Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(3), С. 230 - 230
Опубликована: Фев. 21, 2024
Cardiac
troponin
serum
concentration
is
the
primary
marker
used
for
diagnosis
of
acute
coronary
syndrome.
Moreover,
measurement
cardiac
important
risk
stratification
in
patients
with
pulmonary
embolism.
The
level
also
a
general
myocardial
damage,
regardless
etiology.
purpose
this
study
to
conduct
literature
review
and
present
most
information
regarding
current
state
knowledge
on
chronic
cardiovascular
disease
(CVD),
as
well
relationships
between
features
subclinical
dysfunction.
According
research
conducted
date,
CVDs,
such
syndrome,
lower
extremities'
ischemia,
cerebrovascular
disease,
are
characterized
by
higher
concentrations
than
people
without
CVD.
data
indicate
that
correlated
markers
dysfunction
system,
intima-media
thickness,
pulse
wave
velocity,
ankle-brachial
index,
artery
calcium
index
(the
Agatston
score),
flow-mediated
dilation.
However,
further
needed
various
patient
subpopulations
different
clinical
contexts.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 75 - 75
Опубликована: Дек. 21, 2022
The
role
of
lipids
is
essential
in
any
phase
the
atherosclerotic
process,
which
considered
a
chronic
lipid-related
and
inflammatory
condition.
traditional
lipid
profile
(including
evaluation
total
cholesterol,
triglycerides,
high-density
lipoprotein,
low-density
lipoprotein)
well-established
tool
to
assess
risk
atherosclerosis
as
such
has
been
widely
used
pillar
cardiovascular
disease
prevention
target
pharmacological
treatments
clinical
practice
over
last
decades.
However,
other
non-traditional
have
emerged
possible
alternative
predictors
cardiometabolic
addition
single
or
panel
lipids,
they
better
reflect
overall
interaction
between
lipid/lipoprotein
fractions.
Therefore,
this
review
deals
with
involvement
characterizing
pathophysiology
atherosclerosis,
discussing
some
recently
proposed
indices
and,
light
available
knowledge,
their
actual
potential
new
additive
tools
stratify
patients
hyperlipidemia
well
therapeutic
targets
practice.
AL-Kindy College Medical Journal,
Год журнала:
2024,
Номер
20(1), С. 4 - 13
Опубликована: Апрель 1, 2024
Fetal
growth
restriction
is
a
significant
contributor
to
fetal
morbidity
and
mortality.
In
addition,
there
are
heightened
maternal
risks
associated
with
surgical
operations
their
accompanying
dangers.
Monitoring
development
crucial
objective
of
prenatal
care
effective
methods
for
early
diagnosis
restriction,
allowing
prompt
management
timely
intervention
improve
the
outcomes.
Screening
can
be
achieved
via
many
modalities;
it
medical,
biochemical,
or
radiological.
Some
recommended
combining
more
than
one
better
Currently,
inconsistency
about
best
method
screening.
this
review,
comprehensive
evaluation
current
radiological
used
including
serial
scan,
Doppler
velocimetry,
biophysical
profile
offered.
Limitations,
potential
enhancements
area
were
specifically
analyzing
effectiveness.
Moreover,
recently
developed
experimental
techniques
presented
how
integrate
them
into
practice
enhance
follow-up
performance
results.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(11), С. 3815 - 3815
Опубликована: Июнь 1, 2023
Introduction:
There
are
several
pathologic
mechanisms
involved
in
diabetic
nephropathy,
but
the
role
of
oxidative
stress
seems
to
be
one
most
important.
Sodium-glucose
cotransporter
2
(SGLT2)
inhibitors
a
relatively
new
class
antidiabetic
drugs
that
might
also
have
some
other
effects
addition
lowering
glucose.
The
aim
this
study
was
evaluate
possible
SGLT2
inhibitor
empagliflozin
on
and
renal
function
diabetes.
Methods:
Male
Wistar
rats
were
randomly
divided
into
four
groups:
control,
control-treated,
diabetic,
diabetic-treated
(n
=
8
per
group).
Diabetes
induced
by
single
intraperitoneal
dose
streptozotocin
(50
mg/kg).
treated
animals
received
for
5
weeks
(20
mg/kg/day/po).
All
groups
sacrificed
36th
day,
blood
tissue
samples
collected.
Serum
levels
urea,
uric
acid,
creatinine,
glucose
determined.
level
malondialdehyde
(MDA)
glutathione
(GLT),
as
well
activity
catalase
(CAT)
superoxide
dismutase
(SOD),
measured
all
groups.
Data
analyzed
using
one-way
Anova
paired
T-tests,
p
≤
0.05
considered
significant.
Results:
significantly
increased
urea
(p
<
0.001),
acid
creatinine
0.001)
serum,
while
activities
CAT
SOD
reduced.
GLT
reduced
MDA
non-treated
animals.
Treatment
with
improved
function,
shown
reduction
serum
0.03),
0.001).
Empagliflozin
antioxidant
capacity
increasing
0.035)
0.02)
content
0.01)
damage
Conclusions:
It
uncontrolled
diabetes
induces
insufficiency
decreasing
defense
inducing
stress.
additional
benefits
glucose—-reversing
these
processes,
improving
antioxidative
capacity,
function.
Journal of Neuroimmunology,
Год журнала:
2024,
Номер
391, С. 578363 - 578363
Опубликована: Май 3, 2024
Neurological
diseases
with
a
neurodegenerative
component
have
been
associated
alterations
in
the
cerebrovasculature.
At
anatomical
level,
these
are
centred
around
changes
cerebral
blood
flow
and
vessel
organisation.
molecular
there
is
extensive
expression
of
cellular
adhesion
molecules
increased
release
pro-inflammatory
mediators.
Together,
has
found
to
negatively
impact
blood-brain
barrier
integrity.
Systemic
inflammation
accelerate
exacerbate
endothelial
dysfunction,
neuroinflammation
degeneration.
Here,
we
review
role
cerebrovasculature
dysfunction
disease
discuss
potential
contribution
intermittent
systemic
causing
pathology,
highlighting
possible
mechanism
that
may
allow
broad-spectrum
therapeutic
targeting
future.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(4), С. 1356 - 1356
Опубликована: Фев. 8, 2023
Hyperglycaemia-induced
oxidative
stress
and
inflammation
contribute
to
vascular
cell
dysfunction
subsequent
cardiovascular
events
in
T2DM.
Selective
sodium-glucose
co-transporter-2
(SGLT-2)
inhibitor
empagliflozin
significantly
improves
mortality
T2DM
patients
(EMPA-REG
trial).
Since
SGLT-2
is
known
be
expressed
on
cells
other
than
the
kidney
cells,
we
investigated
potential
ability
of
regulate
glucose
transport
alleviate
hyperglycaemia-induced
these
cells.Primary
human
monocytes
were
isolated
from
peripheral
blood
healthy
individuals.
Primary
umbilical
vein
endothelial
(HUVECs)
primary
coronary
artery
(HCAECs),
fetoplacental
(HPECs)
used
as
EC
model
cells.
Cells
exposed
hyperglycaemic
conditions
vitro
40
ng/mL
or
100
empagliflozin.
The
expression
levels
relevant
molecules
analysed
by
RT-qPCR
confirmed
FACS.
Glucose
uptake
assays
carried
out
with
a
fluorescent
derivative
glucose,
2-NBDG.
Reactive
oxygen
species
(ROS)
accumulation
was
measured
using
H2DFFDA
method.
Monocyte
chemotaxis
modified
Boyden
chamber
assays.Both
express
SGLT-2.
Hyperglycaemic
did
not
alter
ECs
conditions.
presence
GLUT
inhibitors
revealed
that
inhibition
very
mildly,
but
significantly,
suppressed
However,
detected
significant
suppression
ROS
when
inhibit
function.
readily
exhibited
impaired
behaviour.
co-treatment
reversed
PlGF-1
resistance
phenotype
monocytes.
Similarly,
blunted
VEGF-A
responses
also
restored
empagliflozin,
which
could
attributed
restoration
VEGFR-2
receptor
surface.
induction
completely
recapitulated
most
aberrant
phenotypes
general
antioxidant
N-acetyl-L-cysteine
(NAC)
able
mimic
effects
empagliflozin.This
study
provides
data
indicating
beneficial
role
reversing
dysfunction.
Even
though
both
functional
SGLT-2,
transporter
Therefore,
it
seems
likely
does
directly
prevent
hyperglycaemia-mediated
enhanced
glucotoxicity
inhibiting
uptake.
We
identified
reduction
reason
for
improved
function
In
conclusion,
reverses
independent
partially
its
effects.
Medicina,
Год журнала:
2024,
Номер
60(9), С. 1445 - 1445
Опубликована: Сен. 4, 2024
:
The
interrelationship
between
thyroid
function
and
the
state
of
cardiovascular
system
has
been
investigated
both
in
preclinical
human
studies.
However,
it
remains
unclear
whether
there
is
any
association
hormones
features
subclinical
dysfunction
euthyroid
patients.
Sensors,
Год журнала:
2024,
Номер
24(6), С. 1721 - 1721
Опубликована: Март 7, 2024
Arterial
blood
pressure
monitoring
plays
an
important
role
in
preventive
medicine,
allowing,
selected
cases,
the
identification
of
vascular
dysfunction.
In
this
review,
we
propose
a
new
non-invasive
approach
to
assessment
circulatory
system,
based
on
its
reaction
hypoxia
induced
by
post-occlusive
reactive
hyperemia
(PORH).
Three
key
parameters
can
be
used
for
screening:
Reactive
Hyperemia
Response
(RHR),
which
represents
overall
macro-
and
microcirculation
transient
hypoxia;
Hypoxia
Sensitivity
(HS),
reflects
hypoxia-induced
activation
myogenic
oscillations
microcirculation;
Normoxia
Oscillatory
Index
(NOI),
characterizes
microcirculatory
under
normoxia
conditions.
A
method
assessing
these
parameters,
analogous
simplicity
arterial
measurement,
is
provided
Flow
Mediated
Skin
Fluorescence
(FMSF)
technique.
Reference
values
are
proposed
numerous
test
measurements.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(9), С. 2686 - 2686
Опубликована: Май 2, 2024
Background:
Frailty
is
increasingly
recognized
as
a
significant
health
concern,
particularly
due
to
its
association
with
cardiovascular
pathologies.
This
study
aims
examine
how
vascular
endothelial
dysfunction,
known
premorbid
stage
in
the
pathophysiology
of
diseases,
contributes
link
between
illness
and
frailty.
Methods:
The
inclusion
criteria
allowed
us
focus
on
original
clinical
research
articles
published
English
January
2014
2024,
which
reported
quantitative
assessments
relationship
frailty
dysfunction.
Excluded
from
were
systematic
literature
reviews,
meta-analyses,
editorials,
conference
articles,
theses,
methodological
studies
using
animal
or
cell
culture
models.
Searches
conducted
electronic
databases,
including
Scopus,
ScienceDirect,
Medline,
up
22
2024.
risk
bias
was
assessed
Joanna
Briggs
Institute’s
critical
appraisal
tools.
methods
used
present
synthesize
results
involved
data
extraction
categorization
based
biomolecular
findings
Results:
Following
application
exclusion
criteria,
total
29
identified.
Vascular
dysfunction
associated
increased
phenotypes,
we
also
identified
SGLT-2
inhibitors’
potential
role
an
anti-fragility
treatment
that
affects
found
physical
markers
are
measures
have
predictive
value
for
incident
Furthermore,
some
shown
inflammation
impact
frailty,
innovative
age-related
chronic
measure
has
been
proven
predict
scores.
Conclusions:
current
evidence
suggests
highlighting
need
further
elucidate
underlying
mechanisms.
Medicina,
Год журнала:
2024,
Номер
60(5), С. 813 - 813
Опубликована: Май 15, 2024
Background
and
Objectives:
episodes
of
acute
decompensation
in
chronic
heart
failure
(ADHF),
a
common
health
problem
for
the
growing
elderly
population,
pose
significant
socio-economic
burden
on
public
systems.
Limited
knowledge
is
available
both
endothelial
function
cardio-metabolic
profile
old
adults
hospitalized
due
to
ADHF.
This
study
aimed
investigate
connection
between
asymmetric
dimethylarginine
(ADMA)—a
potent
inhibitor
nitric
oxide—and
key
biomarkers
this
category
high-risk
patients.
Materials
Methods:
pilot
included
83
individuals
with
known
ADHF
history
who
were
admitted
ICU
cardiac
decompensation.
Selected
cardiovascular,
metabolic,
haemogram,
renal,
liver
parameters
measured
at
admission
ICU.
Key
renal
indicators
(serum
creatinine,
sodium,
potassium)
determined
again
discharge.
These
compared
patients
stratified
by
median
ADMA
(114
ng/mL).
Results:
high
showed
significantly
higher
incidence
ischemic
cardiomyopathy
longer
length
hospital
stay
those
low
subjects.
exhibited
urea
creatinine
discharge,
indicating
poorer
function.
Moreover,
their
lipid
was
less
favorable,
elevated
levels
total
cholesterol
HDL.
However,
no
inter-group
differences
observed
other
measured.
Conclusions:
present
findings
disclose
multidimensional,
adverse
ADMA-related
changes
risk
recurrent
episodes.
