Mitochondrial dysfunction in metabolic syndrome

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2020, Номер 1866(10), С. 165838 - 165838

Опубликована: Май 16, 2020

Язык: Английский

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Polyphenols in Metabolic Diseases

Molecules, Год журнала: 2022, Номер 27(19), С. 6280 - 6280

Опубликована: Сен. 23, 2022

Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo vitro, as well reported clinical studies. Considering their free-radical scavenging anti-inflammatory these substances can be used to treat different kinds conditions associated metabolic disorders. Many symptoms syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, cancer neurodegenerative disorders, substantially relieved by dietary PPs. The present study explores the bioprotective properties underlying mechanisms A detailed understanding natural compounds will open up new opportunities for producing unique PP-rich medicinal plans, ultimately affirming benefits.

Язык: Английский

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Possible Mechanisms of Oxidative Stress-Induced Skin Cellular Senescence, Inflammation, and Cancer and the Therapeutic Potential of Plant Polyphenols

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3755 - 3755

Опубликована: Фев. 13, 2023

As the greatest defense organ of body, skin is exposed to endogenous and external stressors that produce reactive oxygen species (ROS). When antioxidant system body fails eliminate ROS, oxidative stress initiated, which results in cellular senescence, inflammation, cancer. Two main possible mechanisms underlie stress-induced One mechanism ROS directly degrade biological macromolecules, including proteins, DNA, lipids, are essential for cell metabolism, survival, genetics. Another one mediate signaling pathways, such as MAPK, JAK/STAT, PI3K/AKT/mTOR, NF-κB, Nrf2, SIRT1/FOXO, affecting cytokine release enzyme expression. natural antioxidants, plant polyphenols safe exhibit a therapeutic potential. We here discuss detail potential selected polyphenolic compounds outline relevant molecular targets. Polyphenols study according their structural classification include curcumin, catechins, resveratrol, quercetin, ellagic acid, procyanidins. Finally, latest delivery (taking curcumin an example) current status clinical research summarized, providing theoretical foundation future generation new pharmaceuticals cosmetics.

Язык: Английский

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Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3370 - 3370

Опубликована: Март 16, 2024

Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had renewed interest in natural-products-based drug discovery. The quest new potential secondary metabolites or enhanced activities existing molecules remains pertinent topic research. Resveratrol belongs to the stilbenoid polyphenols group that encompasses two phenol rings linked by ethylene bonds. Several plant species and foods, including grape skin seeds, are primary of this compound. is known possess potent anti-inflammatory, antiproliferative, immunoregulatory properties. Among notable bioactivities associated with resveratrol, its pivotal role safeguarding intestinal barrier highlighted capacity prevent inflammation regulate gut microbiome. A better understanding how oxidative stress can be controlled using resveratrol capability protect microbiome perspective shed more light on physiological conditions. Additionally, exhibits antitumor activity, proving cancer treatment prevention. Moreover, cardioprotective, vasorelaxant, phytoestrogenic, neuroprotective benefits also reported. pharmaceutical industry continues encounter difficulties administering owing inadequate bioavailability poor solubility, which must addressed simultaneously. This report summarizes currently available literature unveiling pharmacological effects resveratrol.

Язык: Английский

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Effects of the Mediterranean Diet on the Components of Metabolic Syndrome Concerning the Cardiometabolic Risk

Nutrients, Год журнала: 2025, Номер 17(2), С. 358 - 358

Опубликована: Янв. 20, 2025

Metabolic syndrome is a cluster of risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia (intended as an increase in triglyceride levels and reduction HDL cholesterol levels), elevated fasting glucose, that the cardiovascular disease type 2 diabetes. With rising prevalence metabolic syndrome, effective dietary interventions are essential reducing these health risks. The Mediterranean diet, rich fruits, vegetables, whole grains, legumes, nuts, olive oil moderate fish poultry, has shown promise addressing its associated components. This diet’s anti-inflammatory antioxidant properties, primarily due to unsaturated fats, polyphenols, fiber, have improved blood pressure, lipid levels, sensitivity. Adherence diet been linked reductions central obesity both key elements managing syndrome. Regarding management, lowers low-density lipoprotein (LDL) while raising high-density (HDL) cholesterol, enhancing profiles. It also helps regulate glucose likelihood developing Additionally, promotes weight loss improves body composition, particularly by decreasing visceral fat, primary driver according IDF classification. offers holistic approach related chronic diseases. Its positive impact on health, combined with lifestyle changes like increased physical activity, provides sustainable method for global burden this review aimed summarize effects component subsequent cardiometabolic profile.

Язык: Английский

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Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update

Antioxidants, Год журнала: 2019, Номер 8(8), С. 244 - 244

Опубликована: Июль 25, 2019

In recent years, a great deal of attention has been paid to natural compounds due their many biological effects. Polyphenols are class plant derivatives that have widely investigated for preventing and treating oxidative stress-related pathological conditions, such as neurodegenerative cardiovascular diseases, cancer, diabetes mellitus inflammation. Among these polyphenols, resveratrol (RSV) attracted considerable interest owing its high antioxidant free radical scavenging activities. However, the poor water solubility rapid metabolism RSV lead low bioavailability, thus limiting clinical efficacy. After discussing main biochemical mechanisms involved in activities, this review will focus on strategies attempted improve effectiveness, both systemic topical administration. particular, technological approaches involving incorporation into different delivery systems liposomes, polymeric lipid nanoparticles, microemulsions cyclodextrins be illustrated, highlighting potential applications. addition, chemical modifications aimed at improving physicochemical properties described along with results vitro vivo studies.

Язык: Английский

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Mitochondrial dysfunction in nonalcoholic fatty liver disease and alcohol related liver disease

Translational Gastroenterology and Hepatology, Год журнала: 2020, Номер 6, С. 4 - 4

Опубликована: Ноя. 25, 2020

Fatty liver disease constitutes a spectrum of diseases which begin with simple steatosis and may progress to advance stages steatohepatitis, cirrhosis, hepatocellular carcinoma (HCC). The two main etiologies are-alcohol related fatty (ALD) nonalcoholic (NAFLD). NAFLD is global health epidemic strongly associated modern dietary habits life-style. It the second most common cause chronic in US after hepatitis C virus (HCV) infection. Approximately 100 million people are affected this condition alone. Excessive intakes calories, saturated fat refined carbohydrates, sedentary life style have led explosion developing nations as well. ALD third US. Even though predominant trigger for onset different these conditions, they share themes progression from stages. Oxidative stress (OS) considered very significant contributor hepatocyte injury conditions. Mitochondrial dysfunction contributes OS. Role mitochondrial pathogenesis emerging but far completely understood. A better understanding essential more effective preventive therapeutic interventions. Here, we discuss approaches perspective.

Язык: Английский

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Epigenetics, microRNA and Metabolic Syndrome: A Comprehensive Review

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(9), С. 5047 - 5047

Опубликована: Май 10, 2021

Epigenetics refers to the DNA chemistry changes that result in modification of gene transcription and translation independently underlying coding sequence. Epigenetic modifications are reported involve various molecular mechanisms, including classical epigenetic affecting methylation histone small RNA-mediated processes, particularly microRNAs. reversible closely interconnected. They recognised play a critical role as mediators regulation, any alteration these mechanisms has been identified mediate pathophysiological conditions. Moreover, genetic predisposition environmental factors, dietary alterations, lifestyle or metabolic status, interact with human epigenome, highlighting importance factors processes aetiology diseases such MetS. This review will reflect on how both microRNA-regulated associated pathophysiology syndrome. We then focus aspects epigenetic-based strategies used modify MetS outcomes, diet, drugs, epigenome editing tools miRNA-based therapies.

Язык: Английский

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Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2/Keap1/SLC7A11 pathway in a microglia cell line

Pathology - Research and Practice, Год журнала: 2021, Номер 225, С. 153576 - 153576

Опубликована: Авг. 12, 2021

Язык: Английский

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Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies

Antioxidants, Год журнала: 2023, Номер 12(6), С. 1163 - 1163

Опубликована: Май 27, 2023

Mitochondrial fission is a crucial process in maintaining metabolic homeostasis normal physiology and under conditions of stress. Its dysregulation has been associated with several diseases, including, but not limited to, obesity, type 2 diabetes (T2DM), cardiovascular diseases. Reactive oxygen species (ROS) serve vital role the genesis these conditions, mitochondria are both main sites ROS production primary targets ROS. In this review, we explore physiological pathological roles mitochondrial fission, its regulation by dynamin-related protein 1 (Drp1), interplay between health We also discuss potential therapeutic strategies targeting through antioxidant treatments for ROS-induced including effects lifestyle interventions, dietary supplements, chemicals, such as division inhibitor-1 (Mdivi-1) other inhibitors, well certain commonly used drugs This review highlights importance understanding approach to protecting against conditions.

Язык: Английский

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