Natural Resources for Human Health, Год журнала: 2023, Номер 4(1), С. 73 - 74
Опубликована: Авг. 29, 2023
Not Applicable
Язык: Английский
The EPMA Journal, Год журнала: 2024, Номер 15(2), С. 163 - 205
Опубликована: Апрель 18, 2024
Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)
Язык: Английский
Процитировано
15
Cells, Год журнала: 2024, Номер 13(5), С. 390 - 390
Опубликована: Фев. 24, 2024
Aging populations worldwide are placing age-related diseases at the forefront of research agenda. The therapeutic potential natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular molecular-level changes associated with diseases. With this in mind, scientists have introduced a contextual framework guide future aging research, called hallmarks aging. This encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, altered intercellular communication. Propolis, rich array bioactive compounds, functions as potent functional food, modulating metabolism, gut microbiota, immune response, offering significant health benefits. Studies emphasize propolis' properties, such antitumor, cardioprotective, neuroprotective effects, well ability mitigate oxidative stress, DNA damage, pathogenic bacteria growth. article underscores current scientific evidence supporting role controlling molecular characteristics linked hallmarks, hypothesizing geroscience research. aim is discover novel strategies improve quality life older individuals, addressing existing deficits perspectives area.
Язык: Английский
Процитировано
9
Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 3060 - 3079
Опубликована: Апрель 11, 2024
Abstract Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects human estrogens. These compounds do not directly affect functions but can act agonists or antagonists depending on the level of endogenous estrogen in body. Phytoestrogens may an epigenetic mechanism action independent receptors. found more than 300 plant species synthesized through phenylpropanoid pathway, with specific enzymes leading to various chemical structures. primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, lignans. Extensive research animals humans has demonstrated protective phytoestrogens estrogen‐dependent diseases. Clinical trials shown their potential benefits conditions such osteoporosis, Parkinson's disease, certain types cancer. This review provides a concise overview phytoestrogen classification, diversity, biosynthesis discusses therapeutic phytoestrogens, well preclinical clinical development.
Язык: Английский
Процитировано
8
Nanotheranostics, Год журнала: 2023, Номер 7(4), С. 368 - 379
Опубликована: Янв. 1, 2023
Cancer diagnosis and management have been a slow-evolving area in medical science.Conventional therapies by far proved to various limitations.Also, the concept of immunotherapy which was thought revolutionize cancer has presented its range drawbacks.To overcome these limitations nanoparticulate-derived diagnostic therapeutic strategies are emerging.These nanomaterials be explored as they serve prospect for theranostics.Nanoparticles significant yet unclear role screening well therapy cancer.However, nanogels Photodynamic is one such approach developed theranostics.Photoactive theranostics vivid that might prove help manage cancer.Also, utilization quantum dots tool selectively kill cells, especially CNS tumors.Additionally, redox-sensitive micelles targeting tumor microenvironment also an important theranostic tool.This review focuses on exploring agents currently being studied or can further theranostics.
Язык: Английский
Процитировано
19
Deleted Journal, Год журнала: 2024, Номер 5(2), С. 200139 - 200139
Опубликована: Апрель 10, 2024
Phytochemicals encompass a diverse array of bioactive substances originating from plants, exhibiting broad spectrum possible health-promoting effects. Nonetheless, the clinical uses these compounds are restricted due to their limited solubility, stability, bioavailability, and target selectivity. Nanotechnology-based delivery methods present viable approach address problems enhance properties biological activity phytochemicals. Nanoformulations have potential augment pharmacokinetics phytochemicals by means several methods. One surface area solubility is lowering particle size. The process adsorption surfactants onto phytochemical particles can lead formation micelles, which exhibit in water. uptake across many barriers, including intestinal epithelium. To study nanoformulation enhancing therapeutic action Performed systemic review while considering PRISM guidelines. nanoparticles great delivering could help management various diseases. Although, exhaustive research trials yet demanded provide evidential proof for same. In conclusion, utilisation ligand-functionalized enables precise targeting particular cells or tissues. field nanotechnology has significant promise transforming advancement administration medicinal preventative applications. holds addressing obstacles related physicochemical characteristics phytochemicals, hence enabling development enhanced systems advantageous molecules.
Язык: Английский
Процитировано
7
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
6
Applied Sciences, Год журнала: 2024, Номер 14(3), С. 1242 - 1242
Опубликована: Фев. 2, 2024
Bee products have a millennia-old tradition in human apitherapy, thanks to their numerous curative properties. The aim of this study was perform physicochemical characterization, including the percentage water content, dry matter, pH, acidity, impurity protein, ash, and macro micro minerals, evaluate antioxidant activity apiculture products, apilarnil, royal jelly, propolis. Samples were collected from our apiary Banat region Romania 2022 as well market. Apilarnil jelly analyzed pure freeze-dried form, propolis tincture form. Our results show that there is large variability chemical composition three bee studied, depending on form presentation source origin. In case commercial best obtained terms composition, content nutrients. All samples showed values within limits allowed by quality standards. own recorded highest for activity, followed fresh apiary.
Язык: Английский
Процитировано
4
PubMed, Год журнала: 2025, Номер 15(1), С. 126 - 138
Опубликована: Янв. 1, 2025
Propolis, a resinous substance produced by bees, exhibits significant phytochemical and biological properties, which have been explored for various therapeutic applications. This study investigates the composition, antioxidant activity, antibacterial efficacy, anticancer potential of ethanolic extracts from three propolis samples (P1, P2, P3). Phytochemical screening was conducted to determine presence bioactive compounds, such as ascorbic acid, saponins, tannins. Antioxidant activity evaluated using phosphomolybdate (PMA) ferric reducing power (FRP) assays. The efficacy against Salmonella Typhimurium Staphylococcus aureus assessed well diffusion method. Cytotoxicity effects were investigated MTT assay on red blood cells (RBCs) carcinoma cell lines (HepG2, MDA, A549). Gene expression analysis performed RT-qPCR assess upregulation immune response genes (P53, Bcl2, Bax, Ca125, C3). revealed considerable quantities tannins in samples. P1 sample exhibited most substantial with FRP values at 62.9 mg/g DM PMA content 20.7 DM. In assays, demonstrated highest inhibitory zones maximum concentration (400 mg/ml), outperforming standard antibiotic treatments. cytotoxicity preserved percentage RBCs hemolysis showed marked lowest viability observed 3.9 µg/ml. genes, particularly MDA HepG2 upon treatment. underscores potent antioxidant, antibacterial, properties propolis, highlighting its natural agent. activities suggest promising applications combating bacterial infections cancer types, warranting further exploration into molecular mechanisms clinical uses.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2873 - 2873
Опубликована: Март 21, 2025
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation and progressive joint destruction. Recent data underscore oxidative stress as primary factor in the pathophysiology of rheumatoid arthritis, intensifying inflammatory processes tissue damage via overproduction reactive oxygen species (ROS) compromised antioxidant defenses. Current therapies, including disease-modifying antirheumatic drugs (DMARDs), primarily target immune dysregulation but fail to address stress, necessitating novel adjunctive treatment strategies. This review explores potential antioxidant-based therapies complementary approaches RA management. Natural compounds such curcumin, resveratrol, sulforaphane, propolis exhibit strong anti-inflammatory antioxidative properties modulating redox-sensitive pathways, nuclear kappa-light-chain-enhancer activated B cells (NF-κB) erythroid 2-related 2(Nrf2)/heme oxygenase (HO-1). N-acetylcysteine (NAC) replenishes intracellular glutathione, enhancing cellular resilience against stress. Additionally, molecular hydrogen (H2) selectively neutralizes harmful ROS, reducing inflammation. The role vitamin supplementation (D, B12, C, K) regulating responses protecting structures also discussed. aims evaluate efficacy clinical applications RA, emphasizing their mitigating improving outcomes. While preliminary findings are promising, further trials needed establish standardized dosing, long-term safety, integration into current protocols.
Язык: Английский
Процитировано
0
Clinical Complementary Medicine and Pharmacology, Год журнала: 2023, Номер 3(4), С. 100114 - 100114
Опубликована: Сен. 9, 2023
Breast cancer is one of the most common malignancies affecting women worldwide, emphasizing need for effective therapeutic strategies. Phytochemicals derived from plants have gained significant attention due to their potential anticancer properties. This review aims comprehensively assess existing literature on using phytochemical-loaded formulations as a approach breast cancer. By analyzing available evidence, we aim determine benefits and limitations these in terms activity, bioavailability, safety. A systematic search relevant databases was conducted identify studies investigating context treatment. The inclusion criteria encompassed clinical trials, preclinical studies, in-vitro experiments that reported phytochemicals various Data extraction performed ensure reliability validity included studies. highlights diverse range used different Findings suggest exhibit promising effects by targeting multiple signaling pathways progression, including cell proliferation, apoptosis, angiogenesis, metastasis. Moreover, delivery systems, such nanoparticles, liposomes, micelles, enhanced phytochemicals' bioavailability targeted delivery. Phytochemical-loaded hold immense reviewed evidence indicates ability inhibit tumor growth, enhance chemotherapy effectiveness, reduce adverse effects. However, further research warranted optimize formulation strategies, investigate long-term safety profiles, conduct large-scale trials establish efficacy applicability settings. These findings contribute developing novel phytochemical-based therapies cancer, offering new avenues personalized treatment options.
Язык: Английский
Процитировано
10