Antioxidants,
Год журнала:
2023,
Номер
12(4), С. 903 - 903
Опубликована: Апрель 10, 2023
In
the
current
review,
we
focused
on
identifying
aliment
compounds
and
micronutrients,
as
well
addressed
promising
bioactive
nutrients
that
may
interfere
with
NAFLD
advance
ultimately
affect
this
disease
progress.
regard,
targeted:
1.
Potential
NAFLD,
specifically
dark
chocolate,
cocoa
butter,
peanut
butter
which
be
involved
in
decreasing
cholesterol
concentrations.
2.
The
role
of
sweeteners
used
coffee
other
frequent
beverages;
sense,
stevia
has
proven
to
adequate
for
improving
carbohydrate
metabolism,
liver
steatosis,
fibrosis.
3.
Additional
were
shown
exert
a
beneficial
action
namely
glutathione,
soy
lecithin,
silymarin,
Aquamin,
cannabinoids
lower
serum
concentration
triglycerides.
4.
effects
especially
vitamins,
NAFLD.
Even
if
most
studies
demonstrate
vitamins
pathology,
there
are
exceptions.
5.
We
provide
information
regarding
modulation
activity
some
enzymes
related
their
effect
disease.
conclude
can
prevented
or
improved
by
different
factors
through
involvement
signaling,
genetic,
biochemical
pathways
underlie
Therefore,
exposing
vast
knowledge
public
is
particularly
important.
Molecules,
Год журнала:
2022,
Номер
27(19), С. 6613 - 6613
Опубликована: Окт. 5, 2022
Aging
is
characterized
by
an
imbalance
between
damage
inflicted
reactive
oxygen
species
(ROS)
and
the
antioxidative
defenses
of
organism.
As
a
significant
nutritional
factor,
trace
element
selenium
(Se)
may
remodel
gradual
spontaneous
physiological
changes
caused
oxidative
stress,
potentially
leading
to
disease
prevention
healthy
aging.
Se
involved
in
improving
antioxidant
defense,
immune
functions,
metabolic
homeostasis.
An
inadequate
status
reduce
human
life
expectancy
accelerating
aging
process
or
increasing
vulnerability
various
disorders,
including
immunity
dysfunction,
cancer
risk.
This
review
highlights
available
studies
on
effective
role
mechanisms
shows
potential
clinical
implications
related
its
consumption.
The
main
sources
organic
advantages
nanoformulations
were
also
discussed.
Molecules,
Год журнала:
2022,
Номер
27(20), С. 7084 - 7084
Опубликована: Окт. 20, 2022
Aging
is
a
very
complex
process
that
accompanied
by
degenerative
impairment
in
many
of
the
major
functions
human
body
over
time.
This
inevitable
influenced
hereditary
factors,
lifestyle,
and
environmental
influences
such
as
xenobiotic
pollution,
infectious
agents,
UV
radiation,
diet-borne
toxins,
so
on.
Many
external
internal
signs
symptoms
are
related
with
aging
senescence,
including
skin
dryness
wrinkles,
atherosclerosis,
diabetes,
neurodegenerative
disorders,
cancer,
etc.
Oxidative
stress,
consequence
imbalance
between
pro-
antioxidants,
one
main
provoking
factors
causing
aging-related
damages
concerns,
due
to
generation
highly
reactive
byproducts
oxygen
nitrogen
species
during
metabolism,
which
result
cellular
damage
apoptosis.
Antioxidants
can
prevent
these
processes
extend
healthy
longevity
ability
inhibit
formation
free
radicals
or
interrupt
their
propagation,
thereby
lowering
level
oxidative
stress.
review
focuses
on
supporting
antioxidant
system
organism
balancing
diet
through
consumption
necessary
amount
natural
ingredients,
vitamins,
minerals,
polyunsaturated
fatty
acids
(PUFA),
essential
amino
acids,
probiotics,
plants’
fibers,
nutritional
supplements,
polyphenols,
some
phytoextracts,
drinking
water.
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2536 - 2536
Опубликована: Март 10, 2023
Polyphenols
are
an
important
component
of
plant-derived
food
with
a
wide
spectrum
beneficial
effects
on
human
health.
For
many
years,
they
have
aroused
great
interest,
especially
due
to
their
antioxidant
properties,
which
used
in
the
prevention
and
treatment
diseases.
Unfortunately,
as
any
chemical
substance,
depending
conditions,
dose,
interactions
environment,
it
is
possible
for
polyphenols
also
exert
harmful
effects.
This
review
presents
comprehensive
current
state
knowledge
negative
impact
health,
describing
side
polyphenol
intake,
form
supplements.
The
begins
brief
overview
physiological
role
potential
use
disease
prevention,
followed
by
exerted
particular
situations.
individual
chapters
discuss
consequences
polyphenols’
ability
block
iron
uptake,
some
subpopulations
can
be
harmful,
well
inhibition
digestive
enzymes,
intestinal
microbiota,
polyphenolic
compounds
drugs,
hormonal
balance.
Finally,
prooxidative
activity
mutagenic,
carcinogenic,
genotoxic
presented.
According
authors,
there
need
raise
public
awareness
about
supplementation,
case
vulnerable
subpopulations.
Compounds,
Год журнала:
2023,
Номер
3(1), С. 40 - 72
Опубликована: Янв. 5, 2023
Polyphenolic
compounds
(PC)
are
among
the
most
abundant
secondary
metabolites
in
nature.
They
widely
distributed
world
and
can
be
found
fruits,
cereals,
tea,
coffee,
beverages.
Due
to
their
structural
diversity,
polyphenols
have
many
different
properties
biological
effects.
resistant
acid
of
gastric
tract,
very
few
hydrolysed
or
absorbed
stomach.
Significant
portions
ingested
reach
large
intestine
interact
with
local
bacteria,
so-called
gut
microbiota.
Epidemiological
studies
confirm
that
moderate
prolonged
intake
foods
rich
could
prevent
development
cancer
chronic
diseases,
such
as
cardiovascular,
neurodegenerative,
type
2
diabetes,
obesity.
The
current
work
aims
provide
an
updated
overview
on
nature
occurrence
polyphenols,
quantification
methods,
bioaccessibility
bioavailability,
impact
human
health,
namely
through
interactions
Molecules,
Год журнала:
2022,
Номер
27(24), С. 8777 - 8777
Опубликована: Дек. 11, 2022
Polyphenols
are
secondary
metabolites
produced
by
plants,
which
contribute
to
the
plant’s
defense
against
abiotic
stress
conditions
(e.g.,
UV
radiation
and
precipitation),
aggression
of
herbivores,
plant
pathogens.
Epidemiological
studies
suggest
that
long-term
consumption
polyphenols
protects
cardiovascular
disease,
cancer,
osteoporosis,
diabetes,
neurodegenerative
diseases.
Their
structural
diversity
has
fascinated
confronted
analytical
chemists
on
how
carry
out
unambiguous
identification,
exhaustive
recovery
from
plants
organic
waste,
define
their
nutritional
biological
potential.
The
food,
cosmetic,
pharmaceutical
industries
employ
fruits
vegetables
produce
additives,
additional
foods,
supplements.
In
some
cases,
nanocarriers
have
been
used
protect
during
food
processing,
solve
issues
related
low
water
solubility,
transport
them
site
action,
improve
bioavailability.
This
review
summarizes
structure-bioactivity
relationships,
processing
parameters
impact
polyphenol
stability
bioavailability,
research
progress
in
nanocarrier
delivery,
most
innovative
methodologies
for
agri-waste
materials.
Pharmacological Research,
Год журнала:
2023,
Номер
193, С. 106812 - 106812
Опубликована: Июнь 2, 2023
Polyphenols,
also
known
as
phenolic
compounds,
are
chemical
substances
containing
aromatic
rings
well
at
least
two
hydroxyl
groups.
Natural
compounds
exist
widely
in
plants,
which
protect
plants
from
ultraviolet
radiation
and
other
insults.
Phenolic
have
superior
pharmacological
nutritional
properties
(antimicrobial,
antibacterial,
antiviral,
anti-sclerosis,
antioxidant,
anti-inflammatory
activities),
been
paid
more
attention
by
the
scientific
community.
Phenols
can
key
cellular
components
reactive
free
radical
damage,
is
mainly
due
to
their
property
activate
antioxidant
enzymes
alleviate
oxidative
stress
inflammation.
It
inhibit
or
isolate
oxygen
species
transfer
electrons
radicals,
thereby
avoiding
cell
damage.
has
a
regulatory
role
glucose
metabolism,
promising
prospect
prevention
intervention
of
diabetes.
prevents
cardiovascular
disease
regulating
blood
pressure
lipids.
Polyphenols
proliferation
affecting
Erk1/2,
CDK,
PI3K/Akt
signaling
pathways.
function
enhancers
intrinsic
defense
systems,
including
superoxide
dismutase
(SOD)
glutathione
peroxidase
(GPX).
Simultaneously,
they
modulate
multiple
proteins
transcription
factors,
making
them
candidates
investigation
anti-cancer
medications.
This
review
focuses
on
aspects
substances,
natural
origins,
production
process,
disinfection
activity,
functions,
effects
different
tumors.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(4), С. 528 - 528
Опубликована: Апрель 1, 2023
The
immune
system
protects
the
body
from
infectious
agents
such
as
bacteria,
viruses,
or
fungi.
Once
encountered
with
pathogens
antigens,
innate
and
adaptive
arms
of
trigger
a
strong
response
to
eliminate
them
protect
body.
Thus,
well-balanced
immunity
is
pivotal
for
maintaining
human
health,
an
insufficient
level
defense
leads
infections
tumors.
In
contrast,
excessive
functioning
causes
development
autoimmune
diseases
allergies.
Strong
requires
adequate
nutrition,
dietary
interventions,
sufficient
intake
certain
vitamins
(vitamin
C,
vitamin
D,
folic
acid)
minerals
(magnesium,
zinc,
selenium).
Therefore,
nutritional
micronutrient
deficiencies
lead
compromised
immunity.
Several
natural
ingredients
have
shown
potent
immunomodulatory
properties.
immune-enhancing
properties
many
plants
fungi
are
due
containing
bioactive
phytoconstituents
polyphenols,
terpenoids,
β-glucans,
vitamins,
etc.
Probiotics
prebiotics
can
be
used
innovative
tools
reduce
intestinal
inflammation
downregulate
hypersensitivity
reactions.
Plant
sources
melatonin,
multifunctional
molecule
proven
anti-inflammatory
properties,
been
discovered
relatively
recently.
compounds
augment
by
directly
increasing
cytotoxic
activity
killer
cells,
macrophages,
neutrophils.
Many
prevent
cell
damage
their
powerful
antimicrobial,
antioxidant,
present
review
attempts
understand
molecular
mechanisms
underlying
some
plants,
fungi,
animals,
microorganisms,
other
sources.
Metabolites,
Год журнала:
2023,
Номер
13(4), С. 481 - 481
Опубликована: Март 27, 2023
Cancer
is
a
major
cause
of
death
worldwide,
with
multiple
pathophysiological
manifestations.
In
particular,
genetic
abnormalities,
inflammation,
bad
eating
habits,
radiation
exposure,
work
stress,
and
toxin
consumption
have
been
linked
to
cancer
disease
development
progression.
Recently,
natural
bioactive
chemicals
known
as
polyphenols
found
in
plants
were
shown
anticancer
capabilities,
destroying
altered
or
malignant
cells
without
harming
normal
cells.
Flavonoids
demonstrated
antioxidant,
antiviral,
anticancer,
anti-inflammatory
effects.
Flavonoid
type,
bioavailability,
possible
method
action
determine
these
biological
actions.
These
low-cost
pharmaceutical
components
significant
activities
are
beneficial
for
several
chronic
disorders,
including
cancer.
Recent
research
has
focused
primarily
on
isolating,
synthesizing,
studying
the
effects
flavonoids
human
health.
Here
we
attempted
summarize
our
current
knowledge
flavonoids,
focusing
their
mode
better
understand
Journal of Nanotheranostics,
Год журнала:
2023,
Номер
4(3), С. 248 - 279
Опубликована: Июль 1, 2023
Zinc
oxide
nanomaterials
have
been
the
cynosure
of
this
decade
because
their
immense
potential
in
different
biomedical
applications.
It
includes
usage
prognosis
and
treatment
infectious
cellular
diseases,
owing
to
peculiar
physiochemical
properties
such
as
variable
shape,
size,
surface
charge
etc.
Increasing
demand
ZnO
raise
concerns
about
molecular
toxicity
biocompatibility
with
human
cells.
This
review
comprehensively
details
for
Furthermore,
toxicological
types
systems
reviewed.
Moreover,
biocompatible
efficacy
cancer
specific
pathways
has
discussed.
offers
insights
into
current
scenario
signifies
future
extension
on
environmental
