Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Abstract
The
increasing
morbidity
and
mortality
caused
by
multidrug‐resistant
bacteria
alerts
human
beings
to
the
fact
that
conventional
antibiotics
are
no
longer
reliable
effective
alternatives
imperatively
needed.
Owing
wide
range
of
sources,
diverse
structures,
unique
mode
action,
antimicrobial
peptides
have
been
highly
anticipated
extensively
studied
in
recent
years.
Besides,
integration
artificial
intelligence
helps
researchers
gain
access
vast
unexplored
chemical
space,
which
opens
more
opportunities
for
optimization
design
novel
structures.
Moreover,
Due
advances
chemistry
synthetic
biology,
also
begun
focus
on
potential
mimetics
peptides.
In
this
review,
a
comprehensive
discussion
about
natural
synthesized
as
well
their
is
made,
so
provide
summary
field
inspire
follow‐up
research.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 25, 2024
Non-direct
antimicrobial
cationic
peptides
(NDACPs)
are
components
of
the
animal
innate
immune
system.
But
their
functions
and
association
with
(AMPs)
incompletely
understood.
Here,
we
reveal
a
synergistic
interaction
between
AMP
AW1
NDACP
AW2,
which
co-expressed
in
frog
Amolops
wuyiensis.
AW2
enhances
antibacterial
activity
both
vitro
vivo,
while
mitigating
development
bacterial
resistance
eradicating
biofilms.
synergistically
damage
membranes,
facilitating
cellular
uptake
intracellular
target
genomic
DNA.
Simultaneously,
they
trigger
generation
ROS
bacteria,
contributing
to
cell
death
upon
reaching
threshold
level.
Moreover,
demonstrate
that
this
effect
AMPs
NDACPs
is
prevalent
across
diverse
species.
These
findings
unveil
robust
previously
unknown
correlation
as
widespread
defense
strategy
animals.
Antimicrobial
non-direct
secreted
response
invasive
pathogens.
Ye
et
al
show
there
these
two
types
expressed
from
amphibian
Journal of Peptide Science,
Год журнала:
2024,
Номер
30(6)
Опубликована: Янв. 23, 2024
The
rise
of
antimicrobial
resistance
and
multi‐drug
resistant
pathogens
has
necessitated
explorations
for
novel
antibiotic
agents
as
the
discovery
conventional
antibiotics
is
becoming
economically
less
viable
technically
more
challenging
biopharma.
Antimicrobial
peptides
(AMPs)
have
emerged
a
promising
alternative
because
their
particular
mode
action,
broad
spectrum
difficulty
that
microbes
in
to
them.
AMPs
bacitracin,
gramicidin,
polymyxins
daptomycin
are
currently
used
clinically.
However,
susceptibility
proteolytic
degradation,
toxicity
profile,
complexities
large‐scale
manufacture
hindered
development.
To
improve
stability,
methods
such
integrating
non‐canonical
amino
acids
(ncAAs)
into
peptide
sequence
been
adopted,
which
also
improves
potency
action.
benefits
ncAA
incorporation
made
possible
by
solid‐phase
synthesis.
this
method
not
always
suitable
commercial
production
poor
yield,
scale‐up
difficulties,
its
non‐‘green’
nature.
Bioincorporation
integration
an
emerging
field
geared
towards
tackling
challenges
synthesis
green,
cheaper,
scalable
commercialisation
AMPs.
This
review
focusses
on
bioincorporation
ncAAs;
some
associated
with
outlined,
notes
given
how
overcome
these
challenges.
particularly
addressing
two
key
challenges:
AMP
cytotoxicity
microbial
cell
factories
uptake
ncAAs
unfavourable
Overcoming
will
draw
us
closer
greater
yield
environmentally
friendly
sustainable
approach
make
druggable.
Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Abstract
The
increasing
morbidity
and
mortality
caused
by
multidrug‐resistant
bacteria
alerts
human
beings
to
the
fact
that
conventional
antibiotics
are
no
longer
reliable
effective
alternatives
imperatively
needed.
Owing
wide
range
of
sources,
diverse
structures,
unique
mode
action,
antimicrobial
peptides
have
been
highly
anticipated
extensively
studied
in
recent
years.
Besides,
integration
artificial
intelligence
helps
researchers
gain
access
vast
unexplored
chemical
space,
which
opens
more
opportunities
for
optimization
design
novel
structures.
Moreover,
Due
advances
chemistry
synthetic
biology,
also
begun
focus
on
potential
mimetics
peptides.
In
this
review,
a
comprehensive
discussion
about
natural
synthesized
as
well
their
is
made,
so
provide
summary
field
inspire
follow‐up
research.
