Frontiers in Psychiatry,
Год журнала:
2021,
Номер
12
Опубликована: Май 21, 2021
The
microbiota–gut–brain
axis
plays
a
critical
role
in
the
pathogenesis
of
major
depressive
disorder
(MDD)
and
related
subclinical
symptoms.
However,
studies
on
gut
microbiota
MDD
are
inconsistent,
data
MDD's
effects
sleep
lacking.
This
study
aimed
to
analyze
composition
quality
patients
with
MDD.
We
performed
16S
rRNA
sequencing
stool
samples
from
36
45
healthy
controls
(HC).
Sleep
was
assessed
using
Pittsburgh
Quality
Index,
severity
Hamilton
Depression
Scale,
insomnia
Insomnia
Severity
Index.
Forty-eight
targets
showed
significant
differences
between
HC.
In
MDD,
six
were
associated
depression,
11
quality,
3
severity.
At
genus
level,
Dorea
simultaneously
depression
while
Intestinibacter
more
closely
problems.
Coprococcus
independent
depression.
conclusion,
present
findings
enable
better
understanding
relationship
MDD-related
Gut
alterations
may
become
potential
biomarkers
and/or
treatment
for
Annals of Medicine,
Год журнала:
2020,
Номер
52(8), С. 423 - 443
Опубликована: Авг. 10, 2020
As
individuals
age,
the
prevalence
of
neurocognitive
and
mental
health
disorders
increases.
Current
biomedical
treatments
do
not
completely
address
management
these
conditions.
Despite
new
pharmacological
therapy
challenges
managing
diseases
remain.There
is
increasing
evidence
that
Gut
Microbiome
(GM)
microbial
dysbiosis
contribute
to
some
more
prevalent
disorders,
such
as
depression,
anxiety,
obsessive-compulsive
disorder
(OCD),
post-traumatic
stress
(PTSD),
schizophrenia,
bipolar
(BP),
dementia
well
behavioural
psychological
symptoms
(BPSD)
through
microbiota-gut-brain
axis.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(4), С. 1640 - 1640
Опубликована: Фев. 6, 2021
Treatment
of
depression
is
hampered
by
the
failure
to
identify
distinct
symptom
profiles
with
pathophysiologies
that
differentially
respond
treatments.
We
posit
inflammatory
a
meaningful
subtype
associated
specific
symptoms
and
biological
abnormalities.
review
several
upstream,
potentially
causative,
mechanisms
driving
low-grade
inflammation
in
this
depression.
also
discuss
downstream
mediating
link
between
depression,
including
alterations
dopaminergic
neurotransmission
tryptophan
metabolism.
Finally,
we
evidence
for
non-pharmacological
interventions
probiotics,
omega-3
fatty
acids,
physical
exercise
interventions.
While
some
suggests
these
may
be
efficacious
future
clinical
trials
should
consider
enriching
patient
populations
markers,
or
stratify
patients
status,
confirm
refute
hypothesis.
Biomedicine & Pharmacotherapy,
Год журнала:
2020,
Номер
131, С. 110679 - 110679
Опубликована: Авг. 25, 2020
Bupleuri
Radix
(BR)
is
the
dry
root
of
Bupleurum
chinense
DC.
and
scorzonerifolium
Willd.
It
has
functions
evacuation
antipyretic,
soothing
liver
relieving
depression
often
used
to
treat
cold
fever,
chest
rib
swelling
pain,
irregular
menstruation,
uterine
prolapse,
rectocele
other
diseases.
In
this
paper,
botany,
traditional
application,
phytochemistry,
pharmacology
toxicity
BR
were
reviewed.
On
basis
limited
literature,
analytical
method,
quality
control,
processing
effect
pharmacokinetics
summarized
analyzed
for
first
time.
This
review
makes
an
in-depth
discussion
on
shortcomings
current
research
BR,
puts
forward
its
own
views
solutions.
never
been
in
previous
BR.
great
practical
significance
future
scholars
find
a
breakthrough
point
study
So
far,
mechanism
not
satisfactorily
explained.
Moreover,
comprehensive
evaluation
multi-target
network
need
be
further
studied.
future,
more
vitro
vivo
experiments
are
needed
give
full
play
therapeutic
potential
Atypical
antipsychotics,
also
known
as
second-generation
are
commonly
prescribed
treatment
for
psychotic
disorders
in
adults,
well
children
and
adolescents
with
behavioral
problems.
However,
many
cases,
antipsychotics
have
unwanted
side
effects,
such
weight
gain,
potentially
further
increasing
risk
morbidities
including
obesity,
diabetes,
cardiovascular
disease.
While
various
mechanisms
this
gain
been
proposed,
effects
on
metabolic
hormone
signaling,
recent
evidence
points
to
the
importance
of
gut
microbiome
process.
The
microbial
communities
residing
within
affected
by
can
confer
gain.
This
review
summarizes
findings
presents
data
linking
microbiota
alterations
focuses
adolescent
populations,
which
not
previously
received
much
attention,
but
great
interest
because
they
may
be
most
vulnerable
changes
carry
long-term
into
adulthood.
We
present
correlations
between
suggest
some
that
link
them.
A
better
understanding
underlying
lead
design
improved
treatments
fewer
harmful
effects.
Frontiers in Psychiatry,
Год журнала:
2021,
Номер
12
Опубликована: Май 21, 2021
The
microbiota–gut–brain
axis
plays
a
critical
role
in
the
pathogenesis
of
major
depressive
disorder
(MDD)
and
related
subclinical
symptoms.
However,
studies
on
gut
microbiota
MDD
are
inconsistent,
data
MDD's
effects
sleep
lacking.
This
study
aimed
to
analyze
composition
quality
patients
with
MDD.
We
performed
16S
rRNA
sequencing
stool
samples
from
36
45
healthy
controls
(HC).
Sleep
was
assessed
using
Pittsburgh
Quality
Index,
severity
Hamilton
Depression
Scale,
insomnia
Insomnia
Severity
Index.
Forty-eight
targets
showed
significant
differences
between
HC.
In
MDD,
six
were
associated
depression,
11
quality,
3
severity.
At
genus
level,
Dorea
simultaneously
depression
while
Intestinibacter
more
closely
problems.
Coprococcus
independent
depression.
conclusion,
present
findings
enable
better
understanding
relationship
MDD-related
Gut
alterations
may
become
potential
biomarkers
and/or
treatment
for
