Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
153, С. 113374 - 113374
Опубликована: Июль 11, 2022
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
public
health
problem
associated
with
high
mortality
and
morbidity
rates
worldwide.
Presently,
its
complex
pathophysiology
still
unclear,
there
no
specific
drug
to
reverse
NAFLD.
Ferroptosis
an
iron-dependent
non-apoptotic
form
of
cell
death
characterized
by
the
iron-induced
accumulation
lipid
reactive
oxygen
species
(ROS),
which
damage
nucleic
acids,
proteins,
lipids;
generate
intracellular
oxidative
stress;
ultimately
cause
death.
Emerging
evidence
indicates
that
ferroptosis
involved
in
progression
NAFLD,
although
mechanism
action
NAFLD
poorly
understood.
Herein,
we
summarize
certain
diseases,
especially
pathogenesis
discuss
potential
therapeutic
approaches
currently
used
treat
This
review
also
highlights
further
directions
for
treatment
prevention
related
diseases.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 10
Опубликована: Янв. 17, 2022
Osteoporosis
can
be
caused
by
a
multitude
of
factors
and
is
defined
decrease
in
bone
density
mass
the
destruction
microstructure,
resulting
increased
brittleness.
Thus,
it
systemic
disease
which
patients
are
prone
to
fracture.
The
role
ferroptosis
pathogenesis
osteoporosis
has
become
topic
growing
interest.
In
this
review,
we
discuss
cell
morphology,
basic
mechanisms
ferroptosis,
relationship
between
osteoclasts
osteoblasts,
as
well
diabetic
osteoporosis,
steroid-induced
postmenopausal
osteoporosis.
Emerging
biomedical
research
provided
new
insights
into
roles
such
cellular
function,
signaling
pathways,
drug
inhibition,
gene
silencing.
pathophysiology
mechanism
need
further
studied
elucidated
broaden
our
understanding
iron
metabolism
immune
regulation.
Studies
using
animal
models
vivo
vitro
will
help
clarify
provide
ideas
for
elucidation
development
technologies
drugs
treatment
future.
Journal of Neurochemistry,
Год журнала:
2023,
Номер
165(4), С. 487 - 520
Опубликована: Март 13, 2023
Abstract
Over
30
million
people
suffer
from
the
consequences
of
ischemic
stroke.
The
precise
molecular
mechanism
neuronal
damage
during
stroke
remains
unclear;
therefore,
effective
treatment
post‐ischemic
a
critical
challenge.
Recently,
iron
has
emerged
as
crucial
factor
in
post‐reperfusion
injuries,
participating
cell
peroxidation,
excitotoxicity,
and
distinctive
death
pathway,
namely,
ferroptosis.
Since
is
tightly
regulated
brain
important
for
functions,
imbalance
its
metabolism,
including
overload
deficiency,
been
shown
to
impact
outcomes.
This
review
summarizes
current
understanding
pathological
events
associated
with
discusses
relevant
drug
development.
image
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Дек. 10, 2023
Abstract
Ferroptosis,
a
unique
modality
of
cell
death
with
mechanistic
and
morphological
differences
from
other
modes,
plays
pivotal
role
in
regulating
tumorigenesis
offers
new
opportunity
for
modulating
anticancer
drug
resistance.
Aberrant
epigenetic
modifications
posttranslational
(PTMs)
promote
resistance,
cancer
progression,
metastasis.
Accumulating
studies
indicate
that
can
transcriptionally
translationally
determine
vulnerability
to
ferroptosis
functions
as
driver
nervous
system
diseases
(NSDs),
cardiovascular
(CVDs),
liver
diseases,
lung
kidney
diseases.
In
this
review,
we
first
summarize
the
core
molecular
mechanisms
ferroptosis.
Then,
roles
processes,
including
histone
PTMs,
DNA
methylation,
noncoding
RNA
regulation
such
phosphorylation,
ubiquitination,
SUMOylation,
acetylation,
ADP-ribosylation,
are
concisely
discussed.
The
PTMs
genesis
cancers,
NSD,
CVDs,
well
application
PTM
modulators
therapy
these
then
discussed
detail.
Elucidating
mediated
by
will
facilitate
development
promising
combination
therapeutic
regimens
containing
or
PTM-targeting
agents
inducers
be
used
overcome
chemotherapeutic
resistance
could
prevent
addition,
highlight
potential
approaches
chemoresistance
halt
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
153, С. 113374 - 113374
Опубликована: Июль 11, 2022
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
public
health
problem
associated
with
high
mortality
and
morbidity
rates
worldwide.
Presently,
its
complex
pathophysiology
still
unclear,
there
no
specific
drug
to
reverse
NAFLD.
Ferroptosis
an
iron-dependent
non-apoptotic
form
of
cell
death
characterized
by
the
iron-induced
accumulation
lipid
reactive
oxygen
species
(ROS),
which
damage
nucleic
acids,
proteins,
lipids;
generate
intracellular
oxidative
stress;
ultimately
cause
death.
Emerging
evidence
indicates
that
ferroptosis
involved
in
progression
NAFLD,
although
mechanism
action
NAFLD
poorly
understood.
Herein,
we
summarize
certain
diseases,
especially
pathogenesis
discuss
potential
therapeutic
approaches
currently
used
treat
This
review
also
highlights
further
directions
for
treatment
prevention
related
diseases.
