Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin

Inflammation Research, Год журнала: 2022, Номер 71(7-8), С. 817 - 831

Опубликована: Июнь 24, 2022

Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling immune system and leads photoaging state which is reminiscent chronological aging. Over 30 years ago, it was observed that UVR induced an immunosuppressive inhibited contact hypersensitivity.Original review articles encompassing inflammation immunosuppression in aging processes were examined from major databases including PubMed, Scopus, Google Scholar.Currently known treatment can trigger cellular senescence inflammatory skin. Chronic low-grade stimulates counteracting involving expansion cells, e.g., regulatory T cells (Treg), myeloid-derived suppressor (MDSC), dendritic (DCreg). This increased activity not only suppresses function effector called immunosenescence, but also induces bystander degeneration neighboring cells. Interestingly, process involves accumulation pro-inflammatory senescent signs chronic inflammation, inflammaging. There clear evidence inflammaging associated with increase anti-inflammatory activities promote immunosenescence.It seems normal evoke similar driven by system. However, likely there are different molecular mechanisms inducing accelerated processes.

Язык: Английский

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Possible Mechanisms of Oxidative Stress-Induced Skin Cellular Senescence, Inflammation, and Cancer and the Therapeutic Potential of Plant Polyphenols

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3755 - 3755

Опубликована: Фев. 13, 2023

As the greatest defense organ of body, skin is exposed to endogenous and external stressors that produce reactive oxygen species (ROS). When antioxidant system body fails eliminate ROS, oxidative stress initiated, which results in cellular senescence, inflammation, cancer. Two main possible mechanisms underlie stress-induced One mechanism ROS directly degrade biological macromolecules, including proteins, DNA, lipids, are essential for cell metabolism, survival, genetics. Another one mediate signaling pathways, such as MAPK, JAK/STAT, PI3K/AKT/mTOR, NF-κB, Nrf2, SIRT1/FOXO, affecting cytokine release enzyme expression. natural antioxidants, plant polyphenols safe exhibit a therapeutic potential. We here discuss detail potential selected polyphenolic compounds outline relevant molecular targets. Polyphenols study according their structural classification include curcumin, catechins, resveratrol, quercetin, ellagic acid, procyanidins. Finally, latest delivery (taking curcumin an example) current status clinical research summarized, providing theoretical foundation future generation new pharmaceuticals cosmetics.

Язык: Английский

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Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 14, 2023

Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.

Язык: Английский

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Research Progress on Skin Aging and Active Ingredients

Molecules, Год журнала: 2023, Номер 28(14), С. 5556 - 5556

Опубликована: Июль 20, 2023

With the advancement of living standards in modern society and emergence an aging population, increasing number people are becoming interested topic anti-aging. An important feature is skin aging, women particularly concerned about aging. In field cosmetics, market share anti-aging products year by year. This article reviews research development progress related active compounds both domestically internationally recent years. The results show that, terms on popular theories mainly include free radicals oxidative stress theory, inflammation photoaging nonenzymatic glycosyl chemistry theory. ingredients with activities skin, there numerous reports clinical studies human subjects, animal experiments, experimental cell cultures, a variety types. Most against sourced from natural their action mechanisms to scavenging oxygen enhancing antioxidant defenses. review provides references for future products. Although great including ingredients, ideal or still lacking need be further validated. New new artificial products, pharmaceutical forms validations should investigated future.

Язык: Английский

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Insights into the molecular mechanisms, structure-activity relationships and application prospects of polysaccharides by regulating Nrf2-mediated antioxidant response

Carbohydrate Polymers, Год журнала: 2024, Номер 333, С. 122003 - 122003

Опубликована: Фев. 27, 2024

Язык: Английский

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The Promising Role of Polyphenols in Skin Disorders

Molecules, Год журнала: 2024, Номер 29(4), С. 865 - 865

Опубликована: Фев. 15, 2024

The biochemical characteristics of polyphenols contribute to their numerous advantageous impacts on human health. existing research suggests that plant phenolics, whether consumed orally or applied directly the skin, can be beneficial in alleviating symptoms and avoiding development many skin disorders. Phenolic compounds, which are both harmless naturally present, exhibit significant potential terms counteracting effects damage, aging, diseases, wounds, burns. Moreover, play a preventive role possess ability delay progression several disorders, ranging from small discomforting severe potentially life-threatening ones. This article provides concise overview recent therapeutic application for conditions. It specifically highlights studies have investigated clinical trials use polyphenol-based nanoformulations treatment different ailments.

Язык: Английский

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Polyphenols: Secondary Metabolites with a Biological Impression

Nutrients, Год журнала: 2024, Номер 16(15), С. 2550 - 2550

Опубликована: Авг. 3, 2024

Polyphenols are natural compounds which plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols mostly found fruits vegetables. Currently, many diseases waiting for a cure or solution to reduce their symptoms. However, drug other chemical strategies limitations using treatment agent still detection tool diseases, thus researchers need investigate preventive improving treatment. Therefore, it is elucidate polyphenols, bioactivity effects, supplementation, consumption. The disadvantage that they limited bioavailability, although beneficial outcomes with roles. In this context, several different developed improve particularly liposomal nanoparticles. As nutrition one most important factors health, inclusion molecules daily diet significant continues be enthusiastically researched. Nutrition, individuals all ages, key polyphenols.

Язык: Английский

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Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics

Antioxidants, Год журнала: 2023, Номер 12(2), С. 444 - 444

Опубликована: Фев. 10, 2023

Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and increased probability of death. Cellular senescence has been typically considered as anti-proliferative process; however, the chronic accumulation senescent cells contributes tissue dysfunction aging. In this review, we discuss some most important hallmarks biomarkers cellular with special focus on skin biomarkers, reactive oxygen species (ROS), senotherapeutic strategies eliminate or prevent senescence. Although them are not exclusive senescence, expression senescence-associated beta-galactosidase (SA-β-gal) enzyme seems be reliable biomarker for distinguishing from those arrested cell cycle. The presence stable DNA damage response (DDR) secretory phenotype (SASP) mediators ROS representative Senotherapeutics based natural compounds such quercetin, naringenin, apigenin have shown promising results regarding SASP reduction. These seem cells, likely through inhibition pro-survival signaling pathways. studies still required verify their short- long-term effects, these therapies may effective strategy

Язык: Английский

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Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents

Aging Cell, Год журнала: 2023, Номер 22(6)

Опубликована: Апрель 11, 2023

Abstract Despite the growing interest by researchers into cellular senescence, a hallmark of aging, its role in human skin remains equivocal. The is largest and most accessible organ, reacting to external internal environment. Hence, it an organ choice investigate senescence target root‐cause aging processes using senolytic senomorphic agents, including naturally occurring plant‐based derivatives. This review presents different aspects from physiology pathology signaling pathways. Cellular can have both beneficial detrimental effects on skin, indicating that prosenescent antisenescent therapies may be desirable, based context. Knowledge molecular mechanisms involved provide meaningful insights for developing effective therapeutics senescence‐related disorders, such as wound healing cosmetic changes.

Язык: Английский

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The (Poly)phenolic Profile of Separate Winery By-Products Reveals Potential Antioxidant Synergies

Molecules, Год журнала: 2023, Номер 28(5), С. 2081 - 2081

Опубликована: Фев. 22, 2023

The by-products of grapes (Vitis vinifera L.) in the winemaking process present a diverse phytochemical profile (poly)phenols, essentially represented by phenolic acids, flavonoids, and stilbenes, which have health benefits. In winemaking, solid (grape stems pomace) semisolid (wine lees) are generated, negatively impacting sustainability agro-food activity local environment. Although information on grape pomace has been reported, especially concerning research wine lees is necessary to take advantage compositional traits this residue. So, work, an updated, in-depth comparison (poly)phenolic profiles these three resulting matrices industry carried out provide new knowledge interesting data action yeast lactic acid bacteria (LAB) metabolism diversification composition; additionally, we extract complementarities for possible joint application residues. analysis extracts was using HPLC-PDA-ESI-MSn. residues showed significant discrepancies. results obtained that greatest diversity (poly)phenols found grapes, followed closely lees. Through technological insights, it suggested yeasts LAB, responsible fermentation must, might play key role transformation compounds. This would molecules with specific bioavailability bioactivity features, interact different molecular targets and, consequently, improve biological potential underexploited

Язык: Английский

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