.57 26.78 g/100 g), which cover 45.14 53.56% daily values (DVs), with considerable amounts essential amino acids threonine lysine (59.50 42.03%). BP, BB, RJ can considered sources iron, 100 g 141, 198.5, 94.94% DV%, respectively. BP was revealed phenolic flavonoid (105.68 43.91 µg/g) synergetic effect when mixed RJ, resulting increased antioxidant activity, while terms both proteolytic powers (IC

Язык: Английский

Процитировано

29
Biological Activity and Chemical Composition of Propolis from Various Regions of Poland DOI Creative Commons
Magdalena Woźniak, Anna Sip, Lucyna Mrówczyńska

и другие.

Molecules, Год журнала: 2022, Номер 28(1), С. 141 - 141

Опубликована: Дек. 24, 2022

Propolis is one of the bee products, with multiple biological properties used in numerous applications. The research objective was to determine chemical composition and (antibacterial, antifungal, antiviral, antioxidant, cytoprotective activity) propolis extracts collected from various regions Poland. results indicated that total content phenols (116.16–219.41 mg GAE/g EEP) flavonoids (29.63–106.07 QE/g depended on their geographic origin. high epicatechin, catechin, pinobanksin, myricetin, acids: vanillic syringic samples confirmed by chromatographic analysis. Moreover, presence caffeic acid phenethyl ester all samples. origin also influenced its extracts. were characterized moderate DPPH free radical scavenging activity (29.22–35.14%), relatively low ferrous iron chelating (9.33–32.32%). showed protection human red blood cells against radicals generated 2,2’-azobis(2-methylpropionamidine) dihydrochloride (AAPH). exhibited diversified tested pathogenic bacteria limited fungal strains. selected only 2 5 examined HPV (human papillomaviruses) geographical distribution.

Язык: Английский

Процитировано

28