Опубликована: Янв. 1, 2024
Язык: Английский
Marine Drugs, Год журнала: 2024, Номер 22(2), С. 85 - 85
Опубликована: Фев. 11, 2024
In this study, we investigated for the first time anti-inflammatory and immunomodulatory properties of crude polysaccharide (PSHT) extracted from green marine algae Halimeda tuna. PSHT exhibited anti-oxidant activity in vitro through scavenging 1, 1-diphenyl-2-picryl hydroxyl free radical, reducing Fe3+/ferricyanide complex, inhibiting nitric oxide. maintained erythrocyte membrane integrity prevented hemolysis. Our results also showed that exerted a significant anti-edematic effect vivo by decreasing advanced oxidation protein products malondialdehyde levels increasing superoxide dismutase glutathione peroxidase activities rat’s paw model erythrocytes. Interestingly, increased viability murine RAW264.7 macrophages an on lipopolysaccharide-stimulated cells pro-inflammatory molecule levels, including oxide, granulocyte-macrophage colony-stimulating factor (GM-CSF) tumor necrosis factor-alpha (TNF-α). findings indicate could be used as potential immunomodulatory, anti-inflammatory, anti-hemolytic, agent. These explained computational showing building blocks bound both cyclooxygenase-2 (COX-2) TNF-α with acceptable affinities.
Язык: Английский
Процитировано
21
Marine Drugs, Год журнала: 2023, Номер 21(6), С. 323 - 323
Опубликована: Май 26, 2023
Polyphenols are compounds found in various plants and foods, known for their antioxidant anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols other minor nutrients that algae, fish crustaceans. These unique chemical structures exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial antitumor action. Due to these being investigated as possible agents treatment a wide variety conditions, such cardiovascular disease, diabetes, neurodegenerative diseases cancer. This review focuses on applications human health, also, phenolic classes, extraction methods, purification techniques future compounds.
Язык: Английский
Процитировано
39
Frontiers in Nutrition, Год журнала: 2023, Номер 10
Опубликована: Окт. 13, 2023
As the global population continues to grow, demand for dietary protein is rapidly increasing, necessitating exploration of sustainable and nutritious sources. Algae has emerged as a promising food source due their high value ingredients such proteins, well environmental sustainability abundance. However, knowledge gaps surrounding recommendations applications restrict algae’s utilization viable source. This review aims address these by assessing suitability both microalgae macroalgae alternative/complementary sources exploring potential in products. The first section examines algae major analyzing composition bioavailability key components algal biomass, including lipids, fiber, micronutrients. Secondly, biological effects algae, particularly impact on metabolic health are investigated with an emphasis available clinical evidence. While evidence reveals protective glucose lipid homeostasis anti-inflammatory properties, further research required understand longer-term consuming protein, isolates, concentrates health, metabolism. then explores proteins applications, ways overcome sensory limitations, dark pigmentation, taste, odor, order improve consumer acceptance. To maximize valuable sector, future should prioritize production more acceptable biomass explore new advances sciences technology improved Overall, this paper supports utility healthy ingredient widespread use production.
Язык: Английский
Процитировано
32
Marine Drugs, Год журнала: 2023, Номер 21(6), С. 328 - 328
Опубликована: Май 26, 2023
In this study, we characterized the bioactive properties of three important brown seaweed species, Sargassum thunbergii, Undaria pinnatifida, and Saccharina japonica, by subcritical water extraction (SWE), as these species are well known for their beneficial health effects. Their physiochemical properties, including potential antioxidant, antihypertensive, α-glucosidase inhibitory activity, antibacterial activity hydroysates were also analyzed. The highest total phlorotannin, sugar content, reducing content in S. thunbergii hydrolysates 38.82 ± 0.17 mg PGE/g, 116.66 0.19 glucose/g dry sample, 53.27 1.57 respectively. ABTS+ DPPH antioxidant activities obtained japonica (124.77 2.47 46.35 0.01 Trolox equivalent/g, respectively) FRAP was (34.47 0.49 equivalent/g seaweed). addition, extracts showed antihypertensive (≤59.77 0.14%) (≤68.05 1.15%), against foodborne pathogens. present findings provide evidence biological application food, pharmaceutical, cosmetic sectors.
Язык: Английский
Процитировано
25
Algal Research, Год журнала: 2023, Номер 77, С. 103357 - 103357
Опубликована: Дек. 12, 2023
Seaweeds are organisms rich in many bioactive compounds such as proteins, minerals, vitamins, fibers, essential amino acids, pigments, and fatty which give them extraordinary antihypertensive, antidiabetic, antioxidant, anti-inflammatory, antitumoral, antiviral, antimicrobial properties. Seaweed could potentially contribute to future global security functional foods nutraceuticals be an important compound the pharmaceutical biotechnological industries drug development, among other uses. This review focuses on gastronomic point of view discusses compositional nutritional characteristics, topics related consumption, current application technologies, limitations challenges production, market developments this rising market.
Язык: Английский
Процитировано
25
Опубликована: Фев. 27, 2024
The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to production is crucial. This review focuses on seaweed as a sustainable resource for greening processes. Seaweed offers advantages such renewability, abundance, and positive footprint. begins by providing an overview practices the challenges faced achieving sustainability. It then discusses resource, including cultivation techniques benefits. has various applications manufacturing, extracting purifying bioactive compounds with potential therapeutic properties. Seaweed’s role developing green technologies, seaweed-based excipients, biodegradable packaging materials, source energy processes, highlighted. economic implications incorporating solutions are discussed, emphasizing reduced carbon footprint cost-effectiveness. Regulatory industrial perspectives addressed, examining challenges, opportunities implementing manufacturing. Collaboration between academia, industry, regulatory bodies crucial successful integration. presents future directions opportunities, emerging trends innovations areas further research, policy development, industry engagement recommendations. Incorporating into facilitates reduction impact, promotes efficiency, contributes showcases means foster greener addressing concerns, promoting
Язык: Английский
Процитировано
12
Foods, Год журнала: 2023, Номер 12(19), С. 3642 - 3642
Опубликована: Окт. 1, 2023
In a few Southeast Asian nations, seaweeds have been staple of the cuisine since prehistoric times. Seaweeds are currently becoming more and popular around world due to their superior nutritional value medicinal properties. This is because rising seaweed production on global scale substantial research composition bioactivities over past 20 years. By reviewing several articles in literature, this review aimed provide comprehensive information about primary secondary metabolites various classes bioactive compounds, such as polysaccharides, polyphenols, proteins, essential fatty acids, along with bioactivities, single article. also highlights potential development nutraceuticals, particular focus ability enhance human health overall well-being. addition, we discuss challenges opportunities associated advancement pharmaceuticals nutraceuticals derived from seaweeds, well incorporation into different industrial sectors. Furthermore, find that many constituents found demonstrated terms therapeutic attributes, including antioxidative, anti-inflammatory, anticancer, other conclusion, seaweed-based compounds huge play an important role food, nutraceutical, pharmaceutical However, future should pay attention developing efficient techniques for extraction purification toxicity analysis, clinical efficacy, mode action, interactions regular diets.
Язык: Английский
Процитировано
19
Marine Drugs, Год журнала: 2024, Номер 22(5), С. 226 - 226
Опубликована: Май 17, 2024
Utilizing plant-based resources, particularly their by-products, aligns with sustainability principles and circular bioeconomy, contributing to environmental preservation. The therapeutic potential of plant extracts is garnering increasing interest, this study aimed demonstrate promising outcomes from an extract obtained underutilized waste. Chaetomorpha linum, invasive macroalga found in the Orbetello Lagoon, thrives eutrophic conditions, forming persistent mats covering approximately 400 hectares since 2005. biomass C. linum undergoes mechanical harvesting treated as waste, requiring significant human efforts economic resources—A critical concern for municipalities. Despite posing challenges local ecosystems, identified a natural source bioactive metabolites. Phytochemical characterization revealed lipids, amino acids, other compounds anti-inflammatory activity extract. In vitro assays LPS-stimulated RAW 264.7 TNF-α/IFN-γ-stimulated HaCaT cells showed inhibited reactive oxygen species (ROS), nitric oxide (NO), prostaglandin E2 (PGE2) productions, reduced inducible synthase (iNOS) cyclooxygenase-2 (COX-2) expressions via NF-κB nuclear translocation, cells. It also chemokines (TARC/CCL17, RANTES/CCL5, MCP-1/CCL2, IL-8) cytokine IL-1β production cells, suggesting candidate chronic diseases like atopic dermatitis. Finally, silico studies indicated palmitic acid contributor observed effect. This research not only uncovered untapped but laid foundation its integration into promoting sustainable practices, innovative applications across various industries.
Язык: Английский
Процитировано
7
Journal of Cleaner Production, Год журнала: 2024, Номер 453, С. 142191 - 142191
Опубликована: Апрель 10, 2024
In the pursuit of sustainability and circularity, this study aimed to develop a multi-purpose biorefinery pipeline using extracts from green seaweed Codium sp. transforming its post-extracted biomass into biochars, emphasizing holistic resource utilization. Five were evaluated, testing their antioxidant potential, cytotoxicity, photoprotective effects, anti-inflammatory activity, inhibitory capabilities against enzymes hyaluronidase, collagenase, elastase. The ethyl acetate extract showed highest values in ORAC assay, indicating activity. However, no relevant activity was observed FRAP DPPH assays for other extracts. hydroethanolic exhibited best anti-enzymatic capacity, inhibiting elastase by 88% at 200 μg/mL. It also demonstrated effect reduced ROS production (30%) induced UVB exposure. ethanol significantly concentration tumour necrosis factor-alpha (TNF-α) response LPS stimulation, converted biochars conventional slow pyrolysis, hydrothermal carbonization (HTC), acid-mediated (AMC). contained 56–75% C 22–30% O one synthesized HTC had textural development. biochar obtained AMC better performance improving soil water retention suggesting that acid surface chemistry plays more significant role than porosity. produced have potential as source valuable bioactive compounds biomaterials circular economy framework with wide-ranging applications.
Язык: Английский
Процитировано
5
The Yale Journal of Biology and Medicine, Год журнала: 2024, Номер 97(2), С. 205 - 224
Опубликована: Июнь 28, 2024
Neuroinflammation, toxic protein aggregation, oxidative stress, and mitochondrial dysfunction are key pathways in neurodegenerative diseases like Alzheimer's disease (AD). Targeting these mechanisms with antioxidants, anti-inflammatory compounds, inhibitors of Aβ formation aggregation is crucial for treatment. Marine algae rich sources bioactive including carbohydrates, phenolics, fatty acids, phycobiliproteins, carotenoids, vitamins. In recent years, they have attracted interest from the pharmaceutical nutraceutical industries due to their exceptional biological activities, which include anti-inflammation, antioxidant, anticancer, anti-apoptosis properties. Multiple lines evidence unveiled potential neuroprotective effects multifunctional algal compounds application treating managing AD. This article will provide insight into molecular underlying derived based on vitro vivo models neuroinflammation We also discuss as disease-modifying symptomatic treatment strategies AD.AD.Open a separate windowGraphical Abstract.
Язык: Английский
Процитировано
5