Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
153, P. 113374 - 113374
Published: July 11, 2022
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
public
health
problem
associated
with
high
mortality
and
morbidity
rates
worldwide.
Presently,
its
complex
pathophysiology
still
unclear,
there
no
specific
drug
to
reverse
NAFLD.
Ferroptosis
an
iron-dependent
non-apoptotic
form
of
cell
death
characterized
by
the
iron-induced
accumulation
lipid
reactive
oxygen
species
(ROS),
which
damage
nucleic
acids,
proteins,
lipids;
generate
intracellular
oxidative
stress;
ultimately
cause
death.
Emerging
evidence
indicates
that
ferroptosis
involved
in
progression
NAFLD,
although
mechanism
action
NAFLD
poorly
understood.
Herein,
we
summarize
certain
diseases,
especially
pathogenesis
discuss
potential
therapeutic
approaches
currently
used
treat
This
review
also
highlights
further
directions
for
treatment
prevention
related
diseases.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Dec. 10, 2023
Abstract
Ferroptosis,
a
unique
modality
of
cell
death
with
mechanistic
and
morphological
differences
from
other
modes,
plays
pivotal
role
in
regulating
tumorigenesis
offers
new
opportunity
for
modulating
anticancer
drug
resistance.
Aberrant
epigenetic
modifications
posttranslational
(PTMs)
promote
resistance,
cancer
progression,
metastasis.
Accumulating
studies
indicate
that
can
transcriptionally
translationally
determine
vulnerability
to
ferroptosis
functions
as
driver
nervous
system
diseases
(NSDs),
cardiovascular
(CVDs),
liver
diseases,
lung
kidney
diseases.
In
this
review,
we
first
summarize
the
core
molecular
mechanisms
ferroptosis.
Then,
roles
processes,
including
histone
PTMs,
DNA
methylation,
noncoding
RNA
regulation
such
phosphorylation,
ubiquitination,
SUMOylation,
acetylation,
ADP-ribosylation,
are
concisely
discussed.
The
PTMs
genesis
cancers,
NSD,
CVDs,
well
application
PTM
modulators
therapy
these
then
discussed
detail.
Elucidating
mediated
by
will
facilitate
development
promising
combination
therapeutic
regimens
containing
or
PTM-targeting
agents
inducers
be
used
overcome
chemotherapeutic
resistance
could
prevent
addition,
highlight
potential
approaches
chemoresistance
halt
Journal of Neurochemistry,
Journal Year:
2023,
Volume and Issue:
165(4), P. 487 - 520
Published: March 13, 2023
Abstract
Over
30
million
people
suffer
from
the
consequences
of
ischemic
stroke.
The
precise
molecular
mechanism
neuronal
damage
during
stroke
remains
unclear;
therefore,
effective
treatment
post‐ischemic
a
critical
challenge.
Recently,
iron
has
emerged
as
crucial
factor
in
post‐reperfusion
injuries,
participating
cell
peroxidation,
excitotoxicity,
and
distinctive
death
pathway,
namely,
ferroptosis.
Since
is
tightly
regulated
brain
important
for
functions,
imbalance
its
metabolism,
including
overload
deficiency,
been
shown
to
impact
outcomes.
This
review
summarizes
current
understanding
pathological
events
associated
with
discusses
relevant
drug
development.
image
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 20, 2023
Reperfusion
is
essential
for
ischemic
myocardium
but
paradoxically
leads
to
myocardial
damage
that
worsens
cardiac
functions.
Ferroptosis
often
occurs
in
cardiomyocytes
during
ischemia/reperfusion
(I/R).
The
SGLT2
inhibitor
dapagliflozin
(DAPA)
exerts
cardioprotective
effects
independent
of
hypoglycemia.
Here,
we
investigated
the
effect
and
potential
mechanism
DAPA
against
injury
(MIRI)-related
ferroptosis
using
MIRI
rat
model
hypoxia/reoxygenation
(H/R)-induced
H9C2
cardiomyocytes.
Our
results
show
significantly
ameliorated
injury,
reperfusion
arrhythmia,
function,
as
evidenced
by
alleviated
ST-segment
elevation,
biomarkers
including
cTnT
BNP
pathological
features,
prevented
H/R-triggered
cell
viability
loss
vitro.
In
vitro
vivo
experiments
showed
inhibited
upregulating
SLC7A11/GPX4
axis
FTH
inhibiting
ACSL4.
notably
mitigated
oxidative
stress,
lipid
peroxidation,
ferrous
iron
overload,
reduced
ferroptosis.
Subsequently,
network
pharmacology
bioinformatics
analysis
suggested
MAPK
signaling
pathway
was
a
target
common
treatment
phosphorylation
vivo,
suggesting
might
protect
reducing
through
pathway.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
153, P. 113374 - 113374
Published: July 11, 2022
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
public
health
problem
associated
with
high
mortality
and
morbidity
rates
worldwide.
Presently,
its
complex
pathophysiology
still
unclear,
there
no
specific
drug
to
reverse
NAFLD.
Ferroptosis
an
iron-dependent
non-apoptotic
form
of
cell
death
characterized
by
the
iron-induced
accumulation
lipid
reactive
oxygen
species
(ROS),
which
damage
nucleic
acids,
proteins,
lipids;
generate
intracellular
oxidative
stress;
ultimately
cause
death.
Emerging
evidence
indicates
that
ferroptosis
involved
in
progression
NAFLD,
although
mechanism
action
NAFLD
poorly
understood.
Herein,
we
summarize
certain
diseases,
especially
pathogenesis
discuss
potential
therapeutic
approaches
currently
used
treat
This
review
also
highlights
further
directions
for
treatment
prevention
related
diseases.
