Brain Research, Год журнала: 2025, Номер unknown, С. 149752 - 149752
Опубликована: Июнь 1, 2025
Язык: Английский
npj Aging and Mechanisms of Disease, Год журнала: 2021, Номер 7(1)
Опубликована: Авг. 17, 2021
Worldwide, people are getting older, and this prolonged lifespan unfortunately also results in an increased prevalence of age-related neurodegenerative diseases, contributing to a diminished life quality elderly. Age-associated neuropathies typically include diseases leading dementia (Alzheimer's Parkinson's disease), as well eye such glaucoma macular degeneration. Despite many research attempts aiming unravel aging processes their involvement neurodegeneration functional decline, achieving healthy brain remains challenge. The African turquoise killifish (Nothobranchius furzeri) is the shortest-lived reported vertebrate that can be bred captivity displays hallmarks have been described for human aging, which makes it very promising biogerontology model. As vision decline important hallmark manifestation we performed comprehensive characterization fish's visual system. Our work reveals several retina eventually result performance. Moreover, found evidence occurrence events old retina. Altogether, introduce system fast-aging valuable model understand cellular molecular mechanisms underlying central nervous These findings put forward target validation drug discovery rejuvenating or neuroprotective therapies ensuring aging.
Язык: Английский
Процитировано
38
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(22), С. 12606 - 12606
Опубликована: Ноя. 22, 2021
Glyphosate is widely used worldwide as a potent herbicide. Due to its ubiquitous use, it detectable in air, water and foodstuffs can accumulate human biological fluids tissues representing severe health risk. In plants, glyphosate acts an inhibitor of the shikimate pathway, which absent vertebrates. this, international scientific authorities have long-considered compound that has no or weak toxicity humans. However, increasing evidence highlighted formulations animals cells tissues. Thus, despite extension authorization use Europe until 2022, several countries begun take precautionary measures reduce diffusion. been detected urine, blood maternal milk found induce generation reactive oxygen species (ROS) cytotoxic genotoxic effects vitro animal models directly indirectly through metabolite, aminomethylphosphonic acid (AMPA). This review aims summarize more relevant findings on underlying molecular mechanisms glyphosate, with particular focus glyphosate's potential inflammation, DNA damage alterations gene expression profiles well adverse reproduction development.
Язык: Английский
Процитировано
34
Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 3925 - 3938
Опубликована: Сен. 1, 2024
GLP-1 receptor agonists (GLP-1 RA) have been proven to treat several metabolic diseases; however, the effects of RA on polycystic ovary syndrome (PCOS) remain unclear. Here, we aimed investigate whether semaglutide, a novel RA, could alleviate ovarian inflammation in PCOS mice.
Язык: Английский
Процитировано
6
Nutrition Reviews, Год журнала: 2024, Номер unknown
Опубликована: Март 20, 2024
Abstract Context Resveratrol (RV) is a natural compound found in grapes, wine, berries, and peanuts has potential health benefits—namely, neurogenesis improvement. Neurogenesis, which the process through new neurons or nerve cells are generated brain, occurs subventricular zone hippocampus influenced by various factors. RV been shown to increase neural stem cell proliferation survival, improving cognitive function hippocampus-dependent tasks. Thus, provide convergent unbiased conclusion of available evidence on correlation between neurogenesis, systematic review needs be undertaken meticulously with appropriate attention. Objective This study aimed systematically any connection animal models. Data Sources Extraction Based particular selection criteria, 8 original studies that investigated relationship were included. Studies written English published peer-reviewed journals no restrictions starting date publication August 17, 2023, searched Google Scholar PubMed databases. Furthermore, data extracted analyzed independently 2 researchers then reviewed third researcher, discrepancies resolved consensus. project followed PRISMA reporting standards. Analysis In this review, there definite meaning intake, irrespective mechanisms thereof, can boost both hippocampus. Conclusion finding, albeit some limitations, provides plausible indication RV’s beneficial neurogenesis. Indeed, intake may result function, mood regulation, stress resilience, neuroprotection, potentially preventing decline.
Язык: Английский
Процитировано
5
Central Nervous System Agents in Medicinal Chemistry, Год журнала: 2022, Номер 22(3), С. 160 - 174
Опубликована: Сен. 30, 2022
Neuroinflammation is a key component in the etiopathogenesis of neurological diseases and brain aging. This process involves immune system that modulates synaptic functions protects neurons from infection or damage. Hence, knowledge neuroinflammation related pathways modulation by drugs natural compounds functional to developing therapeutic strategies aimed at preserving, maintaining restoring health.This review article summarizes basics signaling pathways, success dietary intervention clinical practice possible development RNA-based for treating diseases.Pubmed search 2012 2022 with keywords molecular mechanisms combination diet, miRNA non-coding RNA.Glial cells-play crucial role neuroinflammation, but several can be activated response different inflammatory stimuli, inducing cell death apoptosis, pyroptosis necroptosis. The has immunomodulatory effects could limit induced microglia astrocytes. Thus inhibiting improving symptoms variety diseases, diet exerts pleiotropic neuroprotective independently spectrum pathophysiological underlying specific disorder. Furthermore, data animal models revealed altered expression noncoding RNAs, particular microRNAs, contributes neuroinflammatory diseases; consequently, may promising alleviate consequences neuroinflammation.Further studies are needed identify new pharmacological targets lay basis more effective selective therapies applied, parallel intervention, treatment neuroinflammation-based diseases.
Язык: Английский
Процитировано
17
Archives of Physiology and Biochemistry, Год журнала: 2021, Номер 130(1), С. 13 - 28
Опубликована: Авг. 11, 2021
A significant increase in the worldwide incidence and prevalence of type 2 diabetic mellitus (T2DM) has elevated need for studies on novel effective therapeutic strategies. Sirtuin 1 (SIRT1) is an NAD + dependent protein deacetylase with a critical function regulation glucose/lipid metabolism, insulin resistance, inflammation, oxidative stress, mitochondrial function. SIRT1 also involved secretion from pancreatic β-cells protecting these cells inflammation stress-mediated tissue damages. In this regard, major activators have been demonstrated to exert beneficial impact reversing T2DM-related complications including cardiomyopathy, nephropathy, retinopathy, neuropathy, hence treating T2DM. Therefore, accumulating number recent investigated efficacy targeting as strategy review we aimed discuss current understanding physiological biological roles SIRT1, then its implication pathogenesis T2DM, potential combating
Язык: Английский
Процитировано
23
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11640 - 11640
Опубликована: Июль 19, 2023
The flow of substances between the blood and central nervous system is precisely regulated by blood-brain barrier (BBB). Its disruption due to unbalanced glucose levels (hyper- hypoglycemia) occurring in metabolic disorders, such as type 2 diabetes, can lead neuroinflammation, increase risk developing neurodegenerative diseases. One most studied natural anti-diabetic, anti-inflammatory, neuroprotective compounds resveratrol (RSV). It activates sirtuin 1 (SIRT1), a key metabolism regulator dependent on cell energy status. aim this study was assess astrocyte SIRT1 response neuroinflammation subsequent RSV treatment, depending systemic glycemia. For purpose, we used an optimized vitro model BBB consisting endothelial cells astrocytes, representing microvascular brain compartments (MC BC), different glycemic backgrounds. Astrocyte-secreted reached highest concentration hypo-, lowest normo-, hyperglycemic Lipopolysaccharide (LPS)-induced caused substantial decrease all backgrounds, observed earliest hyperglycemia. partially counterbalanced effect LPS secretion, remarkably normoglycemia. Our results suggest that abnormal states have worse prognosis for RSV-therapy effectiveness compared
Язык: Английский
Процитировано
9
Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 489, С. 116994 - 116994
Опубликована: Июнь 8, 2024
Язык: Английский
Процитировано
3
Sub-cellular biochemistry/Subcellular biochemistry, Год журнала: 2025, Номер unknown, С. 1 - 49
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(5), С. 837 - 837
Опубликована: Фев. 28, 2025
Physical exercise is an essential component of human health. In recent years, scientific research has focused on identifying natural compounds and formulating new supplements aimed at enhancing athletic performance, accelerating muscle recovery, minimizing the damage caused by physical exertion. The use antioxidants to counteract formation reactive oxygen species (ROS) following activity (PA) already a widely adopted practice. Resveratrol (RES), polyphenol belonging stilbene class, well known for its potent antioxidant anti-inflammatory effects primarily attributed activation sirtuins. RES possesses multiple nutraceutical properties used prevention treatment inflammatory, cardiovascular, neoplastic, infectious diseases, thus attracting attention study in combination with promote well-being. Animal trials combining PA have mainly reported improvements muscle, energy, cardiovascular functions. data presented discussed this narrative review are from Pubmed, Scopus, Human Gene Database (search limited 2011 2025 keywords RES, sirtuins, altogether or each other). This gathers several studies focusing properties, epigenetic activities via potential benefits maintaining health well-being based performed first animals later humans. been conducted various populations, including active adults, sedentary individuals, patients elderly individuals. Some confirmed observed animal experiments. However, some cases, no substantial differences were found between supplementation control group. conclusion, literature still not fully evident, given contrasting number trials, but both successful tools maintenance wellbeing.
Язык: Английский
Процитировано
0