Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
167, С. 115475 - 115475
Опубликована: Сен. 16, 2023
The
vascular
endothelium
is
vital
in
maintaining
cardiovascular
health
by
regulating
permeability
and
tone,
preventing
thrombosis,
controlling
inflammation.
However,
when
oxidative
stress
triggers
endothelial
dysfunction,
it
can
lead
to
chronic
diseases
(CVDs).
This
happens
due
stress-induced
mitochondrial
inflammatory
responses,
reduced
levels
of
nitric
oxide.
These
factors
cause
damage
cells,
leading
the
acceleration
CVD
progression.
Melatonin,
a
natural
antioxidant,
has
been
shown
inhibit
stabilize
function,
providing
protection.
clinical
application
melatonin
prevention
treatment
CVDs
received
widespread
attention.
In
this
review,
based
on
bibliometric
studies,
we
first
discussed
relationship
between
dysfunction
CVDs,
then
summarized
role
atherosclerosis,
hypertension,
myocardial
ischemia-reperfusion
injury,
other
CVDs.
Finally,
potential
use
these
discussed.
Abstract
The
aim
of
this
study
was
to
determine
the
malondialdehyde
(MDA)
level
and
superoxide
dismutase
(
SOD)
activity
in
colchicine
induced
Alzheimer’s
disease
AD),
resveratrol
RS)
treated
RS
+
donepezil
(DPZ)
rat
models.
objective
compare
MDA
SOD
among
these
present
included
3
months
old
male
albino
Wistar
rats,
which
were
in-house
bred
weighting
about
220–250
g.
rats
divided
into
nine
subgroups
control,
sham,
AD
induced,
DPZ
groups
different
doses
combinations.
lipid
peroxidation
product
for
brain
homogenate
measured
by
estimating
levels
thiobarbituric
acid
reactive
substance.
Estimation
done
method
autoxidation
pyrogallol
Marklund
Marklund.
There
a
marked
increase
group
comparison
control
p
<
0.05).
higher
10
20
contrast
In
group,
there
substantial
It
is
also
observed
that
treatment
showed
than
This
that,
had
elevated
MDA,
indicates
poor
oxidative
stress–defence
mechanism.
indicated
improved
activity,
indicating
synergistic
effect
RS.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Март 16, 2022
The
integrity
of
intestinal
barrier
determines
homeostasis,
which
could
be
affected
by
various
factors,
like
physical,
chemical,
and
biological
stimuli.
Therefore,
it
is
considerable
interest
importance
to
maintain
function.
Fortunately,
many
plant
polyphenols,
including
resveratrol,
affect
the
health
barrier.
Resveratrol
has
functions,
such
as
antioxidant,
anti-inflammation,
anti-tumor,
anti-cardiovascular
diseases.
Accumulating
studies
have
shown
that
resveratrol
affects
tight
junction,
microbial
composition,
inflammation.
In
this
review,
we
summarize
effects
on
barriers
well
potential
mechanisms
(e.g.,
inhibiting
growth
pathogenic
bacteria
fungi,
regulating
expression
junction
proteins,
increasing
anti-inflammatory
T
cells
while
reducing
pro-inflammatory
cells),
highlight
applications
in
ameliorating
Life,
Год журнала:
2022,
Номер
12(2), С. 294 - 294
Опубликована: Фев. 16, 2022
Resveratrol
(RSV),
a
plant-derived
polyphenol,
demonstrates
broad-spectrum
health
benefits,
including
anti-proliferative,
anti-inflammatory,
antidiabetic,
anti-ischemic
and
antioxidant
effects.
The
aim
of
this
review
is
to
give
an
important
heads-up
regarding
the
influence
RSV
as
phytoestrogen,
effects
on
most
common
pregnancy-related
complications,
well
its
impact
embryogenesis,
spermatogenesis,
women’s
reproductive
health.
Considering
implications
human
health,
overview
could
provide
groundwork,
encouraging
more
detailed
research
at
clinical
level.
Biomedicines,
Год журнала:
2023,
Номер
11(11), С. 2888 - 2888
Опубликована: Окт. 25, 2023
Cardiovascular
diseases
(CVDs)
are
among
the
leading
causes
of
morbidity
and
mortality
worldwide.
Unhealthy
dietary
habits
have
clearly
been
shown
to
contribute
development
CVDs.
Beyond
primary
nutrients,
a
healthy
diet
is
also
rich
in
plant-derived
compounds.
Natural
polyphenols,
found
fruits,
vegetables,
red
wine,
clear
role
improving
cardiovascular
health.
In
this
review,
we
strive
summarize
results
relevant
pre-clinical
clinical
trials
that
focused
on
some
most
important
natural
such
as
resveratrol
flavonoids.
addition,
aim
identify
their
common
sources,
biosynthesis,
describe
mechanism
action
including
regulatory
effect
signal
transduction
pathways.
Finally,
provide
scientific
evidence
regarding
benefits
moderate,
long-term
wine
consumption.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
167, С. 115475 - 115475
Опубликована: Сен. 16, 2023
The
vascular
endothelium
is
vital
in
maintaining
cardiovascular
health
by
regulating
permeability
and
tone,
preventing
thrombosis,
controlling
inflammation.
However,
when
oxidative
stress
triggers
endothelial
dysfunction,
it
can
lead
to
chronic
diseases
(CVDs).
This
happens
due
stress-induced
mitochondrial
inflammatory
responses,
reduced
levels
of
nitric
oxide.
These
factors
cause
damage
cells,
leading
the
acceleration
CVD
progression.
Melatonin,
a
natural
antioxidant,
has
been
shown
inhibit
stabilize
function,
providing
protection.
clinical
application
melatonin
prevention
treatment
CVDs
received
widespread
attention.
In
this
review,
based
on
bibliometric
studies,
we
first
discussed
relationship
between
dysfunction
CVDs,
then
summarized
role
atherosclerosis,
hypertension,
myocardial
ischemia-reperfusion
injury,
other
CVDs.
Finally,
potential
use
these
discussed.
