Hormone Research in Paediatrics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 24
Published: Jan. 14, 2025
Background:
Childhood
obesity
has
become
a
global
pandemic
and
is
one
of
the
strongest
risk
factors
for
cardiovascular
disease
later
in
life.
The
correlation
epigenetic
marks
with
related
traits
being
elucidated.
This
review
summarizes
latest
research
its
challenges
study
epigenetics
(childhood)
obesity.
Summary:
Epigenome-wide
association
studies
helped
to
identify
novel
targets
methylation
sites
that
are
important
pathophysiology
In
future,
such
will
essential
developing
scores
(MRS)
metabolic
diseases.
Although
MRS
very
promising
predicting
individual
obesity,
implementation
challenging
not
been
introduced
into
clinical
practice
so
far.
Key
Messages:
Future
undoubtedly
discover
numerous
may
be
involved
development
comorbidities,
especially
at
young
age.
contribute
better
understanding
complex
etiology
human
From
perspective,
overarching
aim
generate
robust
reliable
accurate
prediction
comorbidities.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(10), P. 8874 - 8874
Published: May 17, 2023
Curcumin
is
the
principal
curcuminoid
found
in
rhizomes
of
turmeric.
Due
to
its
therapeutic
action
against
cancer,
depression,
diabetes,
some
bacteria,
and
oxidative
stress,
it
has
been
used
widely
medicine
since
ancient
times.
low
solubility,
human
organism
cannot
completely
absorb
it.
Advanced
extraction
technologies,
followed
by
encapsulation
microemulsion
nanoemulsion
systems,
are
currently
being
improve
bioavailability.
This
review
discusses
different
methods
available
for
curcumin
from
plant
material,
identification
resulting
extracts,
beneficial
effects
on
health,
techniques
into
small
colloidal
systems
that
have
over
past
decade
deliver
this
compound.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(10), P. 3291 - 3291
Published: May 20, 2022
(1)
Background:
Dyes
play
an
important
role
in
food,
medicine,
textile,
and
other
industries,
which
make
human
life
more
colorful.
With
the
increasing
demand
for
food
safety,
development
of
natural
dyes
becomes
attractive.
(2)
Methods:
The
literature
was
searched
using
electronic
databases
PubMed,
Web
Science,
SciFinder
this
scoping
review
carried
out
following
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
(PRISMA).
(3)
Results:
248
articles
were
included
review.
This
summarizes
research
progress
on
last
ten
years.
According
to
structural
features,
mainly
include
carotenoids,
polyphenols,
porphyrins,
alkaloids,
some
newest
are
summarized.
Some
pharmacological
activities
anthocyanin,
curcumin,
betalains
10
years
summarized,
biological
effects
regarding
illumination
conditions.
disadvantages
dyes,
including
sources,
cost,
stability,
poor
bioavailability,
limit
their
application.
Here,
feasible
strategies
(potential
resources,
biotechnology,
new
extraction
separation
strategies,
improving
stability)
described,
will
contribute
utilization
dyes.
(4)
Conclusion:
Natural
show
health
benefits
potential
additives.
However,
it
is
necessary
pass
toxicity
tests
quality
receive
many
regulatory
approvals
before
final
entry
into
market
as
colorants
or
drugs.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3617 - 3617
Published: March 23, 2024
Curcumin
is
a
polyphenolic
molecule
derived
from
the
rhizoma
of
Curcuma
longa
L.
This
compound
has
been
used
for
centuries
due
to
its
anti-inflammatory,
antioxidant,
and
antimicrobial
properties.
These
make
it
ideal
preventing
treating
skin
inflammation,
premature
ageing,
psoriasis,
acne.
Additionally,
exhibits
antiviral,
antimutagenic,
antifungal
effects.
provides
protection
against
damage
caused
by
prolonged
exposure
UVB
radiation.
It
reduces
wound
healing
times
improves
collagen
deposition.
Moreover,
increases
fibroblast
vascular
density
in
wounds.
review
summarizes
available
information
on
therapeutic
effect
curcumin
diseases.
The
results
suggest
that
may
be
an
inexpensive,
well-tolerated,
effective
agent
However,
larger
clinical
trials
are
needed
confirm
these
observations
limitations
vivo
use,
such
as
low
bioavailability
after
oral
administration
metabolism.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2721 - 2721
Published: Aug. 15, 2024
Aging-related
disorders
pose
significant
challenges
due
to
their
complex
interplay
of
physiological
and
metabolic
factors,
including
inflammation,
oxidative
stress,
mitochondrial
dysfunction.
Curcumin,
a
natural
compound
with
potent
antioxidant
anti-inflammatory
properties,
has
emerged
as
promising
candidate
for
mitigating
these
age-related
processes.
However,
gaps
in
understanding
the
precise
mechanisms
curcumin’s
effects
optimal
dosages
different
conditions
necessitate
further
investigation.
This
systematic
review
synthesizes
current
evidence
on
potential
addressing
disorders,
emphasizing
its
impact
cognitive
function,
neurodegeneration,
muscle
health
older
adults.
By
evaluating
safety,
efficacy,
action
curcumin
supplementation,
this
aims
provide
insights
into
therapeutic
promoting
healthy
aging.
A
search
across
three
databases
using
specific
keywords
yielded
2256
documents,
leading
selection
15
clinical
trials
synthesis.
Here,
we
highlight
multifaceted
agent
combating
disorders.
The
findings
suggest
that
could
offer
effective
approach
enhancing
quality
life
aging
individuals.
Further
research
well-designed
are
essential
validate
optimize
use
personalized
medicine
approaches
conditions.
Aging-related
disorders
pose
significant
challenges
due
to
their
complex
interplay
of
physiological
and
metabolic
factors,
including
inflammation,
oxidative
stress,
mitochondrial
dysfunction.
Curcumin,
a
natural
compound
with
potent
antioxidant
anti-inflammatory
properties,
has
emerged
as
promising
candidate
for
mitigating
these
age-related
processes.
However,
gaps
in
understanding
the
precise
mechanisms
curcumin's
effects
optimal
dosages
different
conditions
necessitate
further
investigation.
This
systematic
review
synthesizes
current
evidence
on
potential
addressing
disorders,
emphasizing
its
impact
cognitive
function,
neurodegeneration,
muscle
health
older
adults.
By
evaluating
safety,
efficacy,
action
curcumin
supplementation,
this
aims
provide
insights
into
therapeutic
promoting
healthy
aging.
A
search
across
three
databases
using
specific
keywords
yielded
2,256
documents,
leading
selection
15
clinical
trials
synthesis.
Here
we
highlight
multifaceted
agent
combating
disorders.
The
findings
suggest
that
could
offer
effective
approach
enhancing
quality
life
aging
individuals.
Further
research
well-designed
are
essential
validate
optimize
use
personalized
medicine
approaches
conditions.
Drug Design Development and Therapy,
Journal Year:
2025,
Volume and Issue:
Volume 19, P. 2411 - 2432
Published: April 1, 2025
Objective:
To
evaluate
the
therapeutic
potential
of
curcumin
analog
J7
in
protecting
liver
and
regulating
glucose
lipid
metabolism
rats
with
type
2
diabetes.
Methods:
Bioinformatics
methods
were
used
to
identify
signaling
pathways
linked
diabetic
disease.
Diabetic
treated
curcumin,
low-dose
J7,
or
high-dose
function
fibrosis
assessed
through
biochemical
analyses,
histopathology,
immunohistochemistry,
ELISA.
Results:
administration
significantly
improved
lisver
function,
reduced
fibrosis,
regulated
metabolic
profiles
rats.
downregulated
TGF-β
1,
NF-κB
p65,
BAX,
while
upregulating
BCL-2,
showing
superior
effects
traditional
reducing
1
inhibiting
α-SMA
expression.
Conclusion:
demonstrates
as
a
agent
for
managing
complications
diabetes,
effectively
attenuating
modulation
key
proteins.
Plain
Language
Summary:
Diabetes
is
common
condition
that
can
cause
serious
problems
liver,
such
damage
scarring
(fibrosis).
These
are
how
body
handles
sugar
fat.
Right
now,
there
not
many
effective
treatments
diabetes-related
issues.
Our
study
looked
at
new
drug
called
which
based
on
natural
compound
found
turmeric,
see
if
it
could
help
protect
improve
fat
metabolism.
We
rat
model
diabetes
test
J7.
Rats
given
either
low
dose
high
then
measured
well
their
livers
working
examined
tissue
under
microscope.
also
levels
specific
molecules
involved
inflammation,
scarring,
cell
survival.
worked
better
than
regular
curcumin.
It
damage,
handled
fat,
lessened
scarring.
achieved
this
by
affecting
certain
biological
pathways,
like
TGF-β/Smad
pathway
signaling,
players
inflammation.
results
suggest
be
promising
treatment
people
This
highlights
improving
compounds
make
them
more
medicines.
Further
research
needed
explore
might
Keywords:
insulin
resistance,
dysfunction-associated
fatty
disease,
MAFLD,
analog,
pathway,
NF-κB-BCL-2/BAX
axis
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7146 - 7146
Published: April 12, 2023
Polyphenols
have
attracted
tremendous
attention
due
to
their
pro-health
properties,
including
antioxidant,
anti-inflammatory,
antibacterial
and
neuroprotective
activities.
Atherosclerosis
is
a
vascular
disorder
underlying
several
CVDs.
One
of
the
main
risk
factors
causing
atherosclerosis
type
quality
food
consumed.
Therefore,
polyphenols
represent
promising
agents
in
prevention
treatment
atherosclerosis,
as
demonstrated
by
vitro,
animal,
preclinical
clinical
studies.
However,
most
cannot
be
absorbed
directly
small
intestine.
Gut
microbiota
play
crucial
role
converting
dietary
into
absorbable
bioactive
substances.
An
increasing
understanding
field
has
confirmed
that
specific
GM
taxa
strains
mediate
gut
microbiota–atherosclerosis
axis.
The
present
study
explores
anti-atherosclerotic
properties
associated
mechanisms
polyphenols.
Moreover,
it
provides
basis
for
better
relationship
between
polyphenols,
microbiota,
cardiovascular
benefits.
