International Journal of Biometeorology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Deleted Journal, Год журнала: 2023, Номер 1(3)
Опубликована: Июль 1, 2023
Abstract Recently, the interest in extracellular vesicles released by bacteria has rapidly increased. Bacterial (BEVs) have been involved bacteria‐bacteria and bacteria‐host interactions, which strengthen health or bring about various pathologies. However, BEV separation, characterization, functional studies require establishment of guidelines further optimization order to stimulate development science research a following successful transformation into clinical applications. This position paper is authored Microbial Vesicles Task Force Chinese Society for Extracellular (CSEV) composed experienced medical laboratory specialists, microbiologists, virologists, biologists material who are actively engaged research. Herein, we present concise description discover challenges critical gaps current BEV‐based analyses Finally, also offer suggestions considerations improve experimental reproducibility interoperability promote progress field.
Язык: Английский
Процитировано
22
Science Bulletin, Год журнала: 2024, Номер 69(16), С. 2565 - 2579
Опубликована: Июнь 14, 2024
Язык: Английский
Процитировано
13
Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Апрель 5, 2024
Abstract Background Diabetes is a predominant driver of coronary artery disease worldwide. This study aims to unravel the distinct characteristics oral and gut microbiota in diabetic heart (DCHD). Simultaneously, we aim establish causal link between diabetes-driven oral-gut axis increased susceptibility myocardial ischemia–reperfusion injury (MIRI). Methods We comprehensively investigated microbial landscape DCHD using discovery cohort (n = 183) validation chohort 68). Systematically obtained (tongue-coating) fecal specimens were subjected metagenomic sequencing qPCR analysis, respectively, holistically characterize consortia. Next, induced MIRI by administering streptozotocin C57BL/6 mice subsequently potential mechanisms through antibiotic pre-treatment followed gavage with specific bacterial strains ( Fusobacterium nucleatum or from patients) mice. Results Specific signatures such as Lactobacillus, Eubacterium, Roseburia faecis , identified biomarkers DCHD. further validated that Lactobacillus are patients, positive correlation two. Experimental evidence revealed hyperglycemic mice, augmented levels cavity accompanied an imbalance axis, characterized coexistence along elevated cardiac miRNA-21 greater extent damage indicated TTC, HE, TUNEL staining, all which contributed exacerbated MIRI. Conclusion Our findings not only uncover dysregulation diabetes patients but also highlight pivotal intermediary role abundance F. exacerbating Targeting emerges potent strategy for preventing treating Oral-gut transmission constitutes intermediate mechanism influences injury, offering new insights into acute events disease. Graphic
Язык: Английский
Процитировано
12
Current Rheumatology Reports, Год журнала: 2024, Номер 26(4), С. 124 - 132
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
10
The FASEB Journal, Год журнала: 2025, Номер 39(1)
Опубликована: Янв. 6, 2025
The activation of acid-sensing ion channel 1a (ASIC1a) in response to extracellular acidification leads an increase calcium influx, thereby exacerbating the degeneration articular chondrocytes rheumatoid arthritis (RA). It has been suggested that inhibition influx could potentially impede chondrocyte ferroptosis. cystine transporter, solute carrier family 7 member 11 (SLC7A11), is recognized as a key regulator Recent studies suggest tumor suppressor gene p53 facilitates induction ferroptosis by suppressing upregulation SLC7A11. This process mediated nuclear factor erythroid 2-related 2 (NRF2), transcription integral maintenance cellular redox homeostasis and regulation inflammatory responses. study aims investigate role ASIC1a RA determine involvement p53/NRF2/SLC7A11 pathway its underlying mechanism. In vitro experiments revealed acidosis induces reduces expression NRF2 SLC7A11 chondrocytes. Moreover, significantly increased protein levels Pifithrin-α (PFN-α), inhibitor, mitigated acidosis-induced restored diminished Furthermore, PcTx-1, inhibited acidification-induced ferroptosis, enhanced NRF2, reduced expression. vivo demonstrated ASIC1a-specific inhibitor PcTx-1 ameliorated histopathological characteristics ankle joints collagen-induced (CIA) mice, decreased expression, These findings may mitigate RA, via pathway.
Язык: Английский
Процитировано
1
Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
1
Gut Microbes, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 22, 2025
Atherosclerosis is the primary cause of cardiovascular and cerebrovascular diseases. However, current anti-atherosclerosis drugs have shown conflicting therapeutic outcomes, thereby spurring search for novel effective treatments. Recent research indicates crucial involvement oral gastrointestinal microbiota in atherosclerosis. While gut metabolites, such as choline derivatives, been extensively studied reviewed, emerging evidence suggests that bacterial extracellular vesicles (BEVs), which are membrane-derived lipid bilayers secreted by bacteria, also play a significant role this process. BEVs host-microbiota interactions remains insufficiently explored. This review aims to elucidate complex communication mediated along gut-heart axis. In review, we summarize knowledge on BEVs, with specific focus how pathogen-derived contribute promotion atherosclerosis, well from symbionts probiotics may mitigate its progression. We explore potential challenges associated engineered prevention treatment Finally, discuss benefits using atherosclerosis diagnosis treatment, propose future directions address these issues.
Язык: Английский
Процитировано
1
Best Practice & Research Clinical Rheumatology, Год журнала: 2025, Номер unknown, С. 102035 - 102035
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Engineering Microbiology, Год журнала: 2025, Номер unknown, С. 100192 - 100192
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(16), С. 12861 - 12861
Опубликована: Авг. 16, 2023
Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying increased susceptibility to AS CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum. We the existing epidemiological elucidating association between these AS-related diseases, diverse mechanisms which may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation monocyte adhesion aggregation, promotion foam cell formation, all contribute progression destabilization plaques. Notably, intricate interplay among bacteria underscores complex impact on In conclusion, advancing our understanding relationship will undoubtedly offer invaluable insights potential therapeutic avenues prevention management
Язык: Английский
Процитировано
18