Relationship between sodium–glucose cotransporter-2 inhibitors and muscle atrophy in patients with type 2 diabetes mellitus: a systematic review and meta-analysis DOI Creative Commons

Chengdong Xia,

Yufeng Han, Chunhui Yin

и другие.

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Сен. 15, 2023

Aim This study aims to assess the association between sodium–glucose cotransporter type-2 inhibitor (SGLT-2i) treatment and muscle atrophy in patients with type 2 diabetes mellitus (T2DM). Methods We searched six databases from 1 January 2012 May 2023, without language restrictions. The primary outcome was muscle. Secondary outcomes were weight loss, weakness, malaise, or fatigue. Subgroup analyses performed according different definitions of muscle, duration, measurement methods. quality studies assessed using Cochrane tool. evidence Grading Recommendations, Assessment, Development Evaluations (GRADE) Results Nineteen randomized controlled trials (RCTs) involving 1,482 participants included. Compared control group, a meta-analysis showed that T2DM group treated SGLT-2i demonstrated statistically significant reductions lean body mass 0.66 (95% confidence interval (CI), −1.05 −0.27; p = 0.0009) skeletal 0.35 CI, −0.66 −0.04; 0.03). No deaths serious adverse events reported. included low. Conclusions may lead reduction strength compared group. However, there is still lack high-quality evaluate caused by SGLT-2i. Systematic review registration https://inplasy.com/inplasy-2022-12-0061/ , identifier 2022120061.

Язык: Английский

The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy DOI Creative Commons
Huiling Chen, Xiaojing Huang, Meiyuan Dong

и другие.

Diabetes Metabolic Syndrome and Obesity, Год журнала: 2023, Номер Volume 16, С. 1541 - 1554

Опубликована: Май 1, 2023

Abstract: Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass function, is recognized a new complication in elderly patients with type 2 diabetes mellitus (T2DM). Type insulin resistance, chronic inflammation, accumulation advanced glycation products increased oxidative stress, which can negatively affect mass, strength function leading to sarcopenia. There mutual interrelationship between T2DM light pathophysiology mechanism long-term outcome. will accelerate the decline turn lead glucose metabolism disorders, reduced physical activity risk diabetes. However, specific involved has not been thoroughly studied. Therefore, this review aims explore therapeutic strategy related provide insight for future investigations, great significance improving quality life concurrently reducing incidence complications. Keywords: mellitus, sarcopenia, gut microbiota,

Язык: Английский

Процитировано

55
Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments DOI Creative Commons
Ever Espino‐Gonzalez, Emilie Dalbram, Rémi Mounier

и другие.

Cell Metabolism, Год журнала: 2024, Номер 36(6), С. 1204 - 1236

Опубликована: Март 14, 2024

Diabetes represents a major public health concern with considerable impact on human life and healthcare expenditures. It is now well established that diabetes characterized by severe skeletal muscle pathology limits functional capacity quality of life. Increasing evidence indicates also one the most prevalent disorders impaired regeneration, yet underlying mechanisms therapeutic treatments remain poorly established. In this review, we describe cellular molecular alterations currently known to occur during regeneration in people animal models diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, insulin resistance. We role myogenic non-myogenic cell types conditions or without diabetes. Therapies for gaps our knowledge are discussed, while proposing future directions field.

Язык: Английский

Процитировано

22
Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study DOI
Pasquale Mone,

Stefano De Gennaro,

Divina Moriello

и другие.

European Journal of Preventive Cardiology, Год журнала: 2023, Номер 30(12), С. 1283 - 1288

Опубликована: Май 17, 2023

Abstract Aims Pre-diabetes is a condition that confers an increased cardiovascular risk. Frailty very common in hypertensive patients, and insulin resistance has been linked to frailty older adults with diabetes. On these grounds, our aim was evaluate the association between cognitive impairment pre-diabetic frail adults. Methods results We studied consecutive elders presenting at Avellino local health authority of Italian Ministry Health (ASL AV) from March 2021 2022. All them fulfilled following inclusion criteria: previous diagnosis hypertension no clinical or laboratory evidence secondary causes, confirmed pre-diabetes, age >65 years, Montreal Cognitive Assessment (MoCA) Score <26, frailty. enrolled 178 which 141 successfully completed study. observed strong inverse correlation (r = −0.807; P < 0.001) MoCA Homeostatic Model for Insulin Resistance (HOMA-IR). The were by linear regression analysis using as dependent variable, after adjusting several potential confounders. Conclusion Taken together, data highlight first time global function pre-diabetes.

Язык: Английский

Процитировано

33
A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds DOI Creative Commons
Jinjin Pei, Chella Perumal Palanisamy, Phaniendra Alugoju

и другие.

Molecules, Год журнала: 2023, Номер 28(2), С. 604 - 604

Опубликована: Янв. 6, 2023

Globally, millions of people suffer from poor wound healing, which is associated with higher mortality rates and healthcare costs. There are several factors that can complicate the healing process wounds, including inadequate conditions for cell migration, proliferation, angiogenesis, microbial infections, prolonged inflammatory responses. Current therapeutic methods have not yet been able to resolve primary problems; therefore, their effectiveness limited. As a result remarkable properties, bio-based materials demonstrated significant impact on in recent years. In microenvironment, stimulate numerous cellular molecular processes may enhance by inhibiting growth pathogens, preventing inflammation, stimulating potentially converting non-healing environment an appropriately one. The aim this present review article provide overview mechanisms underlying its pathophysiology. development nanomaterials chronic diabetic wounds as well novel methodologies also discussed.

Язык: Английский

Процитировано

27
Frailty and risk of microvascular complications in patients with type 2 diabetes: a population-based cohort study DOI Creative Commons
Yuanjue Wu, Ting Xiong, Xiao Tan

и другие.

BMC Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Дек. 8, 2022

Cross-sectional studies found that frailty was associated with prevalent diabetic microvascular complications (DMC). Longitudinal evidence in this regard is inconclusive and insufficient. We aimed to prospectively evaluate the association of pre-frailty DMC patients type 2 diabetes (T2D).

Язык: Английский

Процитировано

31
Frailty is associated with the progression of prediabetes to diabetes and elevated risks of cardiovascular disease and all-cause mortality in individuals with prediabetes and diabetes: Evidence from two prospective cohorts DOI
Di He, Jun Li,

Yuhao Li

и другие.

Diabetes Research and Clinical Practice, Год журнала: 2022, Номер 194, С. 110145 - 110145

Опубликована: Ноя. 7, 2022

Язык: Английский

Процитировано

23
Evaluación de la enfermedad renal crónica en las personas españolas con diabetes: un estudio llevado a cabo en las consultas de medicina interna DOI
Javier Ena, Juana Carretero Gómez,

Manuel Suárez Tembra

и другие.

Revista Clínica Española, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Процитировано

0
Low Muscle Mass Is Associated with Poorer Glycemic Control and Higher Oxidative Stress in Older Patients with Type 2 Diabetes DOI Open Access
Blanca Alabadí,

Miguel Civera,

Adrián De la Rosa

и другие.

Nutrients, Год журнала: 2023, Номер 15(14), С. 3167 - 3167

Опубликована: Июль 17, 2023

Body composition changes that occur during aging, such as loss of lean mass, are unfavorable at metabolic level and they can explain, in part, the appearance certain age-associated diseases type 2 diabetes (T2D). Separately, T2D is associated with an increase oxidative stress (OS) which negatively affects skeletal muscle. Our aim was to study differences clinical nutritional parameters, disease control, OS a cohort older patients classified according amount mass had. We included 100 adults than 65 years T2D. found women low fat-free muscle have worse control. Moreover, percentile present high value OS. The shows presence (LM) geriatric population diagnosed poorer glycemic control greater

Язык: Английский

Процитировано

11
Association of frailty index with new-onset diabetes: from the China Health and Retirement Longitudinal Study (CHARLS) DOI Creative Commons
Lisha Zhang,

Chao Chu,

Yan Zhang

и другие.

Acta Diabetologica, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

0
Métodos de avaliação da síndrome da fragilidade em pessoas idosas com diabetes: uma revisão integrativa DOI Open Access
T. S. Batista, Isabelle Karine Ramos de Lima, Ilma Kruze Grande de Arruda

и другие.

Ciência & Saúde Coletiva, Год журнала: 2025, Номер 30(2)

Опубликована: Янв. 1, 2025

Resumo O estudo objetiva sintetizar o conhecimento disponível sobre os métodos utilizados para avaliação da síndrome fragilidade em pessoas idosas com diabetes na comunidade. Trata-se de uma revisão integrativa literatura feita nas bases dados LILACS, PubMed, Embase, Web of Science e Scopus. Foram incluídos 19 artigos categorizados base nos tipos instrumentos: unidimensional, que incluem apenas elementos físicos fragilidade, multidimensional, incorpora domínios cognitivos psicossociais. Constatou-se a presença todos incluídos, havendo variação 28,2% 80% instrumentos unidimensionais 9,4% 46,2% multidimensionais. As evidências científicas demonstraram há distinção clara entre vários analisados e, conforme realidade ser aplicada, pontos corte dos itens compõem as escalas devem adaptados população estudo. Diante disso, é necessária realização novos estudos investigar mais simples identificação fim facilitar seu uso atenção primária saúde, ajudando identificar precocemente risco desenvolver fragilidade.

Процитировано

0