Organophosphate pesticide exposure and neurodegeneration

Cortex, Год журнала: 2015, Номер 74, С. 417 - 426

Опубликована: Окт. 23, 2015

Язык: Английский

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Metals and Neurodegeneration

F1000Research, Год журнала: 2016, Номер 5, С. 366 - 366

Опубликована: Март 17, 2016

Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, antioxidant response, to name a few. However, excessive metal accumulation nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, impairing activity of numerous enzymes. Damage caused by result permanent injuries, including severe neurological disorders. Epidemiological clinical studies have shown strong correlation between aberrant exposure number diseases, Alzheimer’s disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain–Barré Gulf War syndrome, Huntington’s multiple Parkinson’s Wilson’s disease. Here, we briefly survey literature relating role metals neurodegeneration.

Язык: Английский

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Manganese salts function as potent adjuvants

Cellular and Molecular Immunology, Год журнала: 2021, Номер 18(5), С. 1222 - 1234

Опубликована: Март 25, 2021

Abstract Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses vaccines. To date, only a few approved use humans, among which aluminum-containing are the ones widely used. However, medical need potent and safe is currently continuously increasing, especially those triggering cellular cytotoxic T lymphocyte activation, urgently needed development efficient virus cancer Manganese an essential micronutrient required diverse biological activities, but its functions immunity remain undefined. We previously reported that Mn 2+ important host defense against cytosolic dsDNA by facilitating cGAS-STING activation alone directly activates cGAS independent dsDNA, leading unconventional catalytic synthesis 2′3′-cGAMP. Herein, we found strongly promoted antigen uptake, presentation, germinal center formation via both NLRP3 activation. Accordingly, colloidal manganese salt (Mn jelly, MnJ) was formulated act not as potentiator also delivery system stimulate humoral responses, inducing antibody production CD4 + /CD8 T-cell proliferation either intramuscular or intranasal immunization. When administered intranasally, MnJ worked mucosal adjuvant, high levels secretory IgA. showed good adjuvant effects all tested antigens, including cell-dependent cell-independent such bacterial capsular polysaccharides, thus indicating it promising candidate.

Язык: Английский

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Environmental Exposures and Parkinson’s Disease

International Journal of Environmental Research and Public Health, Год журнала: 2016, Номер 13(9), С. 881 - 881

Опубликована: Сен. 3, 2016

Parkinson’s disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate nervous system via olfactory bulb, gut, or both and spreads throughout system. is unknown, but several environmental exposures have been associated with PD. Here, we summarize examine evidence for such exposures. We completed comprehensive review of human epidemiologic studies pesticides, selected industrial compounds, metals their association PubMed Google Scholar until April 2016. Most show rotenone paraquat are linked to increased risk PD-like neuropathology. Organochlorines also laboratory studies. Organophosphates pyrethroids limited suggestive animal data Iron has found be elevated brain tissue pathophysiological link unclear. due manganese not demonstrated, though parkinsonian syndrome well-documented. Overall, linking paraquat, rotenone, organochlorines appears strong; however, organophosphates, pyrethroids, polychlorinated biphenyls require further study. related do support an

Язык: Английский

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Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress

Biomaterials, Год журнала: 2019, Номер 224, С. 119467 - 119467

Опубликована: Сен. 11, 2019

Язык: Английский

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Metals associated neurodegeneration in Parkinson’s disease: Insight to physiological, pathological mechanisms and management

Neuroscience Letters, Год журнала: 2021, Номер 753, С. 135873 - 135873

Опубликована: Апрель 2, 2021

Язык: Английский

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Manganese Coordination Micelles That Activate Stimulator of Interferon Genes and Capture In Situ Tumor Antigens for Cancer Metalloimmunotherapy

ACS Nano, Год журнала: 2022, Номер 16(10), С. 16909 - 16923

Опубликована: Окт. 6, 2022

Cancer immunotherapy holds great promise but is generally limited by insufficient induction of anticancer immune responses. Here, a metal micellar nanovaccine developed the self-assembly manganese (Mn), stimulator interferon genes (STING) agonist (ABZI) and naphthalocyanine (ONc) coordinated nanoparticles (ONc-Mn-A) in maleimide-modified Pluronic F127 (malF127) micelles. Owing to synergy between Mn ABZI, nanovaccine, termed ONc-Mn-A-malF127, elevates levels interferon-β (IFNβ) 324- 8-fold vivo, compared use or ABZI alone. As such, activation cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-STING pathway induces sufficient dendritic cell (DC) maturation, eventually resulting death CD8+ T cell-sensitive tumors cell-resistant simultaneously promoting cytotoxic cells NK cells, respectively. Furthermore, with ONc used as chelator an efficient photosensitizer, photoinduced immunogenic (ICD) tumor releases damage-associated molecular patterns (DAMPs) neoantigens from dying primary upon laser irradiation, which are captured situ malF127 then transported DCs. After treatment, addition photothermal therapy, responses characterized level IFNβ further elevated another 4-fold. In murine cancer models, ICD-based metalloimmunotherapy using ONc-Mn-A-malF127 single dose intravenous injection achieved eradication distant tumors. Taken together, offers nanoplatform enhance efficacy ICD based strong abscopal effect.

Язык: Английский

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Consequences of Disturbing Manganese Homeostasis

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14959 - 14959

Опубликована: Окт. 6, 2023

Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a cofactor for many enzymes involved energy metabolism, endogenous antioxidant enzyme systems, neurotransmitter production, and regulation of reproductive hormones. However, overexposure to Mn toxic, particularly central nervous system (CNS) due causing progressive destruction nerve cells. Exposure manganese widespread occurs by inhalation, ingestion, or dermal contact. Associations have been observed between accumulation neurodegenerative diseases such manganism, Alzheimer's disease, Parkinson's Huntington's amyotrophic lateral sclerosis. People genetic associated mutation gene impaired excretion, kidney iron deficiency, vegetarian diet are at particular risk excessive exposure Mn. This review has collected data on current knowledge source exposure, experimental supporting dispersive brain, controversies surrounding reference values biomarkers related status different matrices, competitiveness other metals, (Fe), magnesium (Mg), zinc (Zn), copper (Cu), lead (Pb), calcium (Ca). The disturbed homeostasis body connected susceptibility diseases, fertility, infectious diseases. evidence involvement metabolic type 2 diabetes mellitus/insulin resistance, osteoporosis, obesity, atherosclerosis, non-alcoholic fatty liver was discussed.

Язык: Английский

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Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms

Environmental Pollution, Год журнала: 2024, Номер 345, С. 123563 - 123563

Опубликована: Фев. 13, 2024

Язык: Английский

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Metal Ion Signaling in Biomedicine

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Complex multicellular organisms are composed of distinct tissues involving specialized cells that can perform specific functions, making such life forms possible. Species defined by their genomes, and differences between individuals within a given species directly result from variations in genetic codes. While alterations give rise to disease-causing acquisitions cell identities, it is now well-established biochemical imbalances also lead cellular dysfunction diseases. Specifically, nongenetic chemical events orchestrate metabolism transcriptional programs govern functional identity. Thus, signaling, which broadly defines the conversion extracellular signals into intracellular changes, contribute acquisition diseased states. Metal ions exhibit unique properties be exploited cell. For instance, metal maintain ionic balance cell, coordinate amino acid residues or nucleobases altering folding function biomolecules, catalyze reactions. metals essential signaling effectors normal physiology disease. Deciphering ion challenging endeavor illuminate pathways targeted for therapeutic intervention. Here, we review key processes where play roles describe how targeting has been instrumental dissecting biochemistry this led development effective strategies.

Язык: Английский

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