Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Язык: Английский

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Isolation of phenolic compounds from eco‐friendly white bee propolis: Antioxidant, wound‐healing, and anti‐Alzheimer effects

Food Science & Nutrition, Год журнала: 2023, Номер 12(3), С. 1928 - 1939

Опубликована: Дек. 7, 2023

Abstract This study presents the first findings regarding extraction, isolation, enzyme inhibition, and antioxidant activity. The oral mucosal wound‐healing process was investigated using propolis water extract (PWE) incubation with gingival fibroblast cells concluded that effective on pattern compared to untreated controls. Additionally, phenolic compounds (fraxetin, apigenin, galangin, pinobanksin, chrysin, etc.) were isolated from propolis, their chemical structures elucidated comprehensive spectroscopic methods. anti‐Alzheimer potential activities of PWE some screened revealing inhibitory effects acetylcholinesterase (AChE) IC 50 values ranging 0.45 ± 0.01 1.15 0.03 mM, as well remarkable free‐radical scavenging metal reduction capacities. results suggest these can be used therapeutic agents due properties AChE. It also for purposes since its effect is promising.

Язык: Английский

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Effect of Ficus pumila L. on Improving Insulin Secretory Capacity and Resistance in Elderly Patients Aged 80 Years Old or Older Who Develop Diabetes After COVID-19 Infection

Nutrients, Год журнала: 2025, Номер 17(2), С. 290 - 290

Опубликована: Янв. 15, 2025

(1) Background: It has been reported that people affected by COVID-19, an infectious disease caused SARS-CoV-2, suffer from various diseases, after infection. One of the most serious problems is increased risk developing diabetes COVID-19 However, a treatment for post-COVID-19 infection not yet established. In this study, we investigated effects Ficus pumila L. extract, which traditionally used to reduce blood glucose levels in Okinawa, on patients who developed (2) Methods: total, 128 rehabilitation aged 80 years old or older were included. The HOMA-β (Homeostatic model assessment β-cell function) and HOMA-IR insulin resistance) assessed evaluate tolerance. (3) Results: decreased Subsequently, 59 given extract their improved ingestion. On other hand, control group did consume showed no improvement both HOMA-IR. (4) Conclusions: ingested infection, stimulated secretion capacity resistance.

Язык: Английский

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Open, Randomised, Controlled Study to Evaluate the Role of a Dietary Supplement Containing Pelargonium sidoides Extract, Honey, Propolis, and Zinc as Adjuvant Treatment in Children with Acute Tonsillopharyngitis

Children, Год журнала: 2025, Номер 12(3), С. 345 - 345

Опубликована: Март 10, 2025

Background/Objectives: A common reason for a pediatrician’s visit is acute tonsillopharyngitis (ATR), which usually caused by viruses. dietary supplement comprising Pelargonium sidoides extract, honey, propolis, and zinc was proposed as an effective adjuvant the management of respiratory tract infections. The study aimed to determine efficacy this in conjunction with standard care (SoC) compared SoC alone, pediatric population affected ATR. Methods: This open randomized (registered on ClinicalTrials.gov: NCT 04899401) involved three Romanian sites specialized care. primary endpoints were changes Tonsillitis Severity Score number patients failing respond (evaluating use ibuprofen or high-dose paracetamol rescue medication). One hundred thirty children, distributed into two groups, enrolled treated six days. Results: results showed overall better performance terms + SoC, lower total ratings day 6 (p = 0.002) sub-scores related erythema throat pain 6. No adverse events reported. Investigators found compliance be optimal. Conclusions: administration ATR safe superior alone efficacy. confirmed that tested optimum treatment infections suitable daily clinical practice pediatricians.

Язык: Английский

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Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease

Molecules, Год журнала: 2025, Номер 30(8), С. 1672 - 1672

Опубликована: Апрель 8, 2025

Parkinson’s disease (PD) is a complex neurodegenerative disorder with debilitating non-motor symptoms, including gastrointestinal dysfunction, cardiovascular abnormalities, mood and anxiety disorders, cognitive decline, sleep disturbances, respiratory pain. Despite their significant impact on quality of life, these symptoms are often inadequately addressed. Propolis natural bee-derived product, rich in bioactive compounds anti-inflammatory, antioxidant, immunomodulatory, neuroprotective properties, which holds potential PD due to its multitarget multipathway actions, addressing various underlying mechanisms symptom diseases. Preclinical clinical studies suggest that propolis may influence key pathological PD’s symptoms. Evidence points benefits improving cognition, health, alleviating sleep-related issues. Although research remains scarce, findings from related conditions ability associated This review underscores the underexplored therapeutic PD, drawing existing evidence advocating for further fully assess role patient outcomes.

Язык: Английский

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Short-Term Safety and Efficacy of Propolis Inhalation as a Key Component of Apiair Therapy

International Journal of Traditional and Complementary Medicine Research, Год журнала: 2025, Номер 6(1), С. 52 - 60

Опубликована: Апрель 25, 2025

Objective: Recently, interest in beehive air inhalation therapy, also known as Apiair, has increased significantly. Despite this, clinical studies examining its effects remain limited. Propolis, a key component found hive air, been identified playing an important role potential therapeutic benefits. This study aims to evaluate the safety and physiological of propolis-water extract healthy individuals. Materials Methods: A total 20 participants were randomly assigned one two groups double-blind trial. The first group inhaled saline solution, while second received extract. Participants underwent pulmonary function testing, venous blood gas analysis, electrocardiogram (ECG) monitoring before after inhalation. Results: All parameters, including function, gas, ECG measurements, remained within clinically normal limits both groups. No adverse events reported during period. Conclusion: Propolis-water was be safe individuals, with no significant deviations measures. These findings support propolis provide foundation for further research into respiratory health, contributing broader understanding Apiair applications.

Язык: Английский

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The study of copper oxide nanoparticles based on the pH varying during propolis-mediated synthesis: structure, optical properties, UV-block ability, and malachite green photodegradation

Applied Nanoscience, Год журнала: 2024, Номер 14(3), С. 585 - 602

Опубликована: Март 1, 2024

Язык: Английский

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Exosome-mediated regulation of inflammatory pathway during respiratory viral disease

Virology Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Янв. 25, 2024

Abstract Viruses have developed many mechanisms by which they can stimulate or inhibit inflammation and cause various diseases, including viral respiratory diseases that kill people every year. One of the viruses use to induce is exosomes. Exosomes are small membrane nanovesicles (30–150 nm) released from cells contain proteins, DNA, coding non-coding RNA species. They a group extracellular vesicles take up produce mediate communication. Intercellular effect exosomes deliver broad confine biological molecules, containing nucleic acids, lipids, target cell, where convey therapeutic pathogenic consequences through modulation immune processes. Recent research has shown entire virus genomes virions distant cells, then delivered escape system infect cells. Adenoviruses, orthomyxoviruses, paramyxoviruses, syncytial viruses, picornaviruses, coronaviruses, rhinoviruses mostly related diseases. In this article, we will first discuss current knowledge We learn about relationship between infections, mention inflammations caused in airways, role them, finally, examine as mentioned earlier, regulation inflammatory pathways play causing disease.

Язык: Английский

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COUNTERCURRENT CHROMATOGRAPHY ISOLATION OF GREEN PROPOLIS BIOMARKERS: POTENTIAL BLOCKERS OF SARS-COV-2 RBD AND ACE2 INTERACTION

Journal of Chromatography A, Год журнала: 2024, Номер 1734, С. 465265 - 465265

Опубликована: Авг. 13, 2024

Язык: Английский

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Antiviral Potential of Specially Selected Bulgarian Propolis Ex-Tracts: In Vitro Mechanism of Action Against Structurally Differ-Ent Viruses

Опубликована: Июнь 15, 2023

Propolis, or bee glue, is a complex mixture of resins from plant buds and flowers, wax, pollen saliva. It also contains various vitamins, essential oils, mineral salts, trace elements, hormones enzymes. has been found that propolis possesses antimicrobial, antiviral anti-inflammatory properties. We have studied the activity six extracts Bulgarian collected districts Bulgaria. The study was conducted against structurally different viruses: Human coronavirus strain OC-43 (HCoV OC-43) respiratory syncytial virus type 5 (HRSV-5) (enveloped RNA viruses), herpes simplex 1 (HSV-1) DNA virus), rhinovirus 14 (HRV-14) (non-enveloped virus) adenovirus 2 (HadV-2) virus). influence on internal replicative cycle viruses determined using cytopathic effect (CPE) inhibition test. virucidal capacity, their adsorption stage protective uninfected cells were by end-point dilution method. Residual viral infectivity in samples compared to untreated controls Δlgs calculated. When administered during replication, most demonstrated strongest HCoV OC-43. viability extracellular virions expressed degree studied, significantly stronger those with an envelope. Almost all inhibited step host cell, some them showed healthy before they subjected infection. Our results enlarge knowledge about action could open new perspectives for its application infections treatment.

Язык: Английский

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