Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)

Опубликована: Апрель 13, 2023

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, oxidative damage to the microenvironment. Given their complex nature, diabetic remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown trigger hyperinflammation excessive cellular apoptosis, play pivotal role pathogenesis of wounds. ROS-scavenging nanosystems recently emerged as smart multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory pro-angiogenic ability treatments predestines these promising options for treatment Yet, this context, therapeutic applicability efficacy be elucidated. Herein, ROS is deciphered, properties strengths capacity summarized. In addition, current challenges such potential future directions discussed through clinical-translational lens.

Язык: Английский

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Adipose‐Derived Mesenchymal Stem Cell‐Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin Regeneration

Advanced Science, Год журнала: 2023, Номер 10(30)

Опубликована: Сен. 15, 2023

Wound healing is an urgent clinical challenge, particularly in the case of chronic wounds. Traditional approaches to wound have limited therapeutic efficacy due lengthy times, risk immune rejection, and susceptibility infection. Recently, adipose-derived mesenchymal stem cell-derived exosomes (ADSC-exos) emerged as a promising modality for tissue regeneration repair. In this study, development novel extracellular matrix hydrogel@exosomes (ECM@exo) reported, which entails incorporation ADSC-exos into hydrogel (ECM hydrogel). This solution forms at physiological temperature (≈37 °C) upon local injection site. ECM@exo enables sustained release from ECM hydrogel, maintains high concentrations The displays good biocompatibility biodegradability. vivo vitro results demonstrate that treatment effectively reduces inflammation promotes angiogenesis, collagen deposition, cell proliferation, migration, thereby accelerating process. Overall, innovative approach offers new avenue via biological with controlled exosome release.

Язык: Английский

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A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds

Bioactive Materials, Год журнала: 2024, Номер 34, С. 298 - 310

Опубликована: Янв. 3, 2024

Mesenchymal stem cell derived exosomes (MSC-Exos) demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic properties. Chitosan (CS) exhibits excellent biocompatibility accelerates cellular migration, adhesion, proliferation. The ions released from bioactive glass (BG) titanium dioxide (TiO

Язык: Английский

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M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing

Materials Today Bio, Год журнала: 2023, Номер 20, С. 100649 - 100649

Опубликована: Апрель 30, 2023

Due to local overactive inflammatory response and impaired angiogenesis, current treatments for diabetic wounds remain unsatisfactory. M2 macrophage-derived exosomes (MEs) have shown considerable potential in biomedical applications, especially since they anti-inflammatory properties that modulate macrophage phenotypes. However, exosome-based strategies still limitations, such as short half-lives instability. Herein, we develop a double-layer microneedle-based wound dressing system (MEs@PMN) by encapsulating MEs the needle tips polydopamine (PDA) nanoparticles backing layer simultaneously suppress inflammation improve angiogenesis at site.

Язык: Английский

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Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives

Carbohydrate Polymers, Год журнала: 2023, Номер 324, С. 121537 - 121537

Опубликована: Ноя. 2, 2023

Язык: Английский

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Sulfur Vacancy‐Rich Bi₂S_3‐X@PDA Heterojunctions with Light‐Controlled Reactive Oxygen Species Generation and Elimination to Combat Biofilm Infection and Inflammation Caused by Drug‐Resistant Bacteria

Advanced Functional Materials, Год журнала: 2024, Номер 34(26)

Опубликована: Фев. 23, 2024

Abstract Antibacterial photocatalytic therapy (APCT) is one of the most promising non‐antibiotic treatment strategies for biofilm‐infected wounds and inflammation caused by drug‐resistant bacteria. However, it still faces issues such as inadequate single antibacterial capacity lack antioxidant capacity. In this study, a Z‐scheme heterojunction (Bi 2 S 3‐X @PDA) designed using polydopamine (PDA) shell firmly anchored to surface sulfur vacancy‐rich bismuth sulfide nanorods NRs). Under near‐infrared light hydrogen peroxide, Bi @PDA significantly improves efficiency reactive oxygen species generation shows nearly 100% broad‐spectrum effect against multiple bacterial strains biofilms in vitro. Interestingly, activity PDA remarkably downregulates expression pro‐inflammatory factors promotes macrophage reprogramming toward proregenerative M2 phenotype. mouse wound model methicillin‐resistant Staphylococcus aureus biofilm infection, effectively eliminates through APCT/mild photothermal therapy, while reducing normal tissues regulating immune microenvironment, thereby promoting rapid healing. Overall, light‐controlled strategy, which provides both anti‐inflammatory functions, reliable tool combating infection

Язык: Английский

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Emerging trends in the application of hydrogel-based biomaterials for enhanced wound healing: A literature review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129300 - 129300

Опубликована: Янв. 11, 2024

Язык: Английский

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Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions

Biomaterials, Год журнала: 2024, Номер 308, С. 122558 - 122558

Опубликована: Апрель 2, 2024

Язык: Английский

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Macrophage plasticity: signaling pathways, tissue repair, and regeneration

MedComm, Год журнала: 2024, Номер 5(8)

Опубликована: Авг. 1, 2024

Abstract Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) alternatively (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay signaling pathways, transcriptional regulators, epigenetic modifications orchestrates polarization, allowing respond stimuli dynamically. Here, we provide comprehensive overview the cascades governing focusing on roles Toll‐like receptors, signal transducer activator transcription proteins, nuclear microRNAs. We also discuss emerging concepts metabolic reprogramming trained immunity, contributing their functional adaptability. Macrophage plasticity plays pivotal role in repair regeneration, macrophages coordinating inflammation, angiogenesis, matrix remodeling restore homeostasis. By harnessing potential novel therapeutic strategies targeting polarization could be developed for diseases, including chronic wounds, fibrotic disorders, inflammatory conditions. Ultimately, deeper understanding molecular mechanisms underpinning will pave way innovative regenerative medicine engineering approaches.

Язык: Английский

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Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Март 6, 2024

Tibial Cortex Transverse Transport (TTT) represents an innovative surgical method for treating lower extremity diabetic foot ulcers (DFUs), yet its underlying mechanisms remain elusive. Establishing animal model that closely mirrors clinical scenarios is both critical and novel elucidating the of TTT.

Язык: Английский

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