CD8 + T-cell marker genes reveal different immune subtypes of oral lichen planus by integrating single-cell RNA-seq and bulk RNA-sequencing

BMC Oral Health, Год журнала: 2023, Номер 23(1)

Опубликована: Июль 8, 2023

Oral lichen planus (OLP) is a local autoimmune disease induced by T-cell dysfunction that frequently affects middle-aged or elderly people, with higher prevalence in women. CD8 + T cells, also known as killer play an important role the progression and persistence of OLP. In order to identify different OLP subtypes associated cell pathogenesis, consensus clustering was used.In this study, we preprocessed downscaled single-cell dataset GSE211630 cohort downloaded from Gene Expression Omnibus (GEO) finally obtain marker genes cells. Based on expression genes, classified patients into CMGs using unsupervised analysis. The gene profiles were analyzed WGCNA "WGCNA" R package based clinical traits typing results, 108 related pathogenicity-related obtained intersection. Patients once again intersection analysis.After obtaining intersecting cells can be precisely two analysis, subtype B has better immune infiltration providing clinicians reference for personalized treatment.Classification improve our current understanding underlying pathogenesis provides new insights future studies.

Язык: Английский

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Ozone Therapy in Medicine and Dentistry: A Review of the Literature

Dentistry Journal, Год журнала: 2023, Номер 11(8), С. 187 - 187

Опубликована: Авг. 7, 2023

Ozone has been successfully used in medicine for over 100 years due to its microbiological qualities. Its powerful oxidation impact, which results the production of free radicals, and ability cause direct death nearly all microorganisms is basis bactericide, virucide, fungicide properties. also a medicinal impact that speeds up blood flow aids wound healing. may be applied as gas or dissolved water medical purposes. Despite benefits using ozone therapeutically, concerns about use dentistry still exist. We aimed provide summary current uses dentistry. An electronic search was performed English scientific papers published between 2012 2023 PubMed, Cochrane, Google Scholar engines. Ozone, clinical applications, medicine, were terms used. Seventy full-text articles describing therapy included present review. shown several beneficial effects field. However, despite encouraging vitro evidence, not yet demonstrated highly effective.

Язык: Английский

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What can we learn from treatments of oral lichen planus?

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Фев. 15, 2024

Oral lichen planus (OLP), a T-lymphocyte-mediated disease of the oral mucosa, has complex pathogenesis that involves number factors. The is characterized by recurrent episodes and requires continuous follow up, there no curative treatment available. Erosive planus, among others, risk malignant transformation standardized to control its progression. Different clinical subtypes require appropriate treatment. Pharmacological treatments are most widely available have greatest variety options novel pharmacological presented as highlights, including JAK enzyme inhibitors. second photodynamic therapy, which leading physiological In addition, periodontal psychological should not be neglected. this review, we briefly discuss recent developments in therapies for after summarizing used treatments, aiming provide different proposals future

Язык: Английский

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Integrative Approaches for the Diagnosis and Management of Erosive Oral Lichen Planus

Diagnostics, Год журнала: 2024, Номер 14(7), С. 692 - 692

Опубликована: Март 26, 2024

Erosive oral lichen planus (EOLP) represents a significant challenge in dental and medical management due to its chronic inflammatory nature, painful symptoms, impact on quality of life. This study aims evaluate the current diagnostic approach with novel non-invasive techniques, such as dermoscopy, also landscape treatment options for EOLP, focusing efficacy, safety, challenges that it present clinical practice. Through comprehensive literature review, we explored use topical corticosteroids, systemic immunosuppressants, biologics, Janus kinase (JAK) inhibitors treating alongside examining patient compliance, psychological impacts, risk adverse effects recurrence. Our findings reveal while corticosteroids are cornerstone EOLP treatment, offering symptomatic relief, their long-term is limited by side tolerance development. Systemic therapies biologics provide alternatives refractory cases but necessitate careful effect monitoring. JAK show promise an innovative avenue require more evidence safety efficacy. highlights necessity personalized approaches variable disease course response underscoring importance multidisciplinary strategy managing EOLP. The complexity compounded life demands ongoing research into targeted therapies, establishment standardized protocols, development effective outcome measures improve care outcomes.

Язык: Английский

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Impact of diabetes mellitus on patients affected by oral lichen planus: a retrospective study

Frontiers in Oral Health, Год журнала: 2025, Номер 6

Опубликована: Март 31, 2025

Introduction The association between diabetes mellitus (DM) and oral lichen planus (OLP) has been widely reported. However, most of the studies focused on epidemiological aspects shared inflammatory pathways, with few exploring consequences this clinical course OLP. study aims to retrospectively observe impact DM presentation management strategy Methods A total 97 OLP patients were retrieved from Department database. distributed into two groups: “test group” ( n = 47) without “control 50). descriptive statistical analyses performed variables related OLP, general demographic information. Results Regarding primary outcomes variables, symptomatic more susceptible present atrophic lesions at first visit, compared those a significance p 0.0017 0.0016 respectively). Buccal mucosa was generally affected site in both groups notably higher 0.0286). subjected number follow-ups per year 0.0420), prescribed treatments 0.0006), non-cortisone-based 0.0001). In regard secondary statistically significant difference observed concomitant diseases, where diseases 0.0321), particularly cardiopathy 0.0422), arterial hypertension 0.0418), dyslipidemia 0.0411), coagulopathy 0.0411). Discussion highly presented showed treatment prescriptions needed. It seems that clinician should consider as an essential co-factor may influence procedures Considering interdisciplinary involving endocrinologists add value process.

Язык: Английский

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Inefficacy of treatment modalities of oral lichen planus: Evidence-based results

Oral Oncology Reports, Год журнала: 2024, Номер 9, С. 100165 - 100165

Опубликована: Фев. 6, 2024

Oral lichen planus (OLP) manifests as various clinical forms in the oral cavity. Majority of these are symptomatic, and it gradually impedes quality life OLP patients. Long-term untreated symptoms increases malignant transformation rate. Hence, many studies have investigated reported efficacy therapeutic agents managing OLP. For further clarity on effectiveness a agent, we analyzed systematic reviews (SR) which compared different pharmaceutical non-pharmaceutical relieving A total 45 SR was retrieved. Out 8 were selected included comparison all possible for pain reduction resolution The evidence from demonstrated mixed results. There is still insufficient unreliable to support superiority any specific treatment regime with regards its even lack unanimity regarding guideline RCTs required. It strongly evident that existing interventions ineffective treating symptomatic

Язык: Английский

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Molecular docking analysis of major active compounds of pomegranate peel extract (Punica granatum L.) in inhibiting cyclooxygenase enzyme

World Journal of Advanced Research and Reviews, Год журнала: 2023, Номер 20(3), С. 1824 - 1842

Опубликована: Дек. 30, 2023

Background: Inflammation is the body's physiological response to an injury. Injury that affected body can be a chemical agent, physical, or biological agent. Nowadays inflammatory condition treated by eliminating main etiological factor then prescribing anti-inflammatory drugs such as NSAIDs, but according data in 2021 shown 78,8% patients has gastritis side effect. Pomegranate peel extract (PPE) good ability because it containing highest concentration of flavonoid. Objectives: To predict molecular inhibition major active compounds (epigallocatachin gallate, ferulic acid, chlorogenic gallic caffeic cianidanol, epicatechin, and punicalagin) PPE against cyclooxygenase enzyme (COX-1 & COX-2) using silico study. Method: Preparation PPE, prediction their activity, ADMET predicting test, physicochemical docking simulation. Results discussions: In test showed all common compound have potential drugs. All MAC had value Pa > 0.5. distribute systemically score log mucosal permeability < 2.5. negative not toxic triggering dermatitis contact oral mucosa through prediction. The result acid punicalagin protein COX-2 ∆Gbind more than mefenamic arachidonic COX-1 range -3,0 -9,1 kcal/mol which most effective (-4,0 kcal/mol). Conclusion: with best anti-inflammation ferrulic punicalagin.

Язык: Английский

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Genetic Revelation of the Potentially Malignant Disorders in the Oral and Maxillofacial Region

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Апрель 18, 2024

The oral and maxillofacial region is the site of numerous cancer forms. most frequent cancer, which accounts for more than 90% these tumors, squamous cell carcinoma. Genetic changes caused by malignant transformation later result in phenotypic cells. Potentially disorders circumstances can lead to development some malignancies, such as carcinomas (OSCCs). Because OSCC precursor lesions cannot be detected early, 5-year survival rate still only about 50%. Early detection particularly premalignant stage, greatly reduce death morbidity. clinical, histological revelations etiopathogenesis a few potentially are reviewed this chapter.

Язык: Английский

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Evaluation of clinical and demographical finding in patients with oral lichen planus: A retrospective cross sectional study

Wiadomości Lekarskie, Год журнала: 2024, Номер 77(5), С. 1025 - 1032

Опубликована: Янв. 1, 2024

Aim: To learn more about Oral Lichen Planus Iraqi patients, including their background information, symptoms, and prognosis. Materials Methods: From the Maxillofacial Pathology Department, College of Dentistry, Baghdad University, we retrospectively reviewed medical records 68 patients with a histologically confirmed clinical diagnosis oral lichen planus subsequently contacted by phone to evaluate Results: Females were likely than males experience severe pain; reticular form was most prevalent at 38.2%, but erosive type among females. Only 53 responded calls. More 37% those respondents reported involvement second location intra-orally following first manifestation, 20% had extraoral Planus, approximately 22.6% them observed changes in morphology behavior lesion after brief period time, while 26.4% experienced complete remission. Conclusions: have planus. elderly persons pain other. The must be monitored for symptomatic flare-ups over time.

Язык: Английский

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Synthesis and Structural Characterization of Novel Dimers of Dipyridothiazine as Promising Antiproliferative Agents

Molecules, Год журнала: 2023, Номер 28(22), С. 7662 - 7662

Опубликована: Ноя. 19, 2023

Many new isomeric dipyridothiazine dimers have been presented as molecules with anticancer potential. These compounds were obtained in efficient syntheses of 1,6-, 1,8-, 2,7- and 3,6-diazaphenothiazines selected alkylaromatic linkers. The structures these has proven two-dimensional spectroscopic techniques (COSY, NOESY, HSQC HMBC) high-resolution mass spectrometry (HRMS). In silico analyses probable molecular targets performed using the Way2Drug server. All tested for activity against breast cancer line MCF7 colon SW480. Cytotoxicity was assessed on normal L6 muscle cells. had high potential expressed IC50 selectivity index SI. most active derivative, 4c, showed an less than 1 µM SI higher 100. Moreover, characterized by low toxicity towards cells, simultaneously indicating a cytostatic

Язык: Английский

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