The role of resveratrol in neurogenesis: a systematic review

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: March 20, 2024

Abstract Context Resveratrol (RV) is a natural compound found in grapes, wine, berries, and peanuts has potential health benefits—namely, neurogenesis improvement. Neurogenesis, which the process through new neurons or nerve cells are generated brain, occurs subventricular zone hippocampus influenced by various factors. RV been shown to increase neural stem cell proliferation survival, improving cognitive function hippocampus-dependent tasks. Thus, provide convergent unbiased conclusion of available evidence on correlation between neurogenesis, systematic review needs be undertaken meticulously with appropriate attention. Objective This study aimed systematically any connection animal models. Data Sources Extraction Based particular selection criteria, 8 original studies that investigated relationship were included. Studies written English published peer-reviewed journals no restrictions starting date publication August 17, 2023, searched Google Scholar PubMed databases. Furthermore, data extracted analyzed independently 2 researchers then reviewed third researcher, discrepancies resolved consensus. project followed PRISMA reporting standards. Analysis In this review, there definite meaning intake, irrespective mechanisms thereof, can boost both hippocampus. Conclusion finding, albeit some limitations, provides plausible indication RV’s beneficial neurogenesis. Indeed, intake may result function, mood regulation, stress resilience, neuroprotection, potentially preventing decline.

Language: Английский

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The SIRT-1/Nrf2/HO-1 Axis: Guardians of Neuronal Health in Neurological Disorders

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: unknown, P. 115280 - 115280

Published: Oct. 1, 2024

Language: Английский

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Basic Epigenetic Mechanisms

Sub-cellular biochemistry/Subcellular biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 49

Published: Jan. 1, 2025

Language: Английский

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Resveratrol and Physical Activity: A Successful Combination for the Maintenance of Health and Wellbeing?

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 837 - 837

Published: Feb. 28, 2025

Physical exercise is an essential component of human health. In recent years, scientific research has focused on identifying natural compounds and formulating new supplements aimed at enhancing athletic performance, accelerating muscle recovery, minimizing the damage caused by physical exertion. The use antioxidants to counteract formation reactive oxygen species (ROS) following activity (PA) already a widely adopted practice. Resveratrol (RES), polyphenol belonging stilbene class, well known for its potent antioxidant anti-inflammatory effects primarily attributed activation sirtuins. RES possesses multiple nutraceutical properties used prevention treatment inflammatory, cardiovascular, neoplastic, infectious diseases, thus attracting attention study in combination with promote well-being. Animal trials combining PA have mainly reported improvements muscle, energy, cardiovascular functions. data presented discussed this narrative review are from Pubmed, Scopus, Human Gene Database (search limited 2011 2025 keywords RES, sirtuins, altogether or each other). This gathers several studies focusing properties, epigenetic activities via potential benefits maintaining health well-being based performed first animals later humans. been conducted various populations, including active adults, sedentary individuals, patients elderly individuals. Some confirmed observed animal experiments. However, some cases, no substantial differences were found between supplementation control group. conclusion, literature still not fully evident, given contrasting number trials, but both successful tools maintenance wellbeing.

Language: Английский

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Tectorigenin mitigates homocysteine-induced inflammation and ferroptosis in BV-2 microglial cells through promoting the SIRT1/SLC7A11 pathway

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111272 - 111272

Published: March 1, 2025

Ferroptosis and inflammation are central to the pathophysiology of hyperhomocysteinemia (HHcy)-associated neurological disorders. Tectorigenin, a natural flavonoid aglycone extracted from numerous plants, possesses antioxidant, anti-inflammatory, neuroprotective properties. This study aimed investigate whether tectorigenin mitigates elevated homocysteine (Hcy)-induced toxicity in BV-2 microglial cells, focusing on its effects ferroptosis. Cell viability, lactate dehydrogenase (LDH) release, proliferation assays were employed evaluate cell injury. Inflammatory cytokines levels determined by ELISA. markers, including reactive oxygen species (ROS), lipid ROS, malondialdehyde (MDA), 4-hydroxy-nonenal (4-HNE), mitochondrial membrane potential (MMP), ATP, Fe2+ content, antioxidant enzymes (superoxide dismutase [SOD] catalase [CAT]) activities evaluated. mRNA protein expressions analyzed qRT-PCR western blotting, respectively. Our findings revealed that pretreatment significantly alleviated Hcy-induced injury inflammatory response cells. Furthermore, reduced peroxidation, enhanced capacity, ferroptotic death Hcy-treated Importantly, ferroptosis inhibitor Fer-1 also inflammation. Mechanistically, activated SIRT1/SLC7A11 pathway, silencing SIRT1 reversed protective effects. Collectively, these results indicate attenuates inhibiting through activation pathway.

Language: Английский

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Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway

Chinese Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: 23(3), P. 299 - 310

Published: March 1, 2025

Language: Английский

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Adult Neurogenesis Is Regulated by the Endocannabinoid and Kisspeptin Systems

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3977 - 3977

Published: April 23, 2025

Neurogenesis is considered the most robust form of plasticity in adult brain. To better decipher this process, wwe evaluated potential crosstalk Kisspeptin and Endocannabinoid Systems (KPS ECS, respectively) on hippocampal neurogenesis. Male adolescent rats were exposed to kisspeptin-10 (KP10) endocannabinoid anandamide (AEA) administered alone or combination with type 1 cannabinoid receptor (CB1R) antagonist SR141716A. The expression Kiss1 (Kiss1R) has been characterized for first time rat hippocampus together CB1R Transient Receptor Potential Vanilloid ion channel (TRPV1). Results show that both systems inhibit neurogenesis by reducing extracellular signal-regulated kinase (ERK) signaling. Despite little differences Kiss1R CB1R, TRPV1 enhanced KP10 AEA treatments, suggesting as a common thread. administration reduces dentate gyrus, while does not. KPS, unlike promotes estrogen α (ER-α) glyceraldehyde-3-phosphate dehydrogenase (GAPDH), also upregulating sirtuin (SIRT1), brain-derived-neurotrophic factor (BDNF), c-Jun. These findings suggest interaction between ECS KPS could be involved fine-tuning neurogenesis, highlighting novel role KPS.

Language: Английский

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The hippo pathway: a molecular bridge between environmental cues and pace of life

BMC Ecology and Evolution, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Abstract The pace of life (POL) is shaped by a complex interplay between genetic and environmental factors, influencing growth, maturation, lifespan across species. Hippo signaling pathway, key regulator organ size cellular homeostasis, has emerged as central integrator cues that modulate POL traits. In this review, we explore how the pathway links factors—such temperature fluctuations dietary energy availability—to molecular mechanisms governing metabolic balance, hormonal signaling, reproductive timing. Specifically, highlight regulatory interactions sensors (AMPK, mTOR, SIRT1 DLK1-Notch), well signals (IGF-1, kisspeptin, leptin, cortisol, thyroid sex steroids), which together orchestrate life-history traits, including growth rates, sexual with particular emphasis on their role in Furthermore, consider its potential coordinator POL-related processes, such telomere dynamics epigenetic mechanisms, within broader network. By integrating insights from biology eco-evolutionary perspectives, propose future directions to dissect pathway’s regulation taxa. Understanding these will provide new perspectives organisms adaptively adjust strategies response variability.

Language: Английский

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Neuroprotective effects of saxagliptin against radiation-induced cognitive impairment: Insights on Akt/CREB/SIRT1/BDNF signaling pathway

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 489, P. 116994 - 116994

Published: June 8, 2024

Language: Английский

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Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 466 - 466

Published: March 20, 2025

Metabolic dysfunction leading to non-alcoholic fatty liver disease (NAFLD) exhibits distinct molecular and immune signatures that are influenced by factors like gut microbiota. The microbiome interacts with the via a bidirectional relationship gut–liver axis. Microbial metabolites, sirtuins, responses pivotal in different metabolic diseases. This extensive review explores complex multifaceted interrelationship between sirtuins microbiota, highlighting their importance health disease, particularly hepatocellular carcinoma (HCC). Sirtuins (SIRTs), classified as group of NAD+-dependent deacetylases, serve crucial modulators wide spectrum cellular functions, including pathways, inflammatory response, process senescence. Their subcellular localization diverse functions link them various conditions, NAFLD cancer. Concurrently, comprising microorganisms, significantly influences host metabolism responses. Recent findings indicate modulate microbiota composition function, while can affect sirtuin activity. is relevant disorders, where dysbiosis contributes progression. highlights recent on roles specific maintaining implications HCC development. Understanding these interactions offers potential therapeutic avenues for managing diseases linked dysregulation pathology.

Language: Английский

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